Category: 1194-02-1

Sikari, Rina; Chakraborty, Gargi; Guin, Amit Kumar; Paul, Nanda D. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Nickel-Catalyzed [4 + 2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation》.Recommanded Product: 4-Fluorobenzonitrile The article contains the following contents:

Nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles via C-H/N-H bond activation, providing straightforward atom-economic access to a wide variety of multisubstituted quinazolines, is reported. Mechanistic investigation revealed that the in situ formed amidines from the coupling of benzylamines and nitriles direct the nickel catalyst to activate the ortho-C-H bond of the Ph ring of the benzylamine. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

De Jesus Silva, Jordan; Bartalucci, Niccolo; Jelier, Benson; Grosslight, Samantha; Gensch, Tobias; Schuenemann, Claas; Mueller, Bernd; Kamer, Paul C. J.; Coperet, Christophe; Sigman, Matthew S.; Togni, Antonio published their research in Helvetica Chimica Acta in 2021. The article was titled 《Development and Molecular Understanding of a Pd-Catalyzed Cyanation of Aryl Boronic Acids Enabled by High-Throughput Experimentation and Data Analysis》.SDS of cas: 1194-02-1 The article contains the following contents:

A synthetic method for the palladium-catalyzed cyanation of aryl boronic acids RB(OH)2 (R = 4-fluorophenyl, naphthalen-2-yl, thiophen-3-yl, etc.) using bench stable and non-toxic N-cyanosuccinimide has been developed. High-throughput experimentation facilitated the screen of 90 different ligands and the resultant statistical data anal. identified that ligand σ-donation, π-acidity and sterics are key drivers that govern yield. Categorization into three ligand groups – monophosphines, bisphosphines and miscellaneous – was performed before the anal. For the monophosphines, the yield of the reaction increases for strong σ-donating, weak π-accepting ligands, with flexible pendant substituents. For the bisphosphines, the yield predominantly correlates with ligand lability. The applicability of the designed reaction to a wider substrate scope was investigated, showing good functional group tolerance in particular with boronic acids bearing electron-withdrawing substituents. This work outlines the development of a novel reaction, coupled with a fast and efficient workflow to gain understanding of the optimal ligand properties for the design of improved palladium cross-coupling catalysts. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1SDS of cas: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.SDS of cas: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Synthesis and Characterization of Ultrapure HKUST-1 MOFs as Reusable Heterogeneous Catalysts for the Green Synthesis of Tetrazole Derivatives》 was published in ChemistrySelect in 2020. These research results belong to Kal-Koshvandi, Afsaneh Taheri; Maleki, Ali; Tarlani, Aliakbar; Soroush, Maral Rahim. Recommanded Product: 4-Fluorobenzonitrile The article mentions the following:

An ultrapure HKUST-1 MOFs synthesized through a precised methodol. as a heterogeneous catalyst for a green approach to the synthesis of tetrazole derivatives via two-, three-, and four-component reactions in milder reaction conditions was presented. Various preparation methods to produce HKUST-1 such as microwave irradiation, reflux, hydrothermal technique, and ultrasonication was precisely compared and it was proved that the best result was obtained during the hydrothermal technique. This was the first design, preparation, characterization and application in the present of HKUST-1 MOFs to the synthesis of the biol. and pharmaceutically important tetrazole compounds in green conditions. Moreover, plausible mechanisms of reactions was suggested for the catalytic activity of the presented catalyst. The catalyst was characterized by various techniques such as FT-IR, SEM, EDX, and XRD. Addnl., HKUST-1 was recoverable as well as reusable without any significant loss of its activity, which strongly supports the heterogeneous nature of the catalyyst. This novel catalysis protocol offered several advantages such as eco-friendly conditions, lower reaction time, milder reaction conditions, excellent catalytic activity and an easy separation of the catalyst make it a good heterogeneous system. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Joy, F.; Peter, F.; Gokul, P. C.; Nizam, A.; Chinnam, S. published an article in 2022. The article was titled 《UV-Promoted Metal- and Photocatalyst-Free Direct Conversion of Aromatic Aldehydes to Nitriles》, and you may find the article in Russian Journal of Organic Chemistry.Quality Control of 4-Fluorobenzonitrile The information in the text is summarized as follows:

An efficient, simple and catalyst-free UV-induced functional group transformation of aromatic aldehydes to nitriles was reported. The developed strategy delivered various functionalized aromatic nitriles with high yields and purity. The UV irradiation activated the carbonyl group of aldehydes and lead to the formation of aldoxime intermediate, further resulting in the generation of nitriles. The striking highlights of the reported methodol. were simple reaction conditions, good yields, UV-promoted transformation and catalyst-free synthesis. Due to the above-mentioned advantages, the methodol. provided a hand towards environmentally friendly chem. synthesis. In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1Quality Control of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Quality Control of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Chahkamali, Farhad Omarzehi; Sobhani, Sara; Sansano, Jose Miguel published an article in Catalysis Letters. The title of the article was 《Water-Dispersible Pd-N-Heterocyclic Carbene Complex Immobilized on Magnetic Nanoparticles as a New Heterogeneous Catalyst for Fluoride-Free Hiyama, Suzuki-Miyaura and Cyanation Reactions in Aqueous Media》.Reference of 4-Fluorobenzonitrile The author mentioned the following in the article:

Pd-N-heterocyclic carbine complex immobilized on magnetic nanoparticles was synthesized and characterized by different techniques such as FT-IR, XPS, TEM, EDX, FESEM, VSM, TGA and ICP. The synthesized catalyst was used as a new water dispersible heterogeneous catalyst in the fluoride-free Hiyama, Suzuki-Miyaura and cyanation reactions in pure water. By this method, different types of biaryls and aryl nitriles were synthesized in good to high yields by the reaction of a variety of aryl iodides, bromides and chlorides with triethoxyphenylsilane, phenylboronic acid and K4[Fe(CN)6]·3H2O, resp. The presence of sulfonates as hydrophilic groups on the surface of the catalyst confers a highly water dispersible, active and yet magnetically recoverable Pd catalyst. The possibility to perform the reaction in water as a green medium, ease of the catalyst recovery and reuse by magnetic separation, and the absence of any additives or co-solvents make this method as an eco-friendly and economical protocol for the synthesis of biaryl derivatives and aryl nitriles.4-Fluorobenzonitrile(cas: 1194-02-1Reference of 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Reference of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《An Experimental Acidity Scale for Intramolecularly Stabilized Silyl Lewis Acids》 were Kuenzler, Sandra; Rathjen, Saskia; Merk, Anastasia; Schmidtmann, Marc; Mueller, Thomas. And the article was published in Chemistry – A European Journal in 2019. HPLC of Formula: 1194-02-1 The author mentioned the following in the article:

A new NMR-based Lewis acidity scale is suggested and its application is demonstrated for a family of silyl Lewis acids. The reaction of p-fluorobenzonitrile (FBN) with silyl cations that are internally stabilized by interaction with a remote chalcogenyl or halogen donor yields silylated nitrilium ions with the silicon atom in a trigonal bipyramidal coordination environment. The 19F NMR chem. shifts and the 1J(CF) coupling constants of these nitrilium ions vary in a predictable manner with the donor capability of the stabilizing group. The spectroscopic parameters are suitable probes for scaling the acidity of Lewis acids. These new probes allow for the discrimination between very similar Lewis acids, which is not possible with conventional NMR tests, such as the well-established Gutmann-Beckett method. In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Asian Journal of Organic Chemistry included an article by Kim, Jihyeon; Golime, Gangadhararao; Kim, Hun Young; Oh, Kyungsoo. Safety of 4-Fluorobenzonitrile. The article was titled 《Copper(II)-Catalyzed Aerobic Oxidation of Amines: Divergent Reaction Pathways by Solvent Control to Imines and Nitriles》. The information in the text is summarized as follows:

The Cu(OAc)2-catalyzed aerobic oxidations of amines to imines RR1CH=NR2 [R = H, Me; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.; R2 = cyclohexyl, Ph, Bn, etc.] and nitriles R3CN [R3 = n-heptyl, Ph, 2-thienyl, etc.] were identified under solvent control conditions and in the presence of mol. oxygen. By modulating the aerobic oxidation pathways of Cu(OAc)2 catalyst in different reaction solvents, the selective formations of homo-coupled imines, cross-coupled imines and nitriles were achieved from amine derivatives In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Kulkarni, Pravin S.; Sarda, Swapnil R.; Khandebharad, Amol U.; Farooqui, Mazahar; Agrawal, Brijmohan R. published an article in Asian Journal of Chemistry. The title of the article was 《Synthesis and biological screening of novel 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole derivatives》.Safety of 4-Fluorobenzonitrile The author mentioned the following in the article:

A new series of 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole I [R = H, 4-Cl, 3,4-(OCH3)2; R1 = H, 4-F, 2-CH3, 3-CH3, 4-CH3] have been synthesized by a cyclocondensation reaction of Et 5-(4-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate II with aryl imidoxime R1C6H4C(=NOH)NH2. The newly synthesized pyrazolyl-1,2,4-oxadiazole derivatives I were characterized by spectroscopic techniques and screened for in vitro antibacterial activity against Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178), Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) and in vitro antifungal activity against Aspergillus niger (ATCC 504) Candida albicans (NCIM 3100). The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

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Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1194-02-1In 2019 ,《Ru (III) Schiff-base complex anchored on nanosilica as an efficient and retrievable catalyst for hydration of nitriles》 was published in Applied Organometallic Chemistry. The article was written by Sultana, Samim; Borah, Geetika; Gogoi, Pradip K.. The article contains the following contents:

Synthesis of a new solid supported Ru (III) Schiff base complex, Ru@imine-nanoSiO2 immobilized on nanosilica obtained from rice husk was reported. The complex was characterized by FTIR, powder X-ray diffraction, BET surface area measurement, UV-vis, SEM-EDX, TEM, ESR, XPS and ICP-AES anal. Using Ru@imine-nanoSiO2 as the catalyst, the hydration of nitriles in i-PrOH at 40 ° was studied which resulted in good isolated yields (60-99%). The catalyst can be recycled and reused up to 5th cycle without any loss in activity. The products were characterized by FTIR, GC-MS and 1H-NMR spectroscopy and compared with authentic samples. After reading the article, we found that the author used 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Chiral Chalcogenyl-Substituted Naphthyl- and Acenaphthyl-Silanes and Their Cations》 was published in Chemistry – A European Journal in 2020. These research results belong to Kuenzler, Sandra; Rathjen, Saskia; Rueger, Katherina; Wuerdemann, Marie S.; Wernke, Marcel; Tholen, Patrik; Girschik, Corinna; Schmidtmann, Marc; Landais, Yannick; Mueller, Thomas. HPLC of Formula: 1194-02-1 The article mentions the following:

Cyclic silylated chalconium borates 13[B(C6F5)4] and 14[B(C6F5)4] with peri-acenaphthyl and peri-naphthyl skeletons were synthesized from unsym. substituted silanes 3, 4, 6, 7, 9 and 10 using the standard Corey protocol (Chalcogen Ch=O, S, Se, Te). The configuration at the chalcogen atom is trigonal pyramidal for Ch=S, Se, Te, leading to the formation of cis- and trans-isomers in the case of phenylmethylsilyl cations. With the bulkier tert-Bu group at silicon, the configuration at the chalcogen atoms is predetermined to give almost exclusively the trans-configurated cyclic silylchalconium ions. The barriers for the inversion of the configuration at the sulfur atoms of sulfonium ions 13 c and 14 a are substantial (72-74 kJ mol-1) as shown by variable temperature NMR spectroscopy. The neighboring group effect of the thiophenyl substituent is sufficiently strong to preserve chiral information at the silicon atom at low temperatures In the experiment, the researchers used many compounds, for example, 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts