Category: 1194-02-1

Name: 4-FluorobenzonitrileIn 2021 ,《Highly Efficient Oxidative Cyanation of Aldehydes to Nitriles over Se,S,N-tri-Doped Hierarchically Porous Carbon Nanosheets》 was published in Angewandte Chemie, International Edition. The article was written by Hua, Manli; Song, Jinliang; Huang, Xin; Liu, Huizhen; Fan, Honglei; Wang, Weitao; He, Zhenhong; Liu, Zhaotie; Han, Buxing. The article contains the following contents:

A series of Se,S,N-tri-doped carbon nanosheets with a hierarchical porous structure was designed (denoted as Se,S,N-CNs-x, x represented the pyrolysis temperature). It was found that the obtained Se,S,N-CNs-1000 was very selective and efficient for oxidative cyanation of various aldehydes including those containing other oxidizable groups into the corresponding nitriles using ammonia as the nitrogen resource below 100°C. Detailed investigations revealed that the excellent performance of Se,S,N-CNs-1000 originated mainly from the graphitic-N species with lower electron d. and synergistic effect between the Se, S, N and C in the catalyst. Besides, the hierarchically porous structure could also promote the reaction. Notably, the unique feature of this metal-free catalyst was that it tolerated other oxidizable groups and showed no activity on further reaction of the products, thereby resulting in high selectivity. Based on the investigations, this is the first work for the synthesis of nitriles via oxidative cyanation of aldehydes over heterogeneous metal-free catalysts. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Name: 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Name: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Bulletin of the Korean Chemical Society included an article by Chia, Poh Wai; Yong, Fu Siong Julius; Mohamad, Habsah; Kan, Su-Yin. Safety of 4-Fluorobenzonitrile. The article was titled 《Cyanation of Anilines to Aryl Nitriles Using tert-Butyl Isocyanide: A Simple and Copper-free Procedure》. The information in the text is summarized as follows:

In this manuscript, a simple and copper-free procedure for the synthesis of aryl nitrile derivatives from anilines is described. Under the improved protocol, the anilines were reacted with tert-Bu isocyanide under a mild reaction condition without the use of solvents and copper catalyst to synthesize benzonitriles. This copper-free Sandmeyer-type reaction could tolerate a range of anilines bearing different functional groups and also can be conducted even without the exclusion of air. In addition, this method has afforded the aryl nitriles I (R1 = H, 4-Cl, 4-Me, 2-F, etc.) in moderate to good yields (52-81%). The obtained results in this study reveal that the tert-Bu isocyanide as a potential cyanide source for the cyanation reaction. In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《A Novel Water-Dispersible/Magnetically Recyclable Pd Catalyst for C-C Cross-Coupling Reactions in Pure Water》 was written by Sobhani, Sara; Habibollahi, Azam; Zeraatkar, Zohre. Recommanded Product: 4-FluorobenzonitrileThis research focused onwater magnetic recyclable palladium catalyst coupling Hiyama Suzuki. The article conveys some information:

A novel water-dispersible magnetically recyclable Pd heterogeneous catalyst, denoted as Pd-γ-Fe2O3-2-ATP-TEG-MME, was initially synthesized and then characterized by diverse methods such as FTIR, TEM, TGA, XPS, VSM, ICP, and elemental anal. The new catalyst was used as a water-dispersible/magnetically separable Pd heterogeneous catalyst for C-C cross-coupling reactions including cyanation of aryl halides, fluoride-free Hiyama and Suzuki reactions in neat water. By using this approach numerous arylcyanides and biaryls were synthesized in good to high yields via the reaction of aryl iodides, bromides, and chlorides (far more extensively available and cheaper than aryl iodides and bromides) with K4[Fe(CN)6]·3H2O, triethoxyphenylsilane, or Ph boronic acid, resp. The presence of triethylene glycol tags with hydrophilic character on the Pd-complex supported on magnetic nanoparticles provides dispersion of the catalyst particles in water, which leads to both higher catalytic performance and also facile catalyst recovery and reuse by successive extraction and final magnetic separation Using water as a green solvent, high turnover number (TON), facile catalyst recovery and reuse, simple workup, and not requiring any additive make this method an ecofriendly protocol for the C-C cross-coupling reactions.4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Triphenylbismuth Dichloride-Mediated Conversion of Thioamides to Nitriles》 were Gopi, Elumalai; Gravel, Edmond; Doris, Eric. And the article was published in European Journal of Organic Chemistry in 2019. Related Products of 1194-02-1 The author mentioned the following in the article:

Thioamides RC(S)NH2 (R = 4-BrC6H4, Ph, 1-naphthyl, pyridin-4-yl, etc.) were efficiently converted to nitriles RCN using the pentavalent triphenylbismuth dichloride in combination with triethylamine. The reaction involved the dehydrosulfurization of primary thioamides to afford substituted aromatic or aliphatic nitriles in good to excellent yields. The process was also successfully extended to the synthesis of cyanamides R1XCN (R1 = Ph, 2-methoxyphenyl; X = NH, NMe) starting from the corresponding thioureas R1XC(S)NH2 and of thiocyanates R1XCN (R1 = 3-methoxyphenyl; X = S) from dithiocarbamates R1XC(S)NH2. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Efficient and chemoselective hydroboration of organic nitriles promoted by TiIV catalyst supported by unsymmetrical acenaphthenequinonediimine ligand》 was written by Banerjee, Indrani; Anga, Srinivas; Bano, Kulsum; Panda, Tarun K.. Safety of 4-FluorobenzonitrileThis research focused ontitanium acenaphthenequinonediimine complex catalyst chemoselective hydroboration organic nitrile; crystal structure mol titanium acenaphthenequinonediimine complex preparation. The article conveys some information:

We report the synthesis, characterization, and utilization of a titanium (IV) complex [(η5-C5H5){L}TiCl2] (1) supported by a monoanionic ligand (L), N-(2, 6-diisopropyl)acenaphthenequinonediimido, as a mol. pre-catalyst for the hydroboration of nitriles. The unsym. N-silylated N-(2, 6-diisopropyl)-N-(trimethylsilyl)-acenaphthenequinonediimine ligand (LSiMe3) was obtained upon the completion of a one-pot reaction between N-(2, 6-diisopropyl)iminoacenaphthenone and lithium hexamethyldisilazide in the presence of trimethylsilyl chloride in 1:1:1 M ratio at 90 °C. The reaction of LSiMe3 with (η5-(C5H5)TiCl3) in equal proportion (1:1) at 60 °C afforded the titanium complex [(η5-C5H5){L}TiCl2] (1) in good yield. The mol. structures of the N-silyl ligand (LSiMe3) and Ti(IV) complex 1 were established by single-crystal X-ray anal. Complex 1 was tested as a pre-catalyst for hydroboration of nitriles with pinacolborane (HBpin) and catecholborane (HBcat) to afford diboryl amines at ambient temperature Titanium complex 1 exhibited high conversion, superior selectivity, and broad functional group tolerance during hydroboration of nitriles with both HBpin and HBcat under mild conditions. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Recommanded Product: 4-FluorobenzonitrileIn 2019 ,《Green and convenient protocols for the efficient reduction of nitriles and nitro compounds to corresponding amines with NaBH4 in water catalyzed by magnetically retrievable CuFe2O4 nanoparticles》 appeared in Research on Chemical Intermediates. The author of the article were Zeynizadeh, Behzad; Mohammad Aminzadeh, Farkhondeh; Mousavi, Hossein. The article conveys some information:

Firstly, CuFe2O4 nanoparticles were prepared by a simple operation. The structure of the mentioned nanoparticles was characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, inductively coupled plasma-optical emission spectrometry, vibrating sample magnetometer and also Brunauer-Emmett-Teller and Barrett-Joyner-Halenda analyses. The prepared magnetically copper ferrite nanocomposite was successfully applied as a simple, cost-effective, practicable and recoverable catalyst on the green, highly efficient, fast, base-free and ligand-free reduction of nitriles and also on the affordable and eco-friendly reduction of nitro compounds with the broad substrate scope to the corresponding amines with NaBH4 in water at reflux in high to excellent yields. In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Fluorination of arylboronic esters enabled by bismuth redox catalysis》 was published in Science (Washington, DC, United States) in 2020. These research results belong to Planas, Oriol; Wang, Feng; Leutzsch, Markus; Cornella, Josep. Synthetic Route of C7H4FN The article mentions the following:

Triarylbismuth complexes undergo oxidative addition to yield difluorobismuth(V) derivatives, which, upon the reductive elimination provide a valuable route for catalytic fluorination of organoboron compounds Bismuth catalysis has traditionally relied on the Lewis acidic properties of the element in a fixed oxidation state. In this paper, we report a series of bismuth complexes that can undergo oxidative addition, reductive elimination, and transmetalation in a manner akin to transition metals. Rational ligand optimization featuring a sulfoximine moiety produced an active catalyst for the fluorination of aryl boronic esters through a bismuth (III)/bismuth (V) redox cycle. Crystallog. characterization of the different bismuth species involved, together with a mechanistic investigation of the carbon-fluorine bond-forming event, identified the crucial features that were combined to implement the full catalytic cycle. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Synthesis of Indoles through Domino Reactions of 2-Fluorotoluenes and Nitriles》 were Mao, Jianyou; Wang, Zhiting; Xu, Xinyu; Liu, Guoqing; Jiang, Runsheng; Guan, Haixing; Zheng, Zhipeng; Walsh, Patrick J.. And the article was published in Angewandte Chemie, International Edition in 2019. HPLC of Formula: 1194-02-1 The author mentioned the following in the article:

A straightforward, practical, and transition-metal-free assembly of 2-aryl indoles was reported. Simply combining readily available 2-fluorotoluenes, nitriles, LiN(SiMe3)2, and CsF enabled the generation of a diverse array of indoles (38 examples, 48-92 % yield). A range of substituents can be introduced into each position of the indole backbone (C4 to C7, and aryl groups at C2), providing handles for further elaboration.4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Planas, Oriol; Peciukenas, Vytautas; Leutzsch, Markus; Noethling, Nils; Pantazis, Dimitrios A.; Cornella, Josep published an article in Journal of the American Chemical Society. The title of the article was 《Mechanism of the Aryl-F Bond-Forming Step from Bi(V) Fluorides》.Safety of 4-Fluorobenzonitrile The author mentioned the following in the article:

The authors describe a combined exptl. and theor. mechanistic study of the C(sp2)-F bond formation from neutral and cationic high-valent organobismuth(V) fluorides, featuring a dianionic bis-aryl sulfoximine ligand. An exhaustive assessment of the substitution pattern in the ligand, the sulfoximine, and the reactive aryl on neutral triarylbismuth(V) difluorides revealed that formation of dimeric structures in solution promotes facile Ar-F bond formation. Noteworthy, theor. modeling of reductive elimination from neutral Bi(V) difluorides agrees with the exptl. determined kinetic and thermodn. parameters. Also, the addition of external fluoride sources leads to inactive octahedral anionic Bi(V) trifluoride salts, which decelerate reductive elimination. However, a parallel anal. for cationic bismuthonium fluorides revealed the crucial role of tetrafluoroborate anion as fluoride source. Both exptl. and theor. analyses conclude that C-F bond formation occurs through a low-energy five-membered transition-state pathway, where the F anion is delivered to a C(sp2) center, from a BF4 anion, reminiscent of the Balz-Schiemann reaction. The knowledge gathered throughout the study permitted a rational assessment of the key parameters of several ligands, identifying the simple sulfone-based ligand family as an improved system for the stoichiometric and catalytic fluorination of arylboronic acid derivatives In the experiment, the researchers used 4-Fluorobenzonitrile(cas: 1194-02-1Safety of 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Safety of 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Aryl dechlorination and defluorination with an organic super-photoreductant》 was published in Photochemical & Photobiological Sciences in 2020. These research results belong to Glaser, Felix; Larsen, Christopher B.; Kerzig, Christoph; Wenger, Oliver S.. HPLC of Formula: 1194-02-1 The article mentions the following:

Direct excitation of the com. available super-electron donor tetrakis(dimethylamino)ethylene (TDAE) with light-emitting diodes at 440 or 390 nm provides a stoichiometric reductant that is able to reduce aryl chlorides and fluorides. The method is very simple and requires only TDAE, substrate, and solvent at room temperature The photoactive excited state of TDAE has a lifetime of 17.3 ns in cyclohexane at room temperature and an oxidation potential of ca. -3.4 V vs. SCE. This makes TDAE one of the strongest photoreductants able to operate on the basis of single excitation with visible photons. Direct substrate activation occurs in benzene, but acetone is reduced by photoexcited TDAE and substrate reduction takes place by a previously unexplored solvent radical anion mechanism. Our work shows that solvent can have a leveling effect on the photochem. available redox power, reminiscent of the pH-leveling effect that solvent has in acid-base chem. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1HPLC of Formula: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.HPLC of Formula: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts