31938-07-5 Archives - Page 2 of 10 - Nitriles-buliding-blocks

Li, Zheyao’s team published research in Dyes and Pigments in 2020 | CAS: 31938-07-5

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Safety of 2-(3-Bromophenyl)acetonitrile

《Transition-metal-free, meta-selective arene CH direct α-aryl cyanomethylation of naphthalimide using a trifluoromethyl directing group》 was published in Dyes and Pigments in 2020. These research results belong to Li, Zheyao; Rao, Caihui; Chen, Lu; Fu, Chao; Zhu, Tingting; Chen, Xi; Liu, Chuanxiang. Safety of 2-(3-Bromophenyl)acetonitrile The article mentions the following:

A method for introducing a substituted aryl acetonitrile group at the C2 position of naphthalimide using trifluoromethyl as the directing group was reported. The transformation was operationally simple, requires mild conditions and was highly regioselective, without the need for a transition metal catalyst. This work provided a novel route for preparing α-diaryl nitrile derivatives I [R = Ph, 3-BrC6H4, 4-MeOC6H4, etc.]. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Huang, Liping’s team published research in Organic Letters in 2012 | CAS: 31938-07-5

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.Synthetic Route of C8H6BrN

In 2012,Huang, Liping; Liu, Yang; Xie, Fuchun; Hu, Youhong published 《An Organic Molecule Modulated Chemoselective Cyclization of Alkynyl Nitriles Tethered to 2-Alkyl Substituted Chromones with Multireactive Sites》.Organic Letters published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

A small organic mol. phenylacetonitrile promoted chemoselective cyclization of (chromen-3-yl)alkynylnitriles to generate a novel tetracyclic or tricyclic chromone scaffold has been discovered. Importantly, the phenylacetonitrile serves as an anion transfer reagent changing the normal reaction of the substrate. In the experiment, the researchers used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Walczynski, Krzysztof’s team published research in Farmaco in 2000 | CAS: 31938-07-5

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Recommanded Product: 31938-07-5

Recommanded Product: 31938-07-5In 2000 ,《Histamine H1 receptor ligands part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives》 was published in Farmaco. The article was written by Walczynski, Krzysztof; Guryn, Roman; Zuiderveld, Obbe P.; Zhang, Ming-Qiang; Timmerman, Henk. The article contains the following contents:

New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the Ph ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-Me substituents (pA2 < 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5) was used in this study.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

De Gussem, Ewoud’s team published research in ChemPhysChem in 2013 | CAS: 31938-07-5

Recommanded Product: 31938-07-5In 2013 ,《Synthesis of the Natural Product Building Block 5-(3-Bromophenyl)-4-hydroxy-5-methylhexan-2-one and its Chiral Characterization by Using Chiroptical Spectroscopy》 appeared in ChemPhysChem. The author of the article were De Gussem, Ewoud; Cornelus, Jelle; Pieters, Sam; Van den Bossche, Dries; Van der Eycken, Johan; Herrebout, Wouter; Bultinck, Patrick. The article conveys some information:

The absolute configuration of 5-(3-bromophenyl)-4-hydroxy-5-methylhexan-2-one, an intermediate in the synthesis of various natural products, is assigned by using vibrational CD (VCD), electronic CD (ECD), and ORD. Exptl. spectra were compared to d. functional theory (DFT) calculations of the mol. with known configuration. These three techniques independently confirm that the absolute configuration is (S)-5-(3-bromophenyl)-4-hydroxy-5-methylhexan-2-one, thus enabling us to assign the absolute configuration with high reliability. The reliability of the VCD anal. was assessed quant. by using the CompareVOA program. In cases in which the agreement between theory and experiment was very good, a value of 10 cm-1 for the triangular weighting function gave a more-realistic discriminative power between enantiomers than the default value of 20 cm-1. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 31938-07-5)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Jun-Qi’s team published research in Organic Letters in 2022 | CAS: 31938-07-5

Zhang, Jun-Qi; Liu, Jiayue; Hu, Dandan; Song, Jinyu; Zhu, Guorong; Ren, Hongjun published an article in 2022. The article was titled 《Rapid and Simple Access to α-(Hetero)arylacetonitriles from Gem-Difluoroalkenes》, and you may find the article in Organic Letters.Category: nitriles-buliding-blocks The information in the text is summarized as follows:

A scalable cyanation of gem-difluoroalkenes to (hetero)arylacetonitriles derivatives RCH(R1)CN [R = Ph, 4-ClC6H4, 4-NO2C6H4, etc.; R1 = H, Me, 2-ClC6H4, etc.] was developed. This strategy features mild reaction conditions, excellent yields, wide substrate scope and broad functional group tolerance. Significantly, in this reaction, aqueous ammonia offers “”N”” source for the “”CN”” reagent and entirely avoided the use of toxic cyanating regents or metal catalysis. Hence, provided a green and alternative method for the synthesis of arylacetonitriles. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Category: nitriles-buliding-blocks)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Quan-Quan’s team published research in ACS Catalysis in 2021 | CAS: 31938-07-5

Zhou, Quan-Quan; Zou, You-Quan; Kar, Sayan; Diskin-Posner, Yael; Ben-David, Yehoshoa; Milstein, David published an article in 2021. The article was titled 《Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration and α-Deuterated Amide Formation via Metal Ligand Cooperation》, and you may find the article in ACS Catalysis.Related Products of 31938-07-5 The information in the text is summarized as follows:

A simple and efficient system for the hydration and α-deuteration of nitriles to form amides RC(O)NH2 [R = Me, Bn, 4-FC6H4, etc.] and α-deuterated nitriles R1CD2CN [R1 = PhCH2CH2, 3-MeC6H4, 3-pyridyl, etc.] catalyzed by a single pincer complex of the earth-abundant manganese capable of metal-ligand cooperation is reported. The deuteration reaction is selective and tolerates a wide range of functional groups, giving the corresponding amides in moderate to good yields. Changing the solvent from tert-butanol to toluene and using D2O results in formation of α-deuterated nitriles in high selectivity. Moreover, α-deuterated amides can be obtained in one step directly from nitriles and D2O in THF. Preliminary mechanistic studies suggest the transformations contributing toward activation of the nitriles via a metal-ligand cooperative pathway, generating the manganese ketimido and enamido pincer complexes as the key intermediates for further transformations. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Al Otaibi, Ahmed’s team published research in RSC Advances in 2014 | CAS: 31938-07-5

In 2014,Al Otaibi, Ahmed; Gordon, Christopher P.; Gilbert, Jayne; Sakoff, Jennette A.; McCluskey, Adam published 《The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles – cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles》.RSC Advances published the findings.Name: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

The Knoevenagel condensation of a series of substituted Ph acetonitriles with 1H-pyrrole-2-carbaldehyde was examined in seven 1-butyl-3-methylimidazolium based ionic liquids and three protic ionic liquids Of these [BMIM][Br] and [BMIM][OH], with catalytic piperidine, proved most efficient affording 3-substituted-(1H-pyrrol-2-yl)acrylonitriles 3-17 in good to excellent yields (98%) while utilization of the protic ionic liquid Pr ammonium nitrate resulted in reduced yields (0-66%). Screening of the 3-substituted-(1H-pyrrol-2-yl)acrylonitriles analogs 3-17 against a panel of 11 cancer cell lines and one normal cell line allowed the identification of a series of compounds with broad spectrum cytotoxicity, but more interestingly a significant degree of MCF-7 breast cancer cell line specificity was evident with 6 (7 to >25 fold) and 13 (5.7 to >80 fold). Other analogs show high level of efficacy against specific cell lines with 10 showing excellent activity against MCF-7 (GI50 = 1.7 μM) and A431 (GI50 = 2.8 μM) cell lines. The most promising of the compounds identified herein were the 4-CF3 substituted 10 and the 3,4-dichloro substituted 13 with excellent activities against MCF-7 and A431 cell lines. The 3,4-dichloro-13 was a 0.56 μM potent inhibitor of MCF-7 cell growth. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Name: 2-(3-Bromophenyl)acetonitrile)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kienle, Marcel’s team published research in Organic Letters in 2010 | CAS: 31938-07-5

In 2010,Kienle, Marcel; Knochel, Paul published 《i-PrI Acceleration of Negishi Cross-Coupling Reactions》.Organic Letters published the findings.Name: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

The Negishi cross-coupling of arylzinc reagents with various bromoanilines is accelerated by the presence of i-PrI (1 equiv) and furnished the expected biaryls within 5-12 min reaction time at 25 °C. Arylzinc reagents can also be cross-coupled under these conditions with a range of aryl bromides bearing an enolizable ester or acidic benzylic protons. In the part of experimental materials, we found many familiar compounds, such as 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Name: 2-(3-Bromophenyl)acetonitrile)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Chao’s team published research in Bioorganic Chemistry in 2020 | CAS: 31938-07-5

《Design, synthesis and SARs of novel telomerase inhibitors based on BIBR1532》 was written by Liu, Chao; Zhou, Hua; Sheng, Xiao Bao; Liu, Xin Hua; Chen, Fei Hu. SDS of cas: 31938-07-5 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

Telomerase has become one of the new popular targets for the development of anti-tumor drugs. Based on the structural characteristics of the BIBR1532 which has entered the stage of clin. research, six series total of 64 new compounds with diverse structural characteristics were designed and synthesized. The inhibitory activity against SGC-7901, MGC-803, SMMC-7721, A375 and GES cell lines and their telomerase inhibitory activity were tested. Among them, eight compounds showed good activity against cancer cells, among them compounds 56, 57 and 59 also showed low toxicity. Some of them showed excellent telomerase inhibitory activity with IC50 values ranging from 0.62μM to 8.87μM. Based on above, in depth structure-activity relationships were summarized, the compounds by replacing Me group with cyanide and retaining amide moiety had good anti-tumor activity, moderate cytotoxicity, and better telomerase inhibitory activity. The results should be used for reference in BIBR1532-based structural optimization for further development of small mol. telomerase inhibitors. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Krishna, Patoju M.’s team published research in RSC Advances in 2015 | CAS: 31938-07-5

In 2015,Krishna, Patoju M.; Ramachary, Dhevalapally B.; Peesapati, Sruthi published 《Azide-acetonitrile “”click”” reaction triggered by Cs2CO3: the atom-economic, high-yielding synthesis of 5-amino-1,2,3-triazoles》.RSC Advances published the findings.Reference of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

Medicinally important 5-amino-1,2,3-triazoles e.g., I, were synthesized via Cs2CO3-catalyzed azide-acetonitrile [3 + 2]-cycloaddn reactions. Aryl azides and arylacetonitriles were employed in this transformation resulting in excellent yields with high regioselectivity. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Reference of 2-(3-Bromophenyl)acetonitrile)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts