Category: 2042-37-7

Kumar, Sunil; Singh, Sohan; Gadwal, Jitendra; Makar, Parvesh; Joshi, Hemant published an article in 2021. The article was titled 《Regioselective C-H arylation of imidazoles employing macrocyclic palladium(II) complex of organoselenium ligand》, and you may find the article in Journal of Organometallic Chemistry.Recommanded Product: 2-Bromobenzonitrile The information in the text is summarized as follows:

In this report, a new air stable bidentate selenium ligand was synthesized by the reaction of 1,8-bis(2-(chloromethyl)phenoxy)octane with sodium salt of phenylselenol. The reaction of this ligand with Pd(CH3CN)2Cl2 in acetonitrile under reflux conditions resulted in 19-membered ring macrocyclic palladium(II) complex. The structure of ligand precursors, ligand, and macrocyclic palladium(II) complex were authenticated by using 1H, 13C{1H} NMR spectroscopy and elemental anal. The obtained air and moisture stable, thermally robust macrocyclic palladium(II) complex was employed as catalyst for regioselective arylation of 1-methylimidazole and 1,2-dimethylimidazole with a variety of aryl bromides. The mild reaction conditions, exclusive C-5 regioselectivity, excellent yields (∼73-95%), low catalyst loading (1.5 mol%) and functional group tolerance are the advantages of this protocol. Homogeneous nature of catalysis process was confirmed with the help of mercury and triphenylphosphine poisoning tests. The catalyst can be recycled and reused with significant loss (22%) in efficiency. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《A Novel Iron-catalyzed One-pot Synthesis of 3-Amino-1,2,4-triazoles》 were Rohand, Taoufik; Mkpenie, Victor N.; El Haddad, Mohammadine; Marko, Istvan E.. And the article was published in Journal of Heterocyclic Chemistry in 2019. Product Details of 2042-37-7 The author mentioned the following in the article:

A novel one-pot synthesis of 3-amino-1,2,4-triazole developed via iron(III) catalyzed route is reported [e.g., benzonitrile + cyanamide + hydroxylamine hydrochloride → I (81%) in presence of FeCl3, PMe3 and base]. The new method is more efficient, simple, and convenient and presents a concise new strategy for the synthesis of 3-amino-1,2,4-triazole derivatives The iron(III) complex intermediate assisted in the intramol. bond cyclization owing to its Lewis acidity or oxidizing properties. A series of aromatic nitriles bearing different electron-donating and electron-withdrawing groups substituted at para and/or ortho positions were also investigated. The position of the substituents affected the yield of the final compound, with the para-substituted substrates giving relatively higher yields. After reading the article, we found that the author used 2-Bromobenzonitrile(cas: 2042-37-7Product Details of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Product Details of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shi, Xinzhe; Zhang, Jian; Roisnel, Thierry; Soule, Jean-Francois; Doucet, Henri published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Palladium-Catalyzed Direct Diarylation of 2-Benzyl-1,2,3-triazole: a Simple Access to 4-Aryl- or 4,5-Diaryl-2-benzyl-1,2,3-triazoles and Phenanthro[9,10-d][1,2,3]triazoles》.HPLC of Formula: 2042-37-7 The article contains the following contents:

The reactivity of 2-benzyl-1,2,3-triazole in palladium-catalyzed direct arylation was studied. The reaction conditions for the selective synthesis of 2-benzyl-4-aryl-1,2,3-triazoles in moderate to high yields using phosphine-free Pd(OAc)2 catalyst and inexpensive KOAc base have been found. Then, from these 4-aryl-1,2,3-triazoles, the palladium-catalyzed C-H bond functionalization of the C5-position allowed the synthesis of the corresponding 4,5-diarylated 2-benzyl-1,2,3-triazoles. This selective 4,5-diarylation of 2-benzyl-1,2,3-triazole was successfully applied for the straightforward building of the π-extended polycyclic heteroaromatic structures phenanthro[9,10-d][1,2,3]triazoles through Pd-catalyzed C4- and C5-intermol. arylations followed by Pd-catalyzed C-H intramol. arylation. In the experiment, the researchers used 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jaime-Figueroa, Saul; Bond, Michael J.; Vergara, J. Ignacio; Swartzel, Jake C.; Crews, Craig M. published an article in 2021. The article was titled 《Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization》, and you may find the article in Journal of Organic Chemistry.Application of 2042-37-7 The information in the text is summarized as follows:

A novel, facile, and expeditious two-step synthesis of series of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and com. available vinyl boronate followed by platinum-catalyzed nitrile hydrolysis and cyclization was described. In the experimental materials used by the author, we found 2-Bromobenzonitrile(cas: 2042-37-7Application of 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Application of 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Sharma, Brijesh M.; Nikam, Arun V.; Lahore, Santosh; Ahn, Gwang-Noh; Kim, Dong-Pyo published an article in Chemistry – A European Journal. The title of the article was 《Cyanide-Free Cyanation of sp2 and sp-Carbon Atoms by an Oxazole-Based Masked CN Source Using Flow Microreactors》.Name: 2-Bromobenzonitrile The author mentioned the following in the article:

This work reports a cyanide-free continuous-flow process for cyanation of sp2 and sp carbons to synthesize aryl, vinyl and acetylenic nitriles from (5-methyl-2-phenyloxazol-4-yl) boronic acid [OxBA] reagent as a sole source of carbon-bound masked -CN source. Non-toxic and stable OxBA reagent is generated by lithiation-borylation of bromo-oxazole, and the consecutive Suzuki-Miyaura cross-coupling with aryl, vinyl, or acetylenic halides and demasking [4+2]/retro-[4+2] sequence were successfully accomplished to give the desired cyano compounds with reasonably good yields in a four-step flow manner. A unique feature of this cyanation protocol in flow enables to cyanate a variety of sp2 and sp carbons to produce a broad spectrum of aryl acetonitrile. It is envisaged that the OxBA based cyanation would replace existing unstable and toxic approaches as well as non-toxic cyanation using two different sources of “”C”” and “”N”” to incorporate the -CN group. In the experiment, the researchers used many compounds, for example, 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Stacking MFI zeolite structures for improved Sonogashira coupling reactions》 was written by Jia, Xicheng; Jiang, Dahong; Tsang, Daniel C. W.; Choi, Jungkyu; Yip, Alex C. K.. HPLC of Formula: 2042-37-7This research focused onZSM5 stacking support palladium catalyst preparation crystallinity; phenylacetylene bromobenzene palladium catalyst Sonogashira coupling; diphenylacetylene preparation. The article conveys some information:

A zeolite with stacking structure was designed by using hydraulic pressing and programmed temperature calcination synthesis procedures. ZSM-5 type zeolites with particle sizes of approx. 100 nm, 1 μm and 2 μm were used to synthesize stacking ZSM-5 with a size ranging from 45 to 63 μm. The prepared ZSM-5 zeolite stacking structure was used as a support to deposit palladium. The performance of the palladium/stacking ZSM-5 was investigated on Sonogashira coupling reactions. Stacking samples with micro-sized units (1 μm and 2 μm) showed a 200-300% higher turnover number (TON) than their unit counterparts. However, stacking samples with nano-sized units (100 nm) showed decreased TON conversion compared with that of their unit counterparts, probably due to partial destruction of the nano-sized ZSM-5 structure during the stacking synthesis process at high temperature The palladium/stacking ZSM-5 (micro-sized units) also showed better conversion on different bromides and alkynes than that of traditional homogenous catalysts. Moreover, the stacking composites showed good durability by recycling 4 runs without losing significant catalytic activity. The design of the stacking MFI structure exhibited improved catalytic activity, sustainability and hierarchical-resemblance properties. In the part of experimental materials, we found many familiar compounds, such as 2-Bromobenzonitrile(cas: 2042-37-7HPLC of Formula: 2042-37-7)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.HPLC of Formula: 2042-37-7

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tang, Shi; Xu, Zhen-Hua; Liu, Ting; Wang, Shuo-Wen; Yu, Jian; Liu, Jian; Hong, Yu; Chen, Shi-Lu; He, Jin; Li, Jin-Heng published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Radical 1,4-Aryl Migration Enabled Remote Cross-Electrophile Coupling of α-Amino-β-Bromo Acid Esters with Aryl Bromides》.Recommanded Product: 2-Bromobenzonitrile The article contains the following contents:

Here an unprecedented, efficient nickel-catalyzed radical relay was reported for the remote cross-electrophile coupling of β-bromo-α-benzylamino acid esters with aryl bromides via 1,4-aryl migration/arylation cascades. β-Bromo-α-benzylamino acid esters were considered as unique mol. scaffolds allowing for aryl migration reactions, which were conceptually novel variants for the radical Truce-Smiles rearrangement. This reaction enabled the formation of two new C(sp3)-C(sp2) bonds using a bench-stable Ni/bipyridine/Zn system featuring a broad substrate scope and excellent diastereoselectivity, which provided an effective platform for the remote aryl group migration and arylation of amino acid esters via redox-neutral C(sp3)-C(sp2) bond cleavage. Mechanistically, this cascade reaction was accomplished by combining two powerful catalytic cycles consisting of a cross-electrophile coupling and radical 1,4-aryl migration through the generation of C(sp3)-centered radical intermediates from the homolysis of C(sp3)-Br bonds and the switching of the transient alkyl radical into a robust α-aminoalkyl radical. The experimental process involved the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Recommanded Product: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is a precursor to the quinazolinones, a class of drugs used to treat autoimmune diseases and coronary heart disease. This substrate molecule undergoes a palladium-catalyzed coupling reaction to form an aromatic ring. The light emission from this reaction can be seen in the reaction solution.Recommanded Product: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kaloglu, Murat; Slimani, Ichraf; Ozdemir, Namik; Gurbuz, Nevin; Hamdi, Naceur; Ozdemir, Ismail published an article in 2021. The article was titled 《The direct C(sp2)-H functionalization and coupling of aromatic N-heterocycles with (hetero)aryl bromides by [PdX2(imidazolidin-2-ylidene)(Py)] catalysts》, and you may find the article in Journal of Organometallic Chemistry.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

A series of air- and moisture-stable imidazolidin-2-ylidene-based new palladium complexes with the general formula [PdX2(NHC)(Py)] were synthesized (NHC = N-heterocyclic carbene, Py = pyridine, X = Cl or I). The structures of the palladium complexes were characterized by different techniques such as 1H NMR, 13C NMR, FT-IR spectroscopy and elemental anal. The more detailed structural characterization of one of the palladium complex was determined by single-crystal X-ray diffraction study. The catalytic activities of all palladium complexes were tested in the direct arylation of five-membered aromatic N-heterocycles such as 3,5-dimethylisoxazole and 1-methyl-1H-pyrrole-2-carboxaldehyde with (hetero)aryl bromides in presence of 1 mol% catalyst loading at 120°C. Desired products were obtained in moderate to good yields. In addition to this study using 2-Bromobenzonitrile, there are many other studies that have used 2-Bromobenzonitrile(cas: 2042-37-7Category: nitriles-buliding-blocks) was used in this study.

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Wang, Hui; Han, Wangyujing; Noble, Adam; Aggarwal, Varinder K. published an article in Angewandte Chemie, International Edition. The title of the article was 《Dual Nickel/Photoredox-Catalyzed Site-Selective Cross-Coupling of 1,2-Bis-Boronic Esters Enabled by 1,2-Boron Shifts》.Name: 2-Bromobenzonitrile The author mentioned the following in the article:

Site-selective transition-metal-catalyzed mono-deboronative cross-couplings of 1,2-bis-boronic esters are valuable methods for the synthesis of functionalized organoboron compounds However, such cross-couplings are limited to reaction of the sterically less hindered primary boronic ester. Herein, we report a nickel/photoredox-catalyzed mono-deboronative arylation of 1,2-bis-boronic esters that is selective for coupling of the more sterically hindered secondary/tertiary position. This is achieved by taking advantage of a 1,2-boron shift of primary β-boryl radicals to the thermodynamically favored secondary/tertiary radicals, which are subsequently intercepted by the nickel catalyst to enable arylation. The mild conditions are amenable to a broad range of aryl halides to give β-aryl boronic ester products in good yields and with high regioselectivity. This method also allows stereodivergent coupling of cyclic cis-1,2-bis-boronic esters to give trans-substituted products. The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Name: 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) is used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity. It is commonly employed in reactions that require an electron-rich species to carry out nucleophilic substitution (or addition) reactions.Name: 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application In Synthesis of 2-BromobenzonitrileIn 2019 ,《Tin-Catalyzed Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles: Homogeneous and Heterogeneous Procedures》 was published in Advanced Synthesis & Catalysis. The article was written by Chretien, Jean-Mathieu; Kerric, Gaelle; Zammattio, Francoise; Galland, Nicolas; Paris, Michael; Quintard, Jean-Paul; Le Grognec, Erwan. The article contains the following contents:

5-Substituted 1H-tetrazoles were prepared by cycloadditions of nitriles with Me3SiN3 in the presence of Bu3SnOMe or Bu3SnOEt in DMF or di-Bu ether. The mechanism of the cycloaddition was studied; the kinetics and the effect of substituents on the relative rates of aryl nitrile cycloadditions, the structures of transition states for cycloaddition and their free energies using DFT calculations, and the structures of stannylated and silylated intermediates in the cycloadditions were determined Polystyrene-bound tin alkoxides were prepared and used as catalysts for the cycloaddition of aryl nitriles with Me3SiN3 to give tetrazoles; the products were formed with < 10 ppm tin residues in six of nine cases (with tin residues not determined for the remaining three cases). The results came from multiple reactions, including the reaction of 2-Bromobenzonitrile(cas: 2042-37-7Application In Synthesis of 2-Bromobenzonitrile)

2-Bromobenzonitrile(cas: 2042-37-7) belongs to a group of ortho-substituted bromobenzenes that have varying hepatotoxicity effects in the presence of rat liver microsomes in vitro. 2-Bromobenzonitrile is also used as a starting material to synthesize novel benzothiophene derivatives that were found to exhibit antibacterial and antifungal activity.Application In Synthesis of 2-Bromobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts