Author: Jessica.F

Some common heterocyclic compound, 16932-49-3, name is 2,6-Dimethoxybenzonitrile, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H9NO2

EXAMPLE 69: Preparation of N-[2-Hydroxy-3-(2-cyano-3-methoxyphenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl) ethylamine Hydrochloride, Compound 118 STR69 Powdered sodium cyanide (9.0 g, 184 mmol) and 2,6-dimethoxybenzonitrile were added to 50 mL of dimethylsulfoxide and heated to 145 C. for 110 min under nitrogen. The reaction was cooled and poured into ether and dilute HCl. The ether layer was separated, washed twice with dilute acid, once with saturated brine, dried over anhydrous sodium sulfate, and concentrated. The yield of 2-cyano-3-methoxyphenol was 8.1 g.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 16932-49-3, its application will become more common.

Application of 214623-57-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 214623-57-1, name is 5-Amino-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Sodium nitrite (l.llg, 16.17 mmol) in water (5 ml) was added with stirring over 15 min to a cold (0 C) solution of A (2.18 g,14.7 mmol) in concentrated hydrochloric acid (7 ml) and ice (10 g). The mixture was stirred at 0 C for a further 20 min. and the cold solution was added over 30 min to a stirred solution (room temperature) of potassium iodide (12.2 g, 73 mmol) in water (15 ml). The mixture was left standing at room temperature overnight and extracted with dichlormethane (2×50 ml). The combined organic extracts were washed successively with 10% NaOH, water, and dried (Na2S04). Evaporation of the solvent and silica gel column chromatography of the residue (Hexanes/EtOAc) gave iodide B (3.46 g, 80%).

The chemical industry reduces the impact on the environment during synthesis 5-Amino-2-methoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Synthetic Route of 135748-35-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135748-35-5, name is 4-Chloro-2,5-difluorobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a [3-(5-Chloro-2-cyano-4-fluorophenoxy)hexyl]methylcarbamic Acid, 1,1-dimethylethyl Ester The subtitle compound was prepared according to the method of Example 3 step (b) using (3-hydroxyhexyl)methylcarbamic acid, 1,1-dimethylethyl ester and 4-chloro-2,5-difluorobenzonitrile in N,N-dimethylformamide. 1H NMR 300 MHz (CDCl3) 7.33 (1H, d), 6.99 (1H, bs), 4.33 (1H, m), 3.34 (2H, m), 2.85 (3H, s), 1.95 (2H, m), 1.70 (2H, m), 1.41 (11H, m), 0.95 (3H, t).

The synthetic route of 4-Chloro-2,5-difluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Electric Literature of 6609-57-0,Some common heterocyclic compound, 6609-57-0, name is 2-Ethoxybenzonitrile, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification.

The synthetic route of 6609-57-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 118431-88-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118431-88-2, name is 3-Cyclopropyl-3-oxopropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Hydrazine hydrochloride 14a or b was refluxed with nitrile 12a,b or c in EtOH overnight. The reaction solution was evaporated in vacuo to furnish the corresponding pyrazolo amine, which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Cyclopropyl-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Application of 151-18-8, A common heterocyclic compound, 151-18-8, name is 3-Aminopropanenitrile, molecular formula is C3H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 7; N-Cbz-3-aminopropionitriIe (18).; 3-Aminopropionitrile 17 (0.56 g, 8.0 mmol) was suspended in water (10 mL) and THF (10 mL). The pH was adjusted to 9.0 by addition of NaOH (0.2 g, 5 mmol). Benzyl chloroformate (1.7 g, 10 mmol) was added dropwise over 2 h at 20-25 0C to the resulting clear solution, and the pH EPO was kept constant at 9.0 by addition of aqueous NaOH (4 M, 2.5 mL). The mixture was stirred for 1 h at pH 9.0, extracted with ethyl acetate, and dried with Na2SO4. The solvents were removed by rotary evaporation to give crude 18 (1.6 g, 98%) as an oil. 1H NMR (400 MHz, OMSO-d6) delta.3 (s, 5H), 5.0 (s, 2H), 3.22 ~ 3.27 (m, 2H), 2.6 (t, 2H5 J= 6.4 Hz).

The synthetic route of 151-18-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 939-83-3, A common heterocyclic compound, 939-83-3, name is 2-Methyl-5-nitrobenzonitrile, molecular formula is C8H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2-cyano-4-nitrotoluene (10 g, 6.17 mmol) benzaldehyde (6.51 g, 6.17 mmol) and potassium carbonate (20 g) in MeOH (200 mL) was heated at reflux for 10 min. The mixture was cooled to ambient temperature over 30 min, whereupon precipitation of the product was complete. The product was isolated by filtration and washed successively with 1N HCl, water and MeOH then air dried. There was obtained 13.0 g of the benzamide (mp 269.8 C) as evident from the lack of a nitrile adsorption in the IR and the appearance of peaks at 3357.1, 3193.6 (-NH2) and 1648.7 cm-1 (H2NC(=O)-); LRMS (M-NO)+ m/z = 238.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 34916-10-4, These common heterocyclic compound, 34916-10-4, name is 4-Oxo-cyclohexanecarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of (Diethylamino)sulfur trifluoride (46.7 g, 289 mmol) in DCM (200 mL) was slowly added to a solution of 4-oxocyclohexanecarbonitrile (32.4 g, 263 mmol) in DCM (400 mL) at 0C. The reaction mixture was stirred for 2 hrs. and quenched with water (100 mL). The organic layer was separated and dried with anhydrous MgSO4. The solvent was concentrated to provide a 7:3 mixture of 4,4-Difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-l-carbonitrile. MCPBA 77% (45 g, 200 mmol) was stirred in CHCl3 (600 mL) for 30 min. The solution was dried with anhydrous Na2SO4 and filtred. The 7:3 mixture of 4,4-Difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-l- carbonitrile was added to the resulting MCPBA solution and stirred at ambient temperature for 18 hrs. The reaction mixture was washed with NaOH 1.5 M (3 x 300 mL) and dried with anhydrous MgSO4. The solvent was concentrated and the residue was distilled under reduced pressure to provide the pure title compound as a colorless liquid. Yield 18.2 g (47%): IHNMR (400 MHz, CHLOROFORM) delta 1.86-1.96 (m, 1 H), 1.95-2.03 (m, 5 H), 2.03-2.22 (m, 2 H), 2.68-2.85 (m, 1 H). EPO [(4,4-Difluorocyclohexyl)methyI]amine

The synthetic route of 34916-10-4 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151-18-8 as follows. Recommanded Product: 151-18-8

5 L of an aqueous solution containing 500 g of beta-aminopropionitrile (previously adjusted to pH 8.0 with concentrated hydrochloric acid) was added to a 10-L jacketed mechanically stirred glass reactor.Further, 250 g of a Nitrile hydrolyzing enzyme resting cell prepared by the method described in the patent CN 101701222B was added thereto, and fully suspended by mechanical stirring (250 rpm), and the temperature of the reaction vessel was controlled to 35 C by a constant temperature water bath, and the reaction time was 6 hours.The progress of the reaction was monitored by HPLC during this time.After the substrate was completely transformed, the reaction solution was heated to 90 C, incubated for 30 min, and the cells and denatured proteins were removed by filtration.The filtrate was concentrated and dried to give a mixture of beta-alanine and buffer salt as a solid, which contained 625 g of beta-aminopropionic acid in a yield of 98.4%.

According to the analysis of related databases, 151-18-8, the application of this compound in the production field has become more and more popular.

Related Products of 1129-35-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1129-35-7, name is Methyl 4-cyanobenzoate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Hydrazine hydrate 64% (v/v) (30.0 mL, 0.33 mol) was heated up to 50-60 C. The methyl ester 3 (0.01 mol) was added and the mixture was heated at reflux for 10 min. The cooling was performed sequentially in water bath, followed by ice bath and dry ice-ethanol bath. The precipitate was filtered and washed with cold water.

The chemical industry reduces the impact on the environment during synthesis Methyl 4-cyanobenzoate. I believe this compound will play a more active role in future production and life.