Category: 100-70-9

Yi, Qiao-Yan published the artcileAnticancer and antibacterial activity in vitro evaluation of iridium(III) polypyridyl complexes, Synthetic Route of 100-70-9, the main research area is iridium polypyridyl complexes apoptosis cell cycle anticancer antibacterial; Antibacterial activity; Apoptosis; Cell cycle distribution; Iridium(III) complexes; Western blot.

Three iridium(III) polypyridyl complexes [Ir(ppy)2(PYTA)](PF6) (1) (ppy = 2-phenylpyridine), [Ir(bzq)2(PYTA)](PF6) (2) (bzq = benzo[h]quinolone) and [Ir(piq)2(PYTA)](PF6) (3) (piq = 1-phenylisoquinoline, PYTA = 2,4-diamino-6-(2′-pyridyl)-1,3,5-triazine) were synthesized and characterized by elemental anal., IR, 1H NMR and 13C NMR. The cytotoxic activity of the complexes toward cancer SGC-7901, Eca-109, A549, HeLa, HepG2, BEL-7402 and normal LO2 cell lines was investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Complex 3 shows the most effective on inhibiting the above cell growth among these complexes. The complexes locate at the lysosomes and mitochondria. AO/EB, Annex V and PI and comet assays indicate that the complexes can induce apoptosis in SGC-7901 cells. Intracellular ROS and mitochondrial membrane potential were examined under fluorescence microscopy. The results demonstrate that the complexes increase the intracellular ROS levels and induce a decrease in the mitochondrial membrane potential. The complexes can enhance intracellular Ca2+ concentration and cause a release of cytochrome c. The autophagy was studied using MDC staining and western blot. Complexes 1-3 can effectively inhibit the cell invasion with a concentration-dependent manner. Addnl., the complexes target tubules and inhibit the polymerization of tubules. The antimicrobial activity of the complexes against S. aureus, E. coli, Salmonella and L. monocytogenes was explored. The mechanism shows that the complexes induce apoptosis in SGC-7901 cells through ROS-mediated lysosomal-mitochondrial, targeting tubules and damage DNA pathways. Three iridium(III) complexes [Ir(N-C)2(PYTA)](PF6) (N-C = ppy, 1; bzq, 2; piq, 3) were synthesized and characterized. The anticancer activity of the complexes against SGC-7901 cells was studied by apoptosis, comet assay, autophagy, ROS, mitochondrial membrane potential, intracellular Ca2+ levels, release of cytochrome c, tubules and western blot anal. The antibacterial activity in vitro was also assayed.

JBIC, Journal of Biological Inorganic Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xue, Wenjie published the artcileN-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification, Computed Properties of 100-70-9, the main research area is thiadiazole hydroxy quinolone carboxamide preparation antibacterial docking pharmacokinetic antitumor; Antibacterial agent; Antibiotic resistance; DNA gyrase B; MRSA; Molecular docking.

In this study, N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamide derivatives I (R1 = Et, cyclopentyl, 3-fluorophenyl, 1,3-thiazol-4-yl, etc.; R2 = Me, Et, n-Pr) were designed and synthesized and evaluated for their antibacterial activity against S. aureus ATCC29213, which led to the identification of ten potent antibacterial agents with min. inhibitory concentration (MIC) values below 1μg/mL. Next, bacterial growth inhibition assays against a panel of drug-resistant clin. isolates, including methicillin-resistant S. aureus, and cytotoxicity assays with HepG2 and HUVEC cells were performed. One of the tested compounds named I [R1 = 1,3-thiazol-2-yl; R2 = Et] (A) showed 2 to 128-times improvement compared with vancomycin in term of antibacterial potency against the tested strains (MICs: 0.25-1μg/mL vs. 1-64μg/mL) and an optimal selective toxicity (HepG2/MRSA, 110.6 to 221.2; HUVEC/MRSA, 77.6-155.2). Further, comprehensive evaluation indicated that (A) did not induce resistance development of MRSA over 20 passages, and it has been confirmed as a bactericidal, metabolically stable, orally active antibacterial agent. More importantly, the S. aureus DNA gyrase B as its potential target is identified and a potential binding mode by mol. docking is proposed. Taken together, the present work reports the most potent derivative of this chem. series (A) and uncovers its potential target, which lays a solid foundation for further lead optimization facilitated by the structure-based drug design technique.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Xu published the artcileCobalt Element Effect of Ternary Mesoporous Cerium Lanthanum Solid Solution for the Catalytic Conversion of Methanol and CO2 into Dimethyl Carbonate, Formula: C6H4N2, the main research area is cerium lanthanum methanol carbon dioxide dimethyl carbonate catalytic conversion; catalyst; cobalt; dimethyl carbonate; oxygen vacancy; solid solution.

A citric acid ligand assisted self-assembly method is used for the synthesis of ternary mesoporous cerium lanthanum solid solution doped with metal elements (Co, Zr, Mg). Their textural property was characterized by X-ray diffraction, transmission electron microscopy, N2 adsorption-desorption, XPS and TPD techniques, and so on. The results of catalytic testing for synthesis of di-Me carbonate (DMC) from CH3OH and CO2 indicated that the DMC yield reached 316 mmol/g on Ce-La-Co solid solution when the reaction temperature was 413 K and the reaction pressure was 8.0 MPa. It was found that Co had synergistic effect with La and Ce, doping of Co on the mesoporous Ce-La solid solution was helpful to increase the surface area of the catalyst, promote CO2 adsorption and activation, and improve the redox performance of solid solution catalyst. The conversion of Co2+ to Co3+ resulted in the continuous redox cycle between Ce4+ and Ce3+ , and the oxygen vacancy content of the catalyst was increased. Studies have shown that the catalytic performance of Ce-La-Co solid solution is pos. correlated with oxygen vacancy content. On this basis, the reaction mechanism of DMC synthesis from CO2 and CH3OH on the catalyst was speculated.

Molecules published new progress about Adsorption (isotherms). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Patil, Prashant published the artcileA new phthalimide based chemosensor for selective spectrophotometric detection of Cu(II) from aqueous medium, Application In Synthesis of 100-70-9, the main research area is phthalimide chemosensor spectrophotometric detection Copper ion; Chemosensor; Cu(2+); DFT; Phthalimide.

A new phthalimide based chemosensor 2-(Pyridin-2-yl-(pyridine-2-ylimino)methyl)isoindoline-1,3-dione (PP3) was synthesized and characterized by IR, LCMS and NMR spectroscopic methods. The metal ions sensing ability of PP3 was examined by naked-eye and UV-Vis absorption techniques. The colorless solution of PP3 turned to yellow upon addition of Cu2+ and a new absorption band appeared at 434 nm. The Job’s plot and HR-MS data confirms the formation of a new complex species between PP3 and Cu2+ in 1:1 binding stoichiometry. The sensor PP3 allowed the detection of Cu2+ down to 1.65 μM without any remarkable interference from the other tested metal cations.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Analytical test strips. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kondoh, Azusa published the artcileFormal umpolung addition of phosphites to 2-azaaryl Ketones under chiral Broensted base catalysis: enantioselective protonation utilizing [1,2]-phospha-Brook rearrangement, Computed Properties of 100-70-9, the main research area is phosphite azaaryl ketone Broensted base enantioselective phospha Brook rearrangement; enantioselective protonation; organocatalysis; organosuperbase; phospha-Brook rearrangement; umpolung.

The formal enantioselective umpolung addition of dialkyl phosphites to 2-azaaryl ketones was developed under Broensted base catalysis. The reaction involved the enantioselective protonation of the transient α-oxygenated (2-azaaryl)methyl anion generated through the 1,2-addition of the anion of dialkyl phosphite to the 2-azaaryl ketone and the subsequent [1,2]-phospha-Brook rearrangement. A chiral bis(guanidino)iminophosphorane organosuperbase efficiently catalyzed the reaction to provide enantio-enriched phosphates in high yields with good to high enantioselectivities. This is a rare example of the catalytic enantioselective protonation of transient carbanions other than enolates, constructing a trisubstituted stereogenic center α to 2-azaarenes.

Chemistry – A European Journal published new progress about 1,2-Addition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Hongpeng published the artcileSynthesis of Silicon-Stereogenic Silanols Involving Iridium-Catalyzed Enantioselective C-H Silylation Leading to a New Ligand Scaffold, Category: nitriles-buliding-blocks, the main research area is crystal structure mol silanol phosphorus silicon heterocycle chiral preparation; iridium catalyst enantioselective carbon hydrogen regioselective silylation stereoselective.

Despite a growing focus on the construction of highly enantioenriched silicon-stereogenic organosilicon compounds, the enantioselective synthesis of silicon-stereogenic silanols through asym. catalysis remains a considerable challenge. Herein, we realized enantioselective construction of silicon-stereogenic diarylsilanols via an Ir-catalyzed C-H silylation of diarylsilanols along with stereospecific substitution or Tamao-Fleming oxidation This strategy gives rise to a class of chiral diol catalyst cores (PSiOLs). Transformation of PSiOLs led to the ligand possessing both Si and P-stereocenters, which is capable of inducing excellent enantioselectivity in the rhodium(I)-catalyzed conjugate 1,4-addition of aryl boronic acids to cyclohexenone.

ACS Catalysis published new progress about 1,4-Addition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Davies, Sarah published the artcileTetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug, Product Details of C6H4N2, the main research area is tetrazine ketoprofen carboxylic acid antiinflammatory drug release; anti-inflammatory drugs; bioorthogonal decaging; inverse electron-demand Diels-Alder reaction; tetrazine; trans-cyclooctene.

In addition to its use for the study of biomols. in living systems, bioorthogonal chem. has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing mols. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2 min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCO-prodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs. ChemBioChem published new progress about Anti-inflammatory agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mavrova, Anelia published the artcileDesign, Cytotoxicity and Antiproliferative Activity of 4-Amino-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylates against MFC-7 and MDA-MB-231 Breast Cancer Cell Lines, Name: Picolinonitrile, the main research area is amino thienopyrimidine carboxylate preparation antitumor antiproliferative; 4-amino-thienopyrimidines; antiproliferation; cytotoxicity; molecular structure; phototoxicity; structure–activity relationship.

Novel 4-amino-thieno[2,3-d]pyrimidine-6-carboxylates substituted at the second position were prepared by cyclocondensation of 2-amino-3-cyano-thiophene and aryl nitriles in an acidic medium. The design of the target compounds was based on structural optimization. The derivatives thus obtained were tested in vitro against human and mouse cell lines. The examination of the compound effects on BLAB 3T3 and MFC-10A cells showed that they are safe, making them suitable for subsequent experiments to establish their antitumor activity. The photoirritancy factor of the compounds was calculated Using the MTT test, the antiproliferative activity to MCF-10A, MCF-7 and MDA-MB-231 cell lines was estimated The best antiproliferative effect in respect to the MCF-7 cell line revealed compound 2 with IC50 4.3 ± 0.11 μg/mL (0.013 μM). The highest selective index with respect to MCF-7 cells was shown by compound 3 (SI = 19.3), and to MDA-MB-231 cells by compound 2 (SI = 3.7). Based on energy anal., the most stable conformers were selected and optimized by means of d. functional theory (DFT). Ligand efficiency, ligand lipophilicity efficiency and the physicochem. parameters of the target 4-amino-thienopyrimidines were determined The data obtained indicated that the lead compound among the tested substances is compound 2.

Molecules published new progress about Antiproliferative agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Jianbing published the artcileTetrazine-mediated bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of nitric oxide in vivo, Name: Picolinonitrile, the main research area is tetrazine mediated isocyanopropyl bioorthogonal removal nitric oxide controlled release.

Bond cleavage bioorthogonal chem. has been widely employed to restore or activate proteins or prodrugs. Nitric oxide (NO), as a free radical mol., has joined the clin. arena of cancer therapy, since high levels of NO could produce a cancer cell growth inhibitory effect. However, the spatiotemporal controlled release of NO remains a great challenge, and bioorthogonal chem. may open a new window. Herein, we described a class of O2-3-isocyanopropyl diazeniumdiolates 3a-f as new bioorthogonal NO precursors, which can be effectively uncaged via tetrazine-mediated bond cleavage reactions to liberate NO and acrolein in living cancer cells, exhibiting potent antiproliferative activity. Furthermore, 3a and tetrazine BTZ were resp. encapsulated into two liposomes. It was found that simultaneous administrations of the two liposomes could specifically release large amounts of NO in the implanted cancer cells in zebrafish, thus generating potent tumor suppression activity in vivo. Our findings indicate that the TZ-labile NO precursors could serve to expand the NO-based smart therapeutics and the scope of bioorthogonal chem. utility in vivo in the near future.

Biomaterials Science published new progress about Antiproliferative agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bachollet, Sylvestre P. J. T. published the artcileSynthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines, Synthetic Route of 100-70-9, the main research area is sphingolipid pyridazine derivative preparation cancer.

A synthetic sphingolipid related to a ring-constrained hydroxymethyl pyrrolidine analog of FTY720 that was known to starve cancer cells to death was chem. modified to include a series of alkoxy-tethered 3,6-substituted 1,2-pyridazines. These derivatives exhibited excellent antiproliferative activity against eight human cancer cell lines from four different cancer types. A 2.5- to 9-fold reduction in IC50 in these cell lines was observed relative to the lead compound, which lacked the appended heterocycle.

ACS Medicinal Chemistry Letters published new progress about Antiproliferative agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts