Category: 1885-29-6

Meesa, Siddi Ramulu published the artcileCatalyst and solvent switched divergent C-H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes, SDS of cas: 1885-29-6, the main research area is indolequinazoline pyridoquinazoline preparation regio chemoselective; aryl quinazolinamine internal alkyne oxidative annulation.

The development of site-selective C-H functionalizations/annulations is one of the most challenging practices in synthetic organic chem. particularly for substrates bearing several similarly reactive C-H bonds. Herein, authors describe catalyst and solvent controlled ortho/peri site-selective oxidative annulation of C-H bonds of N-aryl substituted quinazolin-4-amines with internal alkynes. The ortho C-H selective annulation was observed using Pd-catalyst in DMF to give indole-quinazoline derivatives I (R1 = H, 7-Cl, 6,7-di-OMe; R2 = H, 4-Me, 4-OMe, 4-Cl,etc.; R3 = R4 = Ph, 4-MeC6H4, 2-thienyl, etc.), while, Ru-catalyst in PEG-400 favored the peri C-H bond annulation exclusively to furnish pyrido-quinazoline derivs II.

Organic & Biomolecular Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bilgicli, Hayriye Genc published the artcileComposites of palladium nanoparticles and graphene oxide as a highly active and reusable catalyst for the hydrogenation of nitroarenes, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is graphene oxide supported palladium nanoparticle preparation surface structure; nitrobenzene supported palladium nanocatalyst transfer hydrogenation green chem; aniline preparation.

The composite of palladium nanoparticles and graphene oxide (CPG) was synthesized by a facile and very efficient method that provided chem. selectivity and high catalytic activity. The synthesized CPG was characterized by several techniques such as transmission and high-resolution electron microscopy (TEM and HR-TEM), X-ray diffraction (XRD), Raman spectroscopy and Photoelectron spectroscopy (XPS). CPG was tested for selective reduction of nitroarenes at room temperature After the addition of CPG to the reaction media, catalytic performances were depended upon the cooperative effect of hydrogen activation with Pd nanoparticles, where the lack of electrons favors an excellent performance. Nitroarenes can be bound to the energetically preferred adsorption site for the nitro group in elec. enriched graphene oxide. In addition, the Pd nanoparticles transfer electrons to the graphene oxide which increased the functions of metal and carbon support. CPG exhibited both chemoprotective and high catalytic performance for hydrogenation of nitroarenes at room temperature Aniline derivatives were obtained with high yields under mild conditions and a practical catalytic system was developed by the use of CPG.

Microporous and Mesoporous Materials published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saikia, Rakhee published the artcileRevisiting the synthesis of aryl nitriles: a pivotal role of CAN, Formula: C7H6N2, the main research area is nitrile aryl preparation; aryl iodide or bromide CAN cyanation catalyst copper trifluoromethanesulfonate.

Facilitated by the dual role of ceric ammonium nitrate (CAN), herein a cost-effective approach for the cyanation of aryl iodides/bromides with CAN-DMF as an addition to the existing pool of combined cyanation sources was reported. In addition to being an oxidant, CAN acted as a source of nitrogen in our protocol. The reaction was catalyzed by a readily available Cu(II) salt and the ability of CAN to generate ammonia in the reaction medium was utilized to eliminate the addnl. requirement of a nitrogen source, ligand, additive or toxic reagents. The mechanistic study suggested an evolution of CN- leading to the synthesis of a variety of aryl nitriles ArCN [Ar = Ph, 4-OHC6H4, 4-H2NC6H4, etc.] in moderate to good yields. The proposed mechanism was supported by a series of control reactions and labeling experiments

Organic & Biomolecular Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sudharsan, Murugesan published the artcilePalladium Nanoparticles Incorporated Thiazoline Functionalized Periodic Mesoporous Organosilica: Efficient Catalyst for Selective Hydrogenation & Csp2-Csp2 Bond Formation Reactions, Category: nitriles-buliding-blocks, the main research area is palladium thiazoline nanocatalyst preparation hydrogenation bond formation reaction.

Thiazoline functionalized periodic mesoporous organosilica (TPMO) supported palladium nanoparticles (Pd-TPMO) were fabricated through a co-condensation approach and successive incorporation of palladium nanoparticles using a double-solvent technique. The TPMO and Pd-TPMO were characterized through 29Si MAS NMR, FTIR, SAXS, XPS, FESEM, TEM and N2 adsorption-desorption, which revealed the morphol. and physicochem. properties of the materials. The catalytic performance of Pd-TPMO was evaluated for hydrogenation of industrially important compounds such as styrene epoxide, furfural, nitrobenzene and Csp2-Csp2 bond-formation reactions. The Pd-TPMO mediated catalytic reactions were found to be effective in producing the corresponding products such as 2-phenylethanol, furfuryl alc., aniline with excellent yields and selectivity. The size and stability of palladium nanoparticles within the confined organosilica framework promotes excellent activity and recyclability of the catalyst without a significant loss in the yields for hydrogenation and Csp2-Csp2 bond-formation reactions.

ChemistrySelect published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Huantian published the artcileSynthesis of 1H-Indazoles and Quinazolines Using Additive Intermediates of Grignard Reagents to 2-Amino Benzonitriles, Category: nitriles-buliding-blocks, the main research area is aminobenzonitrile bromide iron chloride catalyst one pot heterocyclization; indazole preparation; bromide aminobenzonitrile ester bismuth chloride catalyst one pot heterocyclization; quinazoline preparation.

A convenient and efficient approach to 1H-indazoles in one-pot under air atm., using additive intermediates of Grignard reagents to 2-aminobenzonitriles via a FeCl3/Bpy catalyzed N-N coupling was developed. Besides, such intermediates could reacted with esters in one-pot to yield quinazolines promoted by BiCl3/Ph3P. Both 1H-indazoles and quinazolines were prepared in good to excellent yields. The possible mechanisms for the formation of 1H-indazoles and quinazolines were proposed.

ChemistrySelect published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dutta, Apurba published the artcileBase promoted metal-free approach towards synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones under microwave irradiation, Quality Control of 1885-29-6, the main research area is quinazolinone dihydroquinazolinone preparation microwave irradiation green chem.

A metal, solvent and oxidant free approach has been developed for the synthesis of quinazolin-4(3H)-ones in a concise and convergent fashion under microwave irradiation Using the same metal free catalyst 2,3-dihydroquinazolin-4(1H)-ones were also synthesized in water as green and sustainable solvent. Starting from 2-aminobenzonitriles and carbonyls, the desired products were isolated in good to excellent yields. These protocols provided a simplistic and an expeditious approach for the assembly of diverse structural quinazolinones.

Sustainable Chemistry and Pharmacy published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Zijuan published the artcilePalladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines, SDS of cas: 1885-29-6, the main research area is quinazoline aryl preparation; aminobenzonitrile boronic acid triethyl orthocarboxylate tandem heterocyclization palladium catalyst.

A one-pot method for joining three sep. components leading to an assortment of 4-arylquinazolines I (R1 = H, 6-Cl, 7-Cl, 8-Cl, 6-Me, 6-Br; R2 = H, Me, Ph; R3 = C6H5, 4-ClC6H4, 4-CH3C6H4, etc.) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)-C(sp2) coupling followed by intramol. C-N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand II.

Synthesis published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mohamed, Asmaa H. published the artcileSynthesis of novel quinazolines via nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides with dimethyl acetylenedicarboxylate and 2-(dicyanomethylene)indan-1,3-dione, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazoline preparation; amino arylbenzimidamide preparation dimethyl acetylenedicarboxylate cycloaddition; dicyanomethylene indan dione amino arylbenzimidamide preparation cycloaddition.

Synthesis of novel tetrahydroquinazoline-2-carboxylate I (R = H, Me; R1 = H, Cl; R2 = H, Me, Cl; R3 = H, Me) and arylaminoquinazoline-2-carboxylate II in good yields has been established via the nucleophilic cycloaddition of 2-amino-N’-arylbenzimidamides III on di-Me acetylenedicarboxylate. Moreover, the reaction of 2-amino-N’-arylbenzimidamides III with 2-(dicyanomethylene)indan-1,3-dione to give 3,4-dihydroquinazolin derivatives IV is studied. A plausible mechanism for the formation of the products is presented.

Monatshefte fuer Chemie published new progress about Benzamidines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Estruch-Blasco, Manel published the artcileRadical Arylation of Triphenyl Phosphite Catalyzed by Salicylic Acid: Mechanistic Investigations and Synthetic Applications, Formula: C7H6N2, the main research area is phosphonate aryl preparation organocatalytic diazonium arylation triphenyl phosphite; aromatic amine diazotization radical coupling triphenyl phosphite preparation arylphosphonate.

A straightforward and scalable methodol. to synthesize di-Ph arylphosphonates at 20° within 1-2 h is reported using inexpensive salicylic acid as the catalytic promoter of the reaction. Reaction of aromatic amines ArNH2 with P(OPh)3 and Bu nitrite in the presence of 10 mol% of salicylic acid afforded arylphosphonates ArP(O)(OPh)2 with up to 94% yield. Mechanistic investigations suggest that the reaction proceeds via radical-radical coupling, consistent with the so-called persistent radical effect. The reaction tolerated a wide range of functional groups and heteroaromatic moieties. The synthetic usefulness and the unique reactivity of the obtained phosphonates were demonstrated in different one-step transformations.

Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts