Category: 100-70-9

Liu, Lang published the artcileA practical strategy for construction and regulation of multi-functional triazepinium salts via highly efficient I2-catalyzed cyclization, Product Details of C6H4N2, the main research area is iodine catalyzed cyclization triazolamine ketone triazepinium synthesis; solid state fluorescence triazepinium salt.

Synthesis of new functional organic mols. is a critical path that may greatly accelerate the evolution of organic optoelectronic materials. We have achieved a facile synthesis strategy to produce unique saddle-shaped multi-functional triazepinium salts that exhibit excellent solid-state fluorescence. Their fluorescence performance could be easily regulated by adjusting the dihedral angle between the main skeleton and the substituted moiety, giving a large Stokes shift, non-aggregation quenching, long lifetime, and multilevel-redox characteristics. Thus, e.g., cyclization of triazolamine I with acetone under I2 catalysis in DMSO at 80° for 10 h afforded triazepinium II.I- (85%).

Green Chemistry published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shan, Xiang-Huan published the artcileCopper-catalyzed oxidative benzylic C-H cyclization via iminyl radical from intermolecular anion-radical redox relay, Product Details of C6H4N2, the main research area is nitrile alkylaryl halide copper catalyst oxidative heterocyclization; indole preparation.

The combination of base-promoted benzylic C-H cleavage and copper-catalyzed carbanion-radical redox relay was reported. Catalytic amount of naturally abundant and inexpensive copper salt, such as copper(II) sulfate, was used for anion-radical redox relay without any external oxidant. By avoiding using N-O/N-N homolysis or radical initiators to generate iminyl radicals, this strategy realized modular synthesis of N-H indoles and analogs from abundant feedstocks, such as toluene and nitrile derivatives, and also enabled rapid synthesis of large scale pharmaceuticals.

Nature Communications published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kudashev, Anton published the artcileSite-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones, Category: nitriles-buliding-blocks, the main research area is aryl heteroaryl alkyl propanone chemoselective preparation; heteroaryl ketone aryl iodide arylation catalyst palladium; C−H activation; arylation; palladium; site-selectivity.

A ligand-controlled site-selective C(sp3)-H arylation of heteroaromatic ketones had been developed using Pd catalysis to gave ArC(O)CHR1CH2R2 [Ar = thiazol-2-yl, 2-pyridyl, 2-quinolyl, etc.; R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, Me, ph, etc.]. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- or β-arylation was realized by addition of a pyridone ligand. The α-arylation process showed broad scope and high site- and chemoselectivity, whereas the β-arylation was more limited. Mechanistic investigations suggested that α-arylation occurs through C-H activation/oxidative addition/reductive elimination whereas β-arylation involves desaturation and aryl insertion.

Chemistry – A European Journal published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moghaddam, Firouz Matloubi published the artcileAn advancement in the synthesis of nano Pd@magnetic amine-Functionalized UiO-66-NH2 catalyst for cyanation and O-arylation reactions, Related Products of nitriles-buliding-blocks, the main research area is palladium magnetic amine MOF UiO66 NH2 preparation thermal stability; benzonitrile preparation; phenyl aryl ether preparation.

The magnetic MOF-based catalytic system has been reported here to be an efficient catalyst for synthesis of benzonitriles and diarylethers of aryl halides under optimal conditions. The MOF catalyst was built based on magnetic nanoparticles and UiO-66-NH2 which further modified with 2,4,6-trichloro-1,3,5-triazine and 5-Ph tetrazole at the same time and the catalyst structure was confirmed by various techniques. This new modification has been applied to increase anchoring palladium into the support. Furthermore, the products’ yields were obtained in good to excellent for all reactions under mild conditions which result from superior activity of the synthesized heterogeneous catalyst containing palladium. Also, the magnetic property of the MOF-based catalyst makes it easy to sep. from reaction mediums and reuse in the next runs.

Scientific Reports published new progress about Aromatic ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samanta, Partha Kumar published the artcileMesoporous silica supported samarium as recyclable heterogeneous catalyst for synthesis of 5-substituted tetrazole and 2-substituted benzothiazole, Name: Picolinonitrile, the main research area is mesoporous silica supported samarium catalyst tetrazole benzothiazole synthesis.

Synthesis of nitrogen-containing heterocycles such as tetrazoles and benzothiazoles gains immense importance as they are omnipresent structural modules often utilized in pharmaceuticals. In the present study, well ordered MCM-41 type mesoporous silica with large pore (l-MSN) was synthesized and impregnated with samarium nitrate (Sm@l-MSN). Due to high abundance of samarium relative to many catalytically active transition metals (e.g. Ru, Ir, Pt), it may offer an opportunity to develop sustainable catalysts for organic conversions. The synthesized materials were characterized using nitrogen sorption, SEM, energy-dispersive X-ray, elemental mapping and transmission electron microscopy. The catalytic efficiency of the materials was explored for the synthesis of tetrazoles and benzothiazoles, two very important heterocyclic moieties in medicinal chem. and biol. The catalyst was readily recovered and recycled up to five consecutive runs without noteworthy loss of activity or leaching.

Journal of Porous Materials published new progress about Benzothiazoles Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Yi published the artcileAlkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides, HPLC of Formula: 100-70-9, the main research area is aluminum diketiminate alkyl complex preparation hydroboration nitrile carbodiimide catalyst; crystal structure aluminum diketiminate alkyl complex; mol structure aluminum diketiminate alkyl complex.

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields.

Organometallics published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kong, Xianqiang published the artcileCyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds, Product Details of C6H4N2, the main research area is trimethylammonium salt tosyl cyanide chemoselective electrocatalytic cyanation; nitrile preparation; azido methylbutenol trimethylammonium salt chemoselective electrocatalytic cyanomethylation; acetonitrile preparation.

A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Si-Zhan published the artcileCopper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile, Product Details of C6H4N2, the main research area is iodoarene dimethyl aminomalononitrile copper catalyst cyanation; aryl nitrile preparation.

A copper-promoted cyanation of aryl iodides was successfully developed by using N,N-di-Me aminomalononitrile as the cyanide source with moderate toxicity and better stability. The reaction featured broad substrate scope, excellent reaction yields, readily available catalyst, and simple reaction conditions.

Tetrahedron Letters published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rammal, Fatima published the artcilePhotochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms, Computed Properties of 100-70-9, the main research area is silyl hydroxymethyl pyridine preparation; methoxy pyridinium methylsulfate tert butyldimethylsilane silylation photochem.

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions.

ACS Catalysis published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhong, Long-Jin published the artcileBenzylic C-H heteroarylation of N-(benzyloxy)phthalimides with cyanopyridines enabled by photoredox 1,2-hydrogen atom transfer, Safety of Picolinonitrile, the main research area is pyridinyl diarylmethanol preparation; benzyloxy phthalimide cyanopyridine benzylic heteroarylation iridium photoredox catalysis.

A visible light initiated α-C(sp3)-H arylation of N-(benzyloxy)phthalimides with cyanopyridines for the construction of highly valuable pyridinyl-containing diarylmethanols, including bioactive motif-based analogs, is reported. This method enables arylation of the C(sp3)-H bonds adjacent to an oxygen atom through alkoxy radical formation by O-N bond cleavage, 1,2-hydrogen atom transfer (HAT), arylation and C-CN bond cleavage cascades, and offers a means to exploit 1,2-HAT modes to incorporate functional groups for constructing functionalized alcs.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts