Author: Jessica.F

Shackelford, Scott A. published the artcileElectrophilic tetraalkylammonium nitrate nitration. II. Improved anhydrous aromatic and heteroaromatic mononitration with tetramethylammonium nitrate and triflic anhydride, including selected microwave examples, HPLC of Formula: 5653-62-3, the main research area is nitration aromatic heteroaromatic tetramethylammonium nitrate trifluoromethanesulfonic anhydride; microwave nitration aromatic heteroaromatic tetramethylammonium nitrate.

A new one-pot nitration employing tetramethylammonium nitrate and trifluoromethanesulfonic anhydride in dichloromethane to provide a ready source of the nitronium triflate nitrating agent is presented. Rapid and selective nitration with a variety of aromatic and heteroaromatic substrates is achieved resulting in the synthesis of several novel organic compounds A distinct advantage is the removal of undesired byproducts by aqueous workup. This very mild nitration permits large-scale syntheses and gives high isolated product yields that often require no further purification This tetramethylammonium nitrate-based nitration also has been applied to microwave-assisted conditions, and the results with several compounds are outlined.

Journal of Organic Chemistry published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, HPLC of Formula: 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shackelford, Scott A. published the artcileElectrophilic tetraalkylammonium nitrate nitration. II. Improved anhydrous aromatic and heteroaromatic mononitration with tetramethylammonium nitrate and triflic anhydride, including selected microwave examples. [Erratum to document cited in CA138:169603], Quality Control of 5653-62-3, the main research area is erratum nitration aromatic heteroaromatic tetramethylammonium nitrate trifluoromethanesulfonic anhydride; microwave nitration aromatic heteroaromatic tetramethylammonium nitrate erratum.

The correct structure of product 37b in Table 5 on page 271 is given. On page 274, the last sentence before the Exptl. Section should read, “”One known compound was obtained for the first time by direct nitration, and…””. On page 2 in the last sentence of the Supporting Information and on page 3 in line 2 of the Supporting Information, “”(431 mmol)”” should be “”(4310 mmol)””.

Journal of Organic Chemistry published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Quality Control of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xue, Gaijun published the artcileCopper-Catalyzed Oxidative C-C Bond Cleavage of Alkyl-(Hetero)arenes Enabling Direct Access to Nitriles, Safety of Picolinonitrile, the main research area is aryl nitrile preparation copper catalyst; alkyl hetero arene oxidative carbon bond cleavage cyanation.

The cleavage and functionalization of C-C bonds has emerged as a powerful tool for discovery of new transformations. Herein, authors report a protocol that enables direct synthesis of nitriles via copper-catalyzed oxidative cleavage and cyanation of C-C bonds in a wide variety of multicarbon alkyl-substituted (hetero)arenes. Detailed mechanistic studies reveal that a tandem oxidative process is involved in this transformation.

Organic Letters published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Garcia-Alvarez, Rocio published the artcileArene-Ruthenium(II) Complexes Containing Inexpensive Tris(dimethylamino)phosphine: Highly Efficient Catalysts for the Selective Hydration of Nitriles into Amides, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is ruthenium aminophosphine sandwich complex preparation catalyst hydration nitrile; areneruthenium aminophosphine sandwich complex preparation crystal structure hydration catalyst; mol structure areneruthenium aminophosphine sandwich complex; amide aromatic preparation.

The catalytic hydration of nitriles into amides, in H2O under neutral conditions, was studied using arene-Ru(II) derivatives containing the com. available and inexpensive ligand tris(dimethylamino)phosphine. Among them, best results were obtained with [RuCl2(η6-C6Me6){P(NMe2)3}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11,400 h-1). The process was operative with both aromatic, heteroaromatic, aliphatic, and α,β-unsaturated organonitriles and showed a high functional group tolerance. The stability of [RuCl2(η6-C6Me6){P(NMe2)3}] in H2O was evaluated, observing its progressive decomposition into the less-active dimethylamine-Ru(II) complex [RuCl2(η6-C6Me6)(NHMe2)] by hydrolysis of the coordinated P(NMe2)3 ligand. The x-ray crystal structure determination of the toluene complex [RuCl2(η6-C6H5Me){P(NMe2)3}] is also included.

Organometallics published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muddagoni, Narasimha published the artcileTin ( IV ) chloride catalyzed one-pot synthesis, characterization and docking studies of 4-aminoquinoline derivatives as Myt1 inhibitors, Formula: C7H6N2, the main research area is amino benzonitrile aryl methanone tin chloride catalyst heterocyclization; aryl aminoquinoline preparation mol docking.

An efficient and practical method for the series of 4-aminoquinoline derivatives I [R = 3-cyanophenyl, 2,3-dihydro-1H-inden-5-yl, 5-chlorothiophen-2-yl, etc.; R1 = H, Cl] was developed via Tin (lV) chloride catalyzed cascade cyclization from 2-aminobenzonitrile and different acetophenones. These novel chem. entities I were characterized by their 1HNMR, 13CNMR spectra and high-resolution mass spectrometer (HRMS) with their docking studies were performed to identify potential inhibitors of Myt1kinase protein. The synthesized analogs I were docked with Myt1 kinase protein. Among these, compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] were showing promising Glide score, prime-MMGBSA and ADME properties similar to Neratinib, Pelitinib cancer inhibiting drugs of Myt1 kinase protein. The amino acid ASP251of Myt1 kinase protein was consistently binding to novel chem. entities I and existing drugs, indicating that the amino acid is crucial and responsible for its inhibition. Docking studies revealed that the compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] indicated that they can act as strong inhibitors of Myt1 kinase protein as that of comparable existing drugs Neratinib, Pelitinib.

Journal of Heterocyclic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chintawar, Chetan C. published the artcileEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands, Computed Properties of 1885-29-6, the main research area is oxychroman preparation enantioselective DFT; iodoaryl alkene alc oxyarylation gold catalyst; aminochroman preparation enantioselective DFT; aromatic amine iodoaryl alkene aminoarylation gold catalyst.

The enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos) e.g., I was reported. The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes 2-I-3-R1-4-R2-5-R3-6-R4C6OCH2CH=CH2 (R1 = H; R2 = H, F, Me, NO2, etc.; R1R2 = -CH=CHCH=CH-; R3 = H, OMe, C(O)OMe, CF3; R4 = H, Me, OMe) which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans II [R5 = H, Me, Et, i-Pr, (2-bromophenyl)methyl] III (R6 = 4-nitrophenyl, 4-bromo-2-nitrophenyl, 3-cyanothiophen-2-yl, etc.) (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-sym. chiral environment present around nitrogen, imparting a high level of enantioselectivity.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (iodoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Safety of Picolinonitrile, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Synthetic Route of 1885-29-6, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kong, Xianqiang published the artcileCyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds, Product Details of C6H4N2, the main research area is trimethylammonium salt tosyl cyanide chemoselective electrocatalytic cyanation; nitrile preparation; azido methylbutenol trimethylammonium salt chemoselective electrocatalytic cyanomethylation; acetonitrile preparation.

A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiong, Hao published the artcileThe Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones, Product Details of C7H6N2, the main research area is aminoacetophenone tosylhydrazone carbon dioxide fixation carbene insertion reaction; dihydrobenzoxazinone preparation.

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- mol. insertion of hydroxyl to carbene.

Advanced Synthesis & Catalysis published new progress about Benzoxazinones Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts