Author: Jessica.F

Condensation of 3-methyl-6-nitrobenzonitrile and 3-methyl-6-nitrobenzamide with benzaldehyde was written by Macovski, Eugen;Georgescu, Julia. And the article was included in Trav. lab. chim. biol., Faculté sci., Univ. Bucarest in 1946.Recommanded Product: 64113-86-6 This article mentions the following:

Nitration of m-MeC₆H₄CN gives a mixture of 3-methyl-6-nitrobenzonitrile (I), m. 92°, and isomeric nitro compounds removable by steam distillation The distillate with KOH-H₂O₂ gives 3-methyl-2-nitrobenzamide (II), m. 192°, and 3-methyl-5-nitrobenzamide (III), m. 166°. Heating II with BzH 2 hrs. at 160° gives N,N’-benzylidenebis(3-methyl-2-nitrobenzamide), m. 243°; III gives N,N’-benzylidenebis(3-methyl-5-nitrobenzamide), m. 235-7°. I with KOH-H₂O₂ gives 3-methyl-6-nitrobenzamide (IV), m. 176-7°, not hydrolyzed by alc. NaOMe at 37°. BzH converts IV into N,N’-benzylidenebis(3-methyl-6-nitrobenzamide), m. 263°. IV with BzH in the presence of piperidine at 160° gives 3-carbamyl-4-nitrostilbene (V), m. 241°; hydrolysis of 3-cyano-4-nitrostilbene by KOH-H₂O₂ and condensation of IV with BzH in the presence of NaOEt at 37° also give V. In the experiment, the researchers used many compounds, for example, 5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6Recommanded Product: 64113-86-6).

5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 64113-86-6

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Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization was written by Nguyen, Huy H.;Fettinger, James C.;Haddadin, Makhluf J.;Kurth, Mark J.. And the article was included in Tetrahedron Letters in 2015.Computed Properties of C8H5F3N2 This article mentions the following:

A transition metal-free one-pot protocol for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines I [R¹ = 9-Me, 9-Cl, 8,9-(MeO)₂, etc.; R² = H, 2-F, 2-MeO] via the atom economical annulation of Et (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides was developed. This mild and efficient method proceeds via sequential N-alkylation and base-promoted cyclization. Furthermore, optimization data, substrate scope, mechanistic insights and photoluminescence properties were also discussed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Computed Properties of C8H5F3N2).

2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Computed Properties of C8H5F3N2

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Platinum Assisted Tandem P-C Bond Cleavage and P-N Bond Formation in Amide Functionalized Bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o: Synthesis, Mechanistic, and Catalytic Studies was written by Kunchur, Harish S.;Balakrishna, Maravanji S.. And the article was included in Inorganic Chemistry in 2022.Computed Properties of C14H12N2 This article mentions the following:

The reactions of amide functionalized bisphosphine o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o (1) with Pt salts is described. Treatment of 1 with [Pt(COD)Cl₂] yielded a chelate complex, [PtCl₂{o-Ph₂PC₆H₄C(O)N(H)C₆H₄PPh₂-o}κ²-P,P] (2), which on subsequent treatment with LiHMDS formed a novel 1,2-azaphospholene-phosphine complex [PtPhCl{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (3) involving a tandem P–C bond cleavage and P-N bond formation. The same complex 3 on passing dry HCl gas afforded dichloro-complex [PtCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (5). Complex 2 upon refluxing in toluene or treatment of 1 with [Pt(COD)Cl₂] in the presence of a base at room temperature resulted in pincer complex [PtCl{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (4). Reaction of 1 with [Pt(COD)ClMe] at room temperature also afforded the pincer complex [PtMe{o-Ph₂PC₆H₄C(O)N(C₆H₄PPh₂-o)}κ³-P,N,P] (6). Mechanistic studies on 1,2-azaphospholene formation showed the reductive elimination of LiCl to form a phosphonium salt that readily adds one of the P-C bonds oxidatively to the in situ generated Pt⁰ species to form a chelate complex 3. Analogous Pd complex [PdCl₂{o-C₆H₄{C(O)N(o-PPh₂(C₆H₄))P(Ph)}}κ²-P,P] (7) showed excellent catalytic activity toward N-alkylation of amines with alcs. with a very low catalyst loading (0.05 mol %), and the methodol. is very efficient toward the gram scale synthesis of many N-alkylated amines. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Computed Properties of C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Computed Properties of C14H12N2

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Synthesis of substituted thieno[2,3-b]pyrroles was written by Wei, Hongtao;Cai, Jin;Sun, Min;Ji, Min. And the article was included in Heteroatom Chemistry in 2007.Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate This article mentions the following:

Thieno[2,3-b]pyrroles were synthesized through three steps: Gewald synthesis, alkylation, and Thorpe-Ziegler cyclization. Di-Et 3,6-bis((ethoxycarbonyl)methyl)-4-amino-6H-thieno-[2,3-b]pyrrole-2,5- dicarboxylate was obtained by one-pot method in DMF in good yield and high quality. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Application In Synthesis of Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate

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N-Alkylation of aniline derivatives by use of potassium cation-exchanged Y-type zeolite was written by Onaka, Makoto;Umezono, Akihiro;Kawai, Motomitsu;Izumi, Yusuke. And the article was included in Journal of the Chemical Society, Chemical Communications in 1985.Formula: C14H12N2 This article mentions the following:

Zeolite K-Y effectively promoted the N-alkylation of p-RC₆H₄NH₂ (R = NO₂, CN, CO₂Et, H, Cl, Me) with R¹Br (R¹ = CH₂CH:CH₂, CH₂Ph) or Me₂SO₄ in PhMe or C₆H₆ at 50°-reflux for 5-15 h to give 55-90% yield of 3.9-50:1 mixtures of p-RC₆H₄NHR¹ and p-RC₆H₄NR¹₂ (R as before, R¹ = CH₂CH:CH₂, CH₂Ph, Me). Results were compared with those for the analogous γ-alumina-promoted alkylation. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Formula: C14H12N2

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Guanidine derivatives. XVI. Synthesis of alkylated 4-alkoxyphenylacetonitriles and substituted guanidines was written by Ovsepyan, T. R.;Petrosyan, A. S.;Aroyan, A. A.. And the article was included in Armyanskii Khimicheskii Zhurnal in 1973.Recommanded Product: 5351-07-5 This article mentions the following:

4-ROC6H4CR1R2CN (I; R,R2 = Me, Et, Pr; R1 = H, Me, Et, Pr) were prepared (38.3-70.2%) by the reaction of 4-ROC6H4CH2CN with NaNH2 and the corresponding R1X and R2X (X = halo). Catalytic reduction of I over Ni-Cr2O3 gave 64.2-85.5% 4-ROC6H4CR1R2CH2NH2 (II). Reaction of II with MeSC(:NH)NH2.5H2SO4 gave, 36.7-74.1% 4-ROC6H4CR1R2CH2NHC(:NH)NH2.5H2SO4. 4-ROC6H4CH2NHCSNHNHC(:NH)NH2.HNO3 (R = Me, Et, Pr) were prepared (13.9-19.0%) by the reaction of 4-ROC6H4CH2NCS with H2NNHC(:NH)NH2.HNO3. In the experiment, the researchers used many compounds, for example, 2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5Recommanded Product: 5351-07-5).

2-(4-Methoxyphenyl)-2-methylpropanenitrile (cas: 5351-07-5) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 5351-07-5

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Quantum chemistry calculations of 2-aminopyrimidine-5-carbonitrile Dye sensitizer for solar cells was written by Arul, S.;Senthilnathan, T.. And the article was included in Journal of Ultra Chemistry in 2017.Name: 2-Aminopyrimidine-5-carbonitrile This article mentions the following:

Quantum chem. calculations of energies, geometries, electronic structures, polarizabilities, and hyperpolarizabilities of organic dye sensitizer 2-aminopyrimidine-5-carbonitrile were studied based on ab initio HF and D. Functional Theory (DFT) using the hybrid functionals B3LYP. UV-visible (UV-Vis) spectrum was investigated by Time Dependent DFT (TDDFT). Features of the electronic absorption spectrum in the visible and near-UV regions were assigned based on TDDFT calculations The electronic absorption bands are assigned to π→π* transitions. Calculated results suggest that the three excited states with the lowest excited energies in 2-aminopyrimidine-5-carbonitrile is due to photo induced electron transfer processes. The interfacial electron transfer between semiconductor TiO₂ electrode and dye sensitizer 2-aminopyrimidine-5-carbonitrile is due to an electron injection process from excited dye to the semiconductor’s conduction band. The role of amine and nitrile group in 2-aminopyrimidine-5-carbonitrile geometries, electronic structures, and electronic absorption spectra were analyzed in Dye sensitizer solar cell (DSSC) give good conversion efficiency. In the experiment, the researchers used many compounds, for example, 2-Aminopyrimidine-5-carbonitrile (cas: 1753-48-6Name: 2-Aminopyrimidine-5-carbonitrile).

2-Aminopyrimidine-5-carbonitrile (cas: 1753-48-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Name: 2-Aminopyrimidine-5-carbonitrile

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Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin was written by Sviripa, Vitaliy M.;Burikhanov, Ravshan;Obiero, Josiah M.;Yuan, Yaxia;Nickell, Justin R.;Dwoskin, Linda P.;Zhan, Chang-Guo;Liu, Chunming;Tsodikov, Oleg V.;Rangnekar, Vivek M.;Watt, David S.. And the article was included in Organic & Biomolecular Chemistry in 2016.Product Details of 3218-45-9 This article mentions the following:

Advanced prostate tumors usually metastasize to the lung, bone, and other vital tissues and are resistant to conventional therapy. Prostate apoptosis response-4 protein (Par-4) is a tumor suppressor that causes apoptosis in therapy-resistant prostate cancer cells by binding specifically to a receptor, Glucose-regulated protein-78 (GRP78), found only on the surface of cancer cells. 3-Arylquinolines or “arylquins” induce normal cells to release Par-4 from the intermediate filament protein, vimentin and promote Par-4 secretion that targets cancer cells in a paracrine manner. A structure-activity study identified arylquins that promote Par-4 secretion, and an evaluation of arylquin binding to the hERG potassium ion channel using a [³H]-dofetilide binding assay permitted the identification of structural features that separated this undesired activity from the desired Par-4 secretory activity. A binding study that relied on the natural fluorescence of arylquins and that used the purified rod domain of vimentin (residues 99-411) suggested that the mechanism behind Par-4 release involved arylquin binding to multiple sites in the rod domain. In the experiment, the researchers used many compounds, for example, 2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9Product Details of 3218-45-9).

2-(2,3-Dichlorophenyl)acetonitrile (cas: 3218-45-9) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Product Details of 3218-45-9

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Superacidic Cyclization of Activated Anthranilonitriles into 2-Unsubstituted-4-aminoquinolines was written by Lavrard, Hubert;Larini, Paolo;Popowycz, Florence. And the article was included in Organic Letters in 2017.Category: nitriles-buliding-blocks This article mentions the following:

4-Aminoquinolines were prepared in a three-step synthesis starting from substituted anthranilonitriles. The condensation on 1,1,1-trichloro-4-ethoxybut-3-enone proceeded efficiently either neat or in refluxing EtOH. Cyclization in superacidic trifluoromethanesulfonic acid provided unstable intermediate, which upon treatment with NaOEt in ethanol, afforded the expected esters. Theor. investigations pointed out a monoprotonated nitrilium as the reactive species during the cyclization process. In the experiment, the researchers used many compounds, for example, 2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5Category: nitriles-buliding-blocks).

2-Amino-3,5-dibromobenzonitrile (cas: 68385-95-5) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Category: nitriles-buliding-blocks

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Thienopyridines: nitric oxide synthase inhibitors with potent In vivo activity was written by Beaton, H.;Boughton-Smith, N.;Hamley, P.;Ghelani, A.;Nicholls, D. J.;Tinker, A. C.;Wallace, A. V.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Related Products of 55406-13-8 This article mentions the following:

5-Substituted 7-amino-4,5-tetrahydrothieno[2,3-c]pyridines and 6-substituted 4-amino-6,7-dihydrothieno[3,2-c]pyridines were shown to be exceptionally potent inhibitors of inducible and neuronal nitric oxide synthase. Selectivity and potency could be modulated by variation of the 5- or 6-substituent. In the experiment, the researchers used many compounds, for example, 3-Methylthiophene-2-carbonitrile (cas: 55406-13-8Related Products of 55406-13-8).

3-Methylthiophene-2-carbonitrile (cas: 55406-13-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Related Products of 55406-13-8

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Nitrile – Wikipedia,
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