Category: 20099-89-2

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Reference of 20099-89-2.

Gui, Qing-Wen;Wang, Bin-Bin;Zhu, Sha;Li, Fu-Long;Zhu, Meng-Xue;Yi, Min;Yu, Jia-Ling;Wu, Zhi-Lin;He, Wei-Min research published 《 Four-component synthesis of 3-aminomethylated imidazoheterocycles in EtOH under catalyst-free, oxidant-free and mild conditions》, the research content is summarized as follows. With green ethanol as the sole solvent, 3-aminomethylated imidazoheterocycles I [R¹ = H, 6-Me, 7-Me, etc.; R² = Ph, 4-ClC₆H₄, 2-furanyl, etc.; R³ = Bn, n-Bu, CH₂CH₂CN, etc.; R⁴ = H, Me, i-Pr, etc.; R³R⁴ = CH₂(CH₂)₂CH₂, CH₂(CH₂)CH₂, CH₂CH₂OCH₂CH₂, R³ = R⁴ = Et, i-Pr] were synthesized via a four-component reaction of 2-aminopyridines with 2-bromoacetophenones dichloromethane and amines at ambient temperature under metal-free, oxidant-free and mild conditions.

Reference of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. HPLC of Formula: 20099-89-2.

Fu, Haigen;Lam, Heather;Emmanuel, Megan A.;Kim, Ji Hye;Sandoval, Braddock A.;Hyster, Todd K. research published 《 Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions》, the research content is summarized as follows. The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, the authors report an “ene”-reductase catalyzed asym. hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the “ene”-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Addnl., wild-type NCR can catalyze intermol. couplings with precise stereochem. control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

HPLC of Formula: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 20099-89-2.

Fultariya, Chirag R.;Harsora, Jalpa P. research published 《 Synthesis, antimicrobial activity and cytotoxicity of 2-substituted benzimidazole incorporated with thiazole》, the research content is summarized as follows. Two new series 2-(2-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylidene)hydrazinyl)-4-(aryl)thiazoles I (R = H, 4-CH₃, 2-Cl, etc.) and 2-(2-(1-(1-methyl-1H-benzo[d]imidazol-2-yl)ethyl)hydrazinyl)-4-(aryl)thiazoles II (R =H, 4-CH₃, 2-Cl, etc.) encompassing benzimidazole incorporated with thiazole have been synthesized using rational approach. These thiazole derivatives I have been reduced at the site of formation of Schiff base (>CH = N0) to obtain final compounds II. Compounds I and II have been screened for their in vitro antibacterial and antifungal actions against four strains each. Among the screened compounds, I (R = 2-Cl, 4-Cl, 4-Br, 4-F, 2,4-diCl, 2,4-diF) and II (R = 2-Cl, 4-Cl, 4-Br, 2,4-diF) have emerged as highly effective antibacterial agents, while compounds I (R = 2-Cl, 4-Cl, 4-Br, 2,4-diF) and II (R = 2,4-diF) have come out as most potent antifungal mols. Comparison of outcomes of antibacterial and antifungal screening of compounds I and II directed that antimicrobial potential of unreduced derivatives I is higher than reduced derivatives II. SAR study reveals that presence of halogen (-F, -Cl, -Br) substituents is accountable for significant antimicrobial potential. Also the results of preliminary MTT cytotoxicity assay on HeLa cells indicates that antimicrobial activity of I (R = 4-Cl, 4-Br, 4-F, 2,4-diCl, 2,4-diF) and II (R = 4-Cl, 4-Br, 2,4-diF) is accompanied by low extent of cytotoxic concentrations

SDS of cas: 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Product Details of C9H6BrNO.

Gao, Feng;Ferlin, Francesco;Bai, Rongxian;Li, Minghao;Vaccaro, Luigi;Gu, Yanlong research published 《 Replacing halogenated solvents by a butyl acetate solution of bisphenol S in the transformations of indoles》, the research content is summarized as follows. A Bu acetate solution of bisphenol S (BPS) was proved to be able to replace hazardous halogenated solvents in the transformation of indoles. Measurement with Kamlet-Taft solvatochromic parameters disclosed that the polarity of the BPS-containing Bu acetate was enhanced greatly. The protocol not only conferred a convenient way to minimize the use of halogenated solvents in the synthesis of indole derivatives, but also enabled successful recycling of both the Bu acetate solvent and BPS additive, strengthening the greenness of the reaction systems.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Product Details of C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Name: 4-(2-Bromoacetyl)benzonitrile.

Gaykar, Rahul N.;George, Malini;Guin, Avishek;Bhattacharjee, Subrata;Biju, Akkattu T. research published 《 An Umpolung Oxa-[2,3] Sigmatropic Rearrangement Employing Arynes for the Synthesis of Functionalized Enol Ethers》, the research content is summarized as follows. An oxa-[2,3] sigmatropic rearrangement involving arynes was reported featuring the umpolung of ketones, where the C=O bond polarity was reversed. The in situ-generated sulfur ylides from β-keto thioethers and arynes underwent efficient rearrangement allowing the facile and robust synthesis of functionalized enol ethers I [R = Me, Ph, 2-thienyl, etc.; R¹ = Me, Et, Ph, etc., R² = Ph, 2,5-di-MeC₆H₃, 1-naphthyl, etc.; X = O, N] in high yields and excellent functional group compatibility. Preliminary mechanistic studies rule out the possibility of Pummerer-type rearrangement operating in this case.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Synthetic Route of 20099-89-2.

Eissa, Ahmed G.;Barrow, Denise;Gee, Julia;Powell, Lauren E.;Foster, Paul A.;Simons, Claire research published 《 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors》, the research content is summarized as follows. One in every eight women will be diagnosed with breast cancer during their lifetime and approx. 70% of all patients are estrogen receptor (ER) pos. depending upon estrogen for their growth accounting for third generation aromatase (CYP19A1) inhibitors being the mainstay in the treatment of ER-pos. breast cancer. Despite the success of current aromatase inhibitors, acquired resistance occurs after prolonged therapy. Although the precise mechanisms of resistance are not known, lack of cross resistance among aromatase inhibitors drives the need for a newer generation of inhibitors to overcome this resistance alongside minimising toxicity and adverse effects. Novel triazole-based inhibitors were designed based on previously published parent compound 5a, making use of the now available crystal structure of CYP19A1 (PDB 3S79), to make modifications at specific sites to explore the potential of dual binding at both the active site and the access channel. Modifications included adding long chain substituents e.g. but-2-ynyloxy and pent-2-ynyloxy at different positions including the most active compound 13h with IC50 value in the low picomolar range (0.09 nM). Aromatase inhibition results paired with mol. dynamics studies provided a clear structure activity relationship and favorable dual binding mode was verified. Toxicity assays and CYP selectivity profile studies for some example compounds were performed to assess the safety profile of the prepared inhibitors providing the basis for the 4th generation nonsteroidal aromatase inhibitors.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Synthetic Route of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application of C9H6BrNO.

Eltyshev, Alexander K.;Dzhumaniyazov, Timur H.;Suntsova, Polina O.;Minin, Artem S.;Pozdina, Varvara A.;Dehaen, Wim;Benassi, Enrico;Belskaya, Nataliya P. research published 《 3-Aryl-2-(thiazol-2-yl)acrylonitriles assembled with aryl/hetaryl rings: Design of the optical properties and application prospects》, the research content is summarized as follows. New fluorescent thiazoles were designed and synthesized based on a 3-aryl-2-(thiazol-2-yl)acrylonitrile core. Three synthetic approaches were developed to introduce specific combinations of substituents at the 2-, 4- and 5-thiazole positions. The obtained thiazolyl-2-acrylonitriles exhibited a wide range of fluorescent colors (from green to red), long wavelength maxima and intensity depending on the combination of the substituents located at rings A, B and C. The expanded photophys. investigation established the best substituent combinations to increase their emission. Absorption and emission were studied in solvents with different polarities, as well as in DMSO-water and dioxane-water mixtures The thiazoles showed multifunctional properties and exhibited good emission in the solid phase and in suspension (aggregation induced enhancement emission/AIEE effect). Photophys. investigations revealed a large Stokes shift, significant pos. solvatochromism, and the tunability of the color and intensity. Sharp strengthening of the emission intensity of the thiazoles was observed upon stimulation with some acid (H₂SO₄ and BF₃·OEt₂) in solvents and in the solid phase (HCl). State-of-the-art quantum mech. calculations were performed to interpret the exptl. findings. Biol. experiments revealed the good penetration of the thiazoles into living cells and the accumulation both in lysosomes and, to a lesser extent, near membranes.

Application of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. COA of Formula: C9H6BrNO.

Eltyshev, Alexander K.;Chernysheva, Nadezhda V.;Minin, Artem S.;Pozdina, Varvara A.;Slepukhin, Pavel A.;Benassi, Enrico;Belskaya, Nataliya P. research published 《 Fluorescent mesoionic 1-(2-aryl-4H-thieno[3,4-d][1,2,3]triazol-2-ium-4-ylidene)ethan-1-olates: One-pot synthesis, photophysics, and biological behavior》, the research content is summarized as follows. This paper reports the one-pot synthesis of a rare type of mesoionic compounds, which are condensed mesoionics. A series of new bicyclic arylthienotriazoliumolates was synthesized by an improved synthetic method. This approach has a large scope of starting materials and was used to obtain diverse structures with outstanding photophys. properties. The pattern of substituents decorating the mesoionic ring was the important factor determining the electronic distributions of the synthesized compounds Pull-pull (A-π-A), push-push (D-π-D), pull-push (A-π-D), and push-pull (D-π-A) systems were designed, synthesized and their absorption, emission, stability, and biol. behavior were studied. Quantum chem. calculations were performed to deepen the knowledge about the absorption and emission properties of these systems and explain their unusual geometries and electronic structures. Confocal microscopy experiments showed that thienotriazoliumolates easily penetrated into living cells and selectively accumulated near the cell membrane, Golgi apparatus, and endoplasmic reticulum.

COA of Formula: C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H6BrNO.

Fang, Xuerong;Li, Jinsi;Zhong, Qianqian;Ming, Xin research published 《 Synthesis and cytostatic activity of emissive 7-thiazolyl-7-deazapurine nucleosides》, the research content is summarized as follows. 7-Functionalized 7-deazapurine fluorescent nucleosides are highly important for biotechnol. applications. Here, 7-substituted 7-deaza-2′-deoxyguanosines, e.g. I, comprising a 4H-cyclopenta[d]thiazole ring are obtained by Hantzsch synthesis reaction of 7-thioamide-7-deaza-2′-deoxyguanosine with aromatic α-bromocarbonyl compounds (61-85%). Their photophys. properties are determined by UV and fluorescence spectroscopy, and the cytostatic activities are evaluated by MTT assay. All compounds exhibit strong solvatochromicity and pH-dependent fluorescence in aqueous solutions, indicating their promising ability to be fluorescent probes. The 7-substituted 7-deaza-2′-deoxyguanosines, e.g. I, exert cytostatic activities, which means they have the potential to be candidate for theranostics.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Product Details of C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Product Details of C9H6BrNO.

Das, Sumit;Singh, Bhagat;Fadikar, Pulak;Barman, Piyali Deb;Paira, Rupankar research published 《 Application of recyclable base-washed graphene oxide for one-pot conversion of 2-aminopyridines into 3-iodo-imidazo[1,2-a]pyridines at room temperature in water》, the research content is summarized as follows. A green synthetic protocol for cyclization of 2-aminopyridines I (R = H, 3-Me, 4-Me, 4-Cl, 4-Br, 5-Cl) with 2-bromoacetophenones R¹C(O)CH₂Br (R¹ = 4-bromophenyl, 3-tert-butylphenyl, naphthalen-2-yl, etc.) to prepare imidazo[1,2-a]pyridines, followed by their successive iodination in one-pot manner to give II (R² = H, 7-Me, 8-Me, 6-Cl, 7-Cl, 7-Br), employing base-washed graphene oxide as the catalyst, in water has been described. The current approach has offered to carry out the reaction in water medium at room temperature and the base-washed graphene oxide catalyst has provided excellent product yield (upto 81%) and can also be recycled effortlessly upto 5 catalytic cycles, through a simple base-wash protocol. The catalyst is an inexpensive, environmentally benign, green, and heterogeneous platform and has been characterized by IR, Raman, SEM and TEM studies.

Product Details of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts