Category: 1885-29-6

Fathalla, Walid published the artcileNovel domino synthesis of 2-(2,3,4-substituted phenyl)quinazolin-4-amine, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is phenyl quinazolin amine preparation; cyanophenyl benzimidoyl isothiocyanate isopropyl amine tandem reaction.

Convenient domino protocol was developed for the synthesis of 2-arylquinazolin-4-amines by the reaction of N-(2-cyanophenyl) substituted benzimidoyl isothiocyanates with iso-Pr amine. The major advantages of this protocol are short reaction times, mild conditions, simple work up, high yields, and pure products. The efficacy of this protocol owes to the competence of synthesis, pure isolation of imidoyl isothiocyanates, and the unique structure conformation of the corresponding intermediate thiourea derivatives

Journal of Heterocyclic Chemistry published new progress about Amines Role: RCT (Reactant), RGT (Reagent), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tavakoli, Ghazal published the artcileThe reductive deaminative conversion of nitriles to alcohols using para-formaldehyde in aqueous solution, Related Products of nitriles-buliding-blocks, the main research area is benzylic alkyl primary alc chemoselective preparation; ruthenium catalyst chemoselective reduction nitrile paraformaldehyde water; mechanism reductive deamination nitrile paraformaldehyde water ruthenium catalyst.

In the presence of [Ru(p-cymene)Cl2]2, paraformaldehyde in H2O/toluene acted as a reductant for the chemoselective reductive deamination of alkyl and aryl nitriles to yield alkyl or benzylic primary alcs. The mechanism of the reaction is studied using the characterization of reaction intermediates by mass spectrometry; dimeric ruthenium complexes are necessary to generate reduced ruthenium complexes from paraformaldehyde, while nitrile coordination generates monomeric complexes of ruthenium which reduce the nitriles to alcs.

Catalysis Science & Technology published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wolinska, Ewa published the artcileChiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction, Product Details of C7H6N2, the main research area is nitro alc preparation enantioselective diastereoselective; aldehyde nitromethane nitroaldol pyridine triazine oxazoline copper catalyst.

Eight pyridine-containing and four 1,2,4-triazine-containing chiral oxazoline ligands incorporating electron-withdrawing substituents have been oxazolines I (R1 = Ph, t-Bu; R2 = H, F; R3 = H, Cl; R4 = H, F, Cl, nitro; R5 = H, Br), II and III synthesized by two-step route including Buchwald-Hartwig amination. Enantio-inducing activity of the ligands has been assessed in the copper-catalyzed asym. nitroaldol reactions and the influence of the electron-withdrawing substituents on the ligands’ activity has been investigated.

Monatshefte fuer Chemie published new progress about Alcohols, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Wanting published the artcileEnantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis, Product Details of C7H6N2, the main research area is enantioselective nitroso aldol oxidative coupling ketocarbonyl aniline; chiral primary amine selenium catalyzed enantioselective nitroso aldol.

An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo- and enantiocontrol.

Organic Letters published new progress about Aldol addition catalysts, stereoselective (N-selective nitroso aldol). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kalaus, Hubert published the artcileA Kinetic Photometric Assay for the Quantification of the Open-Chain Content of Aldoses, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is kinetic photometric quantification aldehyde selective conformation aldose aminobenzamidoxime; Aldehydes; Analytical methods; Carbohydrates; Kinetics; UV/Vis spectroscopy.

Aldoses exist predominantly in the cyclic hemiacetal form, which is in equilibrium with the open-chain aldehyde form. The small aldehyde content hampers reactivity when chem. addresses the carbonyl moiety. This low concentration of the available aldehyde is generally difficult to ascertain. Herein, we demonstrate a new kinetic determination of the (minute) open-chain content (OCC) of aldoses. This kinetic approach exploits the aldehyde-selectivity of 2-aminobenzamidoxime (ABAO), which furnishes a strongly UV-active adduct. Simple formation curves can be measured in a photometer or plate reader for high-throughput screening. Under pseudo-first order kinetics, these curves correlate with a prediction model yielding the relative OCC. The OCCs of all parent aldoses (pentoses and hexoses) were determined referencing against the two tetroses with exceptionally high OCCs and were in very good agreement with literature data. Addnl., the assay was extended towards higher-carbon sugars with unknown OCC and also applied to rationalize a lack of reactivity observed in a recent synthetic investigation.

European Journal of Organic Chemistry published new progress about Aldoses Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sheng, Zhi-Zheng published the artcileAlcohol amine-catalyzed CO2 conversion for the synthesis of quinazoline-2,4-(1H,3H)-dione in water, Formula: C7H6N2, the main research area is quinazoline dione preparation green chem; aminobenzonitrile carbon dioxide cyclization diethanolamine catalyst.

The conversion of CO2 to high value-added chems. in water using environmentally friendly and cost-effective catalysts is a very significant topic. In this work, a green method for the conversion of CO2 catalyzed by alc. amines has been developed. Alc. amines showed considerable activating ability to CO2 in the cyclization with 2-aminobenzonitrile to quinazoline-2,4(1H,3H)-dione in water. Notably, when diethanolamine (DEA) was used as the catalyst, 94% yield of quinazoline-2,4-(1H,3H)-dione could be achieved. A plausible mechanism has been proposed based on the 1H NMR, FT-IR anal. and DFT calculation The excellent catalytic performance is attributed to the combined effect of both the secondary amine and hydroxyl groups on alc. amines with the assistance of water in the formation of carbamate. Water plays a bi-functional role of solvent and co-catalyst in this catalytic process. Catalysts can be easily recovered and reused five times without significant loss of activity.

RSC Advances published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Qi published the artcileEfficient Synthesis of Quinazolinones by Transition-Metal-Free Direct Aerobic Oxidative Cascade Annulation of Alcohols with o-Aminoarylnitriles, Synthetic Route of 1885-29-6, the main research area is quinazolinone preparation green chem; alc aryl nitrile amino aerobic oxidative cascade annulation; aerobic oxidation; alcohols; annulation; o-aminobenzonitriles; quinazolinones.

A mild and atom-economic method was developed for direct and efficient synthesis of quinazolinones I (R1 = H, 5-Cl, 6-Br, 7-CH3, etc.; R2 = C6H5, naphthalen-2-yl, thiophen-2-yl, etc.) through a transition-metal-free aerobic oxidative cascade annulation reaction of widely available o-aminoarylnitriles R32-H2NC6H3CN (R3 = H, 4-CH3, 5-Br, 6-Cl, etc.) and alcs. R2CH2OH. Air could be employed as an effective oxidant under mild conditions, generating water as the only byproduct. Possibly owing to the ”cesium effect”, the water-soluble base CsOH was found to be crucial in all key steps of the reaction mechanism. Because a wide range of substrates can be used to prepare substituted quinazolinones without contamination by transition-metal residues, this method may be of interest for application in pharmaceutical synthesis. Possible reaction paths were also proposed according to control reactions.

ChemSusChem published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Xiang published the artcileDBU coupled ionic liquid-catalyzed efficient synthesis of quinazolinones from CO2 and 2-aminobenzonitriles under mild conditions, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone preparation organic base ionic liquid catalyst; aminobenzonitrile carbon dioxide cyclization diazabicycloundecene ionic liquid catalyst.

An efficient catalytic system of organic base-coupled ionic liquids (ILs) that could catalyze the synthesis of quinazolinones I (R1 = H, OMe, Cl, Br, R2 = H; R1 = H, R2 = Cl) via cyclization of 2-aminobenzonitriles with CO2 under mild conditions (e.g., 60°C, 0.1 MPa) was reported. It was found that 1,8-diazabicyclo[5.4.0]undec-7-ene coupled with 1-butyl-3-methylimidazole acetate ionic liquids, (DBU/[Bmim][OAc]), displayed excellent performance in catalyzing the reactions of CO2 with 2-aminobenzonitriles to give compounds I in high yields at atm. pressure. Moreover, the ILs had high stability and reusability, and could be reused at least five times without considerable decrease in catalytic activity. This protocol could also be conducted on a gram scale, and may have promising and practical applications in the production of quinazolinones.

RSC Advances published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mousavi-Mashhadi, Seyed Ali published the artcileCatalytic hydration of terminal alkynes and nitriles without reducing reagents, acidic promoters and organic solvent over Fe3O4@Starch-Au, Synthetic Route of 1885-29-6, the main research area is alkyne nitrile iron oxide starch gold nanoparticle hydration catalyst.

Magnetic heterogeneous nanoparticles (Fe3O4 NPs) were prepared and functionalized by starch and gold nanoparticles, resp. The characterization of nanocomposite was carried out by several techniques such as FT-IR, XRD, FE-SEM, TEM, EDS, VSM, ICP and TGA. The prepared nanocatalyst, Fe3O4@Starch-Au, was utilized in the synthesis of aryl Me ketones and amides via the activation of multiple bonds in aqueous media. The nanocatalyst was simply recovered and reused for several cycles without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Alkyl aryl ketones Role: IMF (Industrial Manufacture), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Terlizzi, Lorenzo Di published the artcileDyedauxiliary Group Strategy for the α-Functionalization of Ketones and Esters, Application In Synthesis of 1885-29-6, the main research area is arylketone arylazo ester preparation; arylazo sulfone enol silyl ether ketene acetal activation.

The synthesis of α-arylketones and α-arylazo esters has been achieved in mixed organic-aqueous media under photocatalyst- and metal-free conditions via visible light activation of arylazo sulfones in the presence of enol silyl ethers and ketene silyl acetals, resp. The process took place efficiently and exhibits an excellent tolerance for a broad variety of functional groups.

ACS Organic & Inorganic Au published new progress about Acetals, ketene, silyl Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts