Author: Jessica.F

Synthetic Route of 70484-01-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 70484-01-4, name is 4-Bromophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a 250 ml round bottom flask, H001-3 (15 mmol), cuprous iodide (30 mmol),t-BuOK (20 mmol) and 3,4-dicyanobromobenzene (30 mmol) were mixed with dry 1,4-dioxane (100 ml) and stirred at room temperature for 48 hours under a nitrogen atmosphere.The resulting intermediate was added to water, then filtered through a pad of celite, and the filtrate was extracted with dichloromethane.It was then washed with water and dried over anhydrous magnesium sulfate. After filtration and evaporation, the crude product was purified by silica gel column chromatography to obtain the intermediate product H002.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromophthalonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 327056-73-5, The chemical industry reduces the impact on the environment during synthesis 327056-73-5, name is 3-Chloro-5-fluorobenzonitrile, I believe this compound will play a more active role in future production and life.

EXAMPLE 2 ^_(4-{(lJR)-14(R)-(3-CHLORO-5-CYANOPHENOXY)(4- CHLOROPHENYL)METHYL]BUTYL}BENZOYL)~beta-ALANINETo a solution of INTERMEDIATE 1 (100 mg, 0.239 mmol) and 3-chloro-5- fluorobenzonitrile (40.9 mg, 0.263 mmol) in DMF (2 mL) was added potassium tert-butoxide (107 nig, 0.957 mmol), then the resulting mixture was allowed to stir at 120 0C for 16 hours. After being allowed to cool to RT, the mixture was diluted with 2 N HCl (aq) then extracted with EtOAc. The organic layer was washed twice with water then concentrated. The resulting yellow residue was purified by preparative reverse phase HPLC eluting with 30-100% CHaCN/water + 0.1% TFA. Following lyophilization, this afforded the title compound as a white solid. 1H NMR (500 MHz, CD3OD): 6 7.70 (d, J – 8.5 Hz, 2 H); 7.34 (d, J = 8.5 Hz, 2 H); 7.30 (d, J = 8.0 Hz, 2 H); 7.25 (d, J – 8.5 Hz, 2 H); 7.20 (s, 1 H); 7.09 (s, 1 H); 7.06 (s, 1 H); 5.55 (d, J = 6.5 Hz, 1 H); 3.61 (t, J = 7.0 Hz, 2 H); 3.16 (m, 1 H); 2.62 (t, J = 7.0 Hz, 2 H); 1.80 (m, 1 H); 1.54 (m, 1 H); 1.11-1.07 (m, 2 H); 0.78 (t, J = 7.2 Hz, 3 H); LC3 3.93 min. (M+H)+ 523.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloro-5-fluorobenzonitrile, other downstream synthetic routes, hurry up and to see.

Electric Literature of 6136-93-2, These common heterocyclic compound, 6136-93-2, name is 2,2-Diethoxyacetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Sodium methylate (54 g, 1 mol) was added to a solution of diethoxyacetonitrile (139 mL, 1 mol) in methanol (500 mL). The reaction mixture was kept at room temperature for 24 g, then the reaction mixture was evaporated, treated with water (500 mL), and the product was extracted with ether (2×300 mL). The combined organic extracts were dried over anhydrous K2CO3 and evaporated to give 114.62 g (60% purity) of methyl 2,2- diethoxyethanimidoate. The obtained crude product was used for the next stage without additional purification.

The synthetic route of 6136-93-2 has been constantly updated, and we look forward to future research findings.

Related Products of 19179-31-8,Some common heterocyclic compound, 19179-31-8, name is 3,5-Dimethoxybenzonitrile, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

An oven-dried three-necked flask was sealed with septa and evacuated/backfilled with N2 several times before starting the reaction. To a mixture of 2.5 M n-BuLi in hexane (4.2 mL, 10.45 mmol) and dry THF, maintained at below -70 C, a solution of N,N-diethyl-2-methylbenzamide (1 g, 5.23 mmol) and 3,5-dimethoxybenzonitrile (1.11 g, 6.79 mmol) in dry THF was added dropwise, maintaining the temperature below -60 C. The reaction mixture was stirred at -78 C. The reaction mixture was warmed to room temperature and quenched with water. The resulting mixture was extracted with CH2Cl2, the organic extract washed with water, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was then purified by column chromatography (n-hexane:EtOAc = 1:1) to obtain compound 5b as white crystals (1.1 g, 74%). Melting point (mp): 170-173 C. 1H NMR (400 MHz, DMSO-d6): delta 11.56 (s, 1H, NH), 8.21-8.19 (m, 1H, 8-H), 7.75-7.70 (m, 2H, Ar-H), 7.52-7.46 (m, 1H, Ar-H), 7.00 (s, 1H, 4-H), 6.97 (d, J = 2 Hz, 2H, 2,6-(H)2), 6.57 (t, J = 2.2 Hz, 1H, 4-H), 3.83 (s, 6H, 3,5-(OCH3)2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dimethoxybenzonitrile, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 859855-53-1, name is 3-Amino-4-fluorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H5FN2

1.0 g (6.4 mmol) of 2-fluoro-5-cyanoaniline was dissolved in anhydrous dichloromethane in a 25 ml eggplant flask,Dropping at room temperature2.3 g (9.6 mmol)2-chloro-3-methoxybenzenesulfonyl chloride in dichloromethane,Further 0.77 ml (9.6 mmol) of pyridine,Room temperature reaction overnight.The reaction solution was spin-dried to give 0.97 g (yield 48.5%) of intermediate E as a pale yellow solid

According to the analysis of related databases, 859855-53-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 179898-34-1 as follows. COA of Formula: C7H3BrFN

Example 15 1,1-Dimethylethyl [(3-bromo-5-fluorophenyl)methyl]carbamate NaBH4 (1.99 g, 52.5 mmol) was cautiously added to a solution of NiCl2 (1.36 g, 10.5 mmol), Boc2O (4.58 g, 21.0 mmol) and 3-bromo-5-fluorobenzonitrile (2.10 g, 10.5 mmol) in absolute ethanol (30 mL) at 0 C. (vigorous reaction with the formation of a black precipitate). Once the reaction had subsided the mixture was left to stir at room temperature for 30 min. Ethanol was removed under reduced pressure and the precipitate was dissolved in EtOAc, filtered and repeatedly washed with EtOAc. The combined organic phases were washed with saturated NaHCO3, and dried (Na2SO4). After removing the solvent, the product, was purified by flash column chomatography to yield 1,1-dimethylethyl [(3-bromo-5-fluorophenyl)methyl]carbamate (2.20 g, 69%). 1H NMR (400 MHz, CDCl3) delta 1.46 (S, 9H), 4.28-4.32 (m, 2H), 4.87 (br, 1H), 6.93-7.29 (m, 3H); 13C NMR (100 MHz, CDCl3) delta 20.3, 43.6, 44.1, 79.7, 80.0, 113.0, 114.0, 117.7, 122.5, 126.0, 123.0, 141.7, 155.9, 161.5, 164.0.

According to the analysis of related databases, 179898-34-1, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 21423-81-4, name is 3-Chloro-4-methylbenzonitrile, molecular formula is C8H6ClN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H6ClN

Example 45 Preparation of 4-(Bromomethyl)-3-chlorobenzonitrile (CHO) To a stirred solution of 3-chloro-4-methylbenzonitrile (5 g, 25.4 mmol) in carbon tetrachloride (CCl4; 50 mL) under an argon atmosphere was added NBS (5.16 g, 29 mmol), and the mixture was degassed for 30 min. To this was added azobisisobutyronitrile (AIBN; 0.3 g, 1.8 mmol), and the resultant reaction mixture was heated at reflux for 4 h. The reaction mixture was cooled to ambient temperature, washed with H2O, and extracted with CH2Cl2. The combined CH2Cl2 layer was washed with brine, dried over Na2SO4, and concentrated under reduced pressure. The crude compound was purified by flash column chromatography (SiO2, 100-200 mesh; 5% EtOAc in n-Hexane) to afford the title compound as a white solid (4.8 g, 68%): mp 87-88 C.; 1H NMR (400 MHz, CDCl3) delta 7.71 (s, 1H), 7.59 (s, 2H), 4.60 (s, 2H); ESIMS m/z 229.77 ([M+H]+); IR (thin film) 2235, 752, 621 cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21423-81-4, its application will become more common.

Application of 868-54-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 868-54-2, name is 2-Aminoprop-1-ene-1,1,3-tricarbonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Heterocyclic ketene aminals (1 mmol), aryl aldehydes (1.2 mmol), malononitriledimer (1.5 mmol), acetic acid (1 mmol), piperidine (1 mmol) and ethanol (10 mL)were stirred at refluxing for 1 h. After completion of the reaction (confirmed by TLC),the reaction mixture was filtered to afford the crude product, which was furtherwashed with 95% ethanol to give pure product 4.

The synthetic route of 2-Aminoprop-1-ene-1,1,3-tricarbonitrile has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 151-18-8, HPLC of Formula: C3H6N2

Intermediate 28-2 : N-(2-C yanoethyl)-2-(q r,4s)-5 ‘-(4,4,5,5-tetramethyl- 1 ,3,2- dioxaborolan-2-yl)-2′,3′-dihydrospiro[cvclohexane-l,l’-indenel-4-yl)acetamide3-Aminopropionitrile (0.215 mL, 2.94 mmol) was added to a stirred solution of Intermediate 28-3 (725 mg, 1.96 mmol), N-ethyldiisopropylamine (1.023 mL, 5.87 mmol) and PyBROP (1.369 g, 2.94 mmol) in DCM (50 mL). The resulting solution was stirred at ambient temperature for 4 hours. The reaction mixture was evaporated to dryness and redissolved in EtOAc (125 mL), and washed sequentially with 2M HCl (75 mL) and saturated brine (75 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 0 to 100% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford the title compound (900 mg, 109 %) as a white foam.1H NMR (400 MHz, DMSO) delta 1.09 – 1.20 (2H, m), 1.27 (12H, s), 1.42 – 1.46 (2H, m), 1.53 – 1.67 (4H, m), 1.72 – 1.79 (IH, m), 1.90 (2H, t), 2.03 (2H, d), 2.63 (2H, t), 2.81 (2H, t), 3.26 – 3.29 (2H, m), 7.17 (IH, d), 7.46 (IH, d), 7.48 (IH, s), 8.16 (IH, t); m/z 423 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1187-42-4, name is Diaminomaleonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H4N4

General procedure: To a mixture of 2,3-diaminomaleonitrile (1 mmol) and corresponding aromatic aldehyde (1 mmol) in H2O (5 mL), cerium (IV) ammonium nitrate (5 molpercent) was added and the reaction mixture stirred at room temperature for the desired time, as shown in Table 3. After completion of the reaction (reaction progress was monitored by TLC, ethyl acetate/n-hexane, 3:1), cold water (5?10 mL) was addedand the solid was filtered and washed with cold water/ethanol and air-dried to give the Schiff base product.

The synthetic route of 1187-42-4 has been constantly updated, and we look forward to future research findings.