Category: 1194-02-1

The author of 《Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts》 were Sanagawa, Atsushi; Nagashima, Hideo. And the article was published in Organic Letters in 2019. Product Details of 1194-02-1 The author mentioned the following in the article:

Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPiv)2 (Piv = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Wei David; Wang, Fushan; Chang, Youcai; Dong, Zhengping published an article in 2021. The article was titled 《Biomass chitosan-derived nitrogen-doped carbon modified with iron oxide for the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles》, and you may find the article in Molecular Catalysis.Related Products of 1194-02-1 The information in the text is summarized as follows:

Herein, cost-effective, renewable biomass chitosan was used to prepare a N-doped carbon modified with iron oxide catalyst (Fe2O3@NC) for nitrile synthesis. The iron oxide nanoparticles were uniformly wrapped in the N-doped carbon matrix to prevent their aggregation and leaching. Fe2O3@NC-800, which was subjected to carbonization at 800 C, exhibited excellent activity, selectivity and stability in the catalytic ammoxidation of aromatic aldehydes to aromatic nitriles. This study was provided a new method for the fabrication of an efficient and cost-effective catalyst system for synthesizing nitriles.4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Quasi Pd1Ni single-atom surface alloy catalyst enables hydrogenation of nitriles to secondary amines》 were Wang, Hengwei; Luo, Qiquan; Liu, Wei; Lin, Yue; Guan, Qiaoqiao; Zheng, Xusheng; Pan, Haibin; Zhu, Junfa; Sun, Zhihu; Wei, Shiqiang; Yang, Jinlong; Lu, Junling. And the article was published in Nature Communications in 2019. Reference of 4-Fluorobenzonitrile The author mentioned the following in the article:

Hydrogenation of nitriles represents as an atom-economic route to synthesize amines, crucial building blocks in fine chems. However, high redox potentials of nitriles render this approach to produce a mixture of amines, imines and low-value hydrogenolysis byproducts in general. Here we show that quasi at.-dispersion of Pd within the outermost layer of Ni nanoparticles to form a Pd1Ni single-atom surface alloy structure maximizes the Pd utilization and breaks the strong metal-selectivity relations in benzonitrile hydrogenation, by prompting the yield of dibenzylamine drastically from ∼5 to 97% under mild conditions (80°C; 0.6 MPa), and boosting an activity to about eight and four times higher than Pd and Pt standard catalysts, resp. More importantly, the undesired carcinogenic toluene byproduct is completely prohibited, rendering its practical applications, especially in pharmaceutical industry. Such strategy can be extended to a broad scope of nitriles with high yields of secondary amines under mild conditions. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Reference of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 1194-02-1In 2019 ,《Extending the Chemistry of Hexamethylenetetramine in Ruthenium-Catalyzed Amine Oxidation》 was published in Organometallics. The article was written by Kannan, Muthukumar; Muthaiah, Senthilkumar. The article contains the following contents:

A very efficient, highly atom economical, and environmentally benign oxidation of primary and secondary amines using an in situ catalyst system generated from com. available Ru(II) benzene dichloride dimer and hexamethylenetetramine was demonstrated. Mechanistic studies revealed that hexamethylenetetramine acted as a source of hydride to generate the active Ru hydride catalyst and amine oxidation involves a dehydrogenative pathway. In comparison to reported catalyst systems for the dehydrogenative oxidation of amines, this synthetic protocol makes use of a simple Ru precursor and a cheaper additive; it is very selective, leading to the exclusive formation of nitrile/imine compounds Further, it releases H as the only side product, suggesting the potential application of the developed catalyst system in H storage. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Xiangyang; Liu, Lifang; Xiao, Yu; Mehmood, Rashid; Xiao, Yejun; Qi, Yu; Zhang, Fuxiang published their research in Inorganic Chemistry in 2021. The article was titled 《Water-Stable Cobalt-Based MOF for Water Oxidation in Neutral Aqueous Solution: A Case of Mimicking the Photosystem II》.Related Products of 1194-02-1 The article contains the following contents:

Inspired by the highly efficient H2O oxidation of Mn4CaO5 in natural photosynthesis, development of novel artificial H2O oxidation catalysts (WOCs) with structure and function mimicked has inspired extensive interests. A novel 3-dimensional Co-based MOF (GXY-L8-Co) was synthesized for promising artificial H2O oxidation by employing the Co4O4 quasi-cubane motifs with a similar structure as the Mn4CaO5 as the core. The GXY-L8-Co not only shows good chem. stability in common organic solvents or H2O for up to 10 days but also exhibits oxygen evolution performance. The uniform distribution of Co4O4 catalytic active sites confined in the MOF framework should be responsible for the good robustness and catalytic performance. A Co4O4 quasi-cubane motif was synthesized in a Co-MOF with a similar structure to that of the natural oxygen-evolving complex Mn4CaO5 in PSII. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Product Details of 1194-02-1In 2021 ,《Pyridine-Bridged Polybenzimidazole for Use in High-Temperature PEM Fuel Cells》 appeared in ACS Applied Energy Materials. The author of the article were Harilal; Shukla, Avanish; Ghosh, Prakash Chandra; Jana, Tushar. The article conveys some information:

Although pyridine bridged oxypolybenzimidazole (PyOPBI) membranes are considered to be promising high-temperature proton exchange membrane (HT-PEM) materials that have the potential to overcome many obstacles such as solubility, membrane processability, cost, etc., of the mainstream conventional polybenzimidazole (PBI)-based HT-PEM, the weak structural stability of PyOPBI in concentrated phosphoric acid (PA) and poor dimensional and mech. stability have been the crucial issues restraining the performance. To mitigate these bottlenecks, in this work, we successfully synthesized three types of PyOPBIs with flexible aryl ether backbones and bulky substituents by polycondensation reaction of various aryl diacids and pyridine-bridged tetraamine 2,6-bis(3′,4′-diaminophenyl)-4-phenylpyridine (PyTAB) in Eaton’s reagent followed by casting as HT-PEMs. Three designed bulky substitute containing PyOPBI membranes showed considerably high PA loading capacity (16-22 mol of PA/repeat unit) and proton conductivity (0.04-0.078 S/cm) at 180°C as compared to earlier reported unsubstituted PyOPBI membranes (14 mol of PA/repeat unit and 0.007 S/cm at 180°C). In addition, the obtained membranes showcased good chem., mech., thermal, and long-term conductivity stabilities and outstanding stability in concentrated PA. The pendent groups and the bulkiness of the backbone are believed to be the cause behind better stability and facilitating proton transport that results in higher proton conductivity The single cell made from the membrane electrode assembly of these bulky substituted PyOPBI membranes displayed a peak power d. in the range of 144-240 mW cm-2 under H2/O2 at 160°C, which is considerably higher than that for unsubstituted PyOPBI membrane (90.4 mW cm-2). Overall, the current results provide an effective strategy to explore the benefits of structural modulation of PyOPBI using various structurally divergent diacids to enhance HT-PEM properties and suggest a scalable route for the advancement of PBI-based HT-PEM fuel cells. In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Product Details of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Product Details of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and evaluation of new 1,2,4-oxadiazole based trans-acrylic acid derivatives as potential PPAR-α/γ dual agonists》 was written by Kaur, Paranjeet; Bhat, Zahid Rafiq; Bhat, Sana; Kumar, Rakesh; Kumar, Rajan; Tikoo, Kulbhushan; Gupta, Jeena; Khurana, Navneet; Kaur, Jaskiran; Khatik, Gopal L.. Formula: C7H4FN And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

New 1,2,4-oxadiazole-containing trans-cinnamic acids I (R = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-FC6H4, 4-ClC6H4, 4-MeC6H4) were synthesized and evaluated as dual PPAR-α/γ agonists. Using AutoDock Vina, compounds I were identified as potential PPAR α/γ dual agonists comparable to PPAR γ agonist Pioglitazone on the basis of their affinity scores, in-silico toxicity and in-silico ADME properties. These compounds showed better calculated lipophilicity (iLogP), which was found to be from 0.92 to 3.19. Compounds I (R = Ph, 4-FC6H4) were found to be most potent on both PPAR α and γ receptors with EC50 of 0.07 ± 0.0006μM, 0.06 ± 0.0005μM and 0.781 ± 0.008μM, 3.29μM ± 0.03 resp. compared to pioglitazone having EC50 of 32.38 ± 0.2 and 38.03 ± 0.13 for both receptors. The in-vivo evaluation found to reduce the plasma glucose level and total cholesterol level significantly in diabetic rats compared to pioglitazone at 5 mg/kg/day dose for 7 days of treatment. Thus, trans-cinnamic acids I can be further developed as oral therapeutic agents for diabetic interventions as PPAR α/γ dual agonists. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Tris(triazolo)triazine-based emitters for solution-processed blue thermally activated delayed fluorescence organic light-emitting diodes》 was written by Hundemer, Fabian; Crovini, Ettore; Wada, Yoshimasa; Kaji, Hironori; Braese, Stefan; Zysman-Colman, Eli. Quality Control of 4-FluorobenzonitrileThis research focused onTristriazolotriazine emitters processed blue thermally fluorescence organic lightemitting diodes. The article conveys some information:

We report a new emitter 3,4,5-3TCz-TTT based on a tris(triazolo)triazine acceptor that shows thermally activated delayed fluorescence and cross-compare its performance with the recently reported analog, 3DMAC-TTT. These compounds show blue emission and delayed fluorescence with delayed lifetimes on the order of milliseconds. Solution-processed organic light-emitting diodes achieving maximum external quantum efficiencies, EQEmax, of 5.8% for 3,4,5-3TCz-TTT and 11.0% for 3DMAC-TTT.4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Quality Control of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

SDS of cas: 1194-02-1In 2019 ,《Cyanation of Aryl and Heteroaryl Aldehydes Using In-Situ-Synthesized Ag Nanoparticles in Crocus sativus L. Extract》 was published in ChemistrySelect. The article was written by Sajadi, S. Mohammad; Nasrollahzadeh, Mahmoud; Akbari, Reza. The article contains the following contents:

An efficient, inexpensive and simple methodol. was reported for the cyanation of aryl and heteroaryl aldehydes using in situ synthesized silver nanoparticles (Ag NPs) with the use of Crocus sativus L. aqueous extract as a reducing and stabilizing biomedia. Furthermore, stable and cheap silver precursor (AgNO3) along with the non-toxic, efficient and inexpensive cyanide source K4[Fe(CN)6] were used for this reaction. This system provided an alternative protocol to the existing methods for the synthesis of aryl and heteroaryl nitriles. All products were obtained in good to excellent yields under ligand- and organic solvent-free conditions. The fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques were used for the characterization of the biosynthesized Ag NPs. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1SDS of cas: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.SDS of cas: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Catalysis Communications included an article by Ren, Shishuai; Wang, Yangyang; Yang, Fei; Sun, Hongjian; Li, Xiaoyan. Synthetic Route of C7H4FN. The article was titled 《Dehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes》. The information in the text is summarized as follows:

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts