Category: 1885-29-6

Cao, Yu published the artcileSelf-[3+2] annulation reaction of pyridinium salts: synthesis of N-indolizine-substituted pyridine-2(1H)-ones, Quality Control of 1885-29-6, the main research area is benzyolmethyl pyridinium bromide cycloaddition; aroyl arylindolizinyl pyridinone preparation; aniline benzyolmethyl pyridinium bromide cycloaddition; benzoyl phenylindolizinylpyridinylideneamino benzonitrile preparation.

A self-[3+2] annulation reaction of pyridinium salts was developed for the synthesis of N-indolizine-substituted pyridine-2(1H)-ones. This protocol was carried out under mild reaction conditions without any precious catalysts in generally moderate to good yields. Addnl., a plausible mechanism for the transformation was proposed.

New Journal of Chemistry published new progress about [3+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aali, Elaheh published the artcile1-Disulfo-[2,2-bipyridine]-1,1-diium chloride ionic liquid as an efficient catalyst for the green synthesis of 5-substituted 1H-tetrazoles, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is tetrazole preparation green chem; nitrile sodium azide cycloaddition ionic liquid catalyst; disulfo bipyridinium chloride ionic liquid preparation.

A simple, green and efficient method has been developed for the synthesis of 5-substituted 1H-tetrazole derivatives I (R = Bu, thiophen-2-yl, 3,4,5-trimethoxyphenyl, etc.) through [2+3] cycloaddition reaction in good to excellent yields between various benzonitriles RCN and sodium azide. For this purpose, 1-disulfo-[2,2-bipyridine]-1,1-diium chloride ([BiPy](HSO3)2Cl2) system as an ionic liquid catalyst have been extended for the construction of these valuable products. This procedure has significant advantages, including using ethylene glycol as a green solvent. The other advantages of this method are inexpensive and simple preparation of the catalyst, mild reaction conditions, green reaction medium, easy workup, short reaction time, and simple exptl. process.

Journal of Molecular Structure published new progress about [3+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hamsath, Akil published the artcileIntramolecular tetrazine-acryloyl cycloaddition: chemistry and applications, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is coumarin dihydropyridazine preparation; acryloyl ester amide tetrazine intramol cycloaddition.

An unprecedented intramol. [4 + 2] tetrazine-olefin cycloaddition with α,β-unsaturated substrates was discovered. The reaction produces unique coumarin-dihydropyridazine heterocycles that exhibited strong fluorescence with large Stokes shifts and excellent photo- and pH-stability. This property can be used for reaction anal. The rate of cycloaddition was found to be solvent dependent and was determined using exptl. data with a kinetic modeling software (COPASI) as well as DFT calculations (k1 = 0.64 ± 0.019 s-1 and 4.1 s-1, resp.). The effects of steric and electronic properties of both the tetrazine and α,β-unsaturated carbonyl on the reaction were studied and followed the known trends characteristic of the intermol. reaction. Based on these results, authors developed a “”release-then-click”” strategy for the ROS triggered release of methylselenenic acid (MeSeOH) and a fluorescent tracer. This strategy was demonstrated in HeLa cells via fluorescence imaging.

Chemical Science published new progress about [4+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Liguo published the artcileMulticomponent Polymerizations of Alkynes, Sulfonyl Azides, and 2-Hydroxybenzonitrile/2-Aminobenzonitrile toward Multifunctional Iminocoumarin/Quinoline-Containing Poly(N-sulfonylimine)s, Application In Synthesis of 1885-29-6, the main research area is multicomponent polymerization alkyne sulfonylazide hydroxybenzonitrile aminobenzonitrile; multifunctional polysulfonylimine iminocoumarin quinoline sensor antibacterial agent.

Multicomponent polymerizations (MCPs) of diynes, disulfonyl azides, and 2-hydroxybenzonitrile or 2-aminobenzonitrile were reported with the catalysis of CuCl and Et3N, generating iminocoumarin/quinoline-containing poly(N-sulfonylimine)s with high mol. weights (up to 37700 g/mol) and high yields (up tp 96%). MCPs enjoyed a wide monomer scope and high atom economy, releasing N2 as the only byproduct. The fluorescent poly(N-sulfonylimine) was utilized for sensitive and selective detection of Ru3+. The fluorescent poly(N-sulfonylimine) also had antibacterial properties.

ACS Macro Letters published new progress about Aggregation-induced emission. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Riazimontazer, E. published the artcileDesign, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Alzheimer antiAlzheimer tacrine isatin Schiff base acetylcholinesterase butyrylcholinesterase; beta amyloid metal chelation; Acetylcholinesterase; Alzheimer’s disease; Amyloid-beta aggregation; Butyrylcholinesterase; Cholinesterase inhibitors; Isatin Schiff base; Metal chelation; Tacrine.

A series of novel tacrine-isatin Schiff base hybrid derivatives (7a-p) were designed, synthesized and evaluated as multi-target candidates against Alzheimer’s disease (AD). The biol. assays indicated that most of these compounds displayed potent inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) and specific selectivity for AChE over BuChE. It was also found that they act as excellent metal chelators. The compounds 7k(I) and 7m(II) were found to be good inhibitors of AChE-induced amyloid-beta (Aβ) aggregation. Most of the compounds inhibited AChE with the IC50 values, ranging from 0.42 nM to 79.66 nM. Amongst them, I, II and 7p(III), all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, resp. They were 92-, 62- and 41-fold more active than tacrine (IC50 = 38.72 nM) toward AChE. Most of the compounds also showed a potent BuChE inhibition among which 7d(IV) with an IC50 value of 0.11 nM for BuChE is the most potent one (56-fold more potent than that of tacrine (IC50 = 6.21 nM)). In addition, most compounds exhibited the highest metal chelating property. Kinetic and mol. modeling studies revealed that I is a mixed-type inhibitor, capable of binding to catalytic and peripheral site of AChE. Our findings make this hybrid scaffold an excellent candidate to modify current drugs in treating Alzheimer’s disease (AD).

Bioorganic Chemistry published new progress about Amyloid formation inhibitors. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Marchese, Austin D. published the artcileNickel-Catalyzed Enantioselective Carbamoyl Iodination: A Surrogate for Carbamoyl Iodides, COA of Formula: C7H6N2, the main research area is iodooxindole preparation enantioselective; styrene carbamoyl chloride carboiodination nickel catalyst.

This work reports the enantioselective formal transfer of a carbamoyl iodide across 1,1-disubstituted styrenes 2-N(C(O)Cl)R-3-R1-4-R2-5-R3-6-R4-C6C(=CH2)R5 (R = Me, prop-2-en-1-yl, 4-methoxybenzyl; R1 = H, F; R2 = H, F, Cl, OMe, CF3; R3 = H, Cl, OMe, C(O)OCH3; R4 = H, F, OMe; R5 = Me, Ph, cyclopropyl, etc.) using Ni-catalysis. Employing an air-stable Ni(II) precatalyst and a com. available chiral ligand ((S)-tBuPHOX), enantioenriched 3,3-disubstituted iodooxindoles I were obtained in up to 90% yield and up to 97:3 e.r. This methodol. was applied to the total synthesis of (-)-esermethole and (-)-phenserine.

ACS Catalysis published new progress about Carbamoylation (stereoselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Deng, Guobo published the artcileAssembly of Furazan-Fused Quinolines via an Expeditious Metal-Free [2+2+1] Radical Tandem Cyclization Process, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is oxadiazoloquinoline preparation; arylketimine benzonitrile tertbutyl nitrite radical tandem heteroannulation.

A [2+2+1]-NO-segment-incorporating heteroannulative cascade is described. This versatile method, particularly using modular cyanoarylated ketimine substrates 2-CN-3-R-4-R1-5-R2C6HN=C(Me)Ar (Ar = 3-methylphenyl, 4-bromophenyl, thiophen-2-yl, etc.; R = H, Br; R1 = H, Br; R2 = H, Me, F, Cl, Br, MeO, CF3), allows efficient access to structurally diversified quinolines embedded with an oxadiazole core I. This metal-free protocol proceeds smoothly at 30°C, offers easy manipulation of substituents on the quinoline moiety, and tolerates a spectrum of functional groups. D. functional theory calculation revealed that the cyano moiety is crucial to facilitate the early cyclization step in this heteroannulation process and is different from the previously established late cyclization mechanistic interpretation.

Organic Letters published new progress about Density functional theory, B3LYP. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Formenti, Dario published the artcileA State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation, Product Details of C7H6N2, the main research area is cobalt doped carbon metal oxide catalyst preparation surface area; nitrile cobalt doped carbon metal oxide catalyst hydrogenation; amines; cobalt; heterogeneous catalysis; hydrogenation; magnesium oxide.

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700°C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70°C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested com. catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations.

Chemistry – A European Journal published new progress about Adiabatic ionization potential. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aboushady, Dina published the artcileNovel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Optimization of the 2,4-substituents, Product Details of C7H6N2, the main research area is disubstituted quinazoline preparation antibacterial agent improved cytotoxicity profile; Antibacterial; Antimycobacterial; Bacterial resistance; Cytotoxicity; Quinazoline.

The emergence of bacterial resistance has triggered a multitude of efforts to develop new antibacterial agents. There are many compounds in literature that were reported as potent antibacterial agents, however, they lacked the required safety to mammalian cells or no clear picture about their toxicity profile was presented. Inspired by discovered hit from our inhouse library and by previously reported 2,4-diaminosubstituted quinazolines, we describe the design and synthesis of novel 2,4-disubstituted-thioquinazolines (3-13 and 36), 2-thio-4-amino substituted quinazolines (14-33) and 6-substituted 2,4-diamonsubstituted quinazolines (37-39). The synthesized compounds showed potent antibacterial activity against a panel of Gram-pos., efflux deficient E.coli and Mycobacterium smegmatis. The panel also involved resistant strains including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, vancomycin-resistant Enterococcus faecalis and vancomycin-resistant Enterococcus faecium, in addition to Mycobacterium smegmatis. The newly synthesized compounds revealed MIC values against the tested strains ranging from 1 to 64 μg/mL with a good safety profile. Most of the 2-thio-4-amino substituted-quinazolines showed significant antimycobacterial activity with the variations at position 2 and 4 offering addnl. antibacterial activity against the different strains. Compared to previously reported 2,4-diaminosubstituted quinazolines, the bioisosteric replacement of the 2-amino with sulfur offered a successful approach to keep the high antibacterial potency while substantially improving safety profile as indicated by the reduced activity on different cell lines and a lack of hemolytic activity.

Bioorganic Chemistry published new progress about Antibacterial agent resistance. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ochiai, Kotaro published the artcileStructure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists, Application In Synthesis of 1885-29-6, the main research area is phenylferrocene derivative androgen receptor antagonist structure activity relationship; Androgen receptor; Antagonist; Ferrocene; Hydrophobic pharmacophore.

Ferrocene is a representative organometallic compound having a sandwich structure with high stability and hydrophobicity. In this study, we determined the physicochem. properties of a series of nitro- and cyanophenylferrocenes, and evaluated their biol. activity as androgen receptor (AR) antagonists. Ferrocene derivatives exhibited hydrophobicity parameter π values in the range between 2.54 and 3.23, depending on the substituents, indicating that the hydrophobicity of ferrocene is suitable for its application as a hydrophobic core structure of nuclear receptor ligands. The synthesized ferrocene derivatives showed AR-antagonistic activity, and among them, 3-nitrophenylferrocene 14 exhibited the most potent activity with an IC50 value of 0.28 μM. The developed compounds may be candidates for further structural development as AR antagonists. These findings also support the utility of organometallic species as structural options for drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about Androgen receptor antagonists. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts