Category: 1885-29-6

Zhang, Xiaheng published the artcileCopper-mediated synthesis of drug-like bicyclopentanes, Computed Properties of 1885-29-6, the main research area is bicyclopentane preparation copper iridium catalyst propellane nucleophile radical.

Multicomponent reactions are relied on in both academic and industrial synthetic organic chem. owing to their step- and atom-economy advantages over traditional synthetic sequences1. Recently, bicyclo[1.1.1]pentane (BCP) motifs have become valuable as pharmaceutical bioisosteres of benzene rings, and in particular 1,3-disubstituted BCP moieties have become widely adopted in medicinal chem. as para-Ph ring replacements2. These structures are often generated from [1.1.1]propellane via opening of the internal C-C bond through the addition of either radicals or metal-based nucleophiles3-13. The resulting propellane-addition adducts are then transformed to the requisite polysubstituted BCP compounds via a range of synthetic sequences that traditionally involve multiple chem. steps. Although this approach was effective so far, a multicomponent reaction that enables single-step access to complex and diverse polysubstituted drug-like BCP products would be more time efficient compared to current stepwise approaches. Here the authors report a one-step three-component radical coupling of [1.1.1]propellane to afford diverse functionalized bicyclopentanes using various radical precursors and heteroatom nucleophiles via a metallaphotoredox catalysis protocol. This copper-mediated reaction operates on short timescales (five minutes to one hour) across multiple (more than ten) nucleophile classes and can accommodate a diverse array of radical precursors, including those that generate alkyl, α-acyl, trifluoromethyl and sulfonyl radicals. This method was used to rapidly prepare BCP analogs of known pharmaceuticals, one of which is substantially more metabolically stable than its com. progenitor.

Nature (London, United Kingdom) published new progress about Electrochemical redox reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fan, Zhenhua published the artcileMetal-free synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade michael addition / cyclization of methyl-4,4-difluorobut-2-ynoate with 2-aminobenzonitriles, Formula: C7H6N2, the main research area is difluoromethylated quinoline preparation DBU michael cyclization methyl difluorobutynoate aminobenzonitrile.

A facile synthesis of 2-difluoromethylated quinolines via DBU-promoted cascade Michael addition/cyclization between functionalized 2-aminobenzonitriles and Me 4,4-difluorobut-2-ynoate was developed. Various highly functionalized quinolines were assembled in moderate to good yields under mild metal-free reaction conditions.

Tetrahedron published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hori, Hiroto published the artcileCobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups, HPLC of Formula: 1885-29-6, the main research area is heterocycle preparation regioselective chemoselective; olefin cyclization cobalt catalyst.

An efficient synthesis of carbo- and heterocycles, e.g., I using C=C, C=O and C=N bonds under cobalt catalysis has been described. The substituents on olefins, e.g., di-Et ((2-[N-(prop-2-en-1-yl)(4-methoxyphenyl)sulfonamido]phenyl)carbonyl)phosphonate are key for controlling the regio- and chemoselectivity in the initial hydrogen atom transfer step and quaternary carbons are efficiently constructed under mild conditions. Cyclopropane cleavage and tandem cyclization give highly functionalized bicyclic skeletons in a single operation.

Organic & Biomolecular Chemistry published new progress about Chemoselectivity. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeng, Linwei published the artcileRhodium-Catalyzed Atroposelective Click Cycloaddition of Azides and Alkynes, Computed Properties of 1885-29-6, the main research area is triazole preparation enantioselective; azide alkyne atroposelective click cycloaddition rhodium catalyst; Atroposelectivity; Click Chemistry; Cycloaddition; Rhodium Catalysis; Triazoles.

Herein, a rhodium-catalyzed enantioselective click cycloaddition of azides R1N3 (R1 = benzyl, 2-naphthyl, pyridin-3-yl, etc.) and alkynes R3CCR2 (R2 = Ph, 2-naphthyl, cyclopropyl, etc.; R3 = 2-hydroxynaphthalen-1-yl, 6-bromo-2-hydroxynaphthalen-1-yl, 6-hydroxyquinolin-5-yl, etc.) for rapid and modular access to atropisomeric triazoles I in excellent yields and enantioselectivities was reported. The process is mild, efficient and scalable, and features broad substrate scope.

Angewandte Chemie, International Edition published new progress about Atropisomers. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghosh, Tridev published the artcileKOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines, SDS of cas: 1885-29-6, the main research area is amine amide transamidation potassium butoxide; amide preparation; potassium butoxide transamidation mediator.

This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Xueguo published the artcileRhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C-H activation, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is isocoumarin preparation regioselective chemoselective; isoquinolinone preparation regioselective chemoselective; diazo compound phenyloxazole carboxylic acid cyclization rhodium catalyst.

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins I (R = t-Bu, 4-bromophenyl, cyclohexyl, thiophen-2-yl, etc.; R1 = Me, Et, Ph; R2 = Me, Et, t-Bu) and isoquinolinones II (R3 = t-Bu, heptyl, furan-2-yl, etc.) have been realized via Rh(III)-catalyzed C-H activation. Diazo compounds R1C(O)C(=N2)C(O)OR2 act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations.

Chinese Chemical Letters published new progress about C-H bond activation (chemo-, regioselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feng, Fang-Fang published the artcileTungsten-Catalyzed Transamidation of Tertiary Alkyl Amides, HPLC of Formula: 1885-29-6, the main research area is tertiary alkyl amide transamidation tungsten catalyst.

Transamidation has recently emerged as a straightforward and convenient means to diversify amides. However, the kinetically and thermodynamically demanding transamidation of notoriously robust, fully alkyl-substituted tertiary amides still remains a longstanding challenge. Here, a method for the activation of tertiary alkyl amides to streamline transamidation using simple tungsten(VI) chloride as a catalyst and chlorotrimethylsilane as an additive is described. The highly electrophilic and oxophilic tungsten catalyst enables the selective scission of a C-N bond of tertiary alkyl amides to effect transamidation of a myriad of structurally and electronically diverse tertiary alkyl amides and amines. Mechanistic study implies that the synergistic effect of the catalyst and the additive could pronouncedly induce the nucleophilic acyl substitution of tertiary alkyl amide with amine to realize transamidation.

ACS Catalysis published new progress about Transamidation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Zhen published the artcileElemental Sulfur-Promoted Aerobic Dehydrogenative Aromatization of Cyclohexanones with Amines, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dialkyl phenylenediamine naphthylamine preparation; cyclohexanone amine aerobic dehydrogenative aromatization sulfur.

Herein, an elemental sulfur-promoted aerobic dehydrogenation system for the synthesis of N,N’-dialkyl-o-phenylenediamines I (R = H, Me, C6H5, etc.; R1 = i-Pr, c-hexyl, c-pentyl, etc.) and N-substituted 2-naphthylamines II (R1 = c-hexyl, C6H5, 4-ClC6H4, etc.) is reported . Readily available cyclohexanones and amines (especially alkylamines) are transformed smoothly to target products. Aromatic amines can be achieved from all aliphatic reagents under aerobic metal-free reaction conditions. Control reactions show that the combinational use of elemental sulfur and mol. oxygen is exceptionally essential for this dehydrogenative aromatization.

Journal of Organic Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (naphthylamines). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Akram, Manjur O. published the artcileLigand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines, Computed Properties of 1885-29-6, the main research area is ligand enabled gold catalyzed carbon nitrogen cross coupling; cross coupling aryl iodide amine high valent gold intermediate.

The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kamal, Arsala published the artcileVisible Light-Driven Synthesis of Amine-Sulfonate Salt Derivatives: A Step towards Green Approach, Related Products of nitriles-buliding-blocks, the main research area is amine sulfonate salt preparation green chem visible light.

In this work, a novel strategy for the straightforward visible-light-driven synthesis of biol. active, industrially important, and stable amine-sulfonate salts have been reported from p-toluenesulfonic acid and amines, which provide extremely high yield without side product formation. The reaction was performed without catalyst under visible light irradiation and had an excellent functional group tolerance. The structure of the prepared compounds were confirmed through 1H NMR, 13C NMR, and mass spectroscopic studies, and similarly, the mol. structure of compound 3b was established through single-crystal XRD-anal. The advantages of this method meet the requirements of sustainable and green synthetic chem., and it provides a direct way to create valuable amine-sulfonate salt.

Journal of Molecular Structure published new progress about Green chemistry. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts