Author: Jessica.F

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6575-13-9 as follows. SDS of cas: 6575-13-9

2,6-Dimethylbenzonitrile (10 g, 76.2 mmol),N-Bromosuccinimide (12.074 g, 68.6 mmol) and azobisisobutyronitrile (0.563 g, 3 mmol) were dissolved in anhydrous chloroform (241.42 mL), reacted at 65 C for 4 hours and extracted with dichloromethane After drying with anhydrous magnesium sulfate, purification was carried out by chromatography on silica gel (SiO2, n-Hexane: THF = 9: 1) to remove the side products to obtain a product.

According to the analysis of related databases, 6575-13-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92616-49-4, name is 4-Bromo-1-naphthonitrile, A new synthetic method of this compound is introduced below., Formula: C11H6BrN

2-[(1H-Indol-2-yl)hydrazino]acetic acid methyl ester (2.2 g), 4-bromo-1-naphthalenecarbonitrile (2.3 g), CuI (1.0 g), Cs2CO3 (3.0 g),Dimethyl glycine (500 mg) was added to DMSO (50 mL) and replaced by argon gas. The reaction was stirred at 130 C for 12 h.After cooling to room temperature, ethyl acetate and saturated water were added to separate the layers. The ethyl acetate phase was washed twice with saturated brine, dried over anhydrous sodium sulfate and filtered.Concentration under reduced pressure and purification by column chromatography (eluent: dichloromethane:methanol = 10:1, v:v) gave 0.9 g of pure product in 24% yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 77326-36-4,Some common heterocyclic compound, 77326-36-4, name is 2-Amino-6-fluorobenzonitrile, molecular formula is C7H5FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2;: N,N-Dimethyl-2-cyano-3-methoxyphenylsulfonamide (Compound No. 2); 2.1 : 2-Amino-6-methoxybenzonitrile; EPO A solution of 70 g (0.5 mol) of 2-amino-6-fluorobenzonitrile (prepared, e.g. according to US 4,504,660) in 250 ml of N,N-dimethylformamide was prepared, and a solution of 30.6 g (0.55 mol) of sodium methoxide in 70 ml of methanol was added dropwise at room temperature while stirring. The mixture was then refluxed for 5 hours with stirring. The completion of the reaction was monitored by TLC. An additional 25 g of sodium methoxide in 35 ml methanol were added and the reaction mixture was refluxed for an additional 4 hours while stirring. The reaction mixture was concentrated under reduced pressure. The resulting residue was triturated with water, filtered off with suction and the solids obtained were dissolved in ethyl acetate. The resulting solution was concen- trated in vacuo. The obtained residue was triturated with petroleum ether and filtered off with suction. Yield: 48 g (63% of theory) of a brownish solid having a melting point of 143-146C.

The synthetic route of 77326-36-4 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 52133-67-2, name is Ethyl 2-cyano-4,4-diethoxybutyrate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C11H19NO4

General procedure: A mixture of 0.1 mol of acetal 4 or 6-8 and 0.12 mol of 7% aqueous HCl was stirred for 3 h at 70-80C. The product was isolated by distillation.

The synthetic route of Ethyl 2-cyano-4,4-diethoxybutyrate has been constantly updated, and we look forward to future research findings.

Reference of 915394-29-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 915394-29-5, name is 2-(3-Aminophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows.

FIG. 3C shows a modification of Scheme 1 (e.g., Scheme 1A), which uses a different Ring A reactant that results in the Ring A of the product being the structure of Compound 115. Accordingly, variations of Scheme 1 can be implemented to generate the other compounds that fall under Formula A and/or Formula B.Compound 115 is confirmed by the following spectral data: the yellow solid of Compound 115 (37.82 mg, 83.63 u mol, 34.89% yield, 95.630% purity) was confirmed by 1HNMR(EW13467-173-P1A), CNMR(EW13467-173-P1B), LCMS(EW13467-173-P1B) and HPLC(EW13467-173-P1B); LCMS: Retention time: 1.021 min, (M+H)=433.3, 5-95AB_R_220&254.1 cm. EW13467-173-P1B; HPLC: Retention time: 2.403 min, 10-80AB_4min.1 cm. EW13467-173-P1B; NMR: 1H NMR (400 MHz, DMSO-d6) ppm=9.79 (s, 1H), 8.75 (br d, J =4.0 Hz, 1H), 8.28 (br d, J =8.9 Hz, 2H), 8.09 (d, J =8.1 Hz,1H), 7.88 (s, 1H), 7.76-7.67 (m, 1H), 7.48-7.34 (m, 3H), 7.13 (br d, J =7.7 Hz, 1H), 2.69 (s, 3H), 1.72 (s, 6H).

The chemical industry reduces the impact on the environment during synthesis 2-(3-Aminophenyl)-2-methylpropanenitrile. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4475-95-0, name is 2-Amino-2-methylbutanenitrile, A new synthetic method of this compound is introduced below., SDS of cas: 4475-95-0

5:00 g (50.94 mmol) of 2-amino-2-methylbutanonitril [synthesis described in: Lonza AG, US 5,698,704 (1997);Deng, SL et al.Synthesis 2001, 2445;Hjorringgaard, CU et al.. J. Org. Chem 2009, 74, 1329;Ogrel, A. et al.EUR. J. Org. Chem. 2000, 857] were introduced into 50 ml of THF and 6.5 ml of water, 21.83 g (157.92 mmol) of potassium carbonate and treated at 0 C slowly with 7.9 ml (56.04 mmol) Benzylchlorocarbonat (benzylchloroformate) ,After addition of 8 ml THF and 3 ml of water, the reaction mixture was stirred slowly at RT coming overnight.Then was treated with water and extracted three times with ethyl acetate.The combined organic phases were dried over sodium sulfate and concentrated.The residue was dissolved in diethyl ether and precipitated with petroleum ether.The product was filtered off, the solid washed with a little petroleum ether and dried under high vacuum.There were 11:35 g of the target compound (93%. Th.)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 630-18-2,Some common heterocyclic compound, 630-18-2, name is Pivalonitrile, molecular formula is C5H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The title compound is prepared from commercially available materials by those skilled in the art by adaptation of a patent reference (Neighbors et al, US 3,547,621).To a solution of hydroxylamine hydrochloride (6.80 g, 97.9 mmol) in water (15 mL) is added slowly a solution of potassium carbonate (6.15 g, 44.5 mmol) in water (10 mL) and 2,2- dimethyl propionitrile (6.25 g, 89.0 mmol) in ethanol (50 mL). The mixture is stirred at room temperature for 30 min then heated at reflux for 16 h. After this time, dichloromethane (75 mL) and water (50 mL) are added and the aqueous layer is extracted with dichloromethane (3 x 50 mL). The organic layers are combined, washed with brine (20 mL), dried (Na2SO4), filtered and concentrated under reduced pressure to afford the title compound as a white solid (6.15 g, 60%). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.21 (9 H, s), 4.57 (2 H, br. s.), 9.15 (1 H, br. s.).

The synthetic route of 630-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/140089; (2009); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 29509-06-6, The chemical industry reduces the impact on the environment during synthesis 29509-06-6, name is 4-Methyl-3-oxopentanenitrile, I believe this compound will play a more active role in future production and life.

7-A. 5-Isopropyl-isoxazol-3-ylamine.; To a mixture of 4-methyl-3-oxopentanenitrile (11 g, 99 mmol) and water (200 mL) is added NaOH (4.95 g, 124 mmol). Once the NaOH pellets are completely dissolved, hydroxylamine sulfate (8.93 g, 109 mmol) is added and after 5 min the pH is measured (pH 7-8). The reaction is warmed to 40 0C and stirred for 72 h. At this point HCI (13.0 mL, 158 mmol, 37%) is added in one portion and the reaction warmed to 50 0C for 2.5 h. The reaction is removed from the oil bath and allowed to cool to rt. At this point a solution of NaOH (30% in H2O) is added to give a solution of pH 1 1. EtOAc is then added and the layers separated. The water layer is extracted with EtOAc (3 x) until no more product appears in the LCMS of the water layer. The combined organics are dried (Na2SO4) and evaporated to give 5-isopropyl- isoxazol-3-ylamine. MS (ESI) m/z 127.2 (M+1 ).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methyl-3-oxopentanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang; WO2010/66684; (2010); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 16932-49-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16932-49-3, name is 2,6-Dimethoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: :2,6-dimethoxybenzonitrile (501 mg, 3.07 mmol) and4-amino-7-chloroquinoline (548 mg, 3.07 mmol) were dissolved together in 20 mLof anhydrous tetrahydrofuran. The vesselwas swept with nitrogen and chilled in an ice-water bath. Ethereal 3.0 M ethyl magnesium bromide (2.05 mL,6.14 mmol) was added dropwise over 3 min.After briefly forming an off-white solid suspended in a yellow solution,within minutes the mixture became a dark amber homogenous solution with someoff-white solid material remaining. Thevessel was placed in a 75 C oil bath for 21 h before diluting with 60 mL ofwater. The pH was decreased to ca. 14 byaddition of 4 pellets of NaOH. Themixture was then extracted with 60 mL of ethyl acetate, using solid NaCl tofacilitate partitioning. The organicswere dried over MgSO4 and concentrated to 1.27 g of a crude brownoily paste containing mostly unreacted starting materials. Flash chromatography (150 mL silica gel, 50%ethyl acetate / hexane, then neat ethyl acetate, then 10% methanol in ethylacetate) returned 100 mg (9.6%) ofN-(7-chloroquinolin-4-yl)-2,6-dimethoxybenzimidamide (G).

The chemical industry reduces the impact on the environment during synthesis 2,6-Dimethoxybenzonitrile. I believe this compound will play a more active role in future production and life.

Reference:
Article; Hershberger, Paul M.; Hedrick, Michael P.; Peddibhotla, Satyamaheshwar; Mangravita-Novo, Arianna; Gosalia, Palak; Li, Yujie; Gray, Wilson; Vicchiarelli, Michael; Smith, Layton H.; Chung, Thomas D.Y.; Thomas, James B.; Caron, Marc G.; Pinkerton, Anthony B.; Barak, Lawrence S.; Roth, Gregory P.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 262 – 267;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1835-65-0, A common heterocyclic compound, 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile, molecular formula is C8F4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of Exemplified Compounds (P-1-1), (P-2-1), and (P-3-1)Under nitrogen atmosphere, in 50 ml of 1-methyl-2-pyrrolidone, were dissolved 3.0 g (15 mmol) of tetrafluorophthalonitrile, 1.5 g (5.0 mmol) of synthesis intermediate (B), and 0.99 g (10 mmol) of copper chloride (I), and then stirred for 3 hours at 180¡ã C. After cooling the reaction mixture to room temperature, it was poured into 200 ml of a 5percent hydrochloric acid. Consequently, blue crystals were precipitated. These crystals were separated by a filtration under reduced pressure, followed by washing with water and then acetonitrile, and thereafter drying. Further, they were boiled with 50 ml of acetonitrile for 1 hour, and allowed to cool down to room temperature. The resultant precipitates were separated by a filtration under reduced pressure, and then dried. Thereby was obtained 2.2 g (Yield: 45percent) of a mixture (PP-1) (Melting point>200¡ã C.) containing the exemplified compounds (P-1-1), (P-2-1), and (P-3-1) of the present invention; and hexadecafluoro cupper phthalocyanine (F16CuPc).A mixing rate of phthalocyanine derivatives was measured by a liquid chromatography mass spectrometric analysis (LCMS). The result in terms of area ratio was as follows: (P-1-1):(P-2-1):(P-3-1):(F16CuPc)=54.0:26.4:4.1:15.5 (Since a molar absorption intensity of each of (P-1-1), (P-2-1), (P-3-1), and (F16CuPc) at a detecting wavelength of 254 nm is almost same, the ratio measured from the area results in equal to a molar ratio.).Measuring conditions: TSK gel ODS-80Ts (2 mm Phi.x.150 mm), elute: a mixed solution of A/B (volume ratio 3:7) from 0 minute to 15 minutes, and a mixed solution of A/B (volume ratio 15:85) from 15 minutes to 20 minutes) (elute A: water, elute B: a mixed solution of tetrahydrofuran/methanol (volume ratio 9:1)), flow rate: 0.2 ml/min, a detecting wavelength 254 nm, structural determination by atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) (It was confirmed using MS that a peak at the retention time=8.185 minutes was (F16CuPc), a peak at the retention time=11.676 minutes was (P-1-1), a peak at the retention time=13.905 minutes was (P-2-1), and a peak at the retention time=14.350 minutes was (P-3-1)). A peak was detected in the blank at the retention time of from 0 to 4 minutes, so that a measurement was started from 4 minutes.

The synthetic route of 1835-65-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUJIFILM Corporation; US7947826; (2011); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts