Category: 1885-29-6

Saritha, Rajendhiran published the artcileMetal-free, regioselective, visible light activation of 4CzIPN for the arylation of 2H-indazole derivatives, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is arylated indazole regioselective preparation; indazole aniline arylation tetrakiscarbazolyl dicyanobenzene photocatalyst.

Highly regioselective organo photocatalysis of 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) for the arylation of 2H-indazole was demonstrated to obtain arylated indazole derivatives I [R1 = H, Cl, Br, CN; R2 = H, Cl; R3 = H, F, MeO, etc.; R4 = Ph, 4-FC6h4, Bn, etc.; R5 = H, MeO]. The present synthetic route provided a highly safe and easily accessible aniline precursor as an arylation reagent. The photoactivated 4CzIPN organocatalyst was found to be more efficient for single electron transfer without any organic base for the radical reaction. The carbazole-based photocatalyst (4CzIPN) with wide redox potential was stable and recyclable for further reaction transformations. Many indazole and aniline derivatives were used in the reaction and provided the arylated indazole derivatives in good to excellent yield.

RSC Advances published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sajadi, Mahdieh Sadat published the artcilePalladium-catalyzed synthesis of novel trifluoromethylated quinazolinone, N-arylquinazoline and N-benzylquinazoline derivatives, Product Details of C7H6N2, the main research area is trifluoromethylated quinazolinone arylquinazoline benzylquinazoline preparation; aminobenzamide arylbenzimidamide trifluoroacetimidoyl chloride condensation cyclization palladium catalyst.

A simple and palladium-catalyzed procedure for synthesis of a novel series of potentially biol. active trifluoromethyl-substituted quinazolinones and N-arylquinazoline derivatives via condensation-cyclization reaction of 2-aminobenzamide, 2-amino-N’-arylbenzimidamides and 2-amino-N’-benzylbenzimidamides with trifluoroacetimidoyl chlorides has been developed. Noteworthy, this investigation showed the possible of transition-metal-catalyzed activation of trifluoroacetimidoyl chlorides as a carbon trifluoromethylated source for the synthesis of quinazolines and quinazolinone derivatives in good to excellent yields.

Tetrahedron Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Lei published the artcileLn(III)/Chiral Bronsted Acid Catalyzed Asymmetric Cascade Ring Opening/Aza-Piancatelli Rearrangement of D-A Cyclopropanes, Formula: C7H6N2, the main research area is aminocyclopentenone enantioselective synthesis synergistic tandem ring opening Piancatelli rearrangement; synergistic catalyzed cascade ring opening Piancatelli rearrangement cyclopropane aniline.

The first Lewis acid and chiral Bronsted acid cooperatively catalyzed asym. cascade ring opening/aza-Piancatelli rearrangement reaction of furyl-substituted donor-acceptor cyclopropanes is achieved, enabling the construction of functionalized aminocyclopentenones bearing α-quaternary carbon stereocenters in high yields with excellent enantio- and diastereoselectivities under remarkably low catalyst loading of 0.2-1.2 mol %.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rodriguez-Villar, Karen published the artcileSynthesis, antiprotozoal activity, and cheminformatic analysis of 2-Phenyl-2H-indazole derivatives, COA of Formula: C7H6N2, the main research area is phenylindazole preparation cheminformatic antiprotozoal activity SAR; Entamoeba histolytica; Giardia intestinalis; Trichomonas vaginalis; indazole; structure-activity relationships.

Herein, a series of indazole derivatives I [R = H, Cl, OMe, CF3, etc.; R1 = H, Cl, OMe, C(O)OCH3, etc.; R2 = H, C(O)OH, F, OH, etc.] was synthesized and studied as antiprotozoals. The 2-phenyl-2H-indazole scaffolds I were accessed by a one-pot procedure, which includes a combination of ultrasound synthesis under neat conditions as well as Cadogan’s cyclization. Moreover, some compounds were derivatized to have an appropriate set to provide structure-activity relationships (SAR) information. Whereas the antiprotozoal activity of six of these compounds against E. histolytica, G. intestinalis, and T. vaginalis had been previously reported, and the activity of the addnl. 16 compounds I was evaluated against these same protozoa. The biol. assays revealed structural features that favor the antiprotozoal activity against the three protozoans tested, e.g., electron withdrawing groups at the 2-Ph ring. It is important to mention that the indazole derivatives I possess strong antiprotozoal activity and are also characterized by a continuous SAR.

Molecules published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tran, Van Hieu published the artcilePhosphoryl chloride-mediated solvent-free synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers, Category: nitriles-buliding-blocks, the main research area is azacycloalkane preparation green chem; arylamine cyclic ether cyclization reaction.

A solvent- and metal-free protocol for preparation of N-aryl substituted azacycles I (R1 = Ph, 2,4-difluorophenyl, 3-methylphenyl, etc.; R2 = H, Me; n = 1, 2; R3R4 = H, CH2=CH-CH=CH2) from arylamines R1NH2 and cyclic ethers such as THF, 2-methyloxolane, oxane, etc. is described. In this method, the combination of POCl3 and DBU is crucial for conversion of arylamines and cyclic ethers to five- and six-membered azacycles I. Without solvent, a variety of N-aryl-substituted, five-membered azacycles (pyrrolidines, 2-methylpyrrolidines, and piperidine) and six-membered azacycles (isoindolines and tetrahydroisoquinolines) I is synthesized in high yields. This green method provides a sustainable and efficient approach for the preparation of azacycles I from various cyclic ethers.

Tetrahedron Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

He, Yiting published the artcileRegioselective Access to 2-Iminoimidazolidines via AgF-Mediated Cascade Reactions, Computed Properties of 1885-29-6, the main research area is imino imidazolidine preparation regioselective density functional theory; amine propargyl methylthiourea tandem guanylation cyclization silver fluoride catalyst.

A convergent access to substituted 2-iminoimidazolidines I (R = 2-cyanophenyl, 4-acetylphenyl, 4-methylcoumarin-7-yl, etc.) from aromatic amines RNH2 and N-propargyl S-methylthiourea is developed via Ag(I)-mediated cascade guanylation-cyclization reactions. This method features high regioselectivity, excellent efficiency, and mild reaction conditions. Subsequent deprotection of the Boc (tert-butyloxycarbonyl) group under acidic conditions provides expedient access to aryl 2-aminoimidazole derivatives II in a convenient manner.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zalesak, Frantisek published the artcileGeneral synthesis of 1-aryl-6-azaisocytosines and their utilization for the preparation of related condensed 1,2,4-triazines, Product Details of C7H6N2, the main research area is phenylhydrazono cyanoacetylcyanamide preparation heterocyclization; imino phenyl cyanotriazine preparation cyclocondensation; imidazotriazine preparation; triazinoquinazoline preparation; 1,2,4-triazine; 1-aryl-6-azaisocytosine; condensed 1,2,4-triazine; cyclization of arylhydrazones; fused azaisocytosines.

A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles was described. This method was based on coupling diazonium salts with cyanoacetylcyanamide and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides. The 6-azaisocytosines were studied with respect to tautomeric equilibrium and the transformation of functional groups and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-c]-[1,2,4]triazine and the 1,2,4-triazino[2,3-a]quinazolines.

Molecules published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lian, Chang published the artcileVisible-Light-Driven Synthesis of Arylstannanes from Arylazo Sulfones, Related Products of nitriles-buliding-blocks, the main research area is arylazo sulfone preparation photochem stannylation alkyldistannane; arylstannane preparation; aniline derivative diazotization.

The visible-light-driven preparation of (hetero)aryl stannanes was carried out under both photocatalyst- and metal-free conditions via irradiation of arylazo sulfones in the presence of hexaalkyldistannanes. The reaction shows a high efficiency and a wide substrates scope. The resulting crude organotin derivatives can be directly employed in a Stille protocol.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yadav, Jitendra Kumar published the artcileEfficient N-formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst, Formula: C7H6N2, the main research area is aryl formamide preparation green chem; primary aryl amine formic acid formylation solid magnetic nanocatalyst.

Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SO3H) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for N-formylation of primary amines 2-R-3-R1-4-R3-5-R4C6HNH2 (R = H, Cl, F, CN; R1 = H, Me, OH; R3 = H, OMe, Cl, OPh, OH, F; R4 = H, Me) under mild reaction conditions. Exploiting the magnetic nature of Fe3O4, the prepared catalyst was readily recovered from the reaction mixture via an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity. The cost effectiveness, simple methodol., wide substrate tolerance, excellent yield and easy work-up are the addnl. advantages of present catalytic system.

RSC Advances published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rozhkova, Yuliya S. published the artcileSynthesis of Aminoalkyl-Functionalized 4-Arylquinolines from 2-(3,4-Dihydroisoquinolin-1-yl)anilines via the Friedlander Reaction, SDS of cas: 1885-29-6, the main research area is arylquinoline preparation; dihydroisoquinolinyl aniline alpha methylene ketone Friedlander reaction.

A new approach for the efficient and convenient synthesis of novel aminoalkyl-functionalized 4-arylquinolines via the Friedlander reaction of differently substituted 2-(3,4-dihydroisoquinolin-1-yl)anilines with various α-methylene ketones in acetic acid was developed. The reaction allows easy access to a diversity of 4-arylquinoline derivatives in moderate to excellent yields under mild conditions.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts