Category: 3032-92-6

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Name: 4-Ethynylbenzonitrile.

Hulce, Kaitlin R.;Jaishankar, Priyadarshini;Lee, Gregory M.;Bohn, Markus-Frederik;Connelly, Emily J.;Wucherer, Kristin;Ongpipattanakul, Chayanid;Volk, Regan F.;Chuo, Shih-Wei;Arkin, Michelle R.;Renslo, Adam R.;Craik, Charles S. research published 《 Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine》, the research content is summarized as follows. Viruses are responsible for some of the most deadly human diseases, yet available vaccines and antivirals address only a fraction of the potential viral human pathogens. Here, we provide a methodol. for managing human herpesvirus (HHV) infection by covalently inactivating the HHV maturational protease via a conserved, non-catalytic cysteine (C161). Using human cytomegalovirus protease (HCMV Pr) as a model, we screened a library of disulfides to identify mols. that tether to C161 and inhibit proteolysis, then elaborated hits into irreversible HCMV Pr inhibitors that exhibit broad-spectrum inhibition of other HHV Pr homologs. We further developed an optimized tool compound targeted toward HCMV Pr and used an integrative structural biol. and biochem. approach to demonstrate inhibitor stabilization of HCMV Pr homodimerization, exploiting a conformational equilibrium to block proteolysis. Irreversible HCMV Pr inhibition disrupts HCMV infectivity in cells, providing proof of principle for targeting proteolysis via a non-catalytic cysteine to manage viral infection.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Name: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Reference of 3032-92-6.

He, Xin;Kuang, Shuang;Gao, Qian;Xie, YuXin;Ming, Xin research published 《 Bright fluorescent purine analogues as promising probes》, the research content is summarized as follows. Modified bright fluorescent nucleosides that respond to the micro-environment have great potential as probes. A series of novel 8-(phenylethynyl)phenylated 2-amino-2′-deoxyadenosine and 2′-deoxyisoguanosine derivatives have been synthesized by Sonogashira-type coupling reaction and Suzuki reaction. The maximum emission of the new compounds is in the visible region, with strong solvatochromicity and pH-dependent fluorescent properties. Furthermore, some of them exhibit bright fluorescence emissions in various solvents (ε x Φ = 4000-39,000 cm^-1 M^-1). These consequences indicate that purine analogs could respond to the microenvironment and serve as promising fluorescent probes.

Reference of 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. HPLC of Formula: 3032-92-6.

Hou, Zhong-Wei;Li, Laiqiang;Wang, Lei research published 《 Regio- and stereoselective electrochemical selenoalkylation of alkynes with 1,3-dicarbonyl compounds and diselenides》, the research content is summarized as follows. A regio- and stereoselective electrochem. approach for the seleno(monofluoro)alkylation of alkynes with 1,3-dicarbonyl compounds and diselenides has been developed. The electrosynthesis method utilizes C-H substrates as radical precursors and the source of carbon atoms, avoiding dependence on pre-functionalized substrates. A series of selenated alkenes, e.g., I, were prepared with satisfactory outcomes under noble metal-free and oxidizing reagent-free conditions.

HPLC of Formula: 3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile.The prefix cyano- is used interchangeably with the term nitrile in literature. Recommanded Product: 4-Ethynylbenzonitrile.

Hruzd, Mariia;le Poul, Nicolas;Cordier, Marie;Kahlal, Samia;Saillard, Jean-Yves;Achelle, Sylvain;Gauthier, Sebastien;Robin-le Guen, Francoise research published 《 Luminescent cyclometalated alkynylplatinum(II) complexes with 1,3-di(pyrimidin-2-yl)benzene ligands: synthesis, electrochemistry, photophysics and computational studies》, the research content is summarized as follows. In this article, we report on a series of cyclometalated chloro- and alkynyl-platinum(II) complexes [(Pym₂C₆H₂R)PtX] (1–14; Pym = 2-pyrimidinyl-κN; R = H, OMe, CF₃; X = Cl, CCC₆H₄Y, with Y = H, OMe, CN, CHO, NPh₂) bearing various tridentate N-C-N-cyclometalated ligands derived from 1,3-bis(pyrimidin-2-yl)benzene. The X-ray crystal structures of two alkynyl-platinum(II) complexes were determined and other structures were DFT-calculated Electrochem. and DFT-computational studies suggest a ligand-centered reduction on the R¹-substituted N-C-N ligand, whereas oxidation likely occurs either on the Pt-phenylacetylide moiety and/or the cyclometalated ligand. In CH₂Cl₂ solution at room temperature, the complexes show phosphorescent emissions ranging from green to orange, depending on the R¹ and R² substituents on the ligands. In KBr solid state matrix, excluding complexes bearing a trifluoromethyl substituted ligand, all compounds exhibit red emission. The presence of an alkynyl ancillary ligand has limited influence on absorption and emission spectra except in the case of the complex with the strongly electron-donating diphenylamino R² substituent on the alkynyl ligand, for which a significant red-shift was observed The alkynyl Pt(II) complex with OMe groups as both R¹ and R² substituents shows the best emission quantum yield (0.81 in CH₂Cl₂ solution) in this series. The full series of DFT calculated band gaps correlated generally well with the electrochem. and absorption data and reasonably model the impact of the substituents on the electronics of these complexes.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Product Details of C9H5N.

Hu, Guo-Qin;Wang, Cai;Zhao, Fan;Liu, Yao-Wei;Liu, Jing-Hui;Zhao, Bin research published 《 Copper-Catalyzed of Terminal Alkynes with N-Thiosuccinimides to Access Alkynyl Sulfides》, the research content is summarized as follows. Copper-catalyzed thiolation of terminal alkynes with N-thiosuccinimides was developed. The reaction demonstrated an expanded substrate scope and produced various alkynyl sulfides I [R¹ = 4-MeC₆H₄, 4-MeOC(O)C₆H₄, 2-pyridyl, etc.; R² = CH₃, C₆H₅, 4-FC₆H₄, etc.] in moderate to good yields. Gram-scale synthesis and further transformations confirmed the synthetic utility of this methodol. Mechanistic studies revealed that a Cu(I)/Cu(III) catalytic cycle was probably involved in the process of alkynylthiolation.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Product Details of C9H5N

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Application In Synthesis of 3032-92-6.

Hu, Guo-Qin;Yao, Li-Wei;Gui, Shu-Sheng;Geng, Chuang;Zhang, Wen-Yan;Liu, Jing-Hui;Zhao, Bin research published 《 Copper-Catalyzed Cross-Coupling of Arylacetylenes with Bromodifluoroacetamides》, the research content is summarized as follows. A copper-catalyzed radical difluoroalkylation of arylacetylenes with bromodifluoroamides has been developed. The reaction exhibits good functional group tolerance and allows access to a variety of substituted α-alkynyl-α,α-difluoroacetamides in moderate to good yields. The potential for scale-up reaction and products derivatization also makes this method attractive for practical applications. Preliminary mechanistic studies suggest that a radical reaction pathway might be involved in the catalytic system.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Application In Synthesis of 3032-92-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Recommanded Product: 4-Ethynylbenzonitrile.

Hu, Jingcheng;Zeng, Li;Hu, Jiayu;Ma, Rui;Liu, Xue;Jiao, Ying;He, Haoyu;Chen, Siyu;Xu, Zhexi;Wang, Hongfei;Lei, Aiwen research published 《 Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds》, the research content is summarized as follows. Herein, a feasible electrosynthesis method to access 1,4-dicarbonyl compounds such as I [R = Ph, 4-MeC₆H₄, 2-thienyl, etc.; R¹ = Me, OMe, OEt, Oi-Pr; R² = Me; R³ = Me; R²R³ = (CH₂)₃, (CH₂)₄, (CH₂)₅] had been developed from simple alkynes and 1,3-dicarbonyl compounds When the undivided cell was combined with the constant current mode, aryl alkynes containing numerous medicinal motifs with 1,3-dicarbonyl esters or ketones reacted smoothly. External oxidant and catalyst-free conditions conformed to the requirements of green synthesis.

3032-92-6, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., Recommanded Product: 4-Ethynylbenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Category: nitriles-buliding-blocks.

Hua, Hui-Liang;Wang, Guo-Ping;Cheng, Jing-Li;Liang, Yong-Min;Zhao, Jin-Hao research published 《 H₂O₂-Promoted Alkoxyalkylation of Terminal Alkynes Employing Two Strategies with Transition-Metal-Free Conditions》, the research content is summarized as follows. The H₂O₂-promoted alkoxyalkylation of terminal alkynes RC₆H₄CCH [R = H, 2-OMe, 3-F, 4-Et, etc.], 3-ethynyl-pyridine by employing two strategies (thermal/photochem.) was developed, this is the first example of the direct C(sp³)-H functionalization of ethers to prepare 2-vinyl heterocycles I (R¹ = tetrahydrofuran-2-yl, 1,4-dioxan-2-yl, etc.) by using H₂O₂ as the radical initiator and oxidant. Particularly, this transformation could be conducted without expensive photocatalysts or transition metal catalysts under mild conditions.

Category: nitriles-buliding-blocks, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: 4-Ethynylbenzonitrile.

Huang, Qiang;Wang, Wei-Na;Zhu, Shou-Fei research published 《 Iron-Catalyzed Alkylzincation of Terminal Alkynes》, the research content is summarized as follows. Although carbozincation of terminal alkynes is a promising method for the synthesis of alkenylzinc reagents, many challenges, especially the chemo-, regio-, and stereoselectivity, remain to be addressed. The authors herein report an operationally simple, mild method for Fe-catalyzed alkylzincation of terminal alkynes to produce a diverse array of alkenylzinc compounds in high yields with high anti-Markovnikov selectivity and high cis stereoselectivity. Using this method, the authors realized a cis alkylzincation of terminal alkynes, and the method has a wide substrate scope (being suitable for aryl, alkenyl, alkyl, and heteroatom-substituted acetylenes) and good functional group tolerance. Because the C(sp²)-Zn bonds of the products can be readily transformed, the method provides a competitive alternative to traditional methods for the selective synthesis of trisubstituted olefins. The Fe catalyst developed in this study exhibited irreplaceable reactivity in alkyne alkylzincation.

Recommanded Product: 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 3032-92-6, formula is C9H5N, Name is 4-Ethynylbenzonitrile. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Safety of 4-Ethynylbenzonitrile.

Guo, Hongyu;Zhang, Sheng;Li, Yang;Yu, Xiaoqiang;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming research published 《 Palladium-Catalyzed Tail-to-Tail Reductive Dimerization of Terminal Alkynes to 2,3-Dibranched Butadienes》, the research content is summarized as follows. The palladium-catalyzed tail-to-tail reductive dimerization of terminal alkynes was described for the first time. Aromatic terminal alkynes bearing diverse and sensitive functional groups as well as aliphatic terminal alkynes are efficiently transformed to 2,3-dibranched butadienes H₂C(R)CC(R)CH₂ [R = Ph, 2-naphthyl, 2-thienyl, etc.]. The key to achieve a selective tail-to-tail reductive dimerization reaction is to control appropriately the acidity of the reaction solution, which is accomplished by a combined use of pivalic acid and para-toluenesulfonic acid. The tail-to-tail reductive dimerization reaction is proposed to proceed via a cationic alkenyl palladium intermediate under acidic conditions.

Safety of 4-Ethynylbenzonitrile, 4-Ethynylbenzonitrile is a simple benzyl alkyne compound potentially useful as a synthetic fragment and as a test compound for cross-coupling protocols. 4-Ethynylbenzonitrile has been described as a model compound for studying hydrogen bond formation in multifunctional molecules, as it contains four hydrogen bonding sites of which three are π-acceptors.

4-Ethynylbenzonitrile is a useful research compound. Its molecular formula is C9H5N and its molecular weight is 127.14 g/mol. The purity is usually 95%., 3032-92-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts