Category: 1885-29-6

Yilmaz, Ozgur published the artcileSynthesis of New Substituted Diamides. Investigation of Their Antioxidant and Antibacterial Properties, SDS of cas: 1885-29-6, the main research area is aryl diamide preparation antioxidant antibacterial.

Reaction between acyl chloride and substituted aromatic amines for the synthesis of new diamide compounds I [R = Ph, 2-FC6H4, 4-BrC6H4, etc.] was investigated. Compounds I were evaluated for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferrous ions (Fe2+) chelating activities in terms of antioxidant properties. The IC50 value was calculated for the compounds which showed activation in preliminary study and pos. controlled BHT, BHA and trolox. Compounds I were evaluated for antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Enterococcus fecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Enterobacter aerogenes ATCC 13048 and it was determined that compounds I [R = Ph, 2-F3CC6H4] showed activity close to pos. control against S. aureus and E. aerogenes bacteria, resp.

Russian Journal of Bioorganic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sunil Kumar, A. published the artcileSynthesis, characterization, crystal structures and biological screening of 4-amino quinazoline sulfonamide derivatives, Quality Control of 1885-29-6, the main research area is quinazolinylamino sulfonamide preparation crystal structure antibacterial antifungal antitumor human; phenyl benzenesulfonamide dimethyl formamidine condensation.

Three quinazolin-4-ylamino derivatives containing phenylbenzenesulfonamides I [R = Me, F, Cl] were synthesized by reacting (E)-N’-(2-cyanophenyl)-N,N-dimethyl formamidine with 4-amino-N-(phenyl)benzenesulfonamides and structural properties were further examined by single crystal X-ray diffraction method. The X-ray data showed that compounds I [R = Me, Cl] contain two mols. and compound I [R = F] contain one mol. in asym. unit. Comparison of conformation of two distinct mols., in the asym. unit of compounds I [R = Me, Cl] were studied with aid of reported literature. All the synthesized compounds I were tested for their in vitro antiproliferative activity against two breast cancer cell lines (MDA-MB-231 and MCF7), antibacterial and antifungal activities against tested strains. Among the tested compounds, compound I [R = F] observed as highest potent candidate against MDA-MB-231with IC50 of 5.44 μg/mL and compound I [R = Cl] was observed as most potent candidate against Gram-neg. bacterial strains.

Journal of Molecular Structure published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Yi published the artcile2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents, Application In Synthesis of 1885-29-6, the main research area is phenyl triazolyl methylazabicyclooctanone preparation antitumor agent SAR mol docking; Aconitine; Antiproliferative activity; Hsp90 inhibitors; Structural simplification.

In this study, we designed and synthesized a series of I [R = H, 2-OH, 3-OH, 4-OH,..etc]. as potent Hsp90 inhibitors by simplifying and modifying the aconitine scaffold. Among these compounds, I [R = 3-Br] exhibited an excellent antiproliferative activity against LoVo cells with an IC50 value of 0.02μM and a significant Hsp90α inhibitory activity with an IC50 value of 0.71 nM. Mol. docking studies provided a rational binding model of I [R = 3-Br] in complex with Hsp90α. The following cell cycle and apoptosis assays revealed that compound I [R = 3-Br] could arrest cell cycle at G1/S phase and induce cell apoptosis via up-regulation of bax and cleaved-caspase 3 protein expressions while inhibiting the expressions of bcl-2. Moreover, I [R = 3-Br] could inhibit cell migration in LoVo and SW620 cell lines. Consistent with in vitro results, I [R = 3-Br] significantly repressed tumor growth in the SW620 xenograft mouse model.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ji, Dezhong published the artcileDesign, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors, SDS of cas: 1885-29-6, the main research area is aryl amino benzoyl piperidinyl benzamide preparation antitumor smoothened inhibitor; Anthranilamide; Hedgehog signaling pathway; Molecular dynamics; Ring-opening; Smoothened inhibitor.

A series of anthranilamide derivativesI (R = Ph, 1-methyl-1H-pyrazol-5-yl, 4-phenylpyridine, etc.; R1 = 4-F, 2-CF3-4-F, 4-NO2, etc.; X = N, CH) and II was designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound I (R = Ph; R1 = 2-CF3-4-F; R2 = CH) displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50 = 0.48μM) than LY2940680 (IC50 = 0.79μM).

Bioorganic & Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Zhi-hao published the artcileSynthesis, In Vitro Antiplatelet Activity of 4-Ethoxy-isophthalamides, HPLC of Formula: 1885-29-6, the main research area is ethoxyisophthalamide preparation antiplatelet activity.

The structural design, preparation, spectral confirmation of thirteen new 4-ethoxyisophthalamide compounds I (R = 2-OEt, 3-Br, 4-I, etc.; n = 0, 1) were described and completes their preliminary screening of in vitro antiplatelet activity in response to the following inducers: ADP (ADP) and collagen. Among them, when ADP was used as an inducer, compounds having activities higher or close to picotamide and IC50 values revealed that one compound I (R = m-CF3, n = 0) (IC50 : 0.26μmol L-1) was more than three times more active than pos. control drug picotamide. Meanwhile, cytotoxic effects in vitro of compound I (R = 4-I, n = 0) and compound I (R = m-CF3, n = 0) on L929 cells were analyzed. The structure-activity relationship showed that when electron-withdrawing groups nitro or trifluoromethyl are introduced at the meta- or para- position of the two side chain benzene rings, it is beneficial on the whole to the improvement of antiplatelet activity.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Di Terlizzi, Lorenzo published the artcileVisible Light-Driven, Gold(I)-Catalyzed Preparation of Symmetrical (Hetero)biaryls by Homocoupling of Arylazo Sulfones, Formula: C7H6N2, the main research area is arylazo sulfone gold catalyst photochem homocoupling; biaryl preparation.

The preparation of sym. (hetero)biaryls via arylazo sulfones was successfully carried out upon visible light irradiation in the presence of PPh3AuCl as the catalyst. The present protocol led to the efficient synthesis of a wide range of target compounds in an organic-aqueous solvent under photocatalyst-free conditions.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Khan, Danish published the artcileDesign, Synthesis and Characterization of Aurone Based α,β-unsaturated Carbonyl-Amino Ligands and their Application in Microwave Assisted Suzuki, Heck and Buchwald Reactions, Product Details of C7H6N2, the main research area is diaryl aminomethylenebenzofuranone preparation; arylboronic acid aryl bromide palladium catalyst Suzuki Miyaura coupling; biaryl preparation; bromobenzene alkene palladium catalyst microwave assisted Mizoroki Heck reaction; phenyl alkene preparation; bromobenzoic acid aniline palladium catalyst microwave Buchwald Hartwig reaction; phenylamino benzoic acid preparation.

A new series of phosphine-free aurone-based α,β-unsaturated carbonyl-amino bidentate ligands I [R1 = 2-furanyl, Ph, 3-4-dimethoxyphenyl, etc.; R2 = Ph, 3-nitrophenyl, 1-naphthyl, etc.] were synthesized and characterized via different anal. techniques such as IR, 1H-NMR, 13C-NMR and mass spectrometry. Moreover, the structure of ligand I [R1 = 2-furanyl; R2 = 2-nitrophenyl] was also characterized by single-crystal X-ray diffraction. The synthesized ligands I with the PdCl2 salt showed excellent catalytic activity in the Suzuki-Miyaura, Mizoroki-Heck and Buchwald-Hartwig reactions. A broad range of substrates including heterocycles, chalcones and sterically hindered coupling partners were well tolerated in the developed protocol. Addnl., the metal complex formed in the catalytic cycle was characterized by 1H-NMR spectroscopy and mass spectrometry.

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Wangyu published the artcileLewis-Acid-Catalyzed Selective Friedel-Crafts Reaction or Annulation between Anilines and Glyoxylates, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is anilines based diarylmethane preparation; aniline glyoxylate Friedel Craft Lewis acid catalyst; oxoimidazolidine diastereoselective preparation; glyoxylate aniline annulation Lewis acid catalyst.

A Lewis-acid-catalyzed selective reaction between anilines and glyoxylates was developed for synthesis of diarylmethanes or oxoimidazolidines. Under the catalysis of AgOTf, a series of anilines-based diarylmethanes I [R = H, 3-F, 3-CN, etc.; R1 = NH2, NHMe, pyrrolidin-1-yl, etc.; R2 = Me, Et, Ph, 4-MeC6H4], including primary, secondary and tertiary anilines were obtained in moderate to good yields. Moreover, stereoselective oxoimidazolidines II [R3 = 4-Cl, 3-CF3, 4-CO2Et, etc.] were performed with the catalysis of Cu(OAc)2·H2O.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mujahed, Shrouq published the artcileA High-Valent Ru-PCP Pincer Catalyst for Hydrogenation of Carbonyl and Carboxyl Compounds under Molecular Hydrogen, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is high valent ruthenium phosphorus carbon PCP pincer catalyst hydrogenation; carbonyl carboxyl nitrile compound hydrogenation catalyst preparation; crystal mol structure ruthenium phosphorus carbon PCP pincer complex; cooperative catalysis; esters; high-valent ruthenium; hydrogenation; pincer complexes.

Low-valent metals traditionally dominate the domain of catalytic hydrogenation. However, metal-ligand cooperating (MLC) catalytic systems, operating through heterolytic H-H bond splitting by a Lewis acidic metal and a basic ligand site, do not require an electron-rich metal. On the contrary, high-valent metals that induce weaker back donation facilitate heterolytic bond activation. Here authors report, for the first time, the efficient hydrogenation of carbonyl and carboxyl compounds under mol. hydrogen catalyzed by a structurally well-defined RuIV catalyst bearing a bifunctional PCP pincer ligand. The catalyst exhibits reactivity toward mol. hydrogen superior to that of the low-valent analog and allows hydrogen activation even at room temperature

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Synthetic Route of 1885-29-6, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts