Category: 1885-29-6

Fang, Zhongxue published the artcileThe [4+1] cyclization reaction of 2-hydroxylimides and trimethylsulfoxonium iodide for the synthesis of 3-amino-2,3-dihydrobenzofurans, Product Details of C7H6N2, the main research area is amino dihydro benzofuran preparation green chem; hydroxylimide trimethylsulfoxonium iodide cyclization.

The [4+1] cyclization reaction of 2-hydroxylimides I (R1 = H, MeO, Cl; R2 = H, Br, Cl, NO2; R3= H; R2R3 = -CH=CH-CH=CH-; R4 = H, Me; R5 = 2,4,6-trimethylphenyl, quinolin-8-yl, pyrimidin-2-yl, etc.) and trimethylsulfoxonium iodide was investigated. This cyclization reaction exhibits wide scope and compatibility with functional groups. The 3-amino-2,3-dihydrobenzofurans II were obtained in reasonable to high yields under mild conditions. This methodol. was utilized to synthesize highly substituted 3-amino-2,3-dihydrobenzofuran derivatives II.

New Journal of Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Wu published the artcileEnantioselective Hydroxylation of Dihydrosilanes to Si-Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species, Application In Synthesis of 1885-29-6, the main research area is silanol chiral preparation reactivity; crystal structure mol optimized silanol chiral ligand phosphine catalyst; enantioselective hydroxylation dihydrosilane copper phosphine catalyst mechanism transition state; Asymmetric Catalysis; Copper; Metathesis; Silanols; Single-Electron Transfer (SET) Oxidation.

Catalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a highly efficient way to access Si-chiral silanols, yet has remained unknown up to date. Herein, we describe a strategy for realizing this reaction: using an alkyl bromide as a single-electron transfer (SET) oxidant for invoking CuII species and chiral multidentate anionic N,N,P-ligands for effective enantiocontrol. The reaction readily provides a broad range of Si-chiral silanols with high enantioselectivity and excellent functional group compatibility. In addition, we manifest the synthetic potential by establishing two synthetic schemes for transforming the obtained products into Si-chiral compounds with high structural diversity. Our preliminary mechanistic studies support a mechanism involving SET for recruiting chiral CuII species as the active catalyst and its subsequent σ-metathesis with dihydrosilanes.

Angewandte Chemie, International Edition published new progress about Bromocycloalkanes Role: RGT (Reagent), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muthukumar, Alagesan published the artcileZn(OTf)2-catalyzed access to symmetrical and unsymmetrical bisindoles from α-keto amides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is phenyl oxoamide preparation indole zirconium triflate catalyst chemoselective arylation; indolyl phenyl hydroxyamide indole zirconium triflate catalyst chemoselective arylation; bisindolyl phenyl acetamide preparation.

Zn(OTf)2-catalyzed synthesis of 3,3′-bisindolyl acetamides from α-keto amides was developed. Both aromatic α-keto amides substituted with electron-donating as well as -withdrawing groups and aliphatic α-keto amides were well tolerated to provide sym. bisindoles in moderate to excellent yields. The chemoselective bisindolylation of the keto group of α-keto amides in the presence of a simple keto functionality was successfully achieved in good yields. The transformation was further extended to the synthesis of challenging unsym. bisindoles by treating indolyl α-hydroxy amides with substituted indoles. The unsym. bisindoles were isolated in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about Amides, hydroxy Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ram, Shankar published the artcilePolystyrene-Supported Palladium (Pd@PS)-Catalyzed Carbonylative Annulation of Aryl Iodides Using Oxalic Acid as a Sustainable CO Source for the Synthesis of 2-Aryl Quinazolinones, SDS of cas: 1885-29-6, the main research area is reusable polystyrene support palladium catalyst preparation; aminobenzamide iodobenzene oxalic acid palladium catalyst carbonylation heterocyclization; aryl quinazolinone preparation green chem; aminobenzamides; aminobenzonitriles; oxalic acid dihydrate; palladium nanoparticles; quinazolinones.

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o-carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd@PS) nanoparticles (NPs) catalyzed conditions was developed. The oxalic acid were employed as safe, economic, environmentally benign, sustainable and bench-stable, solid CO surrogate under Double-Layer-Vial (DLV) system for the synthesis of 2-aryl quinazolinones. This methodol. does not require any special high-pressure equipment like autoclaves, microwaves, etc. Moreover, a simple procedure for catalyst preparation, catalyst recyclability, easy handling of reaction, additive and base-free generation of CO, excellent to good yields and vast substrate scope were the addnl. features of developed protocol.

Chemistry – A European Journal published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mao, Shuai published the artcileSynthesis of Aryl Trimethylstannane via BF3·OEt2-Mediated Cross-Coupling of Hexaalkyl Distannane Reagent with Aryl Triazene at Room Temperature, Category: nitriles-buliding-blocks, the main research area is triazene cross coupling distannane preparation arylstannane biaryl trifluoroborane catalyst.

BF3·OEt2-mediated cross-coupling of (SnMe3)2 with aryl triazene offers a new strategy for the synthesis of aryl stannane. A variety of synthetically useful aryl trimethylstannanes were produced in moderate to good yields with this metal-free approach. One-pot sequential Stille cross-coupling with different aryl bromides provides a short entry to both sym. and unsym. biaryl compounds

Journal of Organic Chemistry published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Tengfei published the artcileExploration of catalytic species for highly efficient preparation of quinazoline-2,4(1H,3H)-diones by succinimide-based ionic liquids under atmospheric pressure: Combination of experimental and theoretical study, HPLC of Formula: 1885-29-6, the main research area is quinazoline carbon dioxide absorption ionic liquid catalyst.

Cyclization reaction of carbon dioxide (CO2) and 2-aminobenzonitriles is of significance for the sustainable development, however, the harsh reaction condition especially for the high CO2 pressure is still an obstacle. Herein, a novel ionic liquid benzyltrimethylammonium succinimide ([BzTMA+][Suc-]) is designed and synthesized, in which no active hydrogen atom is included in cation. It displays the excellent catalytic activity achieving the 98.8% yield for quinazoline-2,4(1H,3H)-diones even under the atm. pressure. By combination of NMR spectroscopy (1H NMR and 13C NMR), CO2 absorption measurements, d. functional theory (DFT) calculations, and the frontier MO anal., the real catalytic species and synergistic effect of cation and anion on the catalytic performance are elucidated. The [Suc-] anion affords to introduce the CO2 into the organic phase even under the atm. pressure by formation of [Suc-CO-2]. However, the real catalytic species is [BzTMA+] cation and [Suc-] anion rather than [BzTMA+] and [Suc-CO-2]. If the active hydrogen atom is included in the cation, the CO2 absorption capacity of [Suc-] anion would be weakened by the strong interaction between active hydrogen atom in cation and [Suc-] anion resulting in the inferior catalytic behavior. The cooperation of [BzTMA+] and [Suc-] finally results in the high catalytic activity under the atm. pressure. Involvement of active hydrogen atom in cation is not an insurance to prepare the robust catalyst.

Fuel published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Morozov, Vyacheslav published the artcileMetal-Free Rapid Diastereoselective Construction of Isocryptolepine Core via Electrophilic Dearomatization – Intramolecular Michael Addition Sequence, HPLC of Formula: 1885-29-6, the main research area is methoxyphenyl cyclohexanol aryl nitrile diastereoselective elecrophilic dearomatization Michael addition; indoloacridinone preparation; xanthenoindolone preparation.

A method for rapid construction of indolo[3,2-l]acridin-7-one systems bearing isocryptolepine scaffold was described. Metal-free condensation of (4-methoxyphenyl)cyclohexan carbinols with ortho-amino/hydroxybenzonitriles in concentrated sulfuric acid yielded polyannulated compounds with four new stereogenic centers in a highly diastereoselective manner. The reaction included elecrophilic dearomatization of methoxyarene, formation of spirocyclic intermediate and intramol. 1,4-nucleophilic addition sequence.

ChemistrySelect published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samim, Sk. Abdus published the artcileCobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy, COA of Formula: C7H6N2, the main research area is cobalt catalyzed hydration dehydrogenative coupling aminobenzonitrile alc quinazolinone synthesis.

A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alc.-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jatangi, Nagesh published the artcileBase-catalyzed synthesis of quinazolines in aqueous medium, Application In Synthesis of 1885-29-6, the main research area is quinazoline preparation green chem; ketimine preparation aryl isothiocyanate heterocyclization sodium hydroxide catalyst; aminobenzonitrile magnesium bromide Grignard reaction.

An alternative green and step economy reaction of readily available 2-aminobenzonitriles 2-NH2-5-XC6H3CN (X = H, Cl, OCH3, NO2, etc.) with various organometallic reagents RMgBr (R = Ph, 3-methoxyphenyl, Bu, etc.) led to ortho-aminoaryl NAH ketimine 2-NH2-5-XC6H3C(R)=NH species. The subsequent base catalyzed NAC bond formation with various isothiocyanates ArNCS (Ar = Ph, 4-nitrophenyl, 2,4-difluorophenyl, etc.) afforded quinazoline scaffolds I in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.

Tetrahedron Letters published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Synthetic Route of 1885-29-6, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts