Category: 100-70-9

Trivedi, Manoj published the artcileRu(II)- and Ru(IV)-dmso complexes catalyze efficient and selective aqueous-phase nitrile hydration reactions under mild conditions, Application In Synthesis of 100-70-9, the main research area is ruthenium dmso complex catalyst preparation; amide green preparation; nitrile hydration ruthenium catalyst.

New water-soluble ruthenium(II)- and ruthenium(IV)-dmso complexes [RuCl2(dmso)2(NH3)(CH3CN)], [RuCl2(dmso)3(CH3CN)] and [RuCl2(dmso)3(NH3)]·PF6·Cl had been synthesized and characterized using elemental analyzes, IR, 1H and 31P NMR and electronic absorption spectroscopy. The mol. structures of complexes were determined crystallog. The reactivity of complexes had been tested for aqueous-phase nitrile hydration at 60°C in air, and good efficiency and selectivity are shown for the corresponding amide derivatives RC(O)NH2 [R = t-Bu, Ph, 4-BrC6H4, etc.]. Best performance is achieved with complex [RuCl2(dmso)3(NH3)]·PF6·Cl. Amide conversions of 56-99% were obtained with a variety of aromatic, alkyl and vinyl nitriles. The reaction tolerated hydroxyl, nitro, bromo, formyl, pyridyl, benzyl, alkyl and olefinic functional groups. Amides were isolated by simple decantation from the aqueous-phase catalyst. A catalyst loading down to 0.0001 mol% was examined and turnover numbers as high as 990000 were observed The catalyst was stable for weeks in solution and could be reused more than seven times without significant loss in catalytic activity. The gram-scale reaction was also performed to produce the desired product in high yields.

New Journal of Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ounkham, Whalmany L. published the artcileAqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst, Category: nitriles-buliding-blocks, the main research area is aqueous phase nitrile hydration air stable ruthenium catalyst; benzamide amide preparation green chem; aqueous-phase catalysis; homogeneous catalysis; nitrile hydration; ruthenium; sustainable chemistry.

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

Chemistry – A European Journal published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Gadde Sathish published the artcilePaired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source, Quality Control of 100-70-9, the main research area is cyano pyridine amino acid decarboxylative cyanation electrochem; aniline cyano pyridine regioselective cyanation electrochem; aminoacetonitrile preparation.

A decarboxylative cyanation of amino acids under paired electrochem. reaction conditions was developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including N,N-dialkyl aniline and indole derivatives

Organic Letters published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Suryawanshi, Manjusha published the artcileSynthesis, characterization and photophysical properties of novel thiazole substituted pyridine derivatives, Name: Picolinonitrile, the main research area is pyridylthiazole preparation photophys property.

Three series of isomeric 2-pyridyl 4-aryl thiazoles were synthesized by reacting 2/3/4-pyridine thioamides derived from the corresponding nitriles with various 4-substituted phenacyl bromides using Hantzsch thiazole synthesis. Amongst the three isomeric series, 2-pyridyl and 4-pyridyl isomers are found to exhibit better photophys. properties than 3-pyridyl series. 4-Pyridyl isomer with methoxy substituent on Ph ring is found to exhibit high luminescence quantum yield. The relationship between the structure and the photophys. properties have been studied using DFT calculations

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Haloketones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pezzetta, Cristofer published the artcileEnantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach, Computed Properties of 100-70-9, the main research area is benzylic heterocycle preparation enantioselective; heterocyclic carboxylic acid aryl bromide decarboxylative cross coupling; nickel photoredox dual catalysis.

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common com. material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, COA of Formula: C6H4N2, the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moll, Johannnes published the artcileGreen-Light Activation of Push-Pull Ruthenium(II) Complexes, Recommanded Product: Picolinonitrile, the main research area is microwave irradiation preparation ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; crystal mol structure ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; cyclic voltammetry ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence; photocatalysis; photochemistry; photophysics; ruthenium.

Synthesis, characterization, electrochem., and photophysics of homo- and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2”-carboxypyridyl-2,2′-methylamine-pyridyl-pyridine (cpmp) and N,N’-dimethyl-N,N’-dipyridin-2-ylpyridine-2,6-diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron-deficient dipyridyl ketone fragments as electron-accepting sites enabling intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LL’CT) and low-energy metal-to-ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). Complex 22+ shows 3MLCT phosphorescence in the red to near-IR spectral region at room temperature in deaerated acetonitrile solution with an emission quantum yield of 1.3% and a 3MLCT lifetime of 477 ns, whereas 32+ is much less luminescent. This different behavior is ascribed to the energy gap law and the shape of the parasitic excited 3MC state potential energy surface. This study highlights the importance of the excited-state energies and geometries for the actual excited-state dynamics. Aromatic and aliphatic amines reductively quench the excited state of 22+ paving the way to photocatalytic applications using low-energy green light as exemplified with the green-light-sensitized thiol-ene click reaction.

Chemistry – A European Journal published new progress about Charge transfer transition (ligand-to-ligand, metal-to-ligand). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 100-70-9, the main research area is nitrile hydration ruthenium supported manganese oxide catalyst moderate condition.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Amides Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Yanbin published the artcileVanadium-catalyzed Oxidative Conversion of Primary Aromatic Alcohols into Amides and Nitriles with Molecular Oxygen, Quality Control of 100-70-9, the main research area is amide preparation green chem; nitrile preparation green chem; aldehyde preparation green chem; acid preparation green chem; primary alc ammoxidation vanadium catalyst; Alcohol; Amide; Catalytic oxidation; Nitrile; Vanadium.

Herein, a vanadium-based material V-N-C-700 was prepared via a simple and convenient method, and employed for liquid-phase catalytic ammoxidation of alcs. RCH2OH (R = n-Bu, Ph, pyridin-2-yl, etc.) with mol. oxygen. By using V-N-C-700/2-picolinic acid, primary aromatic alcs. were smoothly converted into the amides RC(O)NH2 and nitriles RCN in the presence of urea. The corresponding aldehydes RCHO are the key intermediates, and 2-picolinic acid could significantly enhance oxidation of alcs. into aldehydes. The amides were formed simultaneously along with nitriles, rather than only from nitriles via successive hydration. This work further expands non-noble metal catalysts for the preparation of amides and nitriles.

Chemistry – An Asian Journal published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gurjar, Jitendra published the artcileSulfuryl Fluoride Mediated Conversion of Aldehydes to Nitriles, Category: nitriles-buliding-blocks, the main research area is nitrile polyfunctional probe preparation sulfuryl fluoride; bioorthogonal chemistry; main group elements; nitriles; polyfunctional probes; synthetic methods.

Aliphatic, aromatic, and heteroaromatic aldehydes were readily converted to corresponding nitriles in a one-pot reaction sequence with hydroxylamine and sulfuryl fluoride. The reaction proceeds at room temperature, does not require metal catalysts and special precautions, and produces nitriles in excellent yields. It is compatible with a variety of functional groups, can be performed in aqueous and organic solvents, and is readily scalable to multigram quantities. Mild conditions and high selectivity of the reaction enabled the construction of polyfunctional probes containing nitrile, alkyne, azide, and fluorosulfate groups for further orthogonal derivatization.

Chemistry – A European Journal published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts