Category: 20099-89-2

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Demirtas, Ilknur;Ertas, Erdal;Topal, Sebahat;Ozturk, Turan research published 《 Electropolymers of 4-(thieno[3,2-b]thiophen-3-yl)benzonitrile extended with thiophene, 3-hexylthiophene and EDOT moieties; their electrochromic applications》, the research content is summarized as follows. Three new π-conjugated 4-(thieno[3,2-b]thiophen-3-yl)benzonitrile based monomers having thiophene, 3-hexylthiophene and EDOT at the peripherals were synthesized. Their electropolymerization produced the corresponding electroactive polymers, P1, P2, and P3, which exhibited electrochromic properties with color developments from red to blue, orange-yellow to pale-blue, and purple to pale-gray, resp. Functional design of the monomers with electron deficient benzonitrile at β-position of thieno[3,2-b]thiophene (TT) and electron-rich thienyl groups at the peripherals influenced the HOMO and LUMO levels and, thereby, reduced the band gap of the conjugated polymers. Considering the band gaps of electropolymerized TT based polymers in the literature, the polymer P3, obtained through electropolymerization, had a comparable band gap of 1.73 eV. Electrochromic devices (ECD) of the new polymers displayed different optical contrasts (ΔT%) of 20% at 507 nm, 25% at 443 nm, and 34% at 579 nm for P1/PProDOP, P2/PProDOP, and P3/PProDOP, resp. Furthermore, they had modest switch times of 1.2-1.7 s for bleaching and 0.9-1.7 s for coloring. The polymers, P3/PProDOP, bearing EDOT moieties, had a reasonable coloration efficiency (CE) of 240 cm²/C at 579 nm, excellent permanent memory effect, and high stability of color switch, retaining 88% of its electroactivity after 500 cycles, switching at the applied voltages of -0.2 and + 1.1 V.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C9H6BrNO.

Deshpande, Anant;Dhawale, Shashikant;Bari, Sanjaykumar;Bonde, Chandrakant research published 《 Design, synthesis and biological investigation of some novel quinazolin-4(3H)-one tethered 1,3,4-thiadiazole-thiol motifs as direct enoyl acyl carrier protein reductase inhibitors》, the research content is summarized as follows. In this study two noteworthy pharmacophores quinazolin-4(3H)-one and 1,3,4-thiadiazole through methylene bridge were utilized to design, synthesize and characterize some novel 2-Me quinazolin-4(3H)-one and 6-chloro-2-Me quinazolin-4(3H)-one tethered S-substituted-1,3,4-thiadiazole-thiol structural analogs resp. as direct Mycobacterium Tuberculosis (MTB) enoyl acyl carrier protein reductase (InhA) inhibitors. Structural analogs of quinazolin-4(3H)-one tethered 1,3,4-thiadiazole-thiol I [R = H, Cl; R¹ = 4-Me, 4-F, 3-NO₂, etc.] through methylene bridge by functional group modifications in core scaffold followed by computational studies to select promising compds was designed. The mol. docking of designed compunds was carried out using schrodinger Glide XP into the active site of MTB InhA with protein data bank code (PDB ID: 2H7M). The interactions were evaluated based on the glide G score compared with reference standard isoniazid. Ten new compounds I were synthesized, characterized and screened for their in-vitro antitubercular activity by Microplate Almar Blue Assay (MABA) method followed by cytotoxicity evaluation of compounds I [R = H ; R¹ = 4-F, 4-OMe] using Vero cell line. All the designed compounds of series I had drug-like characteristics and were non-toxic to normal cells. In the mol. docking studies, compounds I [R = H, Cl; R¹ = 4-F, 4-OMe] demonstrated strong binding affinity in the active region of MTB InhA protein and retained necessary amino acid interaction, similar to co-crystal 2H7M. Synthesized compounds I were found to have good antitubercular activity. Out of the series the compounds I [R = H ; R¹ = 4-F, 4-OMe] were found to possess excellent antitubercular activity equipotent to reference standard streptomycin with min. inhibitory concentration (MIC) value of 6.25μg/mL. The cytotoxic potential of compounds I [R = H ; R¹ = 4-F, 4-OMe] showed remarkable selectivity index against Vero cell line. The findings of this study highlighted the importance of tethering two pharmacophoric motifs in one compound to develop novel antitubercular agents that can be exploited as promising leads as direct InhA inhibitors.

Product Details of C9H6BrNO, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Quality Control of 20099-89-2.

De-Zordo Banliat, Arnaud;Grollier, Kevin;Damond, Aurelie;Billard, Thierry;Dagousset, Guillaume;Magnier, Emmanuel;Pegot, Bruce research published 《 Solvent-free nucleophilic selenocyanation with [bmim][SeCN]. Direct access to perfluoroalkylselenide compounds》, the research content is summarized as follows. Available online-1-n-butyl-3-methylimidazolium selenocyanate ([bmim][SeCN]) proved to be a very efficient reagent for selenocyanation of alkyl halides RBr [R = n-decyl, 6-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)hexyl, 9H-fluoren-9-yl, etc.]. As part of an eco-friendly process, no organic solvents were used during the transformation and reaction times were reduced by using microwave as a heating source. The ionic liquid was carefully recycled in two different ways. Selenocyanate compounds RSeCN were successfully transformed into (trifluoromethyl or polyfluoro)selenides RSeR¹ (R¹ = CF₃, CF₂Br, C₂F₅) in a one-pot two step procedure.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. COA of Formula: C9H6BrNO.

Dhanavath, Ramulu;Dharavath, Ravinder;Kothula, Devender;Bitla, Sampath;Yaku, Gugulothu;Birdaraju, Saritha;Puchakayala, Muralidhar Reddy;Atcha, Krishnam Raju research published 《 Synthesis and biological evaluation of novel 2-arylquinoline-3-fused thiazolo [2,3-c]1,2, 4-triazole heterocycles as potential antiproliferative and antimicrobial agents》, the research content is summarized as follows. A series of novel 2-arylquinoline-3-fused thiazolo[2,3-c]1,2,4-triazole heterocycles I [R = H, Me; R¹ = H, Cl, OMe; R² = H, Me; R³ = H, OMe; R⁴ = H, Cl, OMe, CN] were efficiently synthesized using simple conventional methods in good yields. The structure of newly synthesized mols. was characterized on the basis of their IR, ¹H NMR, ¹³C NMR and mass spectral data. Among compounds I, compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe] exhibited highly significant antiproliferative activity against two cancer cell lines C6 (nerve cells) and MCF-7 (human breast adenocarcinoma cells) when compared with standard reference Doxorubicin. In vitro antimicrobial activities of target compounds compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe], I [R = R² = R³ = H ; R¹ = OMe, R⁴ = Cl] were effectuated on Gram-pos. Staphylococcus aurus (ATCC 25923), Bacillus subtilis (ATCC 6633) and Gram-neg. strains Klebsiella Pneumonia (ATCC 31488) and Escherichia coli (ATCC 25966) strains and found to exhibit promising activity against standard Ciprofloxacin drug. Further, when in vitro antifungal activity was conducted on Aspergillus flavus and Aspergillus niger strains compounds I [R = R² = R³ = H ; R¹ = R⁴ = Cl], I [R = R² = R³ = H, Me; R¹ = R⁴ = OMe], I [R = R¹ = R² = R³ = H; R⁴ = Cl], I [R = R¹ = R² = R³ = H; R⁴ = OMe] were exhibited potent activity when compared with standard Fluconazole drug moiety.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., COA of Formula: C9H6BrNO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Quality Control of 20099-89-2.

Dharavath, Ravinder;Sarasija, M.;Ram Reddy, M.;Naga Prathima, K.;Nagarju, N.;Ramakrishna, K.;Ashok, D.;Daravath, Sreenu research published 《 Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones》, the research content is summarized as follows. A series of (3-methyl-7H-furo[2,3-]chromen-2-yl)(aryl)methanones I (R = 4-F, 4-Cl, 4-CN, etc.) were quickly prepared through easily accessible, short-span progress microwave irradiation and conventional heating methods. Further, the in vitro antiproliferative activities were tested against MCF-7 (human breast adenocarcinoma cells) and C-6 (nerve cells) using the MTT assay. The compounds I (R = 4-F) and I (R = 4-CN) a showed better antiproliferative activity than Cisplatin. Addnl., in vitro antibacterial and antifungal activities were carried out against different bacterial and fungal strains. Compounds I (R = 4-F), I (R = 4-Cl), and I (R = 4-CN) showed a substantial inhibition effect than Ciprofloxacin and Fluconazole standard drugs resp., UV-Visible and fluorescence measurements were conducted to assess the interaction of the compounds with CT-DNA compounds I (R = 4-Cl), I (R = 4-Br) and I (R = 4-CN) showed a stronger DNA binding affinity.

Quality Control of 20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Name: 4-(2-Bromoacetyl)benzonitrile.

Diaconu, Dumitrela;Amariucai-Mantu, Dorina;Mangalagiu, Violeta;Antoci, Vasilichia;Zbancioc, Gheorghita;Mangalagiu, Ionel I. research published 《 Ultrasound assisted synthesis of hybrid quinoline-imidazole derivatives: a green synthetic approach》, the research content is summarized as follows. A green, straightforward and efficient study for obtaining hybrid quinoline-imidazole derivatives under ultrasound (US) irradiation as well as under conventional thermal heating (TH) was presented. The reaction pathway involved only two steps: the N-alkylation of imidazole ring and a Huisgen [3 + 2] dipolar cycloaddition reaction of ylides to di-Me acetylenedicarboxylate. For both types of reactions, a green workup procedure under US irradiation was presented. Under US irradiation, the N-alkylation of nitrogen atoms from the imidazole nucleus had outstanding benefits in terms of reaction time, energy consumption and yields and thereby could be considered an environmentally friendly method. Forty new hybrid quinoline-imidazole compounds were synthesized: 18 salts such as I [R = H, CN, Br, etc.], 8 dihydro-benzopyrrolo imidazolo quinoline II, 9 benzopyrrolo-imidazolo quinoline III and 5 dihydro-pyrroloquinoxaline quinoline cycloadducts IV.

Name: 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Safety of 4-(2-Bromoacetyl)benzonitrile.

Chen, Shu-Jie;Chen, Guo-Shu;Deng, Tao;Li, Jia-Hui;He, Zhi-Qing;Liu, Li-Shan;Ren, Hai;Liu, Yun-Lin research published 《 1,2-Dicarbofunctionalization of Trifluoromethyl Alkenes with Pyridinium Salts via a Cycloaddition/Visible-Light-Enabled Fragmentation Cascade》, the research content is summarized as follows. Although trifluoromethyl alkenes have great synthetic potential, their 1,2-difunctionalization has been a challenge. In this Letter, authors disclose the first 1,2-dicarbofunctionalization of trifluoromethyl alkenes with pyridinium salts via a cascade process involving a base-promoted [3+2] cycloaddition followed by a visible-light-mediated Norrish-type-II fragmentation. This protocol allows for the formation of pyridines bearing a trifluoromethyl-substituted quaternary center in moderate to excellent yields under mild conditions.

Safety of 4-(2-Bromoacetyl)benzonitrile, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Quality Control of 20099-89-2.

Chen, Yan;Shatskiy, Andrey;Liu, Jian-Quan;Karkas, Markus D.;Wang, Xiang-Shan research published 《 Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines》, the research content is summarized as follows. An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates CNCH₂C(O)₂R (R = Me, Et) with pyridinium salts, e.g., 2-(2-oxo-2-phenylethyl)-isoquinolinium bromide is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds, e.g., I. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Quality Control of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Category: nitriles-buliding-blocks.

Choi, Sang-Kee;Lee, Youngjun;Yoon, Sang Eun;Choi, Hongseo;Kim, Jonghoon;Kim, Jong H.;Lee, Sanghee;Kim, Wook;Kim, Eunha research published 《 A tetrazine-fused aggregation induced emission luminogen for bioorthogonal fluorogenic bioprobe》, the research content is summarized as follows. Bioorthogonal fluorogenic probes allow spatiotemporally controlled mol. bioimaging with minimal perturbation of the native cellular environment. Due to favorable kinetics and reaction specificity in a physiol. environment, inverse electron-demand Diels – Alder reaction (iEDDA) for bioorthogonal fluorogenic bioimaging has gained immense attention in scientific field; however, the technique still needs to washout excess trans-cyclooctene labels, thereby reducing the robustness and exptl. convenience. In the present study, we report tetrazine-modified aggregation-induced emission luminogens for bioorthogonal fluorogenic bioimaging. We found that a unique mol. design strategy allowed incorporation of tetrazine on aggregation-induced emission luminogens with excellent fluorogenic properties. Moreover, tetrazine modification of aggregation-induced emission luminogens results in non-radiative decay, which induces fluorescence quenching. The systematic tunability of the emission wavelength of the fluorescent core skeleton allowed successful development of three different colorful fluorogenic tetrazine-fluorophores. Furthermore, an aggregate formation study and computational calculations revealed a synergistic fluorescent quenching effect between intramol. charge transfer and tetrazine-mediated non-radiative decay. The final simple conjugation between triphenylphosphonium and tetrazine-fluorophore enabled successful development of fluorogenic probes for spatiotemporally controlled bioorthogonal bioimaging of mitochondria in live cells with the iEDDA without washing the trans-cyclooctene label and tetrazine-fluorophore.

Category: nitriles-buliding-blocks, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., 20099-89-2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 20099-89-2, formula is C9H6BrNO, Name is 4-(2-Bromoacetyl)benzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Related Products of 20099-89-2.

Bora, Prerona;Manna, Suman;Nair, Mrutyunjay A.;Sathe, Rupali R. M.;Singh, Shubham;Sreyas Adury, Venkata Sai;Gupta, Kavya;Mukherjee, Arnab;Saini, Deepak K.;Kamat, Siddhesh S.;Hazra, Amrita B.;Chakrapani, Harinath research published 《 Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation》, the research content is summarized as follows. Persulfides and polysulfides, collectively known as the sulfane sulfur pool along with hydrogen sulfide (H2S), play a central role in cellular physiol. and disease. Exogenously enhancing these species in cells is an emerging therapeutic paradigm for mitigating oxidative stress and inflammation that are associated with several diseases. In this study, we present a unique approach of using the cell′s own enzyme machinery coupled with an array of artificial substrates to enhance the cellular sulfane sulfur pool. We report the synthesis and validation of artificial/unnatural substrates specific for 3-mercaptopyruvate sulfurtransferase (3-MST), an important enzyme that contributes to sulfur trafficking in cells. We demonstrate that these artificial substrates generate persulfides in vitro as well as mediate sulfur transfer to low mol. weight thiols and to cysteine-containing proteins. A nearly 100-fold difference in the rates of H₂S production for the various substrates is observed supporting the tunability of persulfide generation by the 3-MST enzyme/artificial substrate system. Next, we show that the substrate 1a permeates cells and is selectively turned over by 3-MST to generate 3-MST-persulfide, which protects against reactive oxygen species-induced lethality. Lastly, in a mouse model, 1a is found to significantly mitigate neuroinflammation in the brain tissue. Together, the approach that we have developed allows for the on-demand generation of persulfides in vitro and in vivo using a range of shelf-stable, artificial substrates of 3-MST, while opening up possibilities of harnessing these mols. for therapeutic applications.

20099-89-2, 4-(2-Bromoacetyl)benzonitrile, also known as 2-Bromo-4′ -cyanoacetophenone, is a useful research compound. Its molecular formula is C9H6BrNO and its molecular weight is 224.05 g/mol. The purity is usually 95%.
2-Bromo-4′ -cyanoacetophenone can be synthesized from ethylbenzene via aerobic photooxidation using aqueous HBr.
4-(2-Bromoacetyl)benzonitrile is useful for the irreversible inhibitory activity of Glycogen synthase kinase 3 (GSK-3). Phenylhalomethylketones can be used in the study of novel GSK-3 inhibitors., Related Products of 20099-89-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts