Category: 1194-02-1

In 2022,Luo, Ling; Liu, Dan; Lan, Shichao; Gan, Xiuhai published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Design, synthesis and biological activity of novel chalcone derivatives containing an 1,2,4-oxadiazole moiety》.Category: nitriles-buliding-blocks The author mentioned the following in the article:

To discover a lead compound for agricultural use, 34 novel chalcone derivatives I [R1 = H, 4-MeO, 2,4-di-Cl, etc; R2 = H, 4-Me, 4-F, 4-Cl] and II [R1 = H, 4-Me, 4-MeO, 2-Cl, 2,4-di-Cl; R2 = H, 4-Me, 4-F, 4-Cl] containing an 1,2,4-oxadiazole moiety were designed and synthesized. Their nematocidal activities against Bursaphelenchus xylophilus, Aphelenchoides besseyi and Ditylenchus dipsaci and their antiviral activities against tobacco mosaic virus (TMV), pepper mild mottle virus (PMMoV) and tomato spotted wilt virus (TSWV) were evaluated. Biol. assay results indicated that compounds I [R1 = 3-MeO, 4-MeO, R2 = H] showed good nematocidal activities against B. xylophilus, A. besseyi and D. dipsaci, with LC50 values of 35.5, 44.7 and 30.2μg/mL and 31.8, 47.4 and 36.5μg/mL, resp., which are better than tioxazafen, fosthiazate and abamectin. Furthermore, compound I [R1 = 2-MeO, R2 = H] demonstrated excellent protective activity against TMV, PMMoV and TSWV, with EC50 values of 210.4, 156.2 and 178.2μg/mL, resp., which are superior to ningnanmycin (242.6, 218.4 and 180.5μg/mL). In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Category: nitriles-buliding-blocks)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lan, Chunling Blue; Auclair, Karine published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation》.Application of 1194-02-1 The article contains the following contents:

Ammonium chloride promoted the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeded rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it was compatible with other nucleophiles, acid-labile moieties and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatog. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Luo, Ling; Liu, Dan; Lan, Shichao; Gan, Xiuhai published an article in Frontiers in Chemistry (Lausanne, Switzerland). The title of the article was 《Design, synthesis and biological activity of novel chalcone derivatives containing an 1,2,4-oxadiazole moiety》.Category: nitriles-buliding-blocks The author mentioned the following in the article:

To discover a lead compound for agricultural use, 34 novel chalcone derivatives I [R1 = H, 4-MeO, 2,4-di-Cl, etc; R2 = H, 4-Me, 4-F, 4-Cl] and II [R1 = H, 4-Me, 4-MeO, 2-Cl, 2,4-di-Cl; R2 = H, 4-Me, 4-F, 4-Cl] containing an 1,2,4-oxadiazole moiety were designed and synthesized. Their nematocidal activities against Bursaphelenchus xylophilus, Aphelenchoides besseyi and Ditylenchus dipsaci and their antiviral activities against tobacco mosaic virus (TMV), pepper mild mottle virus (PMMoV) and tomato spotted wilt virus (TSWV) were evaluated. Biol. assay results indicated that compounds I [R1 = 3-MeO, 4-MeO, R2 = H] showed good nematocidal activities against B. xylophilus, A. besseyi and D. dipsaci, with LC50 values of 35.5, 44.7 and 30.2μg/mL and 31.8, 47.4 and 36.5μg/mL, resp., which are better than tioxazafen, fosthiazate and abamectin. Furthermore, compound I [R1 = 2-MeO, R2 = H] demonstrated excellent protective activity against TMV, PMMoV and TSWV, with EC50 values of 210.4, 156.2 and 178.2μg/mL, resp., which are superior to ningnanmycin (242.6, 218.4 and 180.5μg/mL). In the experimental materials used by the author, we found 4-Fluorobenzonitrile(cas: 1194-02-1Category: nitriles-buliding-blocks)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lan, Chunling Blue; Auclair, Karine published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation》.Application of 1194-02-1 The article contains the following contents:

Ammonium chloride promoted the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeded rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it was compatible with other nucleophiles, acid-labile moieties and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatog. In addition to this study using 4-Fluorobenzonitrile, there are many other studies that have used 4-Fluorobenzonitrile(cas: 1194-02-1Application of 1194-02-1) was used in this study.

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Application of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2019,Journal of the American Chemical Society included an article by Ghosh, Chandrani; Kim, Suyeon; Mena, Matthew R.; Kim, Jun-Hyeong; Pal, Raja; Rock, Christopher L.; Groy, Thomas L.; Baik, Mu-Hyun; Trovitch, Ryan J.. Formula: C7H4FN. The article was titled 《Efficient Cobalt Catalyst for Ambient-Temperature Nitrile Dihydroboration, the Elucidation of a Chelate-Assisted Borylation Mechanism, and a New Synthetic Route to Amides》. The information in the text is summarized as follows:

N,N-Diborylamines have emerged as promising reagents in organic synthesis; however, their efficient preparation and full synthetic utility have yet to be realized. To address both shortcomings, an effective catalyst for nitrile dihydroboration was sought. Heating CoCl2 in the presence of PyEtPDI afforded the six-coordinate Co(II) salt, [(PyEtPDI)CoCl][Cl]. Upon adding 2 equiv of NaEt3BH, hydride transfer to one chelate imine functionality was observed, giving (κ4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Single-crystal x-ray diffraction and d. functional theory calculations revealed that this compound possesses a low-spin Co(II) ground state featuring antiferromagnetic coupling to a singly reduced imino(pyridine) moiety. Importantly, (κ4-N,N,N,N-PyEtIPCHMeNEtPy)Co was found to catalyze the dihydroboration of nitriles using HBPin with turnover frequencies of up to 380 h-1 at ambient temperature Stoichiometric addition experiments revealed that HBPin adds across the Co-Namide bond to generate a hydride intermediate that can react with addnl. HBPin or nitriles. Computational evaluation of the reaction coordinate revealed that the B-H addition and nitrile insertion steps occur on the antiferromagnetically coupled triplet spin manifold. Formation of the borylimine intermediate occurs following BPin transfer from the borylated chelate arm to regenerate (κ4-N,N,N,N-PyEtIPCHMeNEtPy)Co. Borylimine reduction is in turn facile and follows the same ligand-assisted borylation pathway. The independent hydroboration of alkyl and aryl imines was also demonstrated at 25°. With N,N-diborylamines in hand, their addition to carboxylic acids allowed for the direct synthesis of amides at 120°, without the need for an exogenous coupling reagent. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Formula: C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Formula: C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Gholinejad, Mohammad; Shojafar, Mohammad; Sansano, Jose M.; Mikhaylov, Vladimir N.; Balova, Irina A.; Khezri, Rahimeh published an article in Journal of Organometallic Chemistry. The title of the article was 《Hyperbranched polymer immobilized palladium nanoparticles as an efficient and reusable catalyst for cyanation of aryl halides and reduction of nitroarenes》.Recommanded Product: 1194-02-1 The author mentioned the following in the article:

A new nitrogen-rich hyperbranched polymer comprising imidazolium and triazole moieties was used for stabilization of Pd nanoparticles. The resulting new material, PolyTZ-IL@Pd NPs, I was characterized with different techniques including Fourier-transform IR spectroscopy (FTIR), X-ray diffraction (XRD), XPS, energy dispersive X-Ray (EDX), and transmission electron microscopy (TEM) anal. Compound I was used as an efficient catalyst in the reduction of nitroarenes to amines and cyanation of aryl bromides and iodides. The catalyst showed high stability and recyclability and recycled at least 10 times in reduction of 1-chloro-4-nitrobenzene and 5 times in cyanation of iodobenzene. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Scope and mechanism of nitrile dihydroboration mediated by a β-diketiminate manganese hydride catalyst》 was written by Nguyen, Thao T.; Kim, Jun-Hyeong; Kim, Suyeon; Oh, Changjin; Flores, Marco; Groy, Thomas L.; Baik, Mu-Hyun; Trovitch, Ryan J.. Recommanded Product: 4-Fluorobenzonitrile And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The Manganese hydride dimer, [(2,6-iPr2PhBDI)Mn(μ-H)]2, was found to mediate nitrile dihydroboration, rendering it the 1st Mn catalyst for this transformation. Stoichiometric experiments revealed that benzonitrile insertion affords [(2,6-iPr2PhBDI)Mn(μ-NCHC6H5)]2 en route to N,N-diborylamine formation. D. functional theory calculations reveal the precise mechanism and demonstrate that catalysis is promoted by monomeric species. In the part of experimental materials, we found many familiar compounds, such as 4-Fluorobenzonitrile(cas: 1194-02-1Recommanded Product: 4-Fluorobenzonitrile)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Recommanded Product: 4-Fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Two-step gas adsorption induced by the transmetalation in a two-dimensional metal-organic framework》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Park, Hye Jeong; Oh, Jongbum; Kim, Jiwon; Kim, Jaheon. Related Products of 1194-02-1 The article mentions the following:

Transmetalation or replacement of Zn2+ ions with Cu2+ ions in a two-dimensional metal-organic framework, Zn3(TCPB)2(H2O)2 (H3TCPB = 1,3,5-tri(4-carboxyphenoxy)benzene), gives rise to addnl. gas adsorption, where the addnl. adsorption amount linearly depends on the degree of the transmetalation. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Related Products of 1194-02-1)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Related Products of 1194-02-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Organophotoredox assisted cyanation of bromoarenes via silyl-radical-mediated bromine abstraction》 was written by Shee, Maniklal; Shah, Sk. Sheriff; Singh, N. D. Pradeep. Synthetic Route of C7H4FN And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The insertion of a nitrile (-CN) group into arenes through the direct functionalization of the C(sp2)-Br bond is a challenging reaction. Herein, we report an organophotoredox method for the cyanation of aryl bromides using the organic photoredox catalyst 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) and tosyl cyanide (TsCN) as the nitrile source. A photogenerated silyl radical, via a single electron transfer (SET) mechanism, was employed to abstract bromine from aryl bromide to provide an aryl radical, which was concomitantly intercepted by TsCN to afford the aromatic nitrile. A range of substrates containing electron-donating and -withdrawing groups was demonstrated to undergo cyanation at room temperature in good yields. Thus, e.g., Me 4-bromobenzoate → Me 4-cyanobenzoate (71%) employing 4CzIPN, TsCN, (TMS)3SiOH as silyl radical source, K3PO4 as base, acetone as solvent and irradiation from blue LED. The experimental part of the paper was very detailed, including the reaction process of 4-Fluorobenzonitrile(cas: 1194-02-1Synthetic Route of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used as chemical intermediate, solvent for perfumes and pharmaceuticals, stabilizer for chlorinated solvents, HPLC analysis, catalyst and component of transition-metal complex catalysts.Synthetic Route of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Linlin; Qi, Lin; Chen, Jia-Min; Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Li, Wei; Wang, Li-Jing published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Preparation of selenyl 1,3-oxazines via PhICl2/Cu2O-promoted aminoselenation of O-homoallyl benzimidates with diselenides》.Computed Properties of C7H4FN The article contains the following contents:

A practical electrophilic aminoselenation of O-homoallyl benzimidate with diselenides promoted by PhICl2/Cu2O had been developed. The easily available and stable diselenides were used as selenium sources. Various selenyl 1,3-oxazines I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Ph; R3 = Me, n-Bu, Ph, etc.], which were important frameworks in medicinal and biol. chem., were easily obtained in moderate to good yields for the first time. Easy scaleup and scalability made this method attractive for the preparation of other valuable organoselenides. The experimental process involved the reaction of 4-Fluorobenzonitrile(cas: 1194-02-1Computed Properties of C7H4FN)

4-Fluorobenzonitrile(cas: 1194-02-1) is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.Computed Properties of C7H4FN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts