Author: Jessica.F

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7048-38-6 as follows. Recommanded Product: (5-Chloro-2-methoxyphenyl)acetonitrile

To a solution of 2-(5-chloro-2-methoxyphenyl)acetonitrile (lOg, 47.84mmol) in ethyl formate (50mL) was added sodium metal (4.4g, 95.6mmol) at room temperature. The resulting reaction mixture was heated at 100°C for 3 hours. After completion of the reaction, it was cooled to room temperature, water (100ml) and dichloromethane (100ml) were added to the reaction mixture and the solution was adjusted to pH-3 with the help of concentrated hydrochloric acid. The layers were separated and the aqueous layer was extracted with dichloromethane (2 x 100ml). The combined organics were washed with saturated aqueous sodium chloride solution (150ml), dried over sodium sulphate, filtered and evaporated in vacuo. The crude product was purified by column chromatography using normal phase silica gel. The desired product eluted at around 0.7 to 0.9percent methanol in dichloromethane. Evaporation of the product fractions gave 9g (yield, 77.94percent) of the desired compound as a white solid. LC-MS: m/z = 208.0(M-H).

According to the analysis of related databases, 7048-38-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 17417-09-3, name is 2-Fluoro-5-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17417-09-3, Computed Properties of C7H3FN2O2

Under room temperature, into the 3-amino-4-fluorophenol (3 g, 22.42mmol) and 2-fluoro-5-nitrobenzonitrile (4.19 g, 24.66mmol) into DMF (20 mL) solution added K2CO3 (4.89g, 35.4mmol). The solution was stirred at 80C for 8h, and the solution was extracted with ethyl acetate, washed with saturated sodium chloride, drying with anhydrous sodium sulfate, filtering out insoluble matter, filter and concentrate under reduced pressure, the residue obtained was purified by silica gel column chromatography, (eluent: petroleum ether / ethyl acetate = 5:1 -4:1), and the resulting solution was concentrated under reduced pressure, obtained 1.95 g of a light yellow solid, yield is 35%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-5-nitrobenzonitrile, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 53078-71-0, name is 4-Methoxy-3-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53078-71-0, COA of Formula: C9H9NO

REFERENTIAL EXAMPLE 14 To 9.8 g of 4-methoxy-3-methylbenzonitrile, were added 150 ml of carbon tetrachloride, 10 g of NBS, and 0.4 g of BPO. The mixture was heated under reflux for 2.5 hours. The reaction mixture was cooled in ice, filtered from insolubles and concentrated under reduced pressure. The residue was admixed with n-hexane, stirred for 30 minutes, and collected by filtration to yield 9 g of 3-bromomethyl-4-methoxybenzonitrile; m.p. 102-103 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Electric Literature of 39581-21-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39581-21-0, name is N-Butyl-2-cyano-acetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The synthetic route of N-Butyl-2-cyano-acetamide has been constantly updated, and we look forward to future research findings.

Synthetic Route of 159847-83-3, The chemical industry reduces the impact on the environment during synthesis 159847-83-3, name is Methyl 2-amino-4-cyanobenzoate, I believe this compound will play a more active role in future production and life.

To a solution of 7-ethoxy-2,3-dihydro-2,2-dimethyl-a-(1-methylethyl)-5-benzofuranmethanol (11.3 g, 42.9 mmol) and methyl 2-amino-4-cyanobenzoate (6.30 g, 35.8 mmol) in toluene (40 ml) and acetic acid (25 ml) was added conc. sulfuric acid (5.92 ml, 111 mmol) under ice-cooling, and the mixture was stirred for 2 hours at 80C. Methanol (18 ml) was added dropwise thereto, and the mixture was stirred for 30 minutes at 65C. After cooling, the reaction mixture was combined with ice water, neutralized with sodium hydrogen carbonate, and extracted three times with ethyl acetate. The combined organic layer was extracted three times with 1 M hydrochloric acid, and the combined aqueous layer was neutralized with sodium hydrogen carbonate, and extracted twice with ethyl acetate. The combined organic layer was washed with a saturated aqueous solution of sodium chloride, dried over sodium sulfate, filtered, and concentrated under reduced pressure. To the residue was added ethyl acetate, and the precipitated crystals were removed. The mother liquor was concentrated under reduced pressure, and the residue was purified with a basic silica gel column chromatography (hexane/ethyl acetate, 5:1 followed by 3:1) to give the title compound (7.33 g, yield 49%). Amorphous. 1H NMR (CDCl3) delta 1.24 (6H, s), 1.33 (6H, s), 1.46 (3H, t, J = 7.0 Hz), 2.36 (2H, s), 2.66 (2H, s), 3.89 (3H, s), 4.18 (2H, q, J = 7.0 Hz), 5.76 (2H, s), 6.59 (1H, s), 6.62 (1H, dd, J = 7.8, 1.5 Hz), 6.73 (1H, d, J = 1.5 Hz), 7.85 (1H, d, J = 7.8 Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-amino-4-cyanobenzoate, other downstream synthetic routes, hurry up and to see.

Reference of 107-91-5, A common heterocyclic compound, 107-91-5, name is 2-Cyanoacetamide, molecular formula is C3H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A substituted alkyl methyl ketone or cyclic ketone (1 equiv) and ethyl formate or ethyl acetic(1 equiv) was added dropwise to absolute ether solution of sodium metal (1 equiv) for 1 h whilemaintained below 20 C. After the addition, the reaction was allowed to stir in an ice bath untilthe sodium metal had disappeared. The precipitate was filtered, washed with absolute ether anddried to give the corresponding compound which was directly used for the next step without further purification. To a solution of previous product (1 equiv), and cyanoacetamide (1.05 equiv) in water was stirred6 min at room temperature. The mixture was added dropwise piperidine acetate solution (0.3 equiv),which was prepared from piperidine (1 equiv), acetic acid (1 equiv) and water (5 equiv). The solutionwas heated to reflux for 2 h. Then, the reactor was cooled to room temperature, and adjusted to pH 4 by 4 N hydrochloric acid. The resulting solid was filtered, respectively washed with water and ether,and dried to give the corresponding compound which was purified by recrystallizing using menthol as solvent. 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (1a): 58% yield, white solid, m.p. 264-266 C(lit. [24] 294 C), 1H-NMR (DMSO-d6, 600 MHz): delta 12.31 (br, 1H), 6.16 (s, 1H), 2.30 (s, 3H), 2.22 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3939-09-1 as follows. Formula: C7H3F2N

To a solution of 2,4-difluorobenzonitrile (10 g, 72 mmol) dissolved in tetrahydrofuran (20 mL), and dimethylformamide (40 mL) was added 1,2,4-triazole sodium salt (6.3 g, 70 mmol) and the mixture stirred at 90 0C for 3 h after which the mixture was filtered and the solvent removed. The resulting residue was adsorbed onto silica gel and intermediates 67 and 68 separated by flash chromatography, eluting with 0% to 30% ethyl acetate/hexanes.Intermediate 674-Fluoro-2-(lH-l,2,4-triazol-l-yl)benzonitrile. Colorless needles (2.46 g,18% yield) 1H NMR (500 MHz, CDCl3) delta: 8.89 (IH, s), 8.19 (IH, s), 7.85 (IH, dd, J = 8.7, 5.6 Hz), 7.60 (IH, dd, J= 8.8, 2.4 Hz), 7.28-7.24 (IH, m). LCMS (M+H) calcd for C9H6N4F: 189.05; found: 189.13. Intermediate e 684-(lH-l,2,4-Triazol-l-yl)-2-fluorobenzonitrile. White solid (0.746 g, 6% yield) 1H NMR (500 MHz, CDCl3) delta: 8.66 (IH, s), 8.15 (IH, s), 7.79 (IH, dd, J= 8.5, 6.7 Hz), 7.69 (IH, dd, J= 9.5, 1.8 Hz), 7.65-7.63 (IH, m). LCMS (M+H) calcd for C9H6N4F: 189.05; found: 189.13.

According to the analysis of related databases, 3939-09-1, the application of this compound in the production field has become more and more popular.

Related Products of 13338-63-1,Some common heterocyclic compound, 13338-63-1, name is 3,4,5-Trimethoxyphenylacetonitrile, molecular formula is C11H13NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The solution of NaOH (2.71g, 67.93mmol) in water (20mL) was added at room temperature to the solution of polymethoxyphenylacetonitrile [40] (5.0g, 33.96mmol) and hydroxylamine hydrochloride (4.72g, 67.93mmol) in EtOH (100mL). The reaction mixture was refluxed for 5h, the solvent was evaporated in vacuo, and the residue was washed by water (3×30mL) and dried. Yield 75-80%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,4,5-Trimethoxyphenylacetonitrile, its application will become more common.

Some common heterocyclic compound, 50397-74-5, name is 4-Amino-3-bromobenzonitrile, molecular formula is C7H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C7H5BrN2

General procedure: A mixture of benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (247 mg, 1.0 mmol), 2-bromo-4-methoxyaniline (303 mg, 1.5 mmol) and lithium perchlorate (190 mg, 1.7 mmol) were taken in acetonitrile (3.0 mL). The reaction mixture was heated to 90 C for 18 h. The reaction mixture was diluted with ethyl acetate (20 mL) and washed with water. The organic layer was dried over sodium sulfate and concentrated under reduced pressure, and the product was purified by column chromatography (silica gel, 50% EtOAc/hexanes) to provide benzyl 4-(((2-bromo-4-methoxyphenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate, 5c (358 mg, 80%) as a colourless syrup.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 50397-74-5, its application will become more common.

Synthetic Route of 50594-78-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50594-78-0, name is 5-Fluoro-2-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

Step 1 : 6-(N-(3-cyano-4-nitrophenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N- methylbenzofuran-3-carboxamide A mixture of 5-fluoro-2-nitrobenzonitrile (1 .280 mL, 1 1 .18 mmol), 5-cyclopropyl-2-(4- fluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide (3.0 g, 7.45 mmol) and K2CO3 (3.09 g, 22.36 mmol) in 1 ,2-dimethoxyethane (30 mL) and water (7.5 mL) in a seal tube was heated to 80 0 C overnight. It was cooled down to room temperature, diluted with EtOAc, filtered and the off-white solid was washed with water and then dried in vacuo to give crude desired product as a yellow solid (80 % purity, 3.9 g, 76 %). LCMS {m/z, ES+) = 549 (M+H+)

The chemical industry reduces the impact on the environment during synthesis 5-Fluoro-2-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.