Category: 1194-02-1

Synthetic Route of C7H4FNIn 2022 ,《Development of a ruthenium-aquo complex for utilization in synthesis and catalysis for selective hydration of nitriles and alkynes》 was published in New Journal of Chemistry. The article was written by Saha, Rumpa; Mukherjee, Aparajita; Bhattacharya, Samaresh. The article contains the following contents:

Synthesis of a ruthenium(II)-aquo complex bearing 2,2′ : 6′,2”-terpyridine and a 1,4-diazabutadiene ligand, and exploration of its synthetic utility and catalytic activity are described. Ag+-assisted displacement of the coordinated chloride from the previously reported [Ru(trpy)(L-OCH3)Cl]ClO4 complex [denoted as complex 1; where L-OCH3 represents 1,4-di-(p-methoxyphenyl)azabutadiene] in aqueous ethanol affords the [Ru(trpy)(L-OCH3)(H2O)]2+ complex cation, which was isolated as a perchlorate salt (complex 1a). Complex 1a undergoes facile substitution of the aquo ligand by neutral monodentate ligands giving complexes of type [Ru(trpy)(L-OCH3)(L’)]2+, also isolated as perchlorate salts [L’ = acetonitrile (complex 1b); L’ = DMSO (complex 1c); L’ = 4-picoline (complex 1d) and L’ = PPh3 (complex 1e)]. Complexes 1b-1e can also be synthesized directly from complex 1via the Ag+-assisted displacement of coordinated chloride by the resp. monodentate L’ ligand. The crystal structures of complexes 1a, 1b and 1d were determined The complexes show intense absorptions in the visible and UV regions, the origin of which was probed into with the help of the TDDFT method. Cyclic voltammetry of the complexes shows an irreversible Ru(II)-Ru(III) oxidation within 0.9-1.6 v vs. SCE, and two ligand (trpy and L-R) based reductions on the neg. side of the SCE. The aquo-complex (1a) is found to serve as an efficient catalyst for the hydration of aryl nitriles to the corresponding amides, and aryl alkynes to aldehydes. In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Synthetic Route of C7H4FN

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Nitrile – Wikipedia,
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In 2022,Wang, Shuai; Li, Xin; Jin, Shengnan; Liu, Kang; Dong, Cong; Su, Jianke; Song, Qiuling published an article in Organic Chemistry Frontiers. The title of the article was 《Difluorocarbene-enabled access to 1,3-oxazin-6-ones from enamides》.Recommanded Product: 4-Fluorobenzonitrile The author mentioned the following in the article:

An efficient and general strategy for the construction of 1,3-oxazin-6-ones with high efficiency and chemoselectivity was reported. Instead of using CO as a C1 source, difluorocarbene was introduced as a carbonyl provider. This method featured readily available starting materials and valuable products, good functional group tolerance and simple operation. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Zn-Catalyzed Cyanation of Aryl Iodides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Zhao, Lulu; Dong, Yanan; Xia, Qiangqiang; Bai, Jianfei; Li, Yuehui. COA of Formula: C7H4FN The article mentions the following:

An efficient method for the synthesis of cyanides such as ArCN [Ar = 4-ClC6H4, 4-MeC6H4, 1-naphthyl, etc.] via zinc-catalyzed cyanation of aryl iodides with formamide as cyanogen source was reported. The transformation was promoted by bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into the nitrile products ArCN in good to excellent yields. This approach was an exceedingly simple and benign method for the synthesis of aryl nitriles ArCN and was likely to proceed via a dinuclear-Zn concerted catalysis. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1COA of Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.COA of Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xing, Ai-Ping; Shen, Zhenpeng; Zhao, Zhe; Tian, Xinzhe; Ren, Yun-Lai published their research in Catalysis Communications in 2021. The article was titled 《CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source》.Application of 1194-02-1 The article contains the following contents:

CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles ArCN [Ar = Ph, 2-MeC6H4, 1-naphthyl, etc.] with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C≡N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

HPLC of Formula: 1194-02-1In 2019 ,《A BEt3-Base Catalyst for Amide Reduction with Silane》 appeared in Journal of Organic Chemistry. The author of the article were Yao, Wubing; Fang, Huaquan; He, Qiaoxing; Peng, Dongjie; Liu, Guixia; Huang, Zheng. The article conveys some information:

Reported herein is the development of a simple but practical catalytic system for the selective reduction of amides with hydrosilane or hydrosiloxane. Low-cost and readily available triethylborane (1.0 M in THF), in combination with a catalytic amount of an alkali metal base, was found to catalyze the reduction of all three amide classes (tertiary, secondary, and primary amides) to form amines under mild conditions. In addition, the selective transformation of secondary amides to aldimines and primary amides to nitriles can also be achieved by using a proper combination of BEt3 and base. The scope of these BEt3-base-catalyzed amide hydrosilylation reactions has been explored in depth. Preliminary results of mechanistic studies suggest a modified Piers’ silane Si-H···B activation mode wherein the hydride abstraction by BEt3 is promoted by the coordination of an alkoxide or hydroxide anion to the Si center. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dhawale, Kiran D.; Ingale, Ajit P.; Shinde, Sandeep V.; Thorat, Nitin M.; Patil, Limbraj R. published their research in Synthetic Communications in 2021. The article was titled 《ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles》.HPLC of Formula: 1194-02-1 The article contains the following contents:

