Category: 166329-43-7

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Construction of Azacycles Based on Endo-Mode Cyclization of Allenes, published in 2004-03-19, which mentions a compound: 166329-43-7, mainly applied to reductive cyclization alkylidene azidoalkyl sulfonyl benzene preparation; radical cyclization alkylidene azidoalkyl sulfonyl benzene preparation; dipolar cycloaddition alkylidene azidoalkyl sulfonyl benzene preparation; indole preparation endo cyclization azido allene preparation; quinoline preparation endo cyclization azido allene preparation, Safety of tert-Butyl (2-(bromomethyl)phenyl)carbamate.

A new procedure for constructing monocyclic five- and six-membered azacycles by the endo-mode ring-closing reaction of allenylazido derivatives under neutral conditions has been developed. The azabicyclo[m.n.0] compounds were prepared by applying this newly developed procedure. The seven-membered azacycle was prepared when the allene possessing an unsubstituted carboxyl amido functionality was submitted to the basic conditions. In addition, indole and quinoline skeletons were synthesized using this procedure. For example, the cyclization of a [[1-(alkylidene)-3-(azido)propyl]sulfonyl]benzene derivative (I) using tributyltin hydride gave a tetrahydropyridine intermediate which desilylated and brominated to give a (bromopropyl)tetrahydropyridine transient which completed the ring closure to 1,2,3,5,6,7-hexahydro-8-(phenylsulfonyl)indolizine (II).

There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)NC1=CC=CC=C1CBr)Safety of tert-Butyl (2-(bromomethyl)phenyl)carbamate, and with the development of science, more effects of this compound(166329-43-7) can be discovered.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Product Details of 166329-43-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl (2-(bromomethyl)phenyl)carbamate, is researched, Molecular C12H16BrNO2, CAS is 166329-43-7, about Synthesis of amino substituted benzyltriphenylphosphonium bromides. Author is Hong, Wei; Wang, Hao.

The amino substituted benzyltriphenylphosphonium bromides could be used as Wittig reagents in Wittig reaction and were synthesized efficiently from 2 or 3 or 4-hydroxymethyl anilines by a three-step reaction, protection, bromination and nucleophilic substitution, in total yield of 70%.

Here is a brief introduction to this compound(166329-43-7)Product Details of 166329-43-7, if you want to know about other compounds related to this compound(166329-43-7), you can read my other articles.

Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts