Author: Jessica.F

Adding a certain compound to certain chemical reactions, such as: 623-03-0, name is 4-Chlorobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-03-0, Recommanded Product: 4-Chlorobenzonitrile

General procedure: A two-necked 25.0mL flask fitted with a reflux condenser and septum was charged with aryl halide (1.0mmol), phenylboronic acid (1.2mmol), KOH (2.0mmol), diethyleneglycol-di-n-butylether (0.6mmol, internal standard), and the palladium-pyridine catalyst (0.01mol %) in isopropyl alcohol (1.0mL) was added. The mixture was heated to 82C under an air atmosphere. The conversion was monitored by gas chromatography.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 149793-69-1, name is 3-Fluoro-5-(trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Fluoro-5-(trifluoromethyl)benzonitrile

Example-1: Preparation of 3-fluoro-5-(trifluoromethyl)benzamide : In 2 lit three necked round bottom flask equipped with mechanical stirrer, thermometer and an addition funnel, 3-fluoro-5(trifluoromethyl)benzonitrile (100 g) and dimethylsulfoxide (200 ml) was added at 25-35C and stirred for 20 min. To this, potassium carbonate (220 g) and hydrogen peroxide solution (140 ml) were added at 25-35C and stirred for 90 mins. After completion of reaction, water (1200 ml) was added to the reaction mass and stirred for an hour. Filtered the solid, washed with water, suck dried and then dried at 50-55C under vacuum for 6 hrs to get the title compound. Yield: 103 g.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 658-99-1, name is 2-(3,4-Difluorophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 658-99-1, name: 2-(3,4-Difluorophenyl)acetonitrile

77.1 Synthesis of 3-cyano-3-(3,4-difluoro-phenyl)-pentanedioic acid diethyl ester Prepare by the method of Example 11.1.2 using 3,4-difluorophenylacetonitrile to give the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(3,4-Difluorophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1194-02-1, name is 4-Fluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4-Fluorobenzonitrile

General procedure: To a solution of nitrile 6 (3.3 mmol, 1.0 equiv) in EtOH (15 mL) was added hydroxylamine hydrochloride (4.0 mmol, 1.2 equiv) and NaHCO3 (6.6 mmol, 2.0 equiv). The mixture was refluxed for 4 h. The reaction mixture was diluted with EtOAc, filtered, and concentrated in vacuo. Water was added to the residue and extracted with ethyl acetate (3 x 30 mL), washed with brine (1 x 30 mL), driedover anhydrous MgSO4, and concentrated. The residue was subjected to silica gel chromatography with EtOAc/MeOH (9:1) to make carboxamidine 7.

The synthetic route of 1194-02-1 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53312-81-5, name is 5-Amino-2-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Amino-2-fluorobenzonitrile

Step 12: Preparation for 2-Fluoro-5-((5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazolin-10-yl)amino)benzonitrile To a solution of 10-chloro-5-isopropoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline (0.05 g, 0.18 mmol) in isopropanol (3 mL) was added 4-chloro-3-nitroaniline (0.030 g, 0.20 mmol). The solution was stirred at 80 C. for 4 hours. After cooling to ambient temperature, the solution was concentrated to obtain a yellow solid which was purified by column chromatography on silicon gel (dichloromethane:methanol=100:1) to obtain a yellow solid (0.045 g, yield=55%). 1H NMR (DMSO-d6, 400 MHz): delta 10.54 (s, 1H), 8.76 (s, 1 Hz), 8.24-8.23 (m, 1H), 8.04 (t, 1H, J=8.8 Hz), 7.66 (t, 1H, J=8.8 Hz), 7.21 (s, 1H), 4.79 (dd, 1H, J=6 Hz), 4.60 (s, 2H), 4.45 (s, 2H), 1.40 (d, 6H, J=6 Hz); MS: 381(M+H)+.

According to the analysis of related databases, 53312-81-5, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1009-35-4, HPLC of Formula: C7H3FN2O2

The intermediate E lot used in this Example existed as ~3: 1 S:R mixture of phenyl chirality. To a vial charged with (S)-3-((lr,4S)-4-aminocyclohexyl)-5,5- dimethyl-4-phenyloxazolidin-2-one (0.150 g, 0.520 mmol) were added ACN (1.734 mL), TEA (0.145 mL, 1.040 mmol) and 4-fluoro-3-nitrobenzonitrile (commercially available from Alfa Aesar, Ward Hill, MA) (0.086 g, 0.520 mmol) respectively. The resulting orange solution was shaken at 80°C overnight. The resulting mixture was dried under reduced pressure and the material thus obtained was purified with a 25 g SNAP column ramping EtOAc in heptane from 0 – 100percent with 10percent DCM throughout providing 4-(((l S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3- yl)cyclohexyl)amino)-3-nitrobenzonitrile (0.172 g, 0.396 mmol, 76 percent yield) as a yellow solid. H NMR (400 MHz, CDC13) delta = 8.47 (d, J= 2.0 Hz, 1 H), 8.25 (d, J= 7.4 Hz, 1 H), 7.58 – 7.51 (m, 1 H), 7.47 – 7.28 (m, 4 H), 7.14 (br. s., 1 H), 6.85 (d, J = 9.2 Hz, 1 H), 4.39 (s, 1 H), 3.50 – 3.33 (m, 2 H), 2.24 – 2.06 (m, 3 H), 2.02 – 1.93 (m, 1 H), 1.90 – 1.79 (m, 1 H), 1.62 – 1.49 (m, 4 H), 1.47 – 1.26 (m, 2 H), 0.92 (s, 3 H). m/z (ESI) 435.2 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Electric Literature of 89001-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89001-53-6 name is 2-Methyl-4-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1; Preparation of Compound 6c6c; Step A: Preparation5,6-Dihydro-5-oxo-9-nitro-indeno[l,2-c]isoquinolineTo arefluxing mixture of 2-methyl-4-nitro-benzonitrile (32.4 g, 0.2 mol) and NBS (44.470 g, 0.25 mol) in CCl4 (300 ml) was added ATON (0.325 g) and the resultant EPO reaction mixture was refluxed for 4 hours. The reaction mixture was treated with ABBN (0.325 g, 31 mmol) and refluxed further for 4 hours. The reaction mixture was filtered, and the filtered succinimide was washed with CCl4. The filtrate was concentrated in vacuo to provide a bromo compound (46 g). The bromo compound was dissolved in MeCN (200 ml), and to the reaction mixture was added homophthalic anhydride (30.780 g, 0.19 mol) at room temperature and under inert atmosphere. The reaction mixture was then treated with a solution of triethylamine (84 ml, 0.6 mol) in acetonitrile (100 ml). The reaction mixture was refluxed for 8 hours. The precipitate that formed was removed by filtration and washed with MeCN (100 ml). The washed precipitate was suspended in DMF (300 ml), which was heated at 130 0C, then cooled and filtered. The resultant solid was washed with DMF (100 ml) and dried under vacuum to provide 5,6-Dihydro-5-oxo- 9-nitro-indeno[l,2-c]isoquinoline as a pale yellow solid (18.310 g, 33%). 1H-NMR (DMSO-d6): delta, 4.09 (s, 2H), 7.56 (m, IH), 7.81 – 7.82 (m, 2H), 8.17 (d, J = 8.4 Hz, IH), 8.26 – 8.34 (m, 2H), 8.44 (s, IH), 12.47 (s, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Methyl-4-nitrobenzonitrile, and friends who are interested can also refer to it.

Electric Literature of 21524-39-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21524-39-0, name is 2,3-Difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 2, 3-difluorobenzonitrile (19. 0 g, 137 mmol) and ethanol (200 ml) pre-saturated with ammonia gas was heated at 140C in an autoclave for 8 h (terminal pressure 200 psi). The mixture was allowed to cool to ambient temperature and evaporated to dryness. The residue was dissolved in water (400 ml) and extracted with diethyl ether (2 x 300 ml). The combined organics were washed with water (300 ml) and brine (250 ml), dried over anhydrous magnesium sulfate, filtered and evaporated. Trituration with isohexane (150 ml) afforded 2-amino-3-fluorobenzonitrile (9.8 g, 50%) as an off-white solid: 1H NMR (360 MHz, CDCl3) 8 4.47 (2H, s), 6.65-6. 71 (1H, m), 7.14-7. 20 (2H, m).

The synthetic route of 2,3-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16532-79-9, name is 4-Bromophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 16532-79-9

EXAMPLE 3; Synthesis of N2-((lS)-l-{4′-[1-(aminocarbonyl) cyclopropyl] biphenyl-4-yl}-2, 2-difluoroethyl)-Nl-(l- cyanocyclopropyl)-4-fluoro-L-leucinamide; F F F N ion Razz H,, N Nez H2N Step 1 : Preparation of 1-(4-bromophenyl) cyclopropanecarbonitile; To a room temperature solution of 4-bromophenylacetonitrile (18.0 g) in a solution of 22 mL of sodium hydroxide (50% in water W/W) were added 1-bromo-2-chloroethane and (12.0 mL) and benzyltriethylammonium chloride (627 mg). The mixture was heated at 60 C overnight. The reaction mixture was cooled to room temperature and diethyl ether was added (300 mL) and partitioned. The ether layer was washed with water (100 mL), hydrogen chloride (100 mL, 10% HCI in water) and brine. Then dried with magnesium sulfate and the solvent removed in vacuo. The residue was purified by swish using diethyl ether and hexanes to yield the title compound. ‘H NMR (CD3COCD3) 8 7.60 (2H, d), 7.35 (2H, d), 1.74-1. 80 (2H, m), 1.52-1. 57 (2H, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16532-79-9.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-Bromo-2-methylbenzonitrile

Preparation 13A; 2-methyl-4-? H-pyrrolor2.3-b1Pyridi?-1 -vObenzonitrile; A mixture of 4-bromo-2-methylbenzonitrile (5.45 g, 27.8 mmol), N, N’- dimethyiethyienediamine (0.6 mL, 5.56 mmol), CuI (530 mg, 2.78 mmol), and sodium iodide (7.9 g, 52.8 mmol) in toluene (50 mL) was heated at reflux for 28h. K3PO4 (12.3 g, 58.4 mmol) and 7-azaindole (3.28 g, 27.8 mmol) were added and the mixture was heated at reflux for another 48 h, cooled, filtered, and concentrated. SGC (5% and 10% EtOAc-hexane) of the residue gave the title product as a colorless solid. Yield 2.8 g, 43%. 1H NMR (CDCI3) delta 8.37 (br, 1H), 7.96 (d, 1H, J = 7.5 Hz), 7.86 (s, 1H), 7.80 (d, 1H, J = 8.3 Hz), 7.71 (d, 1H, J = 8.3 Hz), 7.51 (d, 1H1 J = 3.7 Hz), 7.17 (br, 1H)1 6.67 (br, 1H), 2.62 (s, 3H). MS (AP+) m/e 234 (MH+).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.