The synthesis of 2-substituted benzothiazoles I (R1 = H, 5-Cl; R2 = H, 4-OMe, 2-Br, etc.) has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Photocatalytic selective aerobic oxidation of amines to nitriles over Ru/γ-Al2O3: the role of the support surface and the strong imine intermediate adsorption》 was written by Zhu, Pengqi; Zhang, Jin; Wang, Jie; Kong, Peng; Wang, Yunwei; Zheng, Zhanfeng. Application In Synthesis of 4-Fluorobenzonitrile And the article was included in Catalysis Science & Technology in 2020. The article conveys some information:

Hydroxyl coordinated ruthenium dispersed on the surface of γ-Al2O3 can be applied to the selective oxidation of amines with light irradiation and an atm. pressure of O2 at room temperature Sunlight is also an effective light source for the selective aerobic oxidation of primary amines to corresponding nitriles. The high photocatalytic activity and selectivity over Ru/γ-Al2O3 originate from the adsorption of amines and imine intermediates on the abundant surface OH groups of the photocatalyst and further formation of Ru-amide species by ligand exchange of adsorbed amines and imine intermediates with adjacent exposed active Ru sites. Light is introduced to the system successfully via the formation of Ru-amide species, which are used as the light absorption sites of the photocatalytic selective oxidation of amines. Primary amines are directly converted to corresponding nitriles via a two-step oxidative dehydrogenation process.4-Fluorobenzonitrile(cas: 1194-02-1Application In Synthesis of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Application In Synthesis of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
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The author of 《Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO》 were Fang, Wan-Yin; Qin, Hua-Li. And the article was published in Journal of Organic Chemistry in 2019. Electric Literature of C7H4FN The author mentioned the following in the article:

Aryl, α,β-unsaturated, and alkyl nitriles were prepared in one step from the corresponding aldehydes by treatment with hydroxylamine hydrochloride, Na2CO3, SO2F2, and DMSO at ambient temperature In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Electric Literature of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Electric Literature of C7H4FN

Referemce:
Nitrile – Wikipedia,
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《Copper-Catalyzed Tandem Reactions of 2-Amine-[1,3,5]triazines with Nitriles》 was written by Zhang, Li-Yu; Zhang, Chen; Wang, Tao; Shi, Yu-Long; Ban, Meng-Tao; Cui, Dong-Mei. Recommanded Product: 1194-02-1This research focused ontriazolotriazinamine triazinylbenzamide preparation; copper catalyst oxidative aerobic condensation cyclocondensation reaction triazinamine; tandem reaction triazinamine aryl nitrile acetonitrile copper catalyst; triazinamine oxidative cyclocondensation aryl nitrile copper catalyst; arylacetonitrile oxidative condensation triazinamine arylamine copper catalyst. The article conveys some information:

In the presence of CuCl and ZnCl2, [1,3,5]triazinamines I (R = Me2N, Et2N, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl; R1 = R2 = H) underwent aerobic oxidative cyclocondensation reactions with aryl nitriles R3CN (R3 = Ph, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 3,5-Cl2C6H3, 4-F3CC6H4, 4-NCC6H4, 2-thienyl, 4-pyridinyl) to yield [1,2,4]triazolo[1,5-a][1,3,5]triazinamines II (R = Me2N, Et2N, 1-piperidinyl, 4-morpholinyl, 1-pyrrolidinyl; R2 = H; R3 = Ph, 4-MeC6H4, 3-MeC6H4, 4-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 3,5-Cl2C6H3, 4-F3CC6H4, 4-NCC6H4, 2-thienyl, 4-pyridinyl). In the presence of CuBr, [1,3,5]triazinamines I (R = Me2N, 1-piperidinyl, H, Ph; R1 = H; R2 = H, Me, Ph), 2-aminopyrimidine, 2-aminopyridine, and aniline underwent oxidative condensation reactions with arylacetonitriles R4CH2CN (R4 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 3-F3CC6H4) to yield N-triazinylamides I (R = Me2N, 1-piperidinyl, H, Ph; R1 = R4; R2 = H, Me, Ph; R4 = Ph, 4-MeC6H4, 4-MeOC6H4, 2-MeOC6H4, 4-FC6H4, 4-ClC6H4, 3-ClC6H4, 3-F3CC6H4), N-(2-pyrimidinyl)benzamide, N-(2-pyridinyl)benzamide, and N-phenylbenzamide. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Luo, Lan; Liu, Hongqiang; Zeng, Wei; Hu, Wenkang; Wang, Dawei published an article in Applied Organometallic Chemistry. The title of the article was 《BTP-Rh@g-C3N4 as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions》.Related Products of 1194-02-1 The author mentioned the following in the article:

Highly active catalysts play an important role in modern catalysis. A novel and efficient ligand benzotriazole-pyrimidine (BTP) and the corresponding rhodium composite on C3N4 were successfully synthesized. The resulting rhodium composite was fully characterized by SEM (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), thermogravimetric anal. (TGA), and XPS. The obtained composite exhibited good catalytic activity and good recovery performance in the synthesis of quinoxaline from 2-aminobenzyl alc. and benzonitrile, and more than 20 quinoxalines were obtained in good yields. Addnl., it also showed that rhodium composite could achieved good catalytic performance in the synthesis of functionalized ketone through borrowing hydrogen strategy. The results came from multiple reactions, including the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts