Category: 1885-29-6

Chintawar, Chetan C. published the artcileEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands, Computed Properties of 1885-29-6, the main research area is oxychroman preparation enantioselective DFT; iodoaryl alkene alc oxyarylation gold catalyst; aminochroman preparation enantioselective DFT; aromatic amine iodoaryl alkene aminoarylation gold catalyst.

The enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos) e.g., I was reported. The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes 2-I-3-R1-4-R2-5-R3-6-R4C6OCH2CH=CH2 (R1 = H; R2 = H, F, Me, NO2, etc.; R1R2 = -CH=CHCH=CH-; R3 = H, OMe, C(O)OMe, CF3; R4 = H, Me, OMe) which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans II [R5 = H, Me, Et, i-Pr, (2-bromophenyl)methyl] III (R6 = 4-nitrophenyl, 4-bromo-2-nitrophenyl, 3-cyanothiophen-2-yl, etc.) (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-sym. chiral environment present around nitrogen, imparting a high level of enantioselectivity.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (iodoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muddagoni, Narasimha published the artcileTin ( IV ) chloride catalyzed one-pot synthesis, characterization and docking studies of 4-aminoquinoline derivatives as Myt1 inhibitors, Formula: C7H6N2, the main research area is amino benzonitrile aryl methanone tin chloride catalyst heterocyclization; aryl aminoquinoline preparation mol docking.

An efficient and practical method for the series of 4-aminoquinoline derivatives I [R = 3-cyanophenyl, 2,3-dihydro-1H-inden-5-yl, 5-chlorothiophen-2-yl, etc.; R1 = H, Cl] was developed via Tin (lV) chloride catalyzed cascade cyclization from 2-aminobenzonitrile and different acetophenones. These novel chem. entities I were characterized by their 1HNMR, 13CNMR spectra and high-resolution mass spectrometer (HRMS) with their docking studies were performed to identify potential inhibitors of Myt1kinase protein. The synthesized analogs I were docked with Myt1 kinase protein. Among these, compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] were showing promising Glide score, prime-MMGBSA and ADME properties similar to Neratinib, Pelitinib cancer inhibiting drugs of Myt1 kinase protein. The amino acid ASP251of Myt1 kinase protein was consistently binding to novel chem. entities I and existing drugs, indicating that the amino acid is crucial and responsible for its inhibition. Docking studies revealed that the compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] indicated that they can act as strong inhibitors of Myt1 kinase protein as that of comparable existing drugs Neratinib, Pelitinib.

Journal of Heterocyclic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Miao, Changqing published the artcileIodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aminoketone preparation; benzoquinolone preparation; ketone hydroxy aryl amine coupling iodine catalyst.

An iodine-catalyzed coupling of β-hydroxyketones RC(O)(CH2)2OH (R = Me, Ph) with aromatic amines R1NHR2 (R1 = 3-fluorophenyl, biphenyl-4-yl, quinolin-8-yl, etc.; R2 = H, Me) to yield β-aminoketones RC(O)(CH2)2NR1R2 and benzo[h]quinolones I (X = H, Br) have been developed. Noble metallic catalysts, oxidants, α,β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.

Tetrahedron published new progress about Amines, keto Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Salgado, Arturo R. M. published the artcileSynthesis of endo-fused 5-unsubstituted Hexahydro-2H-pyrano[3,2-c]quinolines via Sequential Sc(OTf)3-catalyzed Cationic Imino-Diels-Alder Reaction/N-debenzylation using N-benzylanilines, 3,4-dihydro-2H-pyran and Paraformaldehyde under MW Irradiation, HPLC of Formula: 1885-29-6, the main research area is hexahydropyranoquinoline preparation diastereoselective microwave irradiation; benzylaniline dihydropyran paraformaldehyde Diels Alder debenzylation scandium triflate catalyst; 2- c]quinolones.; Cationic imine Diels-Alder; Lewis acid catalysis; N-debenzylation; microwave irradiation; pyrano[3; scandium triflate.

Hexahydro-2H-pyrano[3,2-c]quinolines I (R = H; R1 = H, Cl, OMe, OH, etc.; RR1 = -(OCH2O)-; R2 = H; R1R2 = -(OCH2O)-; R3 = H, CN, OMe) are known to have antibacterial, antifungal, and antitumor properties. Great efforts have been made to develop new synthetic methods that lead to the synthesis of valuable libraries. Extensive methodologies, low yields, excessive amounts of catalyst and expensive reactants are some of the limitations of current methodologies. A useful and efficient method to construct diversely substituted hexahydro-2Hpyrano[3,2-c]quinolines I into good to excellent yields through a cationic imino-Diels-Alder/N-debenzylation methodol. is developed. The cationic imino-Diels-Alder/N-debenzylation methodol. was used for the preparation of substituted hexahydro-2H-pyrano[3,2-c]quinolines I. It involves the use of Sc(OTf)3 for activation of cationic imino- Diels-Alder cycloaddition reaction of N-benzylanilines R4NHBn (R4 = Ph, 2H-1,3-benzodioxol-5-yl, 2,4-dimethoxyphenyl, etc.), 3,4-dihydro-2H-pyran and paraformaldehyde in MeCN; and microwave irradiation to shorten reaction time to afford new 6-benzyl-hexahydro-2H-pyrano[3,2- c]quinolines I whose catalytic transfer debenzylation reactions with HCO2NH4 in the presence of Pd/C (10%) and methanol give the new 5-unsubstituted pyrano[3,2-c]quinolines I in excellent yields. An efficient method to synthesize hexahydro-2H-pyrano[3,2-c]quinolines I via the cationic imino-Diels-Alder/N-debenzylation methodol. using Sc(OTf)3 0.5% as Lewis Acid catalyst was described. Excellent yields of the products, use of MW irradiation, short times of reactions, and an efficient and highly diversified method are some of the main advantages of this new protocol.

Current Organic Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (benzyl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Chenghao published the artcileRuthenium-catalyzed enantioselective hydrogenation of quinoxalinones and quinazolinones, Application In Synthesis of 1885-29-6, the main research area is quinoxalinone ruthenium catalyst enantioselective hydrogenation; dihydroquinoxalinone preparation; quinazolinone ruthenium catalyst enantioselective hydrogenation; dihydroquinazolinone preparation.

An efficient Ru-catalyzed enantioselective hydrogenation of quinoxalinone and quinazolinone derivatives was successfully developed, provided a straightforward and facile access to chiral dihydroquinoxalinones and dihydroquinazolinones with excellent results (89-98% yields, up to 98% ee). Importantly, the key enantiopure dihydroquinoxalinone intermediate towards the synthesis of a bioactive BRD4 inhibitor was conveniently synthesized by this catalytic hydrogenation methodol.

Organic Chemistry Frontiers published new progress about Aromatic diamines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lesniak, Robert K. published the artcileDiscovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy, Category: nitriles-buliding-blocks, the main research area is pyridinyl indazole preparation protein kinase inhibition mol docking SAR; Kinase inhibitors; LRRK2; Peptides and protein; Rodent models; Selectivity.

The discovery and development of compound I, an indazole-based, G2019S-selective (>2000-fold vs. WT) LRRK2 inhibitor capable of entering rodent brain (Kp = 0.5) and selectively inhibiting G2019S-LRRK2 was reported. The compounds disclosed herein present a starting point for further development of brain penetrant G2019S selective inhibitors that hopefully reduce lung phenotype side-effects and pave the way to providing a precision medicine for people with PD who carry the G2019S mutation.

European Journal of Medicinal Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tao, Shou-Wei published the artcilePalladium-Catalyzed One-Pot Coupling / Cyclization through Mo(CO)6 as the Carbon Monoxide Donor: Synthesis of Quinazolinones, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone preparation; aminobenzamide aryl bromide molybdenum hexacarbonyl carbonylative coupling heterocyclization palladium; aminobenzonitrile aryl bromide molybdenum hexacarbonyl carbonylative coupling heterocyclization palladium.

An efficient and rapid one-pot synthesis of quinazolinones I (R = Ph, [4-(cyanomethyl)phenyl], 2H-1,3-benzodioxol-5-yl, 3,4,5-trimethoxyphenyl, etc.; R1 = H, 8-Me, 7-Cl, etc.; R2 = H, Me, Ph, 4-fluorophenyl) via a three-component carbonylative coupling of 2-aminobenzamide R1-2-NH2C6H3C(O)NHR2 or 2-aminobenzonitrile, Mo(CO)6 and aryl bromides RBr has been developed recently. This method provide a new way to synthesize quinazolinones I which has a wide substrate scope, good functional group tolerance and mild reaction condition.

ChemistrySelect published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Abhilash published the artcileA palladium-catalyzed cascade process for spirooxindole: an alternative way for the synthesis of spiro(indoline-3,2′-quinazolin)-2-ones, Product Details of C7H6N2, the main research area is spiroindolinequinazolinone preparation one pot palladium catalyst; aminobenzonitrile arylboronic acid isatin three component reaction.

A palladium-catalyzed cascade strategy has been developed for one-pot synthesis of functionalized spiro(indoline-3,2′-quinazolin)-2-one derivatives I (R = H, Me; R1 = H, 3-Me, 4-OMe, etc.; R2 = H, Me, F, etc.; R3 = H, Me, Ph, Bn) from readily available starting materials. The reaction proceeds via C-C and two C-N bond formations in a single reaction operation. This method offers an attractive pathway for the synthesis of a broad range of spiro(indoline-3,2′-quinazolin)-2-ones in good yields.

Organic & Biomolecular Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ping, Ran published the artcileCatalytic Conversion of CO2 from Simulated Flue Gases with Aminophenol-Based Protic Ionic Liquids to Produce Quinazoline-2,4(1H,3H)-diones under Mild Conditions, Synthetic Route of 1885-29-6, the main research area is quinazolinedione synthesis carbon dioxide flue gas aminophenol ionic liquid.

Novel aminophenol-based protic ionic liquids (APILs) were designed and synthesized via one-step neutralization, and they were used as catalysts for conversion of 2-aminobenzonitriles and CO2 from simulated flue gases to produce quinazoline-2,4(1H,3H)-diones under mild conditions. The effects of anion-cation structures of APILs, various solvents, reaction parameters, and water contents on the product yields were investigated in detail. The catalyst recyclability and general applicability to different substrates were examined It showed that both the basicity of the reaction media and the synergistic activation of zwitterions to reactants played important roles during the catalysis. The optimum [HTMG][m-AP] catalyst cooperating with the DMF (DMF) solvent could selectively convert CO2 into various quinazoline-2,4(1H,3H)-diones with good to excellent product yields at 60°C and in a 0.1 MPa simulated flue gas atm. In addition, [HTMG][m-AP]/DMF was easily recycled and could be reused in up to five consecutive cycles without an obvious loss of activity. By comparison with the reported catalysts, [HTMG][m-AP]/DMF here showed a superior catalytic performance and a great potential for development. Finally, the activation behaviors of [HTMG][m-AP]/DMF to reactants were studied, and a synergistic catalytic mechanism was proposed.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Qixing published the artcileCopper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water, Synthetic Route of 1885-29-6, the main research area is dihydroquinazolinone preparation nitrobenzonitrile carbonyl Pinner Dimroth rearrangement.

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H)-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H)-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds

Synlett published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts