Author: Jessica.F

Related Products of 874285-03-7, A common heterocyclic compound, 874285-03-7, name is 3-Bromo-2-fluorophenylacetonitrile, molecular formula is C8H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

a) 2- (3 -bromo-2-fluorophenyl)ethanamine To a stirred solution of 2-(3-bromo-2-fluoro-phenyl)acetonitrile (10 g, 44.4 mmol, CAS 874285- 03-7) in THF (100 mL) was added borane-tetrahydrofuran complex 1.0 M in THF (88.8 mL, 88.8 mmol) at 0 C. The mixture was stirred at room temperature for 1 hour then heated to reflux overnight. The reaction mixture was then re-cooled to 0 C and MeOH (50 mL) was added. The mixture was heated to reflux for 90 min. The solvent was removed under vacuum and the residue was partitioned between EtOAc and aqueous 1.0 M HC1. The aqueous phase was made basic with aqueous 1.0 M NaOH then extracted with EtOAc. Organic layers were washed with saturated brine, dried (Na2S04) and concentrated in vacuo to afford the title compound (9.1 g, 94%) as a viscous colorless oil which was used in the next step without further purification.

The synthetic route of 874285-03-7 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69797-49-5, name is 2-Amino-3-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Amino-3-methylbenzonitrile

Dissolve 2-amino-3-methylbenzonitrile (10.0g, 75.6mmol) and DMSO (7mL) in ethyl acetate (140mL), and dropwise add HBr aqueous solution (3mL) at room temperature for 30-60min. After the dropwise addition is completed, the reaction bottle is closed at 50-80 C, and the reaction time is 1-6h. After the reaction was completed, 1M potassium carbonate aqueous solution (150 mL) was added for washing, and dichloromethane (120 * 3) was used for liquid separation, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The target product, 2-amino-5-bromo-3-methylbenzonitrile, was obtained as a yellow solid (13.3 g, 83.1%).

According to the analysis of related databases, 69797-49-5, the application of this compound in the production field has become more and more popular.

Related Products of 191014-55-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 191014-55-8, name is 4-Fluoro-2-methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To 4-fluoro-2-methoxybenzonitrile (3.00 g, 20 mmol) and N-iodosuccinimide (NIS) (4.7 g, 21 mmol) under nitrogen was added TFA (35 mL) and the reaction was stirred at room temperature for 20 hours. The volatiles were removed in vacuo and the residue was taken up in 1:1 ethyl acetate:ether and was washed with aqueous sodium bicarbonate and then brine containing enough sodium sulfite to remove the iodine color. The aqueous layers were back extracted with more 1:1 ethyl acetate:ether and the combined organic layers were dried over sodium sulfate and evaporated. The residue was treated with ether/hexanes to afford clean iodo title product as a white solid. 1H-NMR (500 MHz, CDCl3) delta ppm 3.930 (s, 3H), 6.730 (d, J = 9.4 Hz, 1H), 7.900 (d, J = 6.8 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-2-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 138642-47-4, name is 2-Bromo-5-methoxybenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 2-Bromo-5-methoxybenzonitrile

Step A: KOH (4M, 259.66uL, 3.06eq) and Pd(Ph3P)2Cl2 (47.65mg, 67.88umol, 0.20eq) were added to a solutionof the intermediate 12 (200.00mg, 339.42umol, 1.00eq) and 2-bromo-5-methoxyphenyl cyanide (108.00mg, 509.13umol,1.50eq) in 2-methyltetrahydrofuran. The reaction solution was stirred at 65C under nitrogen atmosphere for 13 hours,then cooled to room temperature, and additional Pd(Ph3P)2Cl2 (20.00mg, 33umol, 0.10eq) was added. The reactionsolution was heated to 65C and stirred for another 3 hours to give 87, which was directly used in the next step. Thereaction solution was cooled to room temperature, then methanol (6.00mL) and water (3.00mL) were added and theresulting mixture was stirred at 35C for 2 hours. Lithium hydroxide (15mg) was added, the reaction solution was heatedto 45C and stirred for 3 hours. The reaction solution was cooled to room temperature, adjusted to pH 5 with 2M HCl,diluted with water, extract with ethyl acetate, dried over sodium sulfate, concentrated and purified by silica gel columnchromatography to give the intermediate 88.

The synthetic route of 2-Bromo-5-methoxybenzonitrile has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 191014-55-8, name is 4-Fluoro-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Fluoro-2-methoxybenzonitrile

General procedure: Intermediate 31 (1 S.2S)-2-(4-[(R)-4-(4-Cvano-phenoxy)-7-fluoro-indan-1 -yloxyl-phenyl)- cvclopropanecarboxylic acid ethyl ester (1 S,2S)-2-[4-((R)-7-Fluoro-4-hydroxy-indan-1 -yloxy)-phenyl]-cyclopropanecarboxylic acid ethyl ester (Intermediate 5, 146 mg, 0.41 mmol), 4-fluorobenzonitrile (55 mg, 0.45 mmol), and cesium carbonate (145 mg, 0.45 mmol) are suspended in dry dimethylformamide (1 0 mL) and stirred for 3 hours at 100 C followed by room temperature overnight. The mixture is diluted with water and extracted with ethyl acetate. The organic extract is dried over sodium sulfate, filtered and the solvent removed. The residue is purified by flash chromatography (10% ethyl acetate in cyclohexane) to give the title compound (Yield 62 mg). LC (METHOD 5): tR = 1 .54 min ; Mass spectrum (ES+): m/z = 458 [M+H]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 191014-55-8.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 175596-01-7, name is Methyl 4-cyano-2-fluorobenzoate, A new synthetic method of this compound is introduced below., COA of Formula: C9H6FNO2

Step 2: methyl 4-[amino(hydroxyimino)methyl]-2-fluorobenzoate To a solution of methyl 4-cyano-2-fluorobenzoate, obtained in Step 1 (486.8 mg; 2.72 mmol) in abs. EtOH (6 ml_) was added hydroxylamine (0.8 ml 13.6 mmol; 5 eq.) (50% in water) and the mixture was heated at 74C overnight. After cooling, a product precipitated. The precipitate was filtered off and dried under vacuum to afford Intermediate 1 as an off-white solid (267.10 mg; 46%). 1H-NMR (DMSO-d6, 300MHz) delta 10.09 (s, 1 H), 7.92 (t, J = 7.91 Hz, 1 H), 7.69 (dd, J = 1.70 Hz, J = 8.10 Hz, 1 H), 7.64 (dd, J = 1.51 , J = 12.81 , 1 H), 6.05 (s, 2H), 3.90 (s, 3H). HPLC (Method B) Rt 2.99 min (Purity: 100%).

The synthetic route of 175596-01-7 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96606-37-0, name is 2,4,6-Trifluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H2F3N

In one embodiment,The 6 mmol of the second reactant was dissolved in 15 ml to 25 ml of the first solvent tetrahydrofuran, and then 0.5 mmol to 2 mmol of the first additive sodium hydride was slowly added.The reaction is carried out for 20-50 minutes under room temperature conditions and under nitrogen.Then add 2 mmol of the first reactant and continue the reaction for 12 hoursTo obtain a mixture including the electroluminescent material.The mixture of the electroluminescent material is cooled to room temperature and poured into distilled water.Extraction with a first extraction solvent, and then washing with a first detergent,Drying with a first desiccant, and then performing chromatography,Obtain the first crude product, and then use the first eluent to obtain the electroluminescent material, and the electroluminescent material is a white solid,The yield was 64%.

According to the analysis of related databases, 96606-37-0, the application of this compound in the production field has become more and more popular.

Reference of 57381-49-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 57381-49-4 as follows.

Into a 19-mL sealed tube was placed 2-bromo-4-chlorobenzonitrile (216 mg, 1.00 mmol), dioxane (1.5 mL), water (0.3 mL), Pd(dppf)Cl2 (36 mg, 0.05 mmol), Na2CO3 (318 mg, 2.97 mmol), and phenylboronic acid (148 mg, 1.21 mmol). The resulting solution was stirred for 16 h at 95oC. The reaction was then quenched by the addition of 25 mL of water. The resulting solution was extracted with ethyl acetate (3×15 mL) and the organic layers were combined. The organic layer was washed with brine (25 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum. The residue purified via a silica gel chromatography with ethyl acetate/petroleum ether (1:20). This resulted in 50 mg (23% yield) of 4-chloro-2-phenylbenzonitrile as a white solid.1H NMR (400 MHz, DMSO-d6, ppm): delta 8.00 (d, J = 8.4 Hz, 1H), 7.74 (d, J = 2.1 Hz, 1H), 7.68 (dd, J = 8.3, 2.2 Hz, 1H), 7.65 – 7.59 (m, 2H), 7.58- 7.48 (m, 3H), 4.04 (dd, J = 1.9, 1.0 Hz,1H).

According to the analysis of related databases, 57381-49-4, the application of this compound in the production field has become more and more popular.

Application of 69395-13-7, These common heterocyclic compound, 69395-13-7, name is 4-(2-Hydroxyethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A Preparation of 4-(2-hydroxyethyl)benzylamine A solution of 0.74 g (0.005 mol) of p-cyanophenethyl alcohol in 50 ml of ethanol containing 10 ml of concentrated hydrochloric acid was hydrogenated at 30 psi using 0.1 g 5% Pd/C for 72 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure.

Statistics shows that 4-(2-Hydroxyethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 69395-13-7.

Related Products of 6136-93-2,Some common heterocyclic compound, 6136-93-2, name is 2,2-Diethoxyacetonitrile, molecular formula is C6H11NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of diethoxyacetonitrile (1 ,120 g, 930 mmol) in MeOH (500 ml_) was added a 17% solution of (NH4)2S in H20 (440 ml_) at rt. The mixture was stirred at rt overnight. The mixture was evaporated in vacuo to approximately 100 ml_ volume and filtered. The solid was washed with cooled water and dried in vacuo to afford the title compound 2 (92 g, 61 %) as a white solid, which was used as such in next step.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,2-Diethoxyacetonitrile, its application will become more common.