Category: 1885-29-6

Hussen, Abdulkadir Shube published the artcileAmmonium Chloride Assisted Microwave Mediated Domino Multicomponent Reaction: An Efficient and Sustainable Synthesis of Quinazolin-4(3H)-imines under Solvent Free Condition, HPLC of Formula: 1885-29-6, the main research area is aminobenzonitrile triethyl orthoformate arylamine ammonium chloride multicomponent tandem cyclocondensation; quinazolinimine preparation microwave irradiation green chem.

A novel multicomponent synthesis of quinazolin-4(3H)-imines starting from simple and readily available inputs was described. An efficient and environmentally benign protocol for the synthesis of biol. significant scaffolds from readily available starting materials such as 2-amino benzonitrile, tri-Et orthoformate and mainly aniline derivatives under metal and solvent-free conditions was reported. Owing to its operational simplicity, step and resource economy and broad substrate scope, this robust methodol. is appealing with respect to the previous research findings in this area.

ChemistrySelect published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Krapf, Michael K. published the artcileSynthesis and biological evaluation of quinazoline derivatives – A SAR study of novel inhibitors of ABCG2, HPLC of Formula: 1885-29-6, the main research area is quinazoline derivative preparation ABCG2 inhibitor multi drug resistance; ABC transporter; ABCG2; Inhibitor; Quinazolines; SAR.

Multidrug resistance (MDR) is a major obstacle for effective chemotherapeutic treatment of cancer frequently leading to failure of the therapy. MDR is often associated with the overexpression of ABC transport proteins like ABCB1 or ABCG2 which efflux harmful substances out of cells at the cost of ATP hydrolysis. One way to overcome MDR is to apply potent inhibitors of ABC transporters to restore the sensitivity of the cells toward cytostatic agents. This study focusses on the synthesis and evaluation of novel 2,4-disubstituted quinazoline derivatives regarding the structure-activity-relationship (SAR), their ability to reverse MDR and their mode of interaction with ABCG2. Hence, the inhibitory potency and selectivity toward ABCG2 was determined Moreover, the intrinsic cytotoxicity and the reversal of MDR were investigated. Interaction type studies with the substrate Hoechst 33342 and conformational analyses of ABCG2 with 5D3 monoclonal antibody were performed for a better understanding of the underlying mechanisms. In our study we could further enhance the inhibitory effect against ABCG2 (compound I, IC50: 55 nM) and identify the structural features that are crucial for inhibitory potency, the impact on transport activity and binding to the protein.

European Journal of Medicinal Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lam, Long Yin published the artcileCopper-Catalyzed Synthesis of Functionalized Aryl Sulfonamides from Sodium Sulfinates in Green Solvents, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl sulfonamide preparation green solvent; sodium aryl sulfinate amine coupling reaction copper.

Functionalized aryl sulfonamides are important building blocks in the pharmaceutical industry. A one-step synthesis catalyzed by a copper salt was developed using stable solid commodity chems. in sulfolane or, alternatively, in green solvents such as γ-valerolactone, iPrOAc, or nBuOAc with acetic acid. The method tolerated diverse functional groups commonly presented in current medicines and drug intermediates. The mechanistic study showed a radical coupling pathway between the sulfonyl and anilinium radicals through the use of K2S2O8 and copper catalyst, resp.

Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Shitao published the artcileSubstituent-controlled chemoselective synthesis of multi-substituted pyridones via a one-pot three-component cascade reaction, Category: nitriles-buliding-blocks, the main research area is arylamine acetylenedicarboxylate ethoxymethylenemalonate cesium carbonate tandem three component cycloaddition; arylpyridone tricarboxylate preparation.

An efficient and concise one-pot strategy for the synthesis of multisubstituted pyridones via a one-pot three-component cascade reaction catalyzed by Cs2CO3 under solvent-free conditions was developed. The substituent-controlled chemoselective cycloaddition process involved steps including a Michael addition/ethanol elimination/intermol. cyclization sequence utilizing anilines, di-Et acetylenedicarboxylate, and di-Et ethoxymethylenemalonate. The synthesis various 2-pyridone and 4-pyridone species (41 examples) were obtained in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ielo, Laura published the artcileTelescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines, Formula: C7H6N2, the main research area is chloro halomethyl trifluoromethyl aziridine preparation chemoselective homologation imine; aziridines; carbenoids; chemoselectivity; homologation; lithium.

A conceptually novel, high-yielding, mono- or bis-homologation was realized with lithium halocarbenoids and enables the one-step, fully chemocontrolled assembly of a new class of quaternary trifluoromethyl aziridines. Trifluoroacetimidoyl chlorides (TFAICs) act as convenient electrophilic platforms, enabling the addition of either one or two homologating elements by simply controlling the stoichiometry of the process. Mechanistic studies highlighted that the homologation event, carried out with two different carbenoids (LiCH2Cl and LiCH2F), leads to fluoromethyl analogs in which the first nucleophile was employed for constructing the cycle and the second for decorating the resulting mol. architecture.

Angewandte Chemie, International Edition published new progress about Aziridines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Weiqiang published the artcileSwitchable and efficient conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones and N-(2-chloroethyl)benzamides, COA of Formula: C7H6N2, the main research area is amidophenyloxazoline chemoselective reaction; chloroethylbenzamide preparation; quinazolinone preparation.

Switchable chemoselective conversion of 2-amido-aryl oxazolines to quinazolin-4(3H)-ones or N-(2-chloroethyl)benzamides was achieved. The former reaction was proposed to involve a PIFA-mediated 6π electrocyclization followed by an in situ nucleophilic substitution, while the latter reaction uses aluminum chloride as a halogenated source through a ring-opening reaction. The reactions proceed smoothly under mild conditions and have excellent functional group compatibility.

Organic Chemistry Frontiers published new progress about Benzamides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sheng, Hui-Yang published the artcileCopper-catalyzed Tandem Cyclization to Access 4-Aminoquinoline Derivatives, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitroethenylaryl aminobenzonitrile copper catalyst tandem Michael heterocyclization oxidation; nitro arylquinolinamine preparation.

An efficient and practical method for the synthesis of 4-aminoquinoline derivativeswas developed via copper-catalyzed cascade cyclization of 2-aminobenzonitrile and nitroolefins. This reaction proceeded through a consecutive Michael addition/cyclization/oxidization protocol, providing 4-aminoquinolines with moderate to excellent yields under mild conditions. This method features readily available materials, one-pot one-step operation, and proceeded without bases.

Chemistry Letters published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Jihyeon published the artcileCopper(II)-Catalyzed Aerobic Oxidation of Amines: Divergent Reaction Pathways by Solvent Control to Imines and Nitriles, HPLC of Formula: 1885-29-6, the main research area is aryl nitrile preparation; benzylamine aerobic oxidation copper catalyst; imine diastereoselective preparation; amine oxidative coupling copper catalyst.

The Cu(OAc)2-catalyzed aerobic oxidations of amines to imines RR1CH=NR2 [R = H, Me; R1 = Ph, 4-MeC6H4, 2-thienyl, etc.; R2 = cyclohexyl, Ph, Bn, etc.] and nitriles R3CN [R3 = n-heptyl, Ph, 2-thienyl, etc.] were identified under solvent control conditions and in the presence of mol. oxygen. By modulating the aerobic oxidation pathways of Cu(OAc)2 catalyst in different reaction solvents, the selective formations of homo-coupled imines, cross-coupled imines and nitriles were achieved from amine derivatives

Asian Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nikpassand, M. published the artcileNovel Route for the Synthesis of 2-Arylquinazolinones Using Magnetic Nanocomposite of Multiwalled Carbon Nanotube, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone preparation green chem; aryl aldehyde aminobenzonitrile multiwalled carbon nanotube catalyst multicomponent.

A series of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones have been synthesized in excellent yields and short reaction time by one-pot reaction of 2-aminobenzonitrile, ammonium hydroxide, and substituted benzaldehydes or 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes in the presence of magnetic multiwalled carbon nanotube (mMWCNT) nanocomposite as a recoverable catalyst at room temperature The proposed methodol. offers several advantages such as mild reaction conditions, green media, excellent yields, simple procedure, and reduced environmental impact. Moreover, the catalyst can be easily recovered using an external magnet and recycled for 5 runs without significant loss of its catalytic activity. The structure of most of the synthesized 2-aryl-2,3-dihydroquinazolin-4(1H)-ones was confirmed by 1H and 13C NMR and FTIR spectra and elemental analyses.

Russian Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dutta, Apurba published the artcileGemini basic ionic liquid as bi-functional catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones at room temperature, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is reusable butanediyl bisdodecylmorpholinium hydroxide preparation thermal stability; cyanoaniline carbonyl compound butanediyl bisdodecylmorpholinium hydroxide tandem condensation; dihydroquinazolinone preparation green chem.

A cascade synthesis of 2,3-dihydroquinazolin-4(1H)-ones was developed from 2-aminobenzonitriles and carbonyl analogs using Gemini basic ionic liquid as green catalyst cum solvent at room temperature Both aldehydes and ketones were condensed with 2-aminobenzonitriles affording good to excellent yields of products. Moreover, the ionic liquids was reused up to 5th cycle without significant loss of catalytic activity.

Tetrahedron Letters published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts