Category: 100-70-9

Gajurel, Sushmita published the artcileCuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level, COA of Formula: C6H4N2, the main research area is triazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst.

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt.

Applied Organometallic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banerjee, Indrani published the artcileAlkali Metal Catalysed Double Hydrophosphorylation of Nitriles and Alkynes, Category: nitriles-buliding-blocks, the main research area is alkali metal silylamide catalyzed hydrophosphorylation nitrile alkyne; crystal mol structure phosphoryl diphenylphosphinic amide.

Catalytic C-P and N-P bond formation via double hydrophosphorylation of nitriles with diphenylphosphine oxide using alkali metal precatalyst [MN(SiMe3)2] (M = Li, Na, K) is reported. The potassium congener was observed to be the most efficient catalyst for converting aryl nitriles to the corresponding N-((diphenyl-phosphoryl)(aryl)methyl)-P,P-diphenylphosphinic amide [ArCHP(O)-Ph2NHP(O)Ph2] at mild temperature (60°) and with neat reactants. Double hydrophosphorylation of alkynes with HP(O)Ph2 is also very effective when [KN(SiMe3)2] is used as a precatalyst at room temperature and gives the corresponding 1,2-diylbis(diphenyl-phosphine) oxide [RCHP(O)Ph2CH2P(O)Ph2] as the product. A wider substrate scope of both reactions is explored.

European Journal of Inorganic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhattacharjee, Jayeeta published the artcileN-Heterocyclic Carbene-Phosphinidenide Complexes as Hydroboration Catalysts, Recommanded Product: Picolinonitrile, the main research area is hydroboration catalyst ruthenium osmium NHC carbene phosphinidene half sandwich; crystal structure mol ruthenium osmium NHC phosphinidene half sandwich; ruthenium osmium heterocyclic carbene phosphinidene half sandwich preparation; mechanism kinetics hydroboration ruthenium catalyst NHC phosphinidenide nitrile.

The reactions of the N-heterocyclic carbene-phosphinidene adducts (NHC)PSiMe3 and (NHC)PH with the dinuclear ruthenium and osmium complexes [(η6-p-cymene)MCl2]2 (M = Ru, Os) afforded the half-sandwich complexes [(η6-p-cymene){(NHC)P}MCl] and [(η6-p-cymene){(NHC)PH}MCl2] with two- and three-legged piano-stool geometries, resp. (NHC = IDipp, IMes; IDipp = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene; IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene). The complexes were initially tested as precatalysts for the hydroboration of benzonitrile, and the most active species, the ruthenium complex [(η6-p-cymene){(IMes)P}RuCl], was further used for the efficient hydroboration of a wide range (ca. 50 substrates) of nitriles, carboxylic esters, and carboxamides in neat pinacolborane (HBpin) under comparatively mild reaction conditions (60-80°C, 3-5 mol % catalyst loading). Preliminary mechanistic and kinetic studies are reported, and stoichiometric reactions with HBpin indicate the initial formation of the monohydride complex [(η6-p-cymene){(IMes)P}RuH] as the putative catalytically active species.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ren, Shishuai published the artcileDehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes, Application In Synthesis of 100-70-9, the main research area is amide nitrile cobalt hydride catalyst dehydration selective safety; nitrile preparation.

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles.

Catalysis Communications published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ruan, Shixiang published the artcileFacile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters, HPLC of Formula: 100-70-9, the main research area is nitrile preparation; primary amide dehydration lead diacetate catalyst.

The synthesis of nitriles RCN [R = n-Pr, 2-MeC6H4, 2-pyridyl, etc.] under mild conditions was achieved via dehydration of primary amides using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only byproduct, water from the system. Both aliphatic and aromatic nitriles could be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chem. calculations, and the crucial role the anionic ligand played in the transformations were revealed.

Molecular Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Kai published the artcileEfficient dehydration of primary amides to nitriles catalyzed by phosphorus-chalcogen chelated iron hydrides, Computed Properties of 100-70-9, the main research area is nitrile preparation; primary amide dehydration phosphorus chalcogen chelated iron hydride catalyst.

A series of phosphorus-chalcogen chelated hydrido iron (II) complexes, (o-(R’2P)-p-R-C6H4Y)FeH(PMe3)3I (R = H, Me; R’ = iPr, Ph; Y = O, S, Se) were synthesized. The catalytic performances of I for dehydration of amides to nitriles were explored by comparing three factors: (1) different chalcogen coordination atoms Y; (2) R’ group of the phosphine moiety; (3) R substituent group at the Ph ring. It is confirmed that I (R = H; R’ = Ph; Y = S) with S as coordination atom has the best catalytic activity and I (R = H; R’ = Ph; Y = Se) with Se as coordination atom has the poorest catalytic activity among complexes I (R = H; R’ = Ph; Y = O), I (R = H; R’ = Ph; Y = S) and I (R = H; R’ = Ph; Y = Se). Electron-rich complex I (R = Me; R’ = iPr; Y = O) is the best catalyst among the seven complexes and the dehydration reaction was completed by using 2 mol% catalyst loading at 60° with 24 h in the presence of (EtO)3SiH in THF. Catalyst I (R = Me; R’ = iPr; Y = O) has good tolerance to many functional groups. Among the seven iron complexes, new complexes I (R = H, Me; R’ = iPr; Y = O) were obtained via the O-H bond activation of the preligands o-iPr2P(C6H4)OH and o-iPr2P-p-Me-(C6H4)OH by Fe(PMe3)4. Both I (R = H, Me; R’ = iPr; Y = O) were characterized by spectroscopic methods and X-ray diffraction anal. The catalytic mechanism was exptl. studied and also proposed.

Applied Organometallic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Stentzel, Michael R. published the artcileFunctionalized fluorenes via dicationic electrophiles, Computed Properties of 100-70-9, the main research area is alc biphenyl ketone cyclization; fluorenyl ether preparation; nitrile biphenyl ketone cyclization; amido fluorene preparation; Carbocation; Heterocycle; Superacid; Superelectrophile.

Dicationic fluorenyl cations were shown to react with nitriles to provide amide-functionalized fluorenes. A similar reaction with alcs. gave ether derivatives The chem. was initiated by the reactions of N-heterocyclic ketones in a superacidic solution This led to cyclizations involving 2-biphenyl groups and formation of the reactive fluorenyl cations.

Tetrahedron Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Doan, Son H. published the artcileTropylium-promoted Ritter reactions, HPLC of Formula: 100-70-9, the main research area is amide preparation microwave continuous flow; alc nitrile Ritter reaction tropylium salt catalyst.

Herein, the development of a new method using salts of the tropylium ion to promote the Ritter reaction was reported. This method works well on a range of alcs., e.g., 1-phenylethanol and nitriles, e.g., acetonitrile, giving the corresponding products, e.g., N-(1-phenylethyl)acetamide in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wei, Xiangyang published the artcileDecyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines, Formula: C6H4N2, the main research area is decyanative cross coupling cyanopyrimidine alc thiol amine; preparation alkoxylpyrimidine aminopyrimidine alkylthiopyrimidine.

The transition metal-free cross-coupling reactions of cyanopyrimidines with aliphatic alcs., thiols (or S-alkylisothiourea salts) and amines, giving the corresponding alkoxylpyrimidines, aminopyrimidines, and alkylthiopyrimidines, are reported. Preliminary mechanistic studies reveal that it probably involves a sequential nucleophilic addition-intramol. rearrangement process, which is promoted by an intramol. N-H···N five-membered hydrogen bonding interaction. The presence of a nitrogen atom next to the cyano group is indispensable. The wide substrate scope with excellent yields makes cyanopyrimidines a promising alternative substrate class to the frequently used pyrimidines halides for the formation of C-O, C-S, and C-N bonds through the decyanative cross-coupling reaction.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kangkang published the artcileEfficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles, Quality Control of 100-70-9, the main research area is iron single atom catalyst preparation; nitrile preparation chemoselective; alc ammoxidation iron catalyst.

Zeolitic imidazolate frameworks derived Fe1-N-C catalysts with isolated single iron atoms were synthesized and applied for selective ammoxidation reactions. For the preparation of the different Fe-based materials, benzylamine as an additive proved to be essential to tune the morphol. and size of ZIFs resulting in uniform and smaller particles, which allowed stable atomically dispersed Fe-N4 active sites. The optimal catalyst Fe1-N-C achieved an efficient synthesis of various aryl, heterocyclic, allylic, and aliphatic nitriles from alcs. in water under very mild conditions. With its chemoselectivity, recyclability, high efficiency under mild conditions this new system complemented the toolbox of catalysts for nitrile synthesis, which were important intermediates with many applications in life sciences and industry.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts