Author: Jessica.F

Photolysis of 1-aryl-3,3-dialkyltriazenes was written by Lippert, Th.;Stebani, J.;Nuyken, O.;Stasko, A.;Wokaun, A.. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 1994.Reference of 4714-63-0 This article mentions the following:

The photolytic decomposition of substituted 1-phenyl-3,3-diethyl-triazenes has been studied using both pulsed XeCl^* excimer excitation at 308 nm, and continuous-wave irradiation with a xenon lamp. Electron-withdrawing substituents in the para position at the Ph ring are found to decrease both the quantum yield of photolysis and the apparent first-order rate constant of decomposition The reaction proceeds according to an overall one-step pathway; anal. of the photolysis products by gas chromatog.-mass spectrometry is consistent with a radical decomposition mechanism. For the compound 1-(4-nitrophenyl)-3,3-diethyl-triazene, an autocatalytic acceleration of the photolysis was observed during the continuous-wave irradiation, using a xenon lamp source. This phenomenon is analyzed in terms of an involvement of the nitro group: photoreduction of the latter functionality involves the creation of solvent radicals in comparatively large concentrations, which are detected by in-situ ESR experiments These radicals may attack and decompose further mols. of the starting material. In the experiment, the researchers used many compounds, for example, 4-(Ethylamino)benzonitrile (cas: 4714-63-0Reference of 4714-63-0).

4-(Ethylamino)benzonitrile (cas: 4714-63-0) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Reference of 4714-63-0

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2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro was written by Rodrigues, Klinger Antonio da Franca;Dias, Cinthia Nobrega de Sousa;Neris, Patricia Lima do Nascimento;Rocha, Juliana da Camara;Scotti, Marcus Tullius;Scotti, Luciana;Mascarenhas, Sandra Rodrigues;Veras, Robson Cavalcante;Almeida de Medeiros, Isac;Keesen, Tatjana de Souza Lima;Bento de Oliveira, Tiago;Alves de Lima, Maria do Carmo;Balliano, Tatiane Luciano;Mendonca de Aquino, Thiago;Olimpio de Moura, Ricardo;Junior, Francisco Jaime Bezerra Mendonca;de Oliveira, Marcia Rosa. And the article was included in European Journal of Medicinal Chemistry in 2015.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:

This study evaluated the effects of 2-amino-thiophene derivatives on the promastigote and amastigote forms of Leishmania amazonensis and their possible mechanisms of action. Initially, the authors evaluated the antileishmanial activity of ten 2-amino-thiophene derivatives on promastigote and axenic amastigote forms of Leishmania amazonensis and their cytotoxicity against murine macrophages and human red blood cells. Three promising compounds were selected for studies of the cell death process using flow cytometry anal. and a DNA fragmentation assay. The effects of the compounds were assessed on intramacrophagic amastigotes, and the modulation of cytokine and NO production was investigated. All thiophene derivatives showed antileishmanial activity against promastigotes and axenic amastigotes with less toxicity for murine macrophages and human red blood cells. The best values were obtained for compounds containing a lateral indole ring. Docking studies suggested that these compounds played an important role in inhibiting trypanothione reductase (TryR) activity. The selected compounds SB-200, SB-44, and SB-83 induced apoptosis in promastigotes involving phosphatidylserine externalization and DNA fragmentation in a pattern similar to that observed for the pos. control. Addnl., SB-200, SB-44, and SB-83 significantly reduced the infection index of macrophages by the parasites; for compounds SB-200 and SB-83 this reduction was associated with increased TNF-α, IL-12, and NO levels. This study demonstrated the effective and selective action of 2-amino-thiophene derivatives against L. amazonensis, resulting in apoptosis-like cell death and immunomodulation in vitro. The results suggest that they are promising compounds for the development of new leishmanicidal drugs. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Recommanded Product: 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile

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Spectroscopic and theoretical studies of arylmethylenemalonodinitriles. I. Electronic spectra was written by Kaneti, J.;Vitanov, D.;Yuchnovski, I.;Yuritsin, V.. And the article was included in Izvestiya po Khimiya in 1978.Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile This article mentions the following:

The UV invisible absorption spectra of arylmethylene (aryl = substituted Ph, 1-naphthyl, 4-biphenylyl, 9-anthryl, etc.) of malonodinitrile are studied using PPP MO calculations The electronic spectra are similar to those of polyenes with the same mol. topol. The introduction of cyano groups in the conjugated system does not give rise to charge-transfer states. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 2-(Anthracen-9-ylmethylene)malononitrile

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A novel adenine-based zinc(II) metal-organic framework featuring the Lewis basic sites for heterogeneous catalysis was written by Zhang, Shixing;He, Hongming;Sun, Fuxing;Zhao, Nian;Du, Jianshi;Pan, Qinhe;Zhu, Guangshan. And the article was included in Inorganic Chemistry Communications in 2017.HPLC of Formula: 55490-87-4 This article mentions the following:

Metal-organic frameworks (MOFs), as a new sort of crystalline materials, have attracted lots of interest in many applications during the past decades. Recently, many efforts were focused on the development of MOFs as heterogeneous catalysis. The authors selected adenine (ad) and tetracarboxylic acid, 5,5′-(1,3,6,8-tetraoxobenzo[Imn] Li et al. (1999), He et al. (2016) phenanthroline-2,7-diyl)bis-1,3-benzenedicarboxylic acid (H₄L), as organic linkers to assemble with Zn(II) ions to construct a novel adenine-based porous MOF. There are three different inorganic clusters in the framework, including ZnO₂N₂, Zn₂O₂N₆, and ZnO₅N clusters. Interesting, the resultant porous MOF, [H₂NMe₂]·[Zn₄(L)_1.5(ad)₃(H₂O)₂]·4DMF, retains free amino groups in the framework, which can be served as Lewis basic sites to catalyze Knoevenagel condensation reaction. The catalytic study exhibits that the as-synthesized MOF with free amino groups can be used as heterogeneous catalysis with remarkable catalytic efforts and good recycle. CCDC 1501692. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4HPLC of Formula: 55490-87-4).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 55490-87-4

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Nitrile – Wikipedia,
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One-pot Reductive Amination of carbonyl Compounds with Nitro Compounds by Transfer Hydrogenation over Co-N_x as catalyst was written by Zhou, Peng;Zhang, Zehui. And the article was included in ChemSusChem in 2017.Formula: C14H12N2 This article mentions the following:

A new method was developed for the synthesis of secondary amines through the one-pot reductive amination of carbonyl compounds with nitro compounds using formic acid as the hydrogen donor over a heterogeneous non-noble-metal catalyst (Co-N_x/C-800-AT, generated by the pyrolysis of the cobalt phthalocyanine/silica composite at 800° under a N₂ atmosphere and subsequent etching by HF). Both nitrogen and cobalt were of considerable importance in the transfer hydrogenation reactions with formic acid. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Formula: C14H12N2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries was written by Hansen, Eric C.;Pedro, Dylan J.;Wotal, Alexander C.;Gower, Nicholas J.;Nelson, Jade D.;Caron, Stephane;Weix, Daniel J.. And the article was included in Nature Chemistry in 2016.Computed Properties of C7H6N2O This article mentions the following:

Ligands are essential for controlling the reactivity and selectivity of reactions catalyzed by transition metals. Access to large phosphine ligand libraries has become an essential tool for the application of metal-catalyzed reactions industrially, but these existing libraries are not well suited to new catalytic methods based on non-precious metals (for example, Ni, Cu and Fe). The development of the requisite nitrogen- and oxygen-based ligand libraries lags far behind that of the phosphines and the development of new libraries is anticipated to be time consuming. Here we show that this process can be dramatically accelerated by mining for new ligands in a typical pharmaceutical compound library that is rich in heterocycles. Using this approach, we were able to screen a structurally diverse set of compounds with minimal synthetic effort and identify several new ligand classes for nickel-catalyzed cross-electrophile coupling. These new ligands gave improved yields for challenging cross-couplings of pharmaceutically relevant substrates compared with those of those of previously published ligands. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Computed Properties of C7H6N2O).

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile carbon shifts are in the range of 115�25 ppm whereas in isonitriles the shifts are around 155�65 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Computed Properties of C7H6N2O

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Study of the microwave-assisted hydrolysis of nitriles and esters and the implementation of this system in rapid microwave-assisted Pd-catalyzed amination was written by Van Baelen, Gitte;Maes, Bert U. W.. And the article was included in Tetrahedron in 2008.Name: 4-(Benzylamino)benzonitrile This article mentions the following:

Microwave-assisted hydrolysis of benzonitriles and Me benzoates has been studied using a toluene/concentrated aqueous KOH two phase system in the presence and absence of phase transfer catalyst. Conditions to allow and avoid smooth hydrolysis could be identified. Based on the latter, the first microwave protocol which allows the rapid Pd-catalyzed amination of aliphatic amines with chlorobenzenes containing sensitive functional groups has been developed. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Name: 4-(Benzylamino)benzonitrile).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Name: 4-(Benzylamino)benzonitrile

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Heterometallic coordination polymers: syntheses, structures and heterogeneous catalytic applications was written by Bansal, Deepak;Pandey, Saurabh;Hundal, Geeta;Gupta, Rajeev. And the article was included in New Journal of Chemistry in 2015.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile This article mentions the following:

A metalloligand Na[Co(L)₂] (1) of the ligand H₂L (N²,N⁶-bis(4,5-dihydrothiazol-2-yl)pyridine-2,6-dicarboxamide) offering appended thiazoline rings has been used for the synthesis of one-dimensional {Co³⁺L₂Zn²⁺(H₂O)₂}·ClO₄ (2), {Co³⁺L₂Cd²⁺}·ClO₄ (3) and {Co³⁺L₂Hg²⁺Cl} (4) coordination polymers. 1 Offers appended thiazoline rings having both soft sulfur and hard nitrogen donors. The crystal structures of 2 and 3 display the coordination of hard thiazoline-N donors to Zn²⁺ and Cd²⁺ ions. 4 Illustrates the bonding through both hard thiazoline-N and soft thiazoline-S donors. The three heterometallic coordination polymers have been used as reusable heterogeneous catalysts for the ring-opening reactions of oxiranes and thiairanes; Knoevenagel condensation of benzaldehydes and benzothialdehydes; and cyanation reactions of aldehydes and carbothialdehydes. The authors’ results demonstrate that the relative size and Lewis acidity of secondary metals potentially control the catalytic outcome via preferential interaction with the substrates. In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile

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New Green, Recyclable Magnetic Nanoparticles Supported Amino Acids as Simple Heterogeneous Catalysts for Knoevenagel Condensation was written by Girija, D.;Bhojya Naik, H. S.;Kumar, B. Vinay;Sudhamani, C. N.;Harish, K. N.. And the article was included in Letters in Organic Chemistry in 2013.SDS of cas: 51473-74-6 This article mentions the following:

Coumarin derivatives were synthesized using magnetically recoverable iron oxide nanoparticles supported amino acids as heterogeneous catalysts via one-pot multi component reaction using MW irradiation Easy recovery of the catalyst using an external magnet, efficient recycling, and reusable without significant loss of their catalytic efficiency makes the protocol greener and sustainable. In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6SDS of cas: 51473-74-6).

7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.SDS of cas: 51473-74-6

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Ruthenium(II) bis(hydrazone) complexes derived from 1,3,4-oxadiazoles: Synthesis, crystal structure and catalytic application in N-alkylation reactions was written by Prakash, Govindan;Ramachandran, Rangasamy;Nirmala, Muthukumaran;Viswanathamurthi, Periasamy;Sanmartin, Jesus. And the article was included in Inorganica Chimica Acta in 2015.Electric Literature of C14H12N2 This article mentions the following:

1,3,4-Oxadiazoles (A-C) were derived via a series of reactions between isoniazid and salicylaldehydes. While reacting the oxadiazoles with [RuHCl(CO)(PPh₃)₃] in the presence of NaOH, mononuclear ruthenium(II) complexes bearing ‘salen’ type N,N’-bis(salicylidene)hydrazone ligands (1–3) were obtained. The oxadiazoles and ruthenium(II) complexes were characterized by anal. and spectral methods. The single crystal XRD analyses of complexes 1 and 2 suggested an octahedral geometry around ruthenium(II) ions in which the bis(hydrazone) act as mononeg. bidentate ligands. Also the presence of an intramol. hydrogen bonding between the hydroxyl proton and one of the azomethine nitrogens in all the complexes. Further, the complexes were proved as versatile catalysts for the N-alkylation of amines with alcs. under optimized reaction conditions. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Electric Literature of C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Electric Literature of C14H12N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts