Category: 1885-29-6

Chen, Zhen-Yu published the artcilePerfluorobutyl Iodide Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-ones, Formula: C7H6N2, the main research area is indolinone preparation; tertiary aminoaryl ketone Stevens rearrangement perfluorobutyl iodide mediated.

The tertiary amine and ketone components of 1-carbonyl-substituted anilines underwent [1,2] and [2,3] Stevens rearrangement reactions, triggered by a C4F9 radical, formed from electron donor-acceptor complexes. This approach enabled the formation of a quaternary ammonium salt and thus a Stevens rearrangement to afford indolin-3-ones such as I [R1 = Me, Et, i-Pr; R2 = Bn, CH2CH=CH2, C(Me)=C=CH2, etc.; R3 = Me, Bn] and II [R4 = H, Cl, Br; R5 = H, MeO, Cl; R6 = H, MeO] under mild conditions.

Advanced Synthesis & Catalysis published new progress about Indolines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sathishkumar, Pushpanathan N. published the artcileTuning acylthiourea ligands in Ru(II) catalysts for altering the reactivity and chemoselectivity of transfer hydrogenation reactions, and synthesis of 3-isopropoxy-1H-indole through a new synthetic approach, Synthetic Route of 1885-29-6, the main research area is ruthenium cymene complex preparation crystal structure; carbonyl compound ruthenium cymene complex catalyst chemoselective transfer hydrogenation; alc preparation; nitroarene ruthenium cymene complex catalyst chemoselective transfer hydrogenation; arylamine preparation.

Ru(II)-p-cymene complexes containing picolyl based pseudo-acylthiourea ligands were synthesized and characterized. The crystallog. study confirmed the mol. structures of all the ligands and one complex. The catalytic activity of the complexes was tested mainly towards transfer hydrogenation of carbonyl compounds and nitroarenes. The influence of steric and electronic effects of the ligands on the chemoselectivity and reactivity were reported. The catalytic activity was enhanced and chemoselectivity was switched after tuning the ligands in the catalysts, compared to their corresponding unmodified Ru(II)-p-cymene complexes. The catalysis was extended to a broad range of substrates including some challenging systems like furfural, benzoylpyridine, benzoquinone, chromanone, etc. The strategy of tuning the bifunctional ligands in the catalysts for effective and selective catalysis worked nicely. Further, the catalysis was extended to one-pot synthesis of 3-isopropoxyindole from 2-nitrocinnamaldehyde, the first synthetic route similar to Baeyer Emmerling indole synthesis. All the catalytic experiments exhibited high conversion and selectivity.

Journal of Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Jingya published the artcileMn(III)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids, Related Products of nitriles-buliding-blocks, the main research area is hydroxyindolenine preparation; acylarom isocyanide preparation boronic acid tandem heterocyclization manganese catalyst.

A Mn(III)-catalyzed cascade cyclization of o-acyl aromatic isocyanides 2-CN-R1C6H3C(O)R2 (R1 = H, 4-F, 3-Me, 2-Cl, etc.; R2 = Me, 2-isocyano-5-methylphenyl, 5-chloro-2-isocyanophenyl, 2-isocyanophenyl) with boronic acids R3B(OH)2 (R3 = Ph, naphthalen-1-yl, thiophen-2-yl, etc.) was carried out via a single-step route to generate a series of 3-hydroxyindolenines I under mild conditions. A plausible mechanism involving a cascade transmetalation, nucleophilic addition and intramol. cyclization sequence was proposed and confirmed. In addition, the reaction procedure featured simple synthesis, wide substrate scope, and excellent functional group compatibility.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Yetong published the artcilePalladium(II)-catalyzed three-component tandem reactions: synthesis of multiply substituted quinolines, Application In Synthesis of 1885-29-6, the main research area is polysubstituted quinoline preparation; aminobenzonitrile arylboronic acid ketone three component tandem palladium catalyst.

The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones allowing the synthesis of polysubstituted quinolines I [R1 = H, 7-Me, 6-F, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Ph, 2-naphthyl, 3-thienyl, etc.; R4 = H, Et, Br, etc.; R2R4 = CH2CH2CH2; CH2(CH2)2CH2, etc.] was reported. This strategy presented a practical, efficient, one-pot procedure that delivered functional quinolines in moderate to good yields with high functional group tolerance. To enrich the synthetic applications in accessing diverse quinolines, a new method for the introduction of halogen substituents into target products was developed as well, which showed potential for further synthetic elaborations.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ji, Meishan published the artcileCatalyst-free, radical-mediated intermolecular 1,2-arylheteroarylation of alkenes by cleaving inert C-C bond, Synthetic Route of 1885-29-6, the main research area is polyarylalkane preparation photochem; aryldiazonium salt alkene radical tandem arylheteroarylation.

A novel photoinduced intermol. 1,2-arylheteroarylation of alkenes RCH=CH2 (R = t-Bu, Ph, furan-2-yl, etc.) and the efficient synthesis of valuable polyarylalkanes R1-2-MeC(O)C6H3CH2CH(R2)R (R1 = H, 4-Cl, 5-Me, etc.; R2 = pyridin-2-yl, thiazol-2-yl, benzothiazol-2-yl, etc.) are reported. The reaction is operationally simple, proceeds under mild conditions and with no addnl. catalyst and reagents. The strategically designed radical cascade reaction is enabled by electron transfer, and involves cleavage of an inert C-C bond. The process features broad functional group compatibility as well as high product transformability.

Science China: Chemistry published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bergagnini-Kolev, Mackenzie published the artcileSynthesis of trifluoromethyl substituted nucleophilic glycine equivalents and the investigation of their potential for the preparation of α-amino acids, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino acid synthesis trifluoromethyl nucleophilic glycine equivalent; substituted pyroglutamic acid synthesis; nickel complex glycine Schiff base phase transfer catalyzed alkylation; oxazoladinone amide unsaturated substituted carboxylic acid Michael addition.

The synthetic preparation of several Ni(II) complexed Schiff bases of glycine will be introduced, as well as investigations into their reactivity and utility. Key to these investigations is the incorporation of electron-withdrawing trifluoromethyl groups within the framework of the conjugated system that stabilizes the enolate derived from the glycine component. Reactivity was evaluated for each of the complexes under phase transfer catalyzed alkylations with hydroxide bases, as well as the DBU catalyzed Michael additions of optically active 3′-substituted-2-oxazoladinone amides of unsaturated carboxylic acids. It was found that the trifluoromethyl containing nucleophilic glycine equivalent were more reactive than their non-trifluoromethyl analogs in both reaction types. Therefore, the application of these modified Ni(II) complexes of glycine Schiff bases are useful for the preparation of α-amino acids through phase transfer catalyzed alkylation as well as the preparation of optically pure β-substituted pyroglutamic acid precursors.

Tetrahedron published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hikawa, Hidemasa published the artcileGold(III)/Sodium Diphenylphosphinobenzene-3-sulfonate (TPPMS) Catalyzed Dehydrative N-Benzylation of Electron-Deficient Anilines in Water, Application In Synthesis of 1885-29-6, the main research area is amine aryl benzyl preparation; aniline benzylation benzylic alc gold sodium diphenylphosphinobenzenesulfonate catalyst.

A strategy for the dehydrative N-benzylation of electron-deficient anilines R1NH2 (R1 = 4-O2NC6H4, 2-Me-3-O2NC6H3, 2-NCC6H4, etc.) in water has been developed. The gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) catalyst is highly effective as a Lewis acid for the activation of alcs. R2R3CHOH (R2 = Ph, 4-CH3C6H4, PhCH:CH, etc.; R3 = H, Ph, 4-FC6H4, 4-ClC6H4) and tolerates aerobic conditions. A Hammett study in the reaction of para-substituted benzhydryl alcs. R2R3CHOH (R2 = 4-MeOC6H4, 4-MeC6H4, Ph, 4-FC6H4, 4-BrC6H4; R3 = Ph) shows neg. σ values, indicating a build-up of cationic charge during the rate-determining sp3 C-O bond-cleavage step. The inverse kinetic solvent isotope effect (KSIE = 0.6) is consistent with a specific acid catalysis mechanism. This simple protocol can be performed under mild conditions in an atom-economic process without the need for base or other additives, furnishing the electron-deficient N-benzylic anilines R1NHCHR2R3 in moderate to excellent yields along with water as a sole co-product.

Synthesis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Su, Tianyue published the artcileSynthesis of Quinazolinones Via a Tandem Hydrogen-Transfer Strategy Catalyzed by N,S Co-doped Carbon-Anchored Co Nanoparticles, Computed Properties of 1885-29-6, the main research area is quinazolinone preparation carbon supported cobalt heterogeneous catalyst; benzyl alc nitrobenzonitrile tandem hydrogen transfer.

A N,S codoped carbon-anchored Co nanoparticle (NP) material (Co@NSC-1) has been developed via the pyrolysis of the mixture of Co/Zn-zeolitic imidazolate frameworks (ZIFs) and thiourea. This catalyst exhibits excellent catalytic activity for the synthesis of quinazolinones from 2-nitrobenzonitriles and benzyl alcs. under additive-free conditions. The superior activity is mainly attributed to the dispersed Co NPs, large sp. surface areas, strong acid-base sites, and the synergistic effects between cobalt NPs and doping of N,S atoms. It is worth noting that Co NPs are protected by the N,S codoped carbon shells of this catalyst, so it displays no significant loss in activity after six runs.

ACS Sustainable Chemistry & Engineering published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Yongke published the artcileCopper-catalyzed tandem oxidative synthesis of quinazolinones from 2-aminobenzonitriles and benzyl alcohols, Quality Control of 1885-29-6, the main research area is quinazolinone preparation green chem; aminobenzonitrile benzyl alc copper catalyst tandem oxidative.

An efficient and practical copper-catalyzed process for the synthesis of substituted quinazolinones I (R1 = C6H5, 4-MeOC6H4, 4-FC6H4, etc.; R2 = 6-Me, 6-OMe, 5-F, etc.) from simple and readily available 2-aminobenzonitriles and benzyl alcs. is described. This method features high functional-group tolerance and could afford a variety of desirable products in good to excellent yields with air as the sole oxidant. Moreover, a possible reaction mechanism is proposed according to the control experiments and reported literature.

Organic Chemistry Frontiers published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dandia, Anshu published the artcileOne-Pot Copper(I)-Catalyzed Synthesis of 2-Aryl-quinazolin-4(3H)-ones via N-benzylation/Csp3-H Oxidation/CN Hydrolysis/Cyclization, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is benzyl bromide aminobenzonitrile copper tandem benzylation oxidation hydrolysis heterocyclization; phenylquinazolinone selective preparation.

A Cu(I)-catalyzed straightforward synthesis of quinazolin-4(3H)-ones was attained by the reaction of 2-aminobenzonitrile with benzyl bromides. The reaction proceeded via one pot N-benzylation/CSp3- H oxidation/CN hydrolysis/cyclization sequence. Numerous controlled experiments were carried out to establish the appropriate mechanism and prerequisite of the reactions. The process was truly selective as only quinazolinones formed as desired product over dihydrogenated quinazolinones.

ChemistrySelect published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts