Category: 2032-34-0

Related Products of 2032-34-0, A common heterocyclic compound, 2032-34-0, name is 3,3-Diethoxypropanenitrile, molecular formula is C7H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Method I. A mixture of Py (4.4 ml) and AcOH (3.0 ml) was stirred and treated by the addition of 5-aminoazole1a-h (0.01 mol) and (2E)-(3-morpholin-4-yl)-acrylonitrile (2) (1.38 g, 0.01 mol). The obtained mixture was refluxed at 150C for 5 h. After refluxing, the mixture was cooled. The precipitate that formed was filtered off, washed with a small amount of EtOH, and dried. Method II. A solution (or suspension) of the appropriate aminoazole 1a-h (0.01 mol) in solvent (15 ml) (EtOH in the case of compound 3a, dioxane in the case of compounds 3b-h) was stirred at 50C and treated by adding 3,3-diethoxypropionitrile (4) (1.5 ml, 0.01 mol), then 36% HCl solution (0.86 ml, 0.01 mol). The reaction mixture was refluxed for 2.5-3 h, the suspension (or solution) was cooled to room temperature, and the target product was isolated by the method indicated for each particular compound.

The synthetic route of 2032-34-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gazizov, Denis A.; Fedotov, Victor V.; Gorbunov, Evgeny B.; Ulomskiy, Evgeny N.; Yeltsov, Oleg S.; Rusinov, Gennady L.; Rusinov, Vladimir L.; Chemistry of Heterocyclic Compounds; vol. 55; 6; (2019); p. 573 – 577; Khim. Geterotsikl. Soedin.; vol. 55; 6; (2019); p. 573 – 577,5;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2032-34-0, name is 3,3-Diethoxypropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2032-34-0, 2032-34-0

a) 7-bromoquinoline-3 -carbonitrileA mixture of 3,3-diethoxypropanenitrile (1.801 mL, 12.00 mmol),2-amino-4-bromobenzaldehyde (2 g, 10.00 mmol) and p-toluenesulfonic acid monohydrate (0.380 g, 2.000 mmol) in toluene (30 mL) was heated under reflux using Dean-Starkapparatus for 3 h. The reaction was cooled, evaporated under reduced pressure, and the residue was dissolved in a small amount of DMF, diluted with chloroform, and washed with aq. NaHCO3 solution. The aqueous layer was extracted with chloroform, and the combined extracts were washed with brine, dried (Na2504), and concentrated in vacuo. Purification by flash chromatography (0-3% methanol in dichloromethane) followed by trituration in diethylether provided the title compound (1.75 g, 75%). ?H NMR (400 MHz, DMSO-d6) oe ppm7.95 (dd, J8.72, 1.89 Hz, 1 H) 8.08 (d, J8.84 Hz, 1 H) 8.38 (d, J2.02 Hz, 1 H) 9.13 (d, J1.52 Hz, 1 H) 9.21 (d, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Diethoxypropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE LLC; ADAMS, Nicholas, David; KIESOW, Terence, John; WIGGALL, Kenneth; WO2013/177253; (2013); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

2032-34-0, A common compound: 2032-34-0, name is 3,3-Diethoxypropanenitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 4 Methyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate (a compound of formula I, R=methyl) Trifluoroacetic acid (70 mL) was mixed with water (11 mL, 0.6 mol) at room temperature, and 2-cyanoacetaldehyde diethylacetal (23 mL, 0.15 mol, commercially available) was added thereto. The mixture was reacted for 12 h at room temperature to obtain a solution 1. In addition, the title compound of example 3 (a compound of formula II, i.e. methyl 4-ethoxy-5-acetylamido-2-aminobenzoate) (30 g, 0.12 mol) was suspended in ethyl acetate (400 mL), and the above obtained solution 1 was added thereto. The reaction mixture first turned to clear and then changed to cloudy. After reacted for 3-5 h at room temperature, the reaction was finished. The reaction mixture was filtered, washed with ethyl acetate and dried to give 35 g of the title compound as an offwhite powder with a yield of 96%. 1HNMR (300 MHz, DMSO) delta 1.39 (t, 3H), 2.06 (s, 3H), 3.82 (s, 3H), 4.25 (q, 2H), 5.14 (d, 1H), 7.05 (s, 1H), 8.21 (t, 1H), 8.41 (s, 1H), 9.02 (s, 1H), 10.41 (d, 1H). MS/ESI: 303.9 (M+H), 326.0 (M+Na), 302.0 (M-H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Diethoxypropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.; US2011/263860; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2032-34-0, name is 3,3-Diethoxypropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2032-34-0

General procedure: Add (0.5 g, 2.8 mmol) aldehyde in a stirred mixture of potassium tertiary-butoxide (0.60 g, 4.23 mmol) and 3, 3,-diethoxypropionitrile(0.63 g, 5.64 mmol) in 5 ml THF. Reflux the reaction mixture for overnight at 60 C, add 20 ml water to the solution and the mixture after cooling. It was extracted with diethyl ether. The organic phase was washed with water, sodium bicarbonate and then brine solution androtary evaporated under vacuum to get reddish oil. Then 20 ml of hydrochloric acid solution (1 M) was added and the solution was refluxedffior 1 h, neutralized and extracted with diethyl ether. The combined organic phase was washed with saturated NaOH solution. The product obtained was puriffied by using hexane/ethyl acetate system by column chromatography.3.2. Synthesis of (E)-3-(4-(diethylamino) phenyl)-2-formylacrylonitrile Red crystalline solid. Yield-68%.Melting point-96-98 C1HNMR (500 MHz, CDCl3): delta = 9.47 (s, 1 H), 7.95 (d, J=8.5 Hz,2 H), 7.65 (s, 1 H), 6.71 (d, J=8.5 Hz, 2 H), 3.49 (q, J=7.0 Hz, 4 H),1.26 (t, J=7.0 Hz, 6 H).13CNMR (126 MHz, CDCl3): delta =187.70, 157.64, 152.43, 135.04,118.91, 116.51, 111.47, 103.65, 44.97, 12.53.CHN analysis: Expected: C, 73.66; H, 7.06; N, 12.27; Results: C,73.62, H, 7.05 N, 12.29. Molecular formula: C14H16N2OFT-IR: 1668(C=O stretch), 2218 (C?N stretch), 1474(Ar-C=Cstretch), 1607(C=C stretch)Mass: Calculated 228.1263 for C14H16N2O found 229.1327 (M+1)

The synthetic route of 2032-34-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bhalekar, Sulochana; Avhad, Kiran; Sekar, Nagaiyan; Journal of Photochemistry and Photobiology A: Chemistry; vol. 371; (2019); p. 223 – 237;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2032-34-0, name is 3,3-Diethoxypropanenitrile, A new synthetic method of this compound is introduced below., 2032-34-0

A mixture of 3,3-diethoxypropanenitrile (1.80 mL, 12.00 mmol), 2-amino-4-bromobenzaldehyde (2g, 10.00 mmol) and p-toluenesulfonic acid monohydrate (0.380 g, 2.000 mmol) in toluene (30 mL) was heated under reflux using Dean-Stark apparatusfor 3 h. The reaction was cooled, evaporated under reduced pressure, and the residue was dissolved in a small amount of N,N-dimethylformamide, diluted with chloroform, and washed with aq sodium bicarbonate solution. The aqueous layer was extracted with chloroform, and the combined extracts were washed with brine, dried (Na2504), and concentrated in vacuo. Purification of the residue by flash chromatography (0-3%methanol in dichloromethane) followed by trituration in diethyl ether provided the titlecompound (1.75 g, 75%). 1H NMR (400 MHz, DMSO-d6) delta ppm 7.95 (dd, J=8.72, 1.89Hz, 1H) 8.08 (d, J=8.84 Hz, 1H) 8.38 (d, J=2.02 Hz, 1H) 9.13 (d, J=1.52 Hz, 1H) 9.21(d, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXOSMITHKLINE LLC; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; SQUIRE, Michael, Damien; WO2013/52716; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts