Author: Jessica.F

Yadav, Kumar Karitkey published the artcileCopper(II) phthalocyanine as an efficient and versatile catalyst for click reactions at room temperature, Recommanded Product: Phthalonitrile, the main research area is copper phthalocyanine catalyst benzyl halide one pot click reaction.

Herein, we report the efficient synthesis of copper(II) phthalocyanines in the presence of DBU as a strong base. These synthesized copper(II) phthalocyanines are utilized as a catalyst for the click reactions of sensitive compounds including metal-free porphyrins under mild reaction conditions at room temperature Further, we have developed a one-pot procedure for the click reactions of benzyl halides with different alkynes in good to excellent yields. The reaction proceeds at room temperature to 40°C and gives 83-99% of products. The reactions are carried out in DMSO solvent. The present reaction condition offers copper(II) phthalocyanines as an efficient and convenient catalyst for different electron-rich and electron-deficient substrates including macrocyclic compounds Electron-deficient substrates and less steric substrates provide a better result. The catalyst is easily separated from the reaction by a simple filtration technique and is reused up to 5 times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Alkynes Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mahmoudi, Boshra published the artcileOxidation/ MCR domino protocol for direct transformation of methyl benzene, alcohol, and nitro compounds to the corresponding tetrazole using a three-functional redox catalytic system bearing TEMPO/Co(III)-porphyrin/ Ni(II) complex, Product Details of C6H4N2, the main research area is alc methylbenzene nitro compound conversion tetrazole oxidation multicomponent domino; safety sodium azide.

A redox catalytic system for oxidation-reduction reactions and the domino preparation of tetrazole compounds from nitro and alc. precursors was designed, prepared and characterized by UV-vis, GPC, TGA, XRD, EDX, XPS, VSM, FE-SEM, TEM, DLS, BET, NMR, and ICP analyses [e.g., toluene → 5-phenyl-1H-tetrazole and nitrobenzene → 1-phenyl-1H-tetrazole]. The catalyst was prepared via several successive steps by demetalation of chlorophyll b, Schiff base formation with allylamine, copolymerization with acrylated TEMPO monomers, complexation with Ni and Co metals (in two different steps), then immobilized on magnetic nanoparticles. The presence of three functional groups including TEMPO, coordinated cobalt, and coordinated nickel in the catalyst, allowed the oxidation of various types of alcs., alkyl benzenes as well as the reduction of nitro compounds by a single catalyst. All reactions yielded up to 97% selectivity for oxidation and reduction reactions. Next, the ability of the catalyst to successfully convert benzylic alcs., methylbenzenes and nitro compounds to their corresponding tetrazoles was studied. Safety: extreme caution is required when handling sodium azide.

Molecular Catalysis published new progress about Alkylbenzenes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sathishkumar, Pushpanathan N. published the artcileTuning acylthiourea ligands in Ru(II) catalysts for altering the reactivity and chemoselectivity of transfer hydrogenation reactions, and synthesis of 3-isopropoxy-1H-indole through a new synthetic approach, Synthetic Route of 1885-29-6, the main research area is ruthenium cymene complex preparation crystal structure; carbonyl compound ruthenium cymene complex catalyst chemoselective transfer hydrogenation; alc preparation; nitroarene ruthenium cymene complex catalyst chemoselective transfer hydrogenation; arylamine preparation.

Ru(II)-p-cymene complexes containing picolyl based pseudo-acylthiourea ligands were synthesized and characterized. The crystallog. study confirmed the mol. structures of all the ligands and one complex. The catalytic activity of the complexes was tested mainly towards transfer hydrogenation of carbonyl compounds and nitroarenes. The influence of steric and electronic effects of the ligands on the chemoselectivity and reactivity were reported. The catalytic activity was enhanced and chemoselectivity was switched after tuning the ligands in the catalysts, compared to their corresponding unmodified Ru(II)-p-cymene complexes. The catalysis was extended to a broad range of substrates including some challenging systems like furfural, benzoylpyridine, benzoquinone, chromanone, etc. The strategy of tuning the bifunctional ligands in the catalysts for effective and selective catalysis worked nicely. Further, the catalysis was extended to one-pot synthesis of 3-isopropoxyindole from 2-nitrocinnamaldehyde, the first synthetic route similar to Baeyer Emmerling indole synthesis. All the catalytic experiments exhibited high conversion and selectivity.

Journal of Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cao, Zhenyu published the artcileSynthesis of 2-pyridyl oxazoline esters and their organocatalytic application to the enantioselective silane reduction of ketones, Category: nitriles-buliding-blocks, the main research area is pyridyl oxazoline ester chiral preparation organocatalyst; chiral alc preparation enantioselective; ketone reduction organocatalyst.

The synthesis of a number of novel chiral 2-pyridyl oxazoline esters I (R = Me, (2R)-2-methylbutanoyl, (pyridin-2-yl)carbonyl, (naphthalen-1-yl)carbonyl, etc.) is reported along with the use of these in the enantioselective organocatalytic reduction of ketones 4-R1C6H4C(O)CH3 (R1 = H, methyl). The chiral alcs. 4-R1C6H4CH(OH)CH3 were prepared in good to excellent yields (up to 99%) and found to catalyze the reduction reactions with good conversions (up to 99%) and in moderate to good enantioselectivities (up to 65% at high conversion and 70% with lower reactivity). The results give an insight into the effects of the catalyst structure on the selectivity observed in the reaction.

ARKIVOC (Gainesville, FL, United States) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Zhen-Yu published the artcilePerfluorobutyl Iodide Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-ones, Formula: C7H6N2, the main research area is indolinone preparation; tertiary aminoaryl ketone Stevens rearrangement perfluorobutyl iodide mediated.

The tertiary amine and ketone components of 1-carbonyl-substituted anilines underwent [1,2] and [2,3] Stevens rearrangement reactions, triggered by a C4F9 radical, formed from electron donor-acceptor complexes. This approach enabled the formation of a quaternary ammonium salt and thus a Stevens rearrangement to afford indolin-3-ones such as I [R1 = Me, Et, i-Pr; R2 = Bn, CH2CH=CH2, C(Me)=C=CH2, etc.; R3 = Me, Bn] and II [R4 = H, Cl, Br; R5 = H, MeO, Cl; R6 = H, MeO] under mild conditions.

Advanced Synthesis & Catalysis published new progress about Indolines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mao, Jianyou published the artcileSynthesis of Indoles through Domino Reactions of 2-Fluorotoluenes and Nitriles, Related Products of nitriles-buliding-blocks, the main research area is fluorotoluene nitrile tandem nucleophilic aromatic substitution heterocyclization; indole preparation; 2-fluorotoluenes; domino reactions; indoles; nitrogen heterocycles.

A straightforward, practical, and transition-metal-free assembly of 2-aryl indoles was reported. Simply combining readily available 2-fluorotoluenes, nitriles, LiN(SiMe3)2, and CsF enabled the generation of a diverse array of indoles (38 examples, 48-92 % yield). A range of substituents can be introduced into each position of the indole backbone (C4 to C7, and aryl groups at C2), providing handles for further elaboration.

Angewandte Chemie, International Edition published new progress about Aryl fluorides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rahimzadeh, Golnaz published the artcileImprovement of the Van Leusen reaction in the presence of β-cyclodextrin as a green and efficient catalyst for synthesis of oxazoles in water, Quality Control of 87150-13-8, the main research area is tosylmethylisocyanide aryl aldehyde reusable cyclodextrin green Van Leusen heterocyclization; aryl oxazole preparation.

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin was described. In aqueous medium using β-cyclodextrin as a supramol. catalyst, tosylmethyl isocyanide was deprotonated by triethylamine and subsequently underwent an addition/cyclization reaction with aldehydes to produce corresponding oxazoles in excellent yields. This protocol improved the Van Leusen reaction with the use of catalytic amounts of base at low temperature in green media.

Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Quality Control of 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dutta, Apurba published the artcileGemini basic ionic liquid as bi-functional catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones at room temperature, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is reusable butanediyl bisdodecylmorpholinium hydroxide preparation thermal stability; cyanoaniline carbonyl compound butanediyl bisdodecylmorpholinium hydroxide tandem condensation; dihydroquinazolinone preparation green chem.

A cascade synthesis of 2,3-dihydroquinazolin-4(1H)-ones was developed from 2-aminobenzonitriles and carbonyl analogs using Gemini basic ionic liquid as green catalyst cum solvent at room temperature Both aldehydes and ketones were condensed with 2-aminobenzonitriles affording good to excellent yields of products. Moreover, the ionic liquids was reused up to 5th cycle without significant loss of catalytic activity.

Tetrahedron Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghanbari, Zahra published the artcileDiastereoselective Synthesis of Some Spiroheterocycles Using Base Reusable Heterogeneous Achiral Nanocatalyst in Aqueous Media, Application In Synthesis of 91-15-6, the main research area is silica coat nickel ferrite support tetrazole preparation thermal stability; aryl aldehyde dione tetrazol catalyst Knoevenagel condensation green chem; spiropyrimidinequinazoline diastereoselective preparation.

This research was based on the synthesis of some new diastereoselective spiroheterocycles relying on the application of nanocatalysts designed from the functionalized magnetic nanoparticles with tetrazole. Also, the achievement of suitable product with stereopurity through base catalytic path. Water as a green solvent, NiFe2O4 magnetic nanoparticles as a separable and reusable catalyst and using simple and high efficiency method were some important advantages of this research.

ChemistrySelect published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nikpassand, M. published the artcileNovel Route for the Synthesis of 2-Arylquinazolinones Using Magnetic Nanocomposite of Multiwalled Carbon Nanotube, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone preparation green chem; aryl aldehyde aminobenzonitrile multiwalled carbon nanotube catalyst multicomponent.

A series of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones have been synthesized in excellent yields and short reaction time by one-pot reaction of 2-aminobenzonitrile, ammonium hydroxide, and substituted benzaldehydes or 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes in the presence of magnetic multiwalled carbon nanotube (mMWCNT) nanocomposite as a recoverable catalyst at room temperature The proposed methodol. offers several advantages such as mild reaction conditions, green media, excellent yields, simple procedure, and reduced environmental impact. Moreover, the catalyst can be easily recovered using an external magnet and recycled for 5 runs without significant loss of its catalytic activity. The structure of most of the synthesized 2-aryl-2,3-dihydroquinazolin-4(1H)-ones was confirmed by 1H and 13C NMR and FTIR spectra and elemental analyses.

Russian Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts