Category: 20099-89-2

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Safety of 4-(2-Bromoacetyl)benzonitrile.

Osmaniye, Derya;Alasan, Ramazan;Saglik, Begum Nurpelin;Levent, Serkan;Ozkay, Yusuf;Kaplancikli, Zafer Asim research published 《 Novel thiazolyl-hydrazone derivatives including piperazine ring: synthesis, in vitro evaluation, and molecular docking as selective MAO-A inhibitor》, the research content is summarized as follows. MAO-A inhibitors are used in the treatment of depression. There are many studies showing that the thiazolyl-hydrazone structure is a pharmacophore structure for the MAO enzyme. In previous studies by our team, activity studies were carried out with thiazolyl-hydrazone derivatives containing pyrrolidine, morpholine, and piperazine. All of them were displayed MAO-A selective inhibition profile. Addnl., derivatives containing piperazine ring were most active. For this purpose, thiazolyl-hydrazone derivatives containing piperazine were synthesized, but this time an active group, formyl group, was added to the piperazine ring as a substituent. Based on this view, new thiazolyl-hydrazone compounds were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. The structure of the compound was tried to be fully elucidated using 2D NMR technique. The compound including 2,4-di-Me substituent (3i) were found to be the most effective agents in the series against MAO-A enzyme with the IC50 value of 0.080 ± 0.003 μM. The docking study of compound 3i revealed that there is a strong interaction between the active sites of hMAO-A and analyzed compound

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Safety of 4-(2-Bromoacetyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Synthetic Route of 20099-89-2.

Palabindela, Rambabu;Guda, Ramu;Ramesh, Gondru;Myadaraveni, Prabhakar;Banothu, Devendar;Ravi, Gangalla;Korra, Rajashekar;Mekala, Himabindu;Kasula, Mamatha research published 《 Novel tryptanthrin hybrids bearing aminothiazoles as potential EGFR inhibitors: design, synthesis, biological screening, molecular docking studies, and ADME/T predictions》, the research content is summarized as follows. A variety of novel tryptanthrin aminothiazole analogs I (R = Ph, 4-NCC₆H₄, 4-HOC₆H₄, etc.) and II possessing a biol. active thiazole moiety were synthesized by the reaction of tryptanthrin thiosemicarbazones with different α-bromo-4-substituted-acetophenones compounds All the novel synthesized compounds were investigated for their in vitro anticancer activity against three human cancer cell lines (MCF-7, A549, and HeLa) by taking cisplatin as a reference drug. The compounds I (R = 4-NCC₆H₄, 4-MeOC₆H₄) displayed excellent anticancer activities against the growth of three human cancer cell lines. EGFR targeting mol. docking investigation revealed that tryptanthrin aminothiazole analogs had better binding energies compared with EGFR inhibitors (Gefitinib, Erlotinib, and Lapatinib). The mol. docking findings back up the exptl. anticancer activity results very well. The compounds were also tested for their antibacterial and antioxidant activities. In silico ADME/T predictions had been performed that these tryptanthrin aminothiazole analogs have a good pharmacokinetic profile.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Name: 4-(2-Bromoacetyl)benzonitrile.

Pandey, Rajat;Singh, Gurdeep;Gour, Vinod;Anand, Ramasamy Vijaya research published 《 Base-mediated sequential one-pot approach for the synthesis of 2,3-disubstituted indoles from 2-(tosylamino)aryl-substituted para-quinone methides》, the research content is summarized as follows. A one-pot approach had been developed for the synthesis of 2,3-disubstituted indoles I [R¹ = H, 4-SMe, Ph, etc.; R = H, 6-Cl, 7-Me] through a base-mediated N-alkylation of 2-(tosylamino)aryl-substitued para-quinone methides with halomethylaryl ketones followed by intramol. cyclization and tosyl group elimination sequence. This one-pot protocol provided direct access to a wide range of 2,3-disubstituted indoles I in moderate to good yields under mild conditions.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Melnichenko, V. E.;Kudryavtseva, T. N.;Grekhneva, E. V.;Lamanov, A. Y.;Kudryavcev, T. A. research published 《 Synthesis of New 2-(6H-Indolo[2,3-b]quinoxalin-6-yl)-1-phenylethan-1-ones》, the research content is summarized as follows. A series of new 2-(6H-indolo[2,3-b]quinoxalin-6-yl)-1-phenylethan-1-ones I (R¹ = H, F, OMe, Cl, Br; R² = H, OMe, CN, NO₂) was synthesized by the reaction of various 6H-indolo[2,3-b]quinoxalines II (R¹ = H, F, OMe, Cl, Br) with 4-substituted 2-bromophenylethan-1-ones in a DMSO-K₂CO₃ system.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Formula: C9H6BrNO.

Moolman, Chantalle;van der Sluis, Rencia;Beteck, Richard M.;Legoabe, Lesetja J. research published 《 Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors》, the research content is summarized as follows. A series of benzofuran-based compounds I [R¹ = H, HO, MeO, Cl; R² = H, HO, MeO, (₅H₂C)N; R³ = H, HO, MeO, Br; R⁴ = H, MeO, Cl; R⁵ = H, F, NC, MeO, Cl, Br] was synthesized and evaluated as inhibitors of recombinantly expressed and purified PfGSK-3 and human glycogen synthase kinase-3 beta (HsGSK-3β). Of this series, five compounds I [R¹ = H; R² = H, MeO; R³ = H, MeO; R⁴ =H, MeO, Cl; R⁵ = H, F, NC, Cl] preferentially inhibited PfGSK-3, with four of these compounds exhibiting IC₅₀ values in the sub-micromolar range (0.00048-0.440μM). Evaluation of the structure-activity relationships required for PfGSK-3 selective inhibition indicated that a C6-OCH₃ substitution on ring A was preferred, while the effect of the ring B substituent on activity, in decreasing order was: C4′-CN > C4′-F > C3′-OCH₃ > C3′,4′-di-Cl. To date, development of PfGSK-3 inhibitors was limited to the 4-phenylthieno[2,3-b]pyridine class. Chalcone-based scaffolds, such as the benzofurans I described herein, are promising new hits which can be explored for future design of PfGSK-3 selective inhibitors.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Electric Literature of 20099-89-2.

Musci, Pantaleo;Colella, Marco;Andresini, Michael;Aramini, Andrea;Degennaro, Leonardo;Luisi, Renzo research published 《 Flow technology enabled preparation of C3-heterosubstituted 1-azabicyclo[1.1.0]butanes and azetidines: accessing unexplored chemical space in strained heterocyclic chemistry》, the research content is summarized as follows. The use of flow technol. as an enabling tool for accessing 1-azabicyclo[1.1.0]butanes bearing strained 3-, 4-, and 5-membered O-heterocycles with C3(N-het)-C2(O-het) connectivity I [R = H, Me, CH₂CH₂Br, etc.; R¹ = Ph, 2-ClC₆H₄, CH:CHC₆H₅, etc.], II [X = 1, 2; R2 = Ph, 2-thienyl, 2-naphthyl, etc.] and III [n = 2, 3; R³ = Ph, 4-BrC₆H₄, 1-naphthyl, etc.] was reported. Reactivity and chemoselectivity (N-ring vs. O-ring) were also evaluated. New chem. space was explored and new structural motifs such as ABB-aziridines IV [n = 1, 2, 3; R⁴ = Boc, Ts; R⁵ = Cl, Br, SPh, etc.; Ar = Ph, 4-FC₆H₄, 4-MeC₆H₄, 4-OMeC₆H₄] or spiro azetidine-oxazetidine V were also reported.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Electric Literature of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Reference of 20099-89-2.

Mane, Kishor D.;Rupanawar, Bapurao D.;Suryavanshi, Gurunath research published 《 Visible Light-Promoted, Photocatalyst-Free C(sp²)-H Bond Functionalization of Indolizines via EDA Complexes》, the research content is summarized as follows. The catalyst and additive-free, photo-driven cross dehydrogenative coupling (CDC) reaction initiated by electron donor-acceptor (EDA) complexes between electron rich indolizines and electron poor quinones had been demonstrated to obtain indolizine coupled quinones I [R = H, Cl; R¹ = H, 1-Me, 7-Me, 8-Me; R² = Ph, 4-MeC₆H₄, 3-BrC₆H₄, etc.; R³ = H, Br, NO₂]. This green transformation revealed the advantages of operational simplicity, mild reaction conditions and good functional group tolerances.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Reference of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Quality Control of 20099-89-2.

Mathew, Bini;Ruiz, Pedro;Dutta, Shilpa;Entrekin, Jordan T.;Zhang, Sixue;Patel, Kaval D.;Simmons, Micah S.;Augelli-Szafran, Corinne E.;Cowell, Rita M.;Suto, Mark J. research published 《 Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-κB activators for the treatment of ALS》, the research content is summarized as follows. ALS is a rare type of progressive neurol. disease with unknown etiol. It results in the gradual degeneration and death of motor neurons responsible for controlling the voluntary muscles. Identification of mutations in the superoxide dismutase (SOD) 1 gene has been the most significant finding in ALS research. SOD1 abnormalities have been associated with both familial as well as sporadic ALS cases. SOD2 is a highly inducible SOD that performs in concurrence with SOD1 to detoxify ROS. Induction of SOD2 can be obtained through activation of NF-κBs. We previously reported that SRI-22819 increases NF-κB expression and activation in vitro, but it has poor ADME properties in general and has no oral bioavailability. Our initial studies were focused on direct modifications of SRI-22819. There were active compounds identified but no improvement in microsomal stability was observed In this context, we focused on making more significant structural changes in the core of the mol. Ataluren, an oxadiazole compound that promotes read-through and expression of dystrophin in patients with Duchenne muscular dystrophy, bears some structural similarity to SRI-22819. Thus, we synthesized a series of SRI-22819 and Ataluren (PTC124) hybrid compounds Several compounds from this series exhibited improved activity, microsomal stability and lower calculated polar surface area (PSA). This manuscript describes the synthesis and biol. evaluation of SRI-22819 analogs and its hybrid combination with Ataluren.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application of C9H6BrNO.

Li, Wangbing;Lu, Zhichao;Hammond, Gerald B.;Xu, Bo research published 《 Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride》, the research content is summarized as follows. An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO₄^2-), which could be reused after filtration. Moreover, A26-SO₄^2- could be used in continuous flow conditions. Water was well-tolerated.

Application of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Related Products of 20099-89-2.

Liu, Jing;Huang, Hong-Li;Wang, Chen;Li, Yinghua;Li, Huaqiang;Hu, Honggang;He, Shipeng;Tang, Hua;Gao, Fei research published 《 Visible-light-driven cascade radical cyclization toward the synthesis of α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives》, the research content is summarized as follows. A visible-light-driven cascade radical cyclization process of N-methacryloyl-2-phenylbenzimidazoles had been established with α-carbonyl alkyl bromides. This protocol provided an efficient and practical method for the synthesis of various α-carbonyl alkyl-substituted benzimidazo[2,1-a]isoquinolin-6(5H)-ones I [R = CH₂CO₂Et, CH₂C(O)Ph, 4-MeC₆H₄C(O)CH₂, etc.; R¹ = H, Me, Br; R² = H, Me, OMe, t-Bu, F; R³ = H, Me, Br; R⁴ = H, F, Cl, Br; R⁵ = H, Me, Cl; R⁶ = H, Me, Cl] in outstanding yields, mild reaction conditions and excellent functional group tolerance.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts