Author: Jessica.F

Rafiee, E. published the artcileCobalt polyoxometalate, [CoW₁₂O₄₀]^5-, as a new reusable catalyst for addition of trimethylsilyl cyanide to carbonyl compounds, Quality Control of 13312-84-0, the publication is Bulletin of the Korean Chemical Society (2005), 26(10), 1585-1587, database is CAplus.

A series of cyanohydrin trimethylsilyl ethers have been prepared via cyanosilylation of various carbonyl compounds with trimethylsilyl cyanide. The reaction was catalyzed with potassium dodecatungstocobaltate trihydrate which was found to be a convenient and reusable catalyst.

Bulletin of the Korean Chemical Society published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Quality Control of 13312-84-0.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Feng, Huan-Xi published the artcileAn Efficient One-Pot Approach to the Construction of Chiral Nitrogen-Containing Heterocycles under Mild Conditions, Related Products of nitriles-buliding-blocks, the publication is Organic Letters (2015), 17(15), 3794-3797, database is CAplus and MEDLINE.

A new, general, and practical procedure for the highly enantioselective synthesis of functionalized nitrogen-containing heterocycles, e.g., I, has been developed. The simple cyclic hemiaminals were directly catalyzed for the first time as nucleophiles in an enamine-based asym. conjugate addition reaction. The practical approach recycles the catalyst and solvent which make it possible for large-scale and diversity-oriented chem. production

Organic Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C9H6N2O2, Related Products of nitriles-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ooi, Takashi published the artcileZr(OtBu)₄ as a new promoter for the Meerwein-Ponndorf-Verley alkynylation and cyanation of aldehydes, Product Details of C8H6ClNO, the publication is Synlett (2000), 69-70, database is CAplus.

Zr(OCMe₃)₄ can serve as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation of aldehydes, and it was found to be particularly attractive in the Meerwein-Ponndorf-Verley cyanation.

Synlett published new progress about 13312-84-0. 13312-84-0 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Alcohol,Benzene Compounds, name is 2-(2-Chlorophenyl)-2-hydroxyacetonitrile, and the molecular formula is C8H6ClNO, Product Details of C8H6ClNO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Ishiyama, Tatsuo published the artcileA stoichiometric aromatic C-H borylation catalyzed by iridium(i)/2,2′-bipyridine complexes at room temperature, SDS of cas: 479411-95-5, the publication is Angewandte Chemie, International Edition (2002), 41(16), 3056-3058, database is CAplus and MEDLINE.

Room-temperature C-H borylation using a stoichiometric amount of arenes and bis(pinacolato)diboron (pin₂B₂) is efficiently catalyzed by iridium(I) complexes generated from [{Ir(OMe)(cod)}₂] (cod = 1,5-cyclooctadiene) and 4,4′-di-tert-butyl-2,2′-bipyridine (dtbpy) in hexane, and provides the corresponding arylboronates in excellent yields. Thus, [{Ir(OMe)(cod)}₂]/dtbpy catalyzed C-H borylation of 1,2-dichlorobenzene with pin₂B₂ in hexane at 25° for 8h gave 82% 3,4-Cl₂C₆H₃Bpin.

Angewandte Chemie, International Edition published new progress about 479411-95-5. 479411-95-5 belongs to nitriles-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Nitrile,Boronic acid and ester,Benzene,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzonitrile, and the molecular formula is C14H15BF3NO2, SDS of cas: 479411-95-5.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Tominaga, Masahide published the artcile24-Fold Endohedral Functionalization of a Self-Assembled M₁₂L₂₄ Coordination Nanoball, Computed Properties of 68569-14-2, the publication is Journal of the American Chemical Society (2005), 127(34), 11950-11951, database is CAplus and MEDLINE.

A ca. 5 nm-sized, roughly spherical hollow complex was assembled from 12 Pd²⁺ ions and 24 bis(4-pyridylethenyl)-substituted bent ligands. By putting a functional group at the curvature of the ligand, the 24 functional groups were precisely arrayed inward within the spherical complex. When oligo(ethylene oxide) was anchored, the void of the hollow complex was tightly filled with a pseudo poly(ethylene oxide) nanoparticle, which showed metal ion (La³⁺) absorption property.

Journal of the American Chemical Society published new progress about 68569-14-2. 68569-14-2 belongs to nitriles-buliding-blocks, auxiliary class Palladium, name is Tetrakis(acetonitrile)palladium(II) Ditriflate, and the molecular formula is C3H9ClOS, Computed Properties of 68569-14-2.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Taylor, Edward C. published the artcileA new synthesis of aminomalononitrile tosylate, Synthetic Route of 5098-14-6, the publication is Synthesis (1980), 801-2, database is CAplus.

The title salt (I) was prepared from NaCH(CN)₂. Thus, 2,4,6-Me₃C₆H₂SO₂ONH₂ was added to NaCH(CN)₂ in THF, the mixture stirred under N₂ 2.5 h at 0°, the 2,4,6-Me₃C₆H₂SO₃Na formed was separated, 4-MeC₆H₄SO₃H added, and the mixture refrigerated overnight to give I.

Synthesis published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C4H4OS, Synthetic Route of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Szczesniak, Piotr published the artcileAsymmetric Synthesis of Cyclic Nitrones via Organocatalytic Michael Addition of Aldehydes to Nitroolefins and Subsequent Reductive Cyclization., HPLC of Formula: 5153-73-1, the publication is ChemistrySelect (2017), 2(9), 2670-2676, database is CAplus.

A direct approach to the synthesis of optically active five-membered cyclic nitrones I [R¹ = H, Me, OBn, etc., R² = H, Et, Ph, etc.; R¹R² = (CH₂)₄, (CH₂)₅; R³ = Ph, 2-naphthyl, 2-thienyl, etc.] was described. The presented strategy was based on organocatalytic Michael addition of aldehydes to trans-nitroalkenes to afford γ-nitroaldehydes II and subsequent reductive cyclization to form 4-substituted-3-(aryl)-3,4-dihydro-2H-pyrrole-1-oxides I. The developed methodol. was successfully applied to the asym. synthesis of Methdilazine.

ChemistrySelect published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C8H17Br, HPLC of Formula: 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Fisher, D. E. published the artcileFate of Banvel T, ioxynil, Tordon, and trifluralin in the dairy cow, Computed Properties of 3336-34-3, the publication is Journal of Dairy Science (1965), 48(12), 1711-15, database is CAplus.

The metabolic fate of 5 ppm. of 4 orally administered herbicides was determined by gas chromatography on neutron activation analysis of total I in the feces, urine, rumen contents, and milk of dairy cows. No residues of Banvel T (2-methoxy-3,5,6-trichlorobenzoic acid), ioxynil (3,5-diiodo-4-hydroxybenzonitrile), or trifluralin (α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine) were found in the milk. Banvel T and Tordon (4-amino-3,5,6-trichloropicolinic acid) were eliminated unchanged in the urine. No ioxynil or a possible metabolite, 3,5-diiodo-4-hydroxybenzoic acid, was found in the milk, urine, or feces by gas chromatography, but neutron activation analysis of total I indicated that substantial amounts of ioxynil and a metabolite, possibly 3-iodo-4-hydroxybenzonitrile, were present. Trifluralin completely disappeared during 24 hrs. in an artificial rumen, possibly due to nitro reduction

Journal of Dairy Science published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Computed Properties of 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Singh, Shivendra published the artcileRapid access of 2,3,4-trisubstituted-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole derivatives via one-pot three component catalytic reaction, Synthetic Route of 5153-73-1, the publication is Tetrahedron Letters (2012), 53(45), 6087-6090, database is CAplus.

A simple, green, and efficient one-pot three component strategy for the synthesis of 2-aryl-3-nitro-4-hydroxy-2,3,4,9-tetrahydrothiopyrano[2,3-b]indoles I [R = Boc, EtO₂C; R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = H, Me] has been achieved by the combination of N-protected-2-chloro-3-formylindoles, sodium hydrosulfide with β-nitrostyrenes R¹CH:C(R²)NO₂ at room temperature in ethanol using DABCO as a catalyst. Furthermore, high enantio- and diastereoselectives’ syntheses of title compounds have been achieved for the first time using cupreidine (5 mol %) as catalyst, providing good to excellent yields.

Tetrahedron Letters published new progress about 5153-73-1. 5153-73-1 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Alkenyl,Nitro Compound,Benzene, name is (E)-4-(2-Nitrovinyl)benzonitrile, and the molecular formula is C10H15ClO3S, Synthetic Route of 5153-73-1.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Frasson, Ilaria published the artcileSynthesis and photocytotoxic activity of [1,2,3]triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines, Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate, the publication is European Journal of Medicinal Chemistry (2019), 176-193, database is CAplus and MEDLINE.

[1,2,3]Triazolo[4,5-h][1,6]naphthyridines and [1,3]oxazolo[5,4-h][1,6]naphthyridines were synthesized with the aim to investigate their photocytotoxic activity. Upon irradiation, oxazolo-naphtapyridines induced light-dependent cell death at nanomolar/low micromolar concentrations (EC₅₀ 0.01-6.59 μM). The most photocytotoxic derivative showed very high selectivity and photocytotoxicity indexes (SI = 72-86, PTI>5000), along with a triplet excited state with exceptionally long lifetime (18.0 μs) and high molar absorptivity (29781 ± 180 M^-1cm^-1 at λ_max 315 nm). The light-induced production of ROS promptly induced an unquenchable apoptotic process selectively in tumor cells, with mitochondrial and lysosomal involvement. Altogether, these results demonstrate that the most active compound acts as a promising singlet oxygen sensitizer for biol. applications.

European Journal of Medicinal Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts