Category: 1885-29-6

Jiang, Ben-Jie published the artcileSynthesis of Quinolines and 2-Functionalized Quinolines by Difluorocarbene Incorporation, Product Details of C7H6N2, the main research area is functionalized quinoline chemoselective preparation; quinoline preparation.

A general method was developed to allow de novo construction of quinolines I [R = Me, cyclopropyl, Ph, etc.] and C2-functionalized quinolines II [R1 = Me, cyclopentyl, Ph; R2 = Ph, Bn, 1-naphthyl, etc.; R3 = H, Me] from ortho-alkenyl anilines in the presence of a difluorocarbene precursor. This method exploited a crucial reactivity of in-situ generation of isocyanides from condensation of primary aniline with difluorocarbene. Subsequent α-addition of isocyanide by neighboring alkenyl group constructs the quinoline ring. Furthermore, when a combination of difluorocarbene precursor and Se are present, selenoisocyanate intermediates were tentatively generated that upon nucleophilic addition by ortho-alkenyl produce 2-SeH quinolines. In the presence of a second nucleophile such as anilines, competing nucleophilic addition of anilines to the selenoisocyanate was preferred, generating selenourea intermediate. Further nucleophilic addition of the ortho-alkenyl to selenourea followed by elimination of H2Se produces 2-aminoquinolines. This allows one-step multi-component modular preparation of various C2-functionalized quinolines from readily available starting compounds This method showed good yields, scope and chemoselectivity. It was operationally convenient and friendly without manipulating unpleasant isocyanides. The difluorocarbene-enabled primary amine to isocyanide conversion may be exploited to develop other interesting reactions.

Advanced Synthesis & Catalysis published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Xian-Dong published the artcileProtic ionic liquid-catalyzed synthesis of oxazolidinones using cyclic carbonates as both CO2 surrogate and sustainable solvent, Related Products of nitriles-buliding-blocks, the main research area is oxazolidinone preparation; aniline cyclic carbonate carboxylative cyclization.

The synthesis of oxazolidinones I [R1 = H, 3-Me, 4-Cl, etc.; R2 = H, Me] via the carboxylative cyclization of anilines with cyclic carbonate using protic ionic liquid 1,8-diazabicyclo[5.4.0]-7-undecenium imidazolide [HDBU][Im] as the bifunctional catalyst under mild conditions without addition of conventional organic solvents was reported. The distinguished features of this protocol included low catalyst loading, wide functionality tolerance and convenient recycling of the catalyst. A series of functional groups such as -Cl, -Br, -CH3, -OCH3 and -NO2 can be well tolerated under the reaction conditions, provided the corresponding products in moderate to good yields (61-92%). In addition, to shed light on the cooperative interactions of [HDBU][Im]/EC and [HDBU][Im]/aniline, NMR technique and DFT study were also performed, resp.

Catalysis Today published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Simmi published the artcileTin(II) triflate Catalysed Synthesis of 3-Methyleneisoindolin-1-ones, SDS of cas: 1885-29-6, the main research area is isoindolinone methylene preparation; acetyl carboxylic acid amine heterocyclization tin triflate catalyst.

A simple and straightforward tin(II) triflate catalyzed facile protocol for the synthesis of 3-methyleneisoindolin-1-ones I (R = 4-BrC6H4, CH2CH(CH3)2, CH2C6H5, etc.; X = C=CH2, CHCH3) and applied to broad range of substrates, which simultaneously offers the functional group tolerance of the reaction and the stability of these scaffolds to the reaction conditions has been described. In addition, in situ reduction of the exocyclic double bond in 3-methyleneisoindolin-1-ones I using PMHS is also reported.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khosravi, Kaveh published the artcileUrea-2,2-dihydroperoxypropane as a Novel and High Oxygen Content Alternative to Dihydroperoxypropane in Several Oxidation Reactions, Synthetic Route of 1885-29-6, the main research area is urea dihydroperoxypropane oxidation; unsaturated ketone alkene epoxidation sulfide oxidation Baeyer Villiger oxidation; aniline phenol bromination oxidative esterification aromatic aldehyde oxidative amidation; aromatic compound thiocyanation pyridine oxidation allylic benzylic alc oxidation.

Urea-2,2-dihydroperoxypropane (UDHPP)- a white crystalline solid oxidant which is formed when urea is recrystallized from dihydroperoxypropane was applied as the terminal oxidant in several oxidative procedures namely epoxidation of α, β-unsaturated ketones and alkenes, oxidation of sulfides to sulfoxides and sulfones, Baeyer-Villiger reaction, bromination and iodation of aniline and phenol derivatives, oxidative esterification, oxidative amidation of aromatic aldehydes, thiocyanation of aromatic compounds, and oxidation of pyridines, oxidation of secondary, allylic and benzylic alcs. All the approaches were carried out under mild conditions and short reaction times and afforded the corresponding products in high yields.

ChemistrySelect published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling published the artcileCopper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Phatake, Vishal V. published the artcile[TBDH][HFIP] ionic liquid catalyzed synthesis of quinazoline-2,4(1H,3H)-diones in the presence of ambient temperature and pressure, Computed Properties of 1885-29-6, the main research area is quinazolinedione preparation green chem bifunctional protic ionic liquid catalyst; aminobenzonitrile carbon dioxide cyclization.

The utilization of carbon dioxide under mild reaction conditions is an important aspect of the sustainable chem. point of view. Herein, authors prepared three bifunctional protic ionic liquids having 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a cation and an alc. anions were prepared by simple neutralization of the super base TBD with proton donor alcs. such as hexafluoroisopropanol (HFIP), TFE (2,2,2-Trifluoroethanol) and TFA (2,2,2-Trifluoroacetic acid). These PILs were used as catalysts for chem. fixation of carbon dioxide into quinazoline-2,4(1H,3H)-diones. [TBDH+][HFIP-] protic ionic liquid (PIL) shows very good result compare to other PILs. As a bifunctional ionic liquid, it simultaneously activates 2-aminobenzonitrile as well as CO2 and shows excellent performance for the conversion of 2-aminobenzonitrile to quinazoline-2,4(1H,3H)-diones in presence of CO2 balloon pressure at 35°C temperature Moreover, the [TBDH+][HFIP-] PIL can be recycled up to six recycle run.

Journal of Molecular Liquids published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Penaranda Gomez, Angelica published the artcileI2/DMSO-Promoted Synthesis of Chromeno[4,3- b]quinolines through an Imine Formation/Aza-Diels-Alder/Aromatization Tandem Reaction under Metal-Catalyst- and Photosensitizer-Free Conditions, SDS of cas: 1885-29-6, the main research area is cinnamyl salicylaldehyde aryl amine iodine catalyst tandem reaction; chromenoquinoline preparation green chem.

A tandem approach was developed for the efficient synthesis of substituted chromeno[4,3- b]quinolines from arylamines and O-cinnamyl salicylaldehydes under metal-catalyst- and photosensitizer-free reaction conditions. This method was based on an inexpensive I2/DMSO system in which mol. iodine first acted as a Lewis acid to promote the formation of the corresponding imine bearing the alkene moiety; then, this species fulfilled a second role by catalyzing an intramol. aza-Diels-Alder cycloaddition to generate the resp. tetrahydrochromenoquinoline as an intermediate. Finally, the dual behavior of DMSO as an oxidant and as a solvent proved crucial at this stage, allowing the regeneration of I2 and promoting the aromatization of the tetrahydrochromenoquinoline intermediates to yield the desired 7-aryl-6 H-chromeno[4,3- b]quinolines. This protocol was mild and easy to perform, features high step-economy (tandem process) and provides a new access to biol. important nitrogen- and oxygen-containing heterocyclic mols.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wilders, Alison M. published the artcilePd-Catalyzed Cross-Coupling of Hindered, Electron-Deficient Anilines with Bulky (Hetero)aryl Halides Using Biaryl Phosphorinane Ligands, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Buchwald Hartwig amination aryl halide palladium phosphine phosphorinane catalyst; phosphorinane oxo preparation phospha Michael addition cyclization dienone; primary phosphine phospha Michael reaction preparation oxophosphorinane amination catalyst; high throughput evaluation Buchwald Hartwig amination aryl halide aniline.

Biaryl phosphorinane ligands derived from addition of biaryl primary phosphines to trans,trans-dibenzylideneacetone (AlisonPhos and AliPhos) form highly active ligands for Pd-catalyzed coupling of hindered, electron-deficient anilines with hindered (hetero)aryl halides, a challenging class of C-N cross-coupling reaction with few precedents. Broad substrate scope and functional group tolerance were observed under the reaction conditions. Computational studies suggest that ligands containing Ph substituents provide greater activity through more favorable aniline binding in the catalytic cycle in comparison to alkyl-substituted phosphorinanes. A general and high-yielding procedure for the synthesis of biaryl phosphorinanes by phospha-Michael addition of primary biarylphosphines to 1,4-dien-3-ones in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), under relatively mild conditions (23-110°C), is also described. HFIP as the solvent significantly accelerates the phospha-Michael addition, allowing the preparation of previously inaccessible ligands and higher yields overall.

ACS Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saritha, Rajendhiran published the artcileCarbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds, HPLC of Formula: 1885-29-6, the main research area is phenyldiazonium tetrafluoroborate arene tetrahydrocarbazole catalyst Gomberg Bachmann arylation; biaryl preparation.

A highly regioselective, carbazole based Electron Donor Acceptor (EDA) catalyzed synthesis of biaryl and aryl-heteroaryl compounds was described. Various indole and carbazole derivatives were screened for the Homolytic Aromatic Substitution (HAS) reaction. Tetrahydrocarbazole (THC) was very efficient for the HAS transformation and proceeded via a complex formation between diazonium salt and electron rich tetrahydrocarbazole. The UV-Vis spectroscopy technique was used to confirm the complex formation. The in-situ generated EDA complex even in a catalytic amount was found to be efficient for the Single Electron Transfer (SET) process without any photoactivation. Biaryl compounds, 2-phenylfuran, 2-phenylthiophene and 2-phenylpyrrole and bioactive compounds such as dantrolene and canagliflozin were synthesized in moderate to excellent yields.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamaguchi, Eiji published the artcileSingle-Electron-Transfer-Initiated Sequential Direct Arylation Reaction of Pyrrole with Aryl Diazonium Salts, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is pyrrole diazonium salt arylation single eletron transfer cobaltocene catalyst.

Direct and sequential arylations of pyrrole with a diazonium salt were initiated by single electron transfer from cobaltocene. The direct arylation reaction of pyrrole was completed within 30 min even at room temperature and the corresponding arylated product was obtained in good yield. The second arylation reaction of monoarylated heteroarenes also proceeded successfully and moderate to good yields of diarylated pyrroles were obtained. A gram-scale reaction also proceeded without decreasing the yield of the product.

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts