31938-07-5 Archives - Page 3 of 10 - Nitriles-buliding-blocks

Donald, James R.’s team published research in Chemical Science in 2019 | CAS: 31938-07-5

According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Synthetic Route of C8H6BrN

In 2019,Chemical Science included an article by Donald, James R.; Berrell, Sophie L.. Synthetic Route of C8H6BrN. The article was titled 《Radical cyanomethylation via vinyl azide cascade-fragmentation》. The information in the text is summarized as follows:

A novel methodol. for radical cyanomethylation was described. The process was initiated by radical addition to the vinyl azide reagent 3-azido-2-methylbut-3-en-2-ol which triggered a cascade-fragmentation mechanism driven by the loss of dinitrogen and the stabilized 2-hydroxypropyl radical, ultimately effecting cyanomethylation. Cyanomethyl group was efficiently introduced into a range of substrates via trapping of α-carbonyl, heterobenzylic, alkyl, sulfonyl and aryl radicals, generated from a variety of functional groups under both photoredox catalysis and non-catalytic conditions. The value of this approach was exemplified by the late-stage cyanomethylation of pharmaceuticals. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

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Nitrile – Wikipedia,
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Chakraborty, Priyanka’s team published research in ACS Catalysis in 2020 | CAS: 31938-07-5

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione or a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands.SDS of cas: 31938-07-5

《C-Alkylation of Various Carbonucleophiles with Secondary Alcohols under CoIII-Catalysis》 was published in ACS Catalysis in 2020. These research results belong to Chakraborty, Priyanka; Garg, Nidhi; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker. SDS of cas: 31938-07-5 The article mentions the following:

Oxindoles have been successfully α-alkylated under Cp*CoIII catalysis by a vast array of secondary alcs., including cyclic, acyclic, sym., and unsym., to produce C-alkylated oxindoles. This protocol was also extended to the α-alkylation of N,N-di-Me barbituric acid and benzyl cyanides. The kinetic profile and other preliminary mechanistic investigations suggest a first-order reaction rate in oxindoles and catalysts. A plausible catalytic cycle is proposed on the basis of the kinetic profile, of other preliminary mechanistic investigations, and of previous mechanistic studies on similar transformations, whereas d. functional theory calculations provide insight into the nature of the active species. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5SDS of cas: 31938-07-5)

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Robertson, Daniel’s team published research in Inorganic Chemistry in 2005 | CAS: 31938-07-5

In 2005,Robertson, Daniel; Cannon, John F.; Gerasimchuk, Nikolay published 《Double-Stranded Metal-Organic Networks for One-Dimensional Mixed Valence Coordination Polymers》.Inorganic Chemistry published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:

The design of new types of metal-organic networks and the search for unusual crystal architecture represents an important task for modern inorganic and materials chem. research. A group of new monosubstituted phenylcyanoximes, containing F, Cl, and Br atoms at the 2, 3, or 4 positions, were synthesized using the high yield nitrosation reaction with CH3-ONO and were spectroscopically (1H NMR, 13C NMR, UV-visible, IR, mass spectrometry) and structurally characterized. Results of x-ray anal. revealed nonplanar trans-anti geometry for 2-chlorophenyl(oximino)acetonitrile, H(2Cl-PhCO); a nonplanar anti configuