Category: 100-70-9

Gu, Yu published the artcileHighly Efficient Synthesis of Alkyl N-Arylcarbamates from CO2, Anilines, and Branched Alcohols with a Catalyst System of CeO2 and 2-Cyanopyridine, Related Products of nitriles-buliding-blocks, the main research area is arylcarbamate preparation; carbon dioxide aniline alc multicomponent reaction cerium dioxide catalyst.

Highly efficient synthesis of alkyl N-arylcarbamates from CO2, anilines, and alcs. using the CeO2 and 2-cyanopyridine catalyst system was substantiated by selecting branched alcs., such as 2-propanol and cyclohexanol, with minimized formation of byproducts, such as dialkyl carbonates and picolinamide. The catalyst system is operable even at low CO2 pressure (≤1 MPa), and the target carbamates were obtained with high arylamine-based yields (up to 94%). Alkyl N-phenylcarbamates were obtained from CO2, anilines, and alcs. with high yield and minimized formation of byproducts by using branched alcs.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pieczykolan, Michal published the artcileAn Efficient Method for the Programmed Synthesis of Multifunctional Diketopyrrolopyrroles, Application In Synthesis of 100-70-9, the main research area is aldehyde primary amine nitrile diethyl oxalacetate diastereoselective cyclization fluorescence; diketopyrrolopyrrole preparation; donor-acceptor systems; dyes; fluorescence; heterocycles; lactams.

A new, transformative methodol. for the preparation of diketopyrrolopyrroles from aldehydes, primary amines, nitriles, and di-Et oxalacetate has been developed. It is now possible to prepare diketopyrrolopyrroles, e.g., I, bearing an ordered arrangement of three different substituents from abundant and com. available materials, allowing the independent regulation of all desired physicochem. properties. For the first time very electron-rich (carbazol-3-yl, dimethylaminophenyl, pyrrolo[3,2-b]pyrrolyl), and sterically hindered substituents (naphthalen-1-yl, quinolin-4-yl, acridin-9-yl, imidazo[1,5-a]pyridin-1-yl, 2-bromophenyl etc.) can be appended to the diketopyrrolopyrrole core by condensation of an appropriate nitrile with a pyrrolidin-2-one intermediate. Even greater synthetic possibilities are related to the fact that such demanding substituents as 4-dimethylaminophenyl, indol-3-yl, and 2-methoxyphenyl can be incorporated from aldehyde precursors, bypassing problems with the nitriles reactivity.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Safety of Picolinonitrile, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Hongjie published the artcileBioinspired Iron-Catalyzed Dehydration of Aldoximes to Nitriles: A General N-O Redox-Cleavage Method, Recommanded Product: Picolinonitrile, the main research area is nitrile preparation chemoselective; aldoxime dehydration bioinspired iron catalyst; benzoisoxazole kemp elimination bioinspired iron catalyst; dehydration kemp elimination bioinspired iron catalyst.

An efficient iron catalyst, Cp*Fe(1,2-Cy2PC6H4O), which rapidly converts various aliphatic and aromatic aldoximes RCH=NOH [R = Pr, Ph, 2H-1,3-benzodioxol-5-yl, etc.] to nitriles RCN with release of H2O at room temp was reported. The catalysis involves redox activation of the N-O bond by a 1e- transfer from the iron catalyst to the oxime. Such redox-mediated N-O cleavage was demonstrated by the isolation of a ferrous iminato intermediate from the reaction of the ketoxime substrate. This iron-catalyzed acceptorless dehydration approach represents a general method for the preparation of nitriles, and it also delivers salicylonitriles R1CN(2-OH) [R1 = Ph, 3-methoxyphenyl, naphthalen-1-yl, etc.] catalyzing the Kemp elimination reaction.

Journal of Organic Chemistry published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uludag, N. published the artcileAn Efficient Synthesis of Nitriles from Aldoximes in the Presence of Trifluoromethanesulfonic Anhydride in Mild Conditions, Computed Properties of 100-70-9, the main research area is aldoxime dehydration reaction; nitrile preparation.

A new and convenient protocol was proposed for the transformation of aldoximes to nitriles using trifluoromethanesulfonic anhydride and triethylamine. The proposed method allowed a range of aldoximes, including aromatic, heterocyclic, aliphatic, and cycloaliphatic aldoximes, to converted to the corresponding nitriles in good to excellent yields.

Russian Journal of Organic Chemistry published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qian, Deyun published the artcileChiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates, Product Details of C6H4N2, the main research area is aryl oxazoline preparation; enecarbamates alkyl halide nickel oxazoline catalyst enantioselective hydroalkylation; alkyl amine preparation.

A nickel-catalyzed hydroalkylation method to assemble a wide range of chiral alkyl amines from enecarbamates (N-Cbz-protected enamines) and alkyl halides with high regio- and enantioselectivity was reported. The method works for both nonactivated and activated alkyl halides and was able to produce enantiomerically enriched amines with two minimally differentiated α-alkyl substituents. The mild conditions led to high functional group tolerance, which is demonstrated in the postproduct functionalization of many natural products and drug mols., as well as the synthesis of chiral building blocks and key intermediates to bioactive compounds

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Schreib, Benedikt S. published the artcileRitter reaction for the synthesis of picolinamides, HPLC of Formula: 100-70-9, the main research area is picolinamide preparation; cyanopyridine alc alkene Ritter reaction.

The synthesis of picolinamides through Ritter reaction of 2-cyanopyridine with alcs. and alkenes is reported. Moreover, a range of addnl. heteroaryl nitriles successfully participate in the amidation reaction. Salient features of the reaction include the operational simplicity and the inexpensive reagents used. The synthetic utility of a camphene derived picolinamide is demonstrated through a palladium-catalyzed C-H arylation reaction.

Tetrahedron published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Yiyong published the artcileSO2F2-Promoted Dehydration of Aldoximes: A Rapid and Simple Access to Nitriles, Name: Picolinonitrile, the main research area is nitrile preparation; aldoxime dehydration.

A rapid, simple and mild process for the dehydration of aldoximes RCH=NOH (R = benzyl, 4-fluorophenyl, naphth-1-yl, pyridin-2-yl, etc.) to give the corresponding nitriles RCN, which utilizes SO2F2 as an efficient reagent, has been developed. A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes proceeded with high efficiency to afford nitriles in excellent to quant. yields with great functional group compatibilities in acetonitrile under ambient conditions. Moreover, the eco-friendly conditions of SO2F2/Na2CO3/aqueous methanol were suitable for converting nitrobenzaldoximes R1C6H4CH=NOH (R1 = 2-nitro, 3-nitro, 4-nitro) into nitrobenzonitriles R1C6H4CN. In addition, a one-pot synthetic strategy of obtaining nitrobenzonitriles R1C6H4CN from nitrobenzaldehydes R1C6H4CHO has been confirmed to be feasible.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pandey, Vipin K. published the artcileSilver-Catalyzed Hydroboration of C-X (X = C, O, N) Multiple Bonds, Synthetic Route of 100-70-9, the main research area is silver catalyst hydroboration carbon oxygen nitrogen multiple bond.

AgSbF6 was developed as an effective catalyst for the hydroboration of various unsaturated functionalities (nitriles, alkenes, and aldehydes). This atom-economic chemoselective protocol works effectively under low catalyst loading, base- and solvent-free moderate conditions. Importantly, this process shows excellent functional group tolerance and compatibility with structurally and electronically diverse substrates (>50 examples). Mechanistic investigations revealed that the reaction proceeds via a radical pathway. Further, the obtained N,N-diborylamines were showcased to be useful precursors for amide synthesis.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

He, Jian published the artcileHighly Efficient Iridium-Based Photosensitizers for Thia-Paterno-Buchi Reaction and Aza-Photocyclization, Synthetic Route of 100-70-9, the main research area is pyridylheteroaryl iridium complex preparation photosensitizer electrochem; crystal structure pyridylheteroaryl iridium complex pyrroloquinolinedione chiral methylthiophenoxyphenylthiaazabicycloheptanedione; mol structure pyridylheteroaryl iridium complex pyrroloquinolinedione chiral methylthiophenoxyphenylthiaazabicycloheptanedione.

Substrates in excited state differ significantly from the corresponding ground state so that they are treated as different chem. species with diverse phys. properties and chem. reactivity. Therefore, applying photocatalytic systems to activate substrates becomes increasingly popular. Although photosensitizers serve as the core of the photocatalytic reaction, the design of a photosensitizer was not taken for granted. By modifying ligands of organometallic complexes to optimize properties of photosensitizers, the authors successfully achieved Ir complexes with long excited triplet-state lifetime, high triplet excited-state energy, strong absorption, and robust stability. The efficacies of the prepared Ir complexes as photosensitizers were evaluated toward various challenging photocycloaddition reactions (e.g., thia-Paterno-Buchi reaction and multicomponent 1-pot aza-photocyclization) between heterocyclic compound maleimides and unsaturated moieties that are not efficient to complete with well-established photosensitizers.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts