Author: Jessica.F

Related Products of 140860-51-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 140860-51-1 as follows.

To a soln. of 2-bromo-4-methoxybenzonitrile (1 g,4.72 mmol )in MeCN (40 rnL) was added Nal (212 g, 14.15 mrnol ) and TMSC1 (1.54 g, 14.15 mmoi). Then the mixture was stirred at 80C overnight, Then the mixture was concentrated in. vacuo and poured into water basified with Na2CO3. The mixture was extracted with EtOAc. The aq. layer was acidified with HC1 and extracted with EtOAc. The organic layer was washed withbrine, dried (Na2SO4). and concentrated in vacuo to give the title compound.

According to the analysis of related databases, 140860-51-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ADAMS, Gregory, L.; COX, Jason, M.; DEBENHAM, John, S.; EDMONDSON, Scott; GILBERT, Eric, J.; GUO, Yan; JIANG, Yu; JOSIEN, Hubert; KIM, Hyunjin, M.; LAN, Ping; MIAO, Shouwu; PLUMMER, Christopher, W.; RAJAGOPALAN, Murali; SHAH, Unmesh; SUN, Zhongxiang; TRUONG, Quang, T.; UJJAINWALLA, Feroze; VELAZQUEZ, Francisco; VENKATRAMAN, Srikanth; SUZUKI, Takao; WANG, Nengxue; (182 pag.)WO2017/205193; (2017); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 133550-33-1, name is 2-Cyano-N-(3-phenylpropyl)acetamide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H14N2O

General procedure: To a stirred solution of N-alkyl-substituted 2-cyanoacetamide 1 (5mmol) in toluene (10 mL) was added NaN3 (3 equiv) and triethylamine hydrochloride salt (3 equiv). The reaction mixture was heated to 90 C for 20 h. Ice-cold H2O (25 mL) was added to the reaction mixture and acidified with aq HCl and stirred at 0 C for 30 min. The precipitated product was collected by filtration, washed with cold H2O(25 mL), and dried in vacuum (Table 1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 133550-33-1.

Reference:
Article; Wang, Yuanze; Patil, Pravin; Doemling, Alexander; Synthesis; vol. 48; 21; (2016); p. 3701 – 3712;,
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These common heterocyclic compound, 109305-98-8, name is 2-Bromo-4,5-dimethoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H8BrNO2

General procedure: S3 (1.5 mmol) was dissolved in NEt3 (5 mL) and degassed for 30 minutes at room temperature. Then PdCl2(PPh3)2 (0.2 mol%), CuI (0.2 mol%) and the alkyne were added to S3/NEt3 solution. The obtained dark brown suspension was stirred for 12 h at 60C. After cooling to room temperature the solvent of the reaction mixture was filtered, and concentrated by rotary evaporation. The crude product was purified by column chromatography (petroleum ether : ethyl acetate = 30:1) to provide 1t-1w (in 76-83% yield).

The synthetic route of 2-Bromo-4,5-dimethoxybenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Xiaodong; Deng, Guobo; Liang, Yun; Tetrahedron Letters; vol. 59; 29; (2018); p. 2844 – 2847;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19295-57-9, name is 3-Hydroxy-2,2-dimethylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 19295-57-9

To a solution of 3-hydroxy-2,2-dimethylpropanenitrile (0.5 g) in dichloromethane (8 ml_) and pyridine (1 .5 ml_) is added at 0C p-toluene-sulfonylchloride (1 .0 g) in portions. The mixture is stirred for 12 hours at room temperature, diluted with diethylether and washed with 1 M aqueous HCI solution and brine. After drying (MgSO4) the solvent is evaporated and the residue is chromatographed on silica gel (petrole ether/ethyl acetate 90:10?50:50) to give the title compound. Yield: 770 mg; Mass spectrum (ESI+): m/z = 254 [M+H]+.

According to the analysis of related databases, 19295-57-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144097; (2013); A1;,
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Related Products of 51632-12-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51632-12-3 as follows.

1-1 (21.3 g, 89.6 mmol) is dissolved in DMF (300 mL). The mixture is cooled to 0 C and NaH (60% in oil suspension, 3.76 g, 94.1 mmol) is added slowly. The mixture is then stirred for a further 15 minutes and methyl iodide (5.9 mL, 94.1 mmol) is added. The reaction mixture is stirred at 0 C to room temperature for 2 hours and then concentrated in vacuo. The residue is partitioned between methylene chloride and brine. The combined organics are dried with Na2S04, filtered and concentrated in vacuo. The residue is purified by flash chromatography (Si02, 0-15% EtOAc in hepatne) to give the title intermediate (21.7 g); m/z 252.3, 254.3 [M/M+2H].

According to the analysis of related databases, 51632-12-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John; LO, Ho Yin; LOKE, Pui Leng; LIU, Weimin; MORWICK, Tina Marie; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee; WO2012/24150; (2012); A1;,
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Synthetic Route of 38791-62-7, The chemical industry reduces the impact on the environment during synthesis 38791-62-7, name is 4-Phenoxyphthalonitrile, I believe this compound will play a more active role in future production and life.

11.3 g of compound 1 was dissolved in 30 ml of methanol, added to 25 ml of 50% sodium hydroxide solution, heated to reflux for 48 h. After completion of the reaction, the pH was adjusted to about 3 with concentrated hydrochloric acid, precipitated by precipitation, filtered and dried to give 10.5 g of compound 2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Phenoxyphthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BEIJING BETA PHARMA, INC.; (43 pag.)TWI582078; (2017); B;,
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Electric Literature of 13519-90-9, A common heterocyclic compound, 13519-90-9, name is 4-Fluoroisophthalonitrile, molecular formula is C8H3FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To (1R,3S)-cyclohexane-1,3-diamine (1.0 g, 8.8 mmol) and 4-fluoroisophthalonitrile (2.7 g, 18.4 mmol)Triethylamine (5.4 ml) was added to a solution of 30 ml of dimethyl sulfoxide. The mixture was purged with nitrogen and heated to stir at 150 C for 3 hours. After cooling to room temperature, the reaction mixture was diluted with water (100 ml) and extracted three times with dichloromethane (100 ml). The organic extracts were combined and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography(230-600 mesh silica gel) purified,Elute with 0-80% ethyl acetate / hexane,Get the title compound,It was a white solid (2.6 g, 81% yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sichuan Yi Lite Bio-pharmaceutical Co., Ltd.; Jiao Guansheng; Zhang Chengpan; (13 pag.)CN109160888; (2019); A;,
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Application of 77532-78-6, The chemical industry reduces the impact on the environment during synthesis 77532-78-6, name is 2-Bromo-6-methylbenzonitrile, I believe this compound will play a more active role in future production and life.

A. N-Butyl-2,3-difluoro-N-[1-(2-piperidin-1-ylmethyl-benzyl)-1H-benzoimidazol-2-ylmethyl]-benzamide A solution of 35 g (0.18 mole) of cyanobromotoluene and 16.18 g (0.19 mole) of piperidine in 300 mL of anhydrous DMF was treated with 73 g (0.5 mole) of K2CO3 at 50 C. for 2 hr. The reaction mixture was filtered through a plug of Celite, washed with 400 mL of ethyl acetate, and the filtrate was partitioned between ethyl acetate and 1/2 saturated brine. The organic layer was dried over anhydrous Na2SO4 and concentrated in vacuo, yielding 36 g (0.18 mole) 100% of 2-Piperidin-1-ylmethyl-benzonitrile. 1H NMR (300 MHz, CDCl3) 7.6 (m, 3H), 7.24 (m, 1H), 3.6 (s, 2H), 2.4 (m, 4H), 1.5 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-6-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DeSimone, Robert W.; Peterson, John; Steenstra, Cheryl; Shen, Yiping; Gustavson, Linda; Bakthavatchalam, Rajagopal; Hutchison, Alan; US2003/216390; (2003); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 138642-47-4, name is 2-Bromo-5-methoxybenzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-5-methoxybenzonitrile

2-Bromo-5-methoxybenzonitrile (1.32 g, 6.23 mmol), 2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (1.36 g, 6.23 mmol), bis(triphenylphosphine)palladiumdichloride (0.437 g, 0.623 mmol) and potassium phosphate monohydrate (4.30 g, 18.68 mmol) were added to toluene (30 mL) and water (3 mL). The reaction mixture was degassed with bubbled nitrogen gas for 30 minutes before being refluxed under nitrogen for 15 h. After cooling, the reaction mixture was filtered through Celite and the organic layer was extracted with ethyl acetate. After removal of the solvents, the crude material was triturated with 40 mL of DCM followed by 50 mL of hexanes to give 8- methoxyphenanthridin-6-amine (0.95g, 68%) as a light yellow solid. The product was confirmed by GC/MS and NMR.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; XIA, Chuanjin; YEAGER, Walter; LI, David Zenan; FIORDELISIO, James; MA, Bin; ELSHENAWY, Zeinab; LAYEK, Suman; BARRON, Edward; KOTTAS, Gregg; BROOKS, Jason; WO2012/116231; (2012); A2;,
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906673-45-8, name is 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 4-(4-Bromo-3-(hydroxymethyl)phenoxy)benzonitrile

30.2 g (0.1 mol) of 4-[(4-bromo-3-hydroxymethyl)phenoxy)]benzonitrile, 300 ml of dichloromethane, and 30.3 g of triethylamine (0.3 mol) were added to the reaction kettle. The reaction was cooled to 0-10 C, 12.96 g of trimethylchlorosilane was added dropwise, the temperature was controlled to not exceed 10 C, stirred at 25 C for 24 h, quenched with water, extracted with dichloromethane, washed with water and dried over anhydrous magnesium sulfate, filtered, and the solvent was recovered to give an oil (31.8 g) , yield 85%;

The synthetic route of 906673-45-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wuhan Polytechnic University; Zhao Ling; Yang Bo; (8 pag.)CN108659024; (2018); A;,
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