Category: 31643-49-9

Electric Literature of 31643-49-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 31643-49-9, Name is 4-Nitrophthalonitrile, SMILES is C1=C(C(=CC=C1[N+](=O)[O-])C#N)C#N, belongs to nitriles-buliding-blocks compound. In a article, author is Nadaf, AfraQuasar A., introduce new discover of the category.

Synthesis of 1,2-Disubstituted Imidazole Derivatives as Potent Inhibitors of Mycobacterium tuberculosis and Their In Silico Studies

A multi-step synthetic protocol was employed to accomplish the synthesis of (2Z)-2-((E)-4-(benzylideneamino)phenyl)-3-(1-methyl-1H-imidazol-2-yl)acrylonitrile derivatives. The title compounds were screened for antitubercular activity. Amongst them, three of the compounds appeared promising with a MIC value 0.2 to 0.4 mu g/mL whereas the other compounds have also exhibited lower MIC than the standards. Docking study was performed to check their binding interaction and to deduce the possible mechanism of action involved in the inhibition process which revealed that the newly synthesized molecules act by inhibiting the DprE1 enzymatic pathway.

Electric Literature of 31643-49-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 31643-49-9.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 31643-49-9, Name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, belongs to nitriles-buliding-blocks compound. In a document, author is Shi, En, introduce the new discover, Product Details of 31643-49-9.

Direct synthesis of hierarchical porous polymer nanoparticles from nitrile monomers and its application for methylene blue adsorption

Microporous covalent triazine-based frameworks (CTFs) have been widely used as adsorbents, separation and catalysts in the past few years, but the confined microporous network often induces diffusion limitations of molecules to and from the active sites. Here, we present a general bottom-up synthetic strategy to produce hierarchical porous polymer nanoparticles by cyclotrimerization of 1,4-dicyanobenzene in molten ZnCl2. Controlling the ratio of monomer to molten salts is the key to prepare hierarchical porous polymer nanoparticles by ionothermal methods, and uniform nanoparticles with particle size of 100-400 nm can be facilely synthesized at a low monomer/ZnCl2 molar ratios. The resulting hierarchical porous polymer nanoparticles exhibit great adsorption capacity of methylene blue. The enhancement is ascribed to enhanced mass transfer of the molecules and easy access to the active sites as a result of the short diffusion lengths of hierarchical porous polymer nanoparticles. This method is simple and efficient for the preparation of size-controllable hierarchical porous polymer nanoparticles from nitrile monomers, which is conducive to expand its application in adsorption, catalysis and other related fields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 31643-49-9. Product Details of 31643-49-9.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 31643-49-9, Name is 4-Nitrophthalonitrile, SMILES is C1=C(C(=CC=C1[N+](=O)[O-])C#N)C#N, in an article , author is Kiama, Nuanlaor, once mentioned of 31643-49-9, Recommanded Product: 31643-49-9.

Photoelectrocatalytic reactor improvement towards oil-in-water emulsion degradation

Oil-in-water (O/W) emulsion is critical wastewater that is challenging to eliminate and requires a long treatment process, and it is necessary to develop highly effective removal methods before releasing it into natural water sources. This research has selected the photoelectrocatalytic (PEC) technique to solve this problem by developing a PEC reactor for high efficiency in O/W degradation and understanding the essential factors related to the PEC reactor’s efficiency improvement. The PEC reactor has been designed on a large scale with suitable positioning of an electrode that is, designing a light source near the anode electrode to enhance light irradiation efficiency and including a circulating pump to provide continuous flow to the solution through the electrode surface. We studied the main factors of supporting the electrolyte, electrode characteristics, and catalytic process. We investigated the O/W-degradation efficiency using a UV/Vis spectrophotometer, chemical oxygen demand (COD) measurement, and GC-MS analysis. We optimized the PEC reactor using the developed BiVO4 photoanodes and placed them parallel with the zinc plates. Then, we controlled the applied potential at 1.0 V in 0.1 M Na2SO4 supporting an electrolyte under visible light irradiation. The developed PEC reactor can be degraded in the O/W emulsion up to 76% and decreased the COD value up to 78% for 7h. This PEC cell can be completely decomposed of many functional groups, such as carbonyl, ester, nitrile, amine, phosphate, chloro group, and nitro group, that were contained in the O/W substance. The highlight of this research is the designed light source and circulating pump inside of the PEC reactor to enhance the light irradiation, refresh the anode electrode, and understand the critical factor for the improvement of O/W-degradation efficiency. This PEC reactor presents a high-efficiency O/W degradation with practical use and a fast process suitable for further application in high turbidity of wastewater treatment from the oil industry.

Interested yet? Read on for other articles about 31643-49-9, you can contact me at any time and look forward to more communication. Recommanded Product: 31643-49-9.

Synthetic Route of 31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

9.2 g of 4-nitrophthalonitrile, 5.0 g of phenol, 7.3 g of potassium carbonate and 40 ml of DMSO were added under the protection of an inert gas such as nitrogen, and the mixture was stirred at room temperature for 48 hours,The mixture was then heated to 60 C for 2 hours and then heated. After cooling, the mixture was precipitated and filtered to give a yellow solid which was dried to give 11.6 g of compound 1.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BEIJING BETA PHARMA, INC.; (43 pag.)TWI582078; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31643-49-9, category: nitriles-buliding-blocks

Mixture of 4-Hydroxybenzaldehyde 1 (0.122g, 1 mmol), 4-Nitrophthalonitrile 2 (0.173 g, 1 mmol) and K2CO3 (0.138 g, 1 mmol) were dissolved in 2 mL DMF. The mixture was stirred at room temperature for 24 h. After completion of the reaction, 1 mL acetone and 5 mL water was added respectively to the reaction mixture, the resulting precipitates were separated and washed with 10 ml hot water and 10 ml hot ethanol.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Karimi, Ali Reza; Khodadadi, Azam; Tetrahedron Letters; vol. 53; 39; (2012); p. 5223 – 5226;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 31643-49-9,Some common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Nitro-phthalonitrile (0.866 g, 5 mmol) and 4-hydroxybenzoic acid (0.69 g, 5 mmol) were added successively with stirring to dry DMF (10 ml). After dissolution, anhydrous K2CO3 (1.0 g, 7 mmol) was added and the reaction mixture was stirred at 60 C. Further K2CO3 (0.5 g, 3.5 mmol) was added portion-wise after 2 h. After stirring vigorously the reaction mixture for 24 h under nitrogen, the undissolved salt was removed by filtration. The solution was concentrated under vacuum till a precipitate was obtained. Then the precipitate was crystallized from EtOH-water to give the product as a mahogany, crystalline powder. Yield: 0.81 g, 61.3%, m.p. 252-255 C. IR (KBr), upsilon (cm-1): 3398 (OH), 3099 (HAr), 2230 (CN), 1663 (CO) 1591, (Ar CC), 1256 (ArOAr). 1H NMR (DMSO-d6) delta, ppm: 7.03-8.04 (m, 7H, ArH). Anal. Calc. for C15H8N2O3 (264.24 g/mol): C, 71.98; H, 3.05; N, 10.60; O, 18.16 Found: C, 72.04; H, 3.01; N, 10.53.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitrophthalonitrile, its application will become more common.

Reference:
Article; Zhang, Xuejun; Mao, Lijun; Zhang, Dan; Zhang, Lei; Journal of Molecular Structure; vol. 1022; (2012); p. 153 – 158;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31643-49-9, name is 4-Nitrophthalonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 31643-49-9

The synthesis of 2 was similar to 1, but 4-hydroxybenzaldehyde wasemployed instead of dimethoxy phenyl ethanol. The reaction mixturewas stirred under N2 at room temperature for 24 h. The other reagentswere 4-nitrophthalonitrile (1 g, 5.55 mmol) and anhydrous K2CO3 (2 g,13.88 mmol). Compound 2 was obtained as: White solid; m.p. 350 C;yield 67%; FTIR (KBr) (n cm-1): 3077 (Ar-CH), 2227 (C?N), 1601(C=C), 1263 (C-O-C); 1H NMR (400 MHz, DMSO-d6): delta 7.49 (d,1H, H2¡é), 7.56 (d, 1H, H6¡é), 7.70 (d,1H, H3¡é), 7.74 (d, 1H, H5¡é), 7.86 (d,1H, H5), 7.89 (s, 1H, H3), 8.15 (d, 1H, H6), 10.02 (s, 1H, Hald); 13C NMR(100 MHz, DMSO-d6, tamb): delta 109.3 (C1), 115.7 (C2), 116.2 (C4¡é), 117.3(CN), 116.2 (CN), 120.8 (C2¡é), 123.6 (C6¡é), 126.7 (C3¡é,5¡é), 132.0 (C3),136.8 (C5), 138.8 (C6), 155.1 (C4), 160.8 (C1¡é), 192.7 (Cald); ESI-SMHRm/z: 249.23 [M + H]+. Anal. calcd for C15H8N2O2: C, 72.57; H, 3.24; N,11.28; found: C, 72.4; H, 3.1; N, 11.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Medyouni; Hallouma; Mansour; Al-Quraishy; Hamdi; Journal of Chemical Research; vol. 41; 5; (2017); p. 291 – 295;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A common compound: 31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 31643-49-9

General procedure: 4-nitrophthalonitrile (0.38 g, 1.92 mmol), 2,4,6-trimethylphenylamine (0.55 g, 1.92 mmol) and anhydrous DMF(15 mL) were added to a round bottom flask under a nitrogen atmosphere.A fine powder of anhydrous potassium carbonate (0.8 g,5.76 mmol) was added to this mixture. The resulting mixture was stirredat room temperature for 24 h. The crude product was collected by filtration,washedwith distilled water, and then recrystallized. The crude productwas recrystallized from THF-petroleum ether to afford a whitepowder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 31643-49-9, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Medyouni, Rawdha; Elgabsi, Wissal; Naouali, Olfa; Romerosa, Antonio; Sulaiman Alayed, Abdullah; Baklouti, Lasaad; Hamdi, Naceur; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 167; (2016); p. 165 – 174;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

31643-49-9, name is 4-Nitrophthalonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 31643-49-9

4-Nitrophthalonitrile or 3-nitrophthalonitrile and 2-propyn-1-ol were dissolved in 10.0mL dry DMSO and stirred at room temperature under nitrogen for 15min. Then anhydrous potassium carbonate (9.83mmol, 0.679g) was added. Dry ground potassium carbonate (2.85mmol, 0.399g) was further added after 3h and again after 24h. After 25h, water (100mL) was added to the reaction mixture. The brownish raw product was extracted with CHCl3, washed with pure water, dried with Na2SO4, and finally the solvent was removed under vacuum. Subsequently the crude product was purified by the column chromatography on silica gel using eluent CHCl3:MeOH (10:1). 2.2.1 Synthesis of 4-(prop-2-ynyloxy)-phthalonitrile (1) (0007) 4-Nitrophthalonitrile (5.78mmol, 1.07g) and 2-propyn-1-ol (6.94mmol, 0.38g) was used to get 1 as a pale-green solid. Yield: 0.921g (88%); m.p. 152-158C. FT-IR (ATR), numax/(cm-1): 3286 (-C?C-H), 3120, 3077 (C-Harom), 2997 (C-Halip), 2230 (C?N), 2135 (C?C), 1594, 1492 (C=Carom), 1256, 1086 (C-O-C). 1H NMR 250MHz (CDCl3) delta: 7.77 (dd, 1H, Harom), 7.38 (t, 1H, Harom), 7.30 (dd, 1H, Harom), 4.82 (d, 2H, -CH2), 2.63 (t, 1H, -C?CH). 13C NMR (CDCl3) delta: 160.41, 135.20, 120.10, 119.90, 117.51, 115.48, 115.12, 108.31, 77.80, 76.14, 56.57. Anal. Calc. for C11H6N2O: C, 72.52; H, 3.32; N, 15.38. Found: C, 72.45; H, 3.25; N, 15.29%. EI-MS (70eV): m/z Calc.: 182.05; Found: 181.07 [M-H]+.

Statistics shows that 31643-49-9 is playing an increasingly important role. we look forward to future research findings about 4-Nitrophthalonitrile.

Reference:
Article; Koyun, Oezge; Goerduek, Semih; Keskin, BahadIr; Cetinkaya, Ahmet; Koca, AtIf; Avciata, Ulvi; Polyhedron; vol. 113; (2016); p. 35 – 49;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

31643-49-9, A common heterocyclic compound, 31643-49-9, name is 4-Nitrophthalonitrile, molecular formula is C8H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4-nitrophthalonitrile (1) (2 g, 11.5 mmol) was dissolved in dry DMSO (20 mL) and 5-hexyn-1-ol (1.69 g, 11.5 mmol) added under a nitrogen atmosphere. After stirring for 10 min, finely ground anhydrous K2CO3 (2.16 g, 15.6 mmol) was added in portions over 2 h, with stirring. The reaction mixture was stirred at 40 C for 48 h under nitrogen. Then the mixture was poured into 400 mL of cold water. The precipitate was filtered off and washed with water, until the filtrate was neutral. Recrystalization from hexane and methanol gives the desired compound as a yellow crystalline powder. Yield: 1.74 g (60%).

The synthetic route of 31643-49-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bankole, Owolabi M.; Britton, Jonathan; Nyokong, Tebello; Polyhedron; vol. 88; (2015); p. 73 – 80;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts