Category: 1885-29-6

Mohsenzadeh, Farshid published the artcileNaturally occurring organic acids for organocatalytic synthesis of pyrroles via Paal-Knorr reaction, COA of Formula: C7H6N2, the main research area is pyrrole Paal Knorr synthesis aniline hexanedione oxalic acid catalysis.

In this study, common naturally occurring organic acids, namely oxalic, malonic, succinic, tartaric and citric acid (as safe, inexpensive, and biodegradable organocatalysts), have been employed for Paal-Knorr pyrrole synthesis. The organocatalyzed reaction proved to be effective in ethanol at 60°C. However, the reaction rate is mainly dominated by the nature and position of functional groups on the aromatic ring of substrate. This metal-free procedure tolerates a series of functional groups and should be considered as an asset to the pharmaceutical industry since no metal contamination could take place during the synthesis of pyrrole scaffolds.

Research on Chemical Intermediates published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yuan published the artcileSynthesis of 3-Amino-7-(N,N-Dimethylamino)-2-Substituted-5-Phenylphenazin-5-Ium Chlorides by Oxidative Cyclization, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dimethylamino phenazinium chloride preparation green chem; toluidine aminodimethyamine aniline oxidative cyclization potassium permanganate; Nitroaniline; aniline; derivatives; oxidative cyclizatio; phenzine; potassium permanganate; synthesis.

Herein, the use of potassium permanganate as an oxidant to synthesize 3-amino-7-(N, N-dimethylamino)-2-substituted-5-phenylphenazin-5-ium chlorides I (X = Me, Et, Br, etc.) via sequential aniline arylation is reported. The synthesized products were obtained via reaction of various o-substituted toluidines with 4-amino-N,N-dimethyamine and aniline using potassium permanganate as an oxidant under different conditions such as temperature, pH, reaction time and the ratio of raw materials. IR (IR) absorption data were acquired on a Thermo Nicolet Nexus 670 FT-IR spectrometer with DTGS KBr detector. The total C, H, N, content was measured by the elemental analyzer. The yields of the products ranging from 42.5% to 75.8% was obtained based on the electrophilic ability of different substituted groups under the temperature of 95°, pH 4.5 and the reaction time of 8hrs. This route is a simple, economic, efficient and environmentally friendly.

Current Organic Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fatahpour, Maryam published the artcileMetal-free greener method for the synthesis of densely functionalized pyrroles via a one-pot three-component reaction, Synthetic Route of 1885-29-6, the main research area is pyrrole green preparation; acetoacetanilide benzoin ammonium acetate three component; benzoin acetoacetanilide aniline three component.

A convenient and straightforward acid-promoted synthesis of a new series of polyfunctionalized pyrroles I [R = H, 4-BrC6H4, 3-O2NC6H4, etc.] was developed based on a one-pot three-component reaction of acetoacetanilide, benzoin, and ammonium acetate/diverse anilines in acetic acid as a green solvent at 100 °C. The other salient benefits of this transformation included being simple reaction conditions, toxic transition-metal-free, no need of column chromatog. purification, moderate to good yields, eco-friendliness and readily available starting materials.

Journal of the Iranian Chemical Society published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ni, Pufan published the artcileSynthesis of Phenols from Aryl Ammonium Salts under Mild Conditions, HPLC of Formula: 1885-29-6, the main research area is aryl quaternary ammonium salt hydroxylation hydroxide; phenol preparation; pyridinyl quaternary ammonium salt hydroxylation hydroxide; hydroxypyridine preparation.

A general method for the synthesis of phenols from electron-deficient aryl ammonium salts or heteroaryl ammonium salts under mild conditions was developed. Benzaldehyde oxime, acetohydroxamic acid, and hydroxylamine hydrochloride were investigated as hydroxide surrogates, resp. With these hydroxide surrogates, a series of phenols were prepared in yields of 20-98%.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bovonsombat, Pakorn published the artcileA novel DMSO-assisted regioselective iodination of aniline analogues, Product Details of C7H6N2, the main research area is aniline iodine DMSO regioselective iodination; iodobenzamine preparation.

A metal- and oxidant-free electrophilic iodination of aniline analogs was achieved in high to excellent yields at room temperature in MTBE with 0 or 3.5 equiv of DMSO. Examined substituents include N-alkyl, N,N-dialkyl, N-morpholinyl and N-piperazinyl as well as Me, Br, CN and CO2CH3 aryl ring substitutions.

Tetrahedron Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bains, Amreen K. published the artcileBorrowing Hydrogen-Mediated N-Alkylation Reactions by a Well-Defined Homogeneous Nickel Catalyst, HPLC of Formula: 1885-29-6, the main research area is borrowing hydrogen mediated nitrogen alkylation aniline alc; well defined homogeneous nickel catalyzed alkylation redox active ligand.

We report herein a well-defined and bench-stable azo-phenolate ligand-coordinated nickel catalyst which can efficiently execute N-alkylation of a variety of anilines by alc. We demonstrate that the redox-active azo ligand can store hydrogen generated during alc. oxidation and redelivers the same to an in-situ-generated imine bond to result in N-alkylation of amines. The reaction has wide scope, and a large array of alcs. can directly couple to a variety of anilines. Mechanistic studies including deuterium labeling to the substrate establishes the borrowing hydrogen method from alcs. and pinpoints the crucial role of the redox-active azo moiety present on the ligand backbone. Isolation of the ketyl intermediate in its trapped form with a radical quencher and higher kH/kD for the alc. oxidation step suggest altogether a hydrogen-atom transfer (HAT) to the reduced azo backbone to pave alc. oxidation as opposed to the conventional metal-ligand bifunctional mechanism. This example clearly demonstrates that an inexpensive base metal catalyst can accomplish an important coupling reaction with the help of a redox-active ligand backbone.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Senadi, Gopal Chandru published the artcileSustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone green preparation; alc amino benzamide cascade oxidative cleavage; ether amino benzamide cascade oxidative cleavage; benzimidazole green preparation; amino benzylamine methoxyethanol cascade oxidative cleavage.

Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

Green Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lv, Cong published the artcileFrom amides to urea derivatives or carbamates with chemospecific C-C bond cleavage at room temperature, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is diaryl acetamide copper catalyst chemoselective bond cleavage; aryl aldehyde preparation; amine pyridinyl diphenylacetamide copper catalyst chemoselective bond cleavage; pyridinyl urea preparation; alc methylpyridinyl diphenylacetamide copper catalyst chemoselective bond cleavage; methylpyridinyl carbamate preparation.

Herein, a significant advancement in this area and present a general method for copper-catalyzed chemospecific C-C bond cleavage of amides to synthesize urea derivatives and carbamates at room temperature was reported. A catalytic process via a resonant six-membered N,O-chelated copper cycle and superoxide radical was proposed according to mechanistic and control experiments The combination of chelation assistance and radical oxygenation strategies opened a door for C-C bond cleavage of common substrates which possess multiple reactive sites and was envision that this broadly applicable method will be of great interest in organic synthesis, the pharmaceutical industry and the agrochem. industry.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiong, Yucong published the artcileBimetallic CoMoO4@C nanorod catalyzes one-pot synthesis of benzimidazoles from benzyl alcohol and o-phenylendiamine without alkali, Synthetic Route of 1885-29-6, the main research area is benzimidazole preparation green chem; alc aromatic diamine coupling carbon supported cobalt molybdenum oxide.

Benzimidazoles possess a series of applications for industrial chem. and biomedicine. However, the complicated synthetic steps and harsh reaction conditions limit its further development. Herein, authors reported an efficient, environmentally friendly, and stable bimetallic CoMoO4@C catalyst, which used low-cost cobalt and molybdenum as the basic raw material. In base-free conditions, it has been proved that the yield could achieve to 99.9% for the synthesis of benzimidazoles with liberating water as the sole byproduct, and the catalyst remains stable and efficient even after five successive cycle tests. Addnl., experiments and characterizations confirm the good oxidation activity of the catalyst benefits from the numerous oxygen vacancies provided by the high concentration of low-valent cobalt (Co2+) and the doping of carbon improves the intermol. transport of electrons. Furthermore, this strategy could potentially be applied in the industrial production of benzimidazoles.

Applied Organometallic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ruan, Banfeng published the artcileSynthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is pyrrolidine oxadiazole preparation anthelmintic structure activity relationship; Anthelmintic; Drug discovery; Haemonchus contortus; Pyrrolidine-oxadiazoles; Structure-activity relationship.

Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to the diseases that they cause. The control of nematodes in livestock animals relies heavily on the use of anthelmintic drugs. However, their extensive use has led to a widespread problem of drug resistance in these worms. Thus, the discovery and development of novel chem. entities for the treatment of parasitic worms of humans and animals is needed. Herein, authors describe the medicinal chem. optimization efforts of a phenotypic hit against Haemonchus contortus based on a pyrrolidine-oxadiazole scaffold I (R = H, 4-Cl, 3-OMe, etc.; R1 = 2-Me, 3-OH, 4-CN, etc.). This led to the identification of compounds with potent inhibitory activities (IC50 = 0.78-22.4μM) on the motility and development of parasitic stages of H. contortus, and which were found to be highly selective in a mammalian cell counter-screen. These compounds could be used as suitable chem. tools for drug target identification or as lead compounds for further optimization.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts