Category: 31643-49-9

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. HPLC of Formula: 31643-49-9.

Akkoc, Berkay;Samsunlu, Taylan;Isik, Seyma;Ozcesmeci, Mukaddes;Atmaca, Goknur Yasa;Erdogmus, Ali;Serhatli, Muge;Hamuryudan, Esin research published 《 Pegylated metal-free and zinc(II) phthalocyanines: synthesis, photophysicochemical properties and in vitro photodynamic activities against head, neck and colon cancer cell lines》, the research content is summarized as follows. In this study, a series of peripherally and non-peripherally tetra-substituted metal-free and zinc(II) phthalocyanines were successfully prepared in good yields by cyclotetramerization of the phthalonitrile derivative bearing a tetraethylene glycol Me ether group at 3- and 4- positions. All newly synthesized compounds were characterized using spectroscopic methods, such as FT-IR, NMR, mass and UV-Vis spectroscopy. To determine the therapeutic potential of the synthesized phthalocyanines, the effects of the substitution pattern (peripheral and non-peripheral) and central metal atom on the photophysicochem. properties were investigated. When comparing their singlet oxygen generation capabilities (Φ_Δ), metallo-phthalocyanine derivatives with zinc (0.73 for 1b and 0.70 for 2b) showed higher singlet oxygen yield than metal-free derivatives (0.21 for 1a and 0.12 for 2a) in DMSO. The photodynamic therapy activities of the water-soluble phthalocyanines were tested via in vitro studies using the A253, FaDu (head and neck cancer cell lines), and HT29 (colon cancer) cell lines. The strongest photodynamic activity was found in 1b and 2b mols. with a metal core among the four mols. studied. The results suggested that the non-peripherally tetra-substituted 1b mol. was regarded as a suitable photodynamic therapy agent due to its light cytotoxicity and secondary impact induced by ROS production

31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., HPLC of Formula: 31643-49-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Application In Synthesis of 31643-49-9.

Alici, Esma Hande;Bilgicli, Ahmet T.;Tuzun, Burak;Gunsel, Armagan;Arabaci, Gulnur;Nilufer Yarasir, M. research published 《 Alkyl chain modified metalophthalocyanines with enhanced antioxidant-antimicrobial properties by doping Ag⁺ and Pd²⁺ ions》, the research content is summarized as follows. In this study, we report the synthesis and characterization of peripheral alkyl chain-substituted metalophthalocyanines [CuPc (3), ZnPc (4), and CoPc (5)] as optically sensitive substances with antifungal and antibacterial properties. Synthesized compounds were characterized by using common spectroscopic methods such as ¹H NMR, ¹³C NMR, FT-IR, MALDI-TOF, fluorescence, and UV-Vis spectroscopy. Aggregation behaviors of phthalocyanines in the presence of Ag⁺ and Pd²⁺ ions were investigated by UV-Vis and fluorescence spectroscopy. The quenching capacity of Ag⁺ and Pd²⁺ ions for 4 was calculated from the Stern-Volmer equation and was found to be 9.76 x 10⁴ mol/L and 2.86 x 10⁵ mol/L for Pd²⁺ and Ag⁺ ions, resp. The binding stoichiometry (n) and binding constant (K_a) of 4 for Ag⁺and Pd²⁺ions were calculated by the changed Benesi-Hildebrand equation. K_a value of 4 for Ag⁺and Pd²⁺ions are 2.57 x 10⁹M ^– 1 and 1.44 x 10⁸M ^– 1, resp. The binding ratio of 4 for Ag⁺and Pd²⁺ions is 1.83 and 1.68, resp. The morphol. features of phthalocyanine derivatives were examined before and after the Ag⁺or Pd²⁺ions treatment by SEM (SEM). In addition, the antioxidant efficiencies of newly synthesized metalophthalocyanines and their Ag⁺ and Pd²⁺ ion-doped aggregates were evaluated using different methods such as DPPH free radical scavenging, iron ion chelating, and reducing power activities. The chem. and biol. activities of phthalonitrile and its metalophthalocyanines were also evaluated by DFT and mol. docking calculations Finally, the antifungal and antibacterial efficiencies of newly synthesized β-substituted phthalocyanines and their Ag⁺ and Pd²⁺ ion-doped forms were investigated using macrobroth dilution and disk diffusion methods.

Application In Synthesis of 31643-49-9, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 31643-49-9, formula is C8H3N3O2, Name is 4-Nitrophthalonitrile. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Product Details of C8H3N3O2.

Alshahrani, Hassan;Dayo, Abdul Qadeer;Liu, Wen-bin research published 《 Development of chopped glass fiber composites with difunctional benzoxazine and bio-based phthalonitrile copolymer: A study of mechanical and thermomechanical properties》, the research content is summarized as follows. The randomly-oriented glass fibers (GF) reinforced composites with Bisphenol A-amine based benzoxazine (BA-a) and bio-based eugenol-based phthalonitrile (EPN) copolymer were developed by an isothermal compression molding technique. The silane coupling agent-treated GF (TGF) reinforced composites showed much better impact strength as compared to as-received GF reinforced composites. A rise of 95.2 MPa, 5.5GPa, 69.1 MPa, and 2.5GPa in flexural strength, flexural modulus, tensile strength, and Young’s modulus were observed, resp. The DMA results confirmed that the storage modulus (E’) and glass transition temperature (Tg) were gradually increased and the damping factor decreased as the TGF reinforcement was raised from 0 to 40 weight%. E’ and T_g values were 3.09 GPa and 27°C, resp., higher than the recorded values for the neat copolymer. The 40 weight% TGF reinforced poly(BA-a/EPN) composite showed the maximum thermal stability values of 475.4, 507.3°C, and 75.43% for T5, T10, and Yc, resp. The LOI values confirm that the TGF/copolymer composites have self-extinguishing properties.

Product Details of C8H3N3O2, 4-Nitrophthalonitrile, also known as 4-Nitrophthalonitrile, is a useful research compound. Its molecular formula is C8H3N3O2 and its molecular weight is 173.13 g/mol. The purity is usually > 95%.
4-Nitrophthalonitrile is a chemical substance that can be synthesized by the reaction of sodium carbonate with 3,4,5-trimethoxybenzyl alcohol. It can also be prepared using nitro phenol and sodium hydroxide. 4-Nitrophthalonitrile has been shown to have high photochemical activity in the presence of light. The frequency shift of its infrared spectrum is indicative of a nucleophilic addition reaction mechanism. 4-Nitrophthalonitrile has been used as an intermediate for producing other chemicals, such as herbicides and pharmaceuticals., 31643-49-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31643-49-9, name is 4-Nitrophthalonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 31643-49-9

Under inert gas (N2), 4-nitro-o-phthalonitrile (9.2 g), phenol (5.0 g), K2CO3 (7.3 g) and DMSO (40 mL) were added into a flask, and were stirred and reacted at room temperature for 48 hrs., then heated to 60 C. and reacted for 2 his. After cooled down, the reaction mixture was filtered and the resulted yellow solid was dried to obtain 11.6 g of Compound 1.

The synthetic route of 31643-49-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kang, Xinshan; Long, Wei; Zhang, Jianxi; Hu, Yunyan; Wang, Yinxiang; US2015/31721; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31643-49-9, Recommanded Product: 4-Nitrophthalonitrile

Under inert gas (N?), 4~Mtro~o~phth.ak>nitrile (9.2 g), phenol (5.0 g), .2CO3 (7.3 g) and DMSO (40 mL) were added into a flask, and were stirred and reacted at room temperature for 48 hrs., then heated to 60 C and reacted for 2 hrs. After cooled down, the reaction mixture was filtered and the resulted yellow solid was dried to obtain 11.6 g of Compound 1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ZHEJIANG BETA PHARMA INCORPORATION; KANG, Xinshan; LONG, Wei; ZHANG, Jianxi; HU, Yunyan; WANG, Yinxiang; WO2013/13609; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31643-49-9, category: nitriles-buliding-blocks

10 g of 2-mercaptopyridine, 14.2 g of 4-nitrophthalonitrile, and 22.6 g of potassium carbonate were suspended in 250 ml of acetone and heated at reflux temperature for 4 hours. The solution was filtered through a pad of celite and a course glass filter to remove residual solids. The solution was concentrated to a crude residue and purified by column chromatography on silica gel eluting the product with a gradient of 0-10% ethyl acetate in dichloromethane. 6.4 g of product was recovered; 1H NMR (200 Mz, CDCl3) delta=8.49-8.53 (m, 1H), 7.84-7.83 (dd, 1H), 7.76-7.71 (m, 2H), 7.68-7.64 (dd, 1H), 7.40-7.36 (dt, 1H), 7.27-7.20 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitrophthalonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FibroGen, Inc.; US2004/254215; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 500 mL three-neck rounde-bottom flask was added resorcinol (16.52 g, 0.15 mol), 4-nitrophthalonitrile (51.94 g, 0.30 mol) and 180 mL DMSO. During the course of the reaction, the K2CO3 (62.19 g, 0.45 mol) was added in three portions at an interval of 20 min. Then the resulting mixture was heated at 40 C for 12 h under nitrogen. After cooling, the product mixture was poured into water. The light yellow filtrate was collected by suction filtration and washed with large amount of water until the filtrate was neutral. The crude product (42.0 g) was purified by rinsing with CH2Cl2 in Buchner funnel and suction flask, and the filtrate was then dried by evaporation under a vacuum at 80 C for 5 h to remove CH2Cl2. The yellow-white powder was obtained in 68.7 wt% yield (28.9 g), m. p. peak at 183 C (sharp) (DSC) at a heat rate of 10 C/min. FTIR (KBr), 2232 (C?N), 1284 (Ar-O-Ar), 1248 (Ar-O-Ar). 1H NMR (400 MHz, DMSO-d6): 8.14-8.11 (d, 2H; Ar H), 7.92 (s, 2H; Ar H), 7.63-7.53 (m, 3H; Ar H), 7.15-7.12 (m, 3H; Ar H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yuan, Ping; Ji, Suchun; Hu, Jianghuai; Hu, Xueping; Zeng, Ke; Yang, Gang; Polymer; vol. 102; (2016); p. 266 – 280;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Propargyl alcohol (0.26 mL, 4.33 mmol) was added into a stirred mixture of 4-nitrophthalonitrile (0.50 g, 2.89 mmol) and anhydrous potassium carbonate (3.19 g, 23.1 mmol) in DMSO (6 cm3) under an argon atmosphere at room temperature. The mixture was stirred at room temperature for three and a half hour under an argon atmosphere, and then distilled to remove DMSO under reduced pressure. Water (100 cm3) was added to the dried mixture, which was then extracted with DCM. The organic layer was dried over MgSO4, and then the solvent was evaporated under reduced pressure. The residue was purified by column chromatography on silica gel eluting with ethyl acetate/hexane to afford 3 as a solid (0.49 g, 85% chemical yield). 1H NMR (400 MHz, CDCl3) delta: 2.57 (t, J = 2.4 Hz, 1H), 4.75 (d, J = 2.4 Hz, 2H), 7.25 (dd, J = 8.8, J = 2.6 Hz, 1H), 7.31 (d, J = 2.6 Hz, 1H), 7.69 (d, J = 8.8 Hz, 1H). 13C NMR (100 MHz, CDCl3) delta: 56.6, 76.2, 77.8, 108.2, 115.2, 115.5, 117.4, 119.9, 120.2, 135.2, 160.5. Anal. Calc. for C, 72.52; H, 3.32; N, 15.38. Found: C, 71.94; H, 3.42; N, 15.48%.

The synthetic route of 31643-49-9 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 31643-49-9

A mixture of 4-nitro-phthalonitrile (3.46 g, 20 mmol), pyridin-3-ol (1.90 g, 20 mmol), K2CO3 (8.29 g, 60 mmol), and DMF (50 ml) was stirred at ambient temperature overnight. The reaction mixture was then combined with another batch of the same reaction performed on the same scale. Subsequently, the solid components were removed by filtration and the filtrate was concentrated in vacuo. To the residue was added water and the mixture was extracted with EtOAc. The organic phase was then washed with brine, dried, and evaporated in vacuo. The residue was recrystallized from EtOAc/MeOH to give 8.3 g of the title compound; 1H NMR (CDCl3): delta=8.56 to 8.59 (m, 1 H), 8.45 to 8.47 (m, 1 H), 7.76 (d, 1 H), 7.42 to 7.44 (m, 2 H), 7.22 to 7.32 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31643-49-9, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31643-49-9, name is 4-Nitrophthalonitrile, This compound has unique chemical properties. The synthetic route is as follows., category: nitriles-buliding-blocks

General procedure: 4-Nitrophthalonitrile (1mmol) 1, hydroxy compound (2mmol) 2 or 7 and dry potassium carbonate (8mmol) were dissolved in 50mL dry DMSO and stirred at room temperature under nitrogen for 48h. The reaction mixture was poured into 200mL distilled water and stirred for 15min. The crude product was recovered by filtration and washed with water. The residue was recrystallized from methanol/water mixture 1:1 and dried under vacuum.

According to the analysis of related databases, 31643-49-9, the application of this compound in the production field has become more and more popular.