Category: 100-70-9

Kalyani, Adula published the artcilePalladium catalyzed nitrile insertion and cyanation of biindoles: Synthesis of indole fused α-carboline scaffolds via double C-H activation, SDS of cas: 100-70-9, the main research area is indole fused alpha carboline preparation; biindole nitrile double carbon hydrogen activation cyclization palladium.

A palladium-catalyzed synthesis of indole fused α-carbolines (pyridodiindoles) from 2,3′-biindoles and nitriles has been developed. This conversion involves the double C-H activation and cyclization of 2,3′-biindoles with nitriles via C-C and C-N bond formation in a single step. However, C-3 cyanated biindoles were formed through a retro-Mannich pathway when the reaction was carried out with Et cyanoacetate.

Tetrahedron Letters published new progress about C-H bond activation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guerriero, Antonella published the artcileSynthesis of New Ruthenium-CAP Complexes and Use as Catalysts for Benzonitrile Hydration to Benzamide, Safety of Picolinonitrile, the main research area is ruthenium triazaphosphatricyclotridecane complex preparation hydration catalyst.

The new bimetallic [Ru2(μ-Cl)3(CAP)6]Cl (1) and monometallic cis,cis,trans-[RuCl2(dmso-S)2(CAP)2] (2) complexes, bearing the water soluble cage-like phosphine CAP (1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane), were synthesized and characterized in solution by NMR spectroscopy and ESI-MS spectrometry. The complexes, endowed with high solubility and stability in water, were applied as catalysts for the proof-of-concept hydration of benzonitrile to benzamide in neat water at 100°C, achieving high conversions with only 1 mol % of catalyst, both in single runs and in catalyst recycling experiments

European Journal of Inorganic Chemistry published new progress about Hydration catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Panomsuwan, Gasidit published the artcileIn situ solution plasma synthesis of silver nanoparticles supported on nitrogen-doped carbons with enhanced oxygen reduction activity, Category: nitriles-buliding-blocks, the main research area is silver nanoparticle nitrogen doped carbon electrocatalyst plasma synthesis; oxygen reduction reaction silver nanoparticle nitrogen doped carbon electrocatalyst.

Silver nanoparticles supported on nitrogen-doped carbons (Ag/NC) were in situ synthesized by a solution plasma process. In the solution plasma, Ag nanoparticles were produced via the sputtering of Ag electrode, while the NC supports were simultaneously synthesized from 2-cyanopyridine (C6H4N2). The results of the characterization show that Ag nanoparticles had good crystallinity and the NC supports possessed an amorphous structure. The oxygen reduction reaction (ORR) catalyzed on Ag/NC proceeded via the co-existence of two and four-electron pathways in alk. solution, with the four-electron pathway being found to be more dominant. An enhanced ORR activity of Ag/NC was attributed to the synergistic effect of Ag nanoparticles and NC supports. Moreover, Ag/NC exhibited long-term durability and high resistance to methanol oxidation in comparison with the com. Pt/C catalyst.

Materials Letters published new progress about Amorphous structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Galani, Sunil M. published the artcileEnhanced Thermocatalytic Activity of Porous Yellow ZnO Nanoflakes: Defect- and Morphology-Induced Perspectives, Application In Synthesis of 100-70-9, the main research area is thermocatalysis porous yellow zinc oxide nanoflake defect morphol; heterogeneous catalysis; nanostructures; oxygen vacancies; tetrazole; zinc oxide.

A simple and effective strategy is reported for the synthesis of yellow ZnO (Y-ZnO) nanostructures with abundant O vacancies on a large scale, through the sulfidation of ZnO followed by calcination. The developed strategy allows retention of the overall morphol. of Y-ZnO compared with pristine ZnO and the extent of O vacancies can be tuned. The influence of O deficiencies, the extent of defect sites, and the morphol. of ZnO on its solution-phase thermocatalytic activity was evaluated in the synthesis of 5-substituted-1H-tetrazoles with different nitriles and Na azide. A reasonable enhancement in the reaction rate was achieved by using Y-ZnO nanoflakes (Y-ZnO NFs) as a catalyst in place of pristine ZnO NFs. The reaction was complete within 6 h at 110° with Y-ZnO NFs, whereas it took 14 h at 120° with pristine ZnO NFs. The catalyst is easy to recycle without a significant loss in catalytic activity.

Chemistry – An Asian Journal published new progress about Catalysis (thermo-). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalyani, Adula published the artcilePalladium catalyzed nitrile insertion and cyanation of biindoles: Synthesis of indole fused α-carboline scaffolds via double C-H activation, SDS of cas: 100-70-9, the main research area is indole fused alpha carboline preparation; biindole nitrile double carbon hydrogen activation cyclization palladium.

A palladium-catalyzed synthesis of indole fused α-carbolines (pyridodiindoles) from 2,3′-biindoles and nitriles has been developed. This conversion involves the double C-H activation and cyclization of 2,3′-biindoles with nitriles via C-C and C-N bond formation in a single step. However, C-3 cyanated biindoles were formed through a retro-Mannich pathway when the reaction was carried out with Et cyanoacetate.

Tetrahedron Letters published new progress about C-H bond activation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guerriero, Antonella published the artcileSynthesis of New Ruthenium-CAP Complexes and Use as Catalysts for Benzonitrile Hydration to Benzamide, Safety of Picolinonitrile, the main research area is ruthenium triazaphosphatricyclotridecane complex preparation hydration catalyst.

The new bimetallic [Ru2(μ-Cl)3(CAP)6]Cl (1) and monometallic cis,cis,trans-[RuCl2(dmso-S)2(CAP)2] (2) complexes, bearing the water soluble cage-like phosphine CAP (1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane), were synthesized and characterized in solution by NMR spectroscopy and ESI-MS spectrometry. The complexes, endowed with high solubility and stability in water, were applied as catalysts for the proof-of-concept hydration of benzonitrile to benzamide in neat water at 100°C, achieving high conversions with only 1 mol % of catalyst, both in single runs and in catalyst recycling experiments

European Journal of Inorganic Chemistry published new progress about Hydration catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cui, Jie published the artcileA conformational transition based fluorescent probe for mapping lysosomal viscosity fluctuations by fluorescence lifetime imaging, Computed Properties of 100-70-9, the main research area is autophagy apoptosis lysosomal viscosity fluorescence lifetime imaging.

The local viscosity within lysosomes fluctuates dynamically under various physiol. and pathol. processes (e.g., autophagy and apoptosis), and has long been regarded as a key indicator to reflect lysosomal status and functionality. Therefore, accurate monitoring of lysosomal viscosity fluctuations is essential for a better understanding of lysosomal function and pathol. Herein, we present a distorted-conformation-induced viscosity-sensitive fluorescent mol. rotor (FMR), BODIPY-P, for quant. monitoring of lysosomal viscosity. BODIPY-P exhibited outstanding performance, including high sensitivity and selectivity to viscosity, dual response mode of fluorescence intensity and fluorescence lifetime, specific lysosome targeting, quick washing-free imaging and excellent intracellular photostability. Utilizing BODIPY-P, we successfully achieved specific mapping and quantifying the fluctuations of lysosomal viscosity during autophagy and apoptosis through dual-mode imaging of fluorescence intensity and fluorescence lifetime. D. functional theory revealed that the intrinsic viscosity-sensitive mechanism of BODIPY-Pwas ascribed to the conformational transition between planar and distortion caused by the rotation of the meso-benzene ring. Our study will spur addnl. research on FMRs, including the in-depth exploration of their underlying viscosity-responsive mechanism and potential applications in viscosity-related physiol. and pathol. investigations.

Sensors and Actuators, B: Chemical published new progress about Absorption spectra. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Leenaers, Pieter J. published the artcileInfluence of Regioregularity on the Optoelectronic Properties of Conjugated Diketopyrrolopyrrole Polymers Comprising Asymmetric Monomers, HPLC of Formula: 100-70-9, the main research area is regioregularity optoelectronic conjugated diketopyrrolopyrrole polymer comprising asym monomer.

Two asym. thiophene (T)/pyridine (Py) flanked diketopyrrolopyrrole (DPP) polymers with a regiorandom and regioregular conjugated backbone are synthesized via a Stille polycondensation to investigate the effect of regioregularity on their optoelectronic properties and photovoltaic performance in fullerene-based polymer solar cells. Surprisingly, both polymers possess very similar optical bandgap, energy levels, and photovoltaic performance. These findings, combined with a factor of 19 reactivity difference between the two end groups of the asym. DPP monomer, intuitively suggest the formation of regular chain segments in the random polymer. However, by modeling the random polymerization reaction with a kinetic Monte Carlo (KMC) simulation, evidence is obtained for exclusive formation of a fully random polymer structure. UV-vis-NIR absorption spectra of three extended DPP chromophores, containing the donor segments (T-T-T, Py-T-Py, and Py-T-T) present in the regiorandom polymer, confirm that regioregularity of the backbone has a negligible influence on the optical properties.

Macromolecules (Washington, DC, United States) published new progress about Absorption spectra. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shit, Manik published the artcileSupramolecular assembly of an Au(III) complex of 2-(3-phenyl-1H-1,2,4-triazol-5-yl)pyridine: Structure, biological studies and charge transportation, Category: nitriles-buliding-blocks, the main research area is crystal structure gold phenyltriazolylpyridine complex; gold phenyltriazolylpyridine preparation biol charge transport study.

An Au(III) complex, [Au(2-ptp)2]Cl (1) (2-ptp = 2-(3-phenyl-1H-1,2,4-triazol-5-yl)pyridine), was characterized by single-crystal x-ray diffraction technique and other spectroscopic data. Presence of different noncovalent interactions gives 3-dimensional supramol. structure. The complex 1 exhibits antibacterial activity against Gram-pos. (MIC) (Staphylococcus aureus [240μg/mL], Bacillus subtilis [645μg/mL]) and Gram-neg. ( Escherichia coli [270μg/mL], Enterococcus faecalis [820μg/mL], Klebsiella pneumonia [785μg/mL]) bacteria. Also, the toxicity of 1 was checked by MTT assay. The complex shows promising anticancer activity against Vero cells and the CC50 is 405μg/mL. The complex also shows improved conductivity (Λ) by one order difference on illumination (Λdark, 7.42 × 10-5 Sm-1 and Λillumination, 2.45 x 10-4 Sm-1).

Applied Organometallic Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Sonika published the artcileVanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach, SDS of cas: 100-70-9, the main research area is oxidovanadium coordination complex preparation antibacterial antifungal; mol structural calculation oxidovanadium coordination complex.

A set of new oxidovanadium(IV) complexes, [VO(4-NO2C6H4CH:CHCONHO)2] (1), [VO(4-NO2C6H4CH:CHCONHO)2(2-CNC5H4N)] (2), and [VO(4-NO2C6H4CH:CHCONHO)2(4-CNC6H4NH2)] (3), were synthesized and characterized by different anal. techniques (magnetic susceptibility, molar conductivity, elemental anal.) and spectroscopic techniques, viz., FTIR, UV-visible, EPR, and mass spectrometry. The magnetic susceptibility, EPR, and ESI-MS data indicate that exists as monomer and a distorted square pyramidal geometry around vanadium is ascertained. The electrochem. study of showed that it is electrochem. active exhibiting VOV/VOIV quasi-reversible redox couple. The biol. activity of 1-3 was studied against various pathogenic bacteria Staphylococcus epidermidis, Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Salmonella paratyphi, and Salmonella typhi, and fungi Brachypsectra fulva, Candida albicans, and Fusarium oxysporum by min. inhibitory concentration (MIC) method. In some cases, the synthesized complexes showed superior antibacterial and antifungal activity than the known standard drugs tetracycline hydrochloride and fluconazole. The cytotoxicity of 1-3 was studied on a human cervix carcinoma HeLa cell derivative (mammalian transformed cell line Hep2c) by MTT assay. D. functional theory (DFT) studies were carried out to determine their relative free energy of formation and optimized mol. structures of 1-3. Time-dependent d. functional theory (TD-DFT) based calculations were performed to find out the frontier MOs and corroborate with the exptl. observed electronic transitions of 1. Other parameters like HOMO, LUMO energies, and global reactivity descriptors clearly support higher biol. activity of 2 and 3 than 1.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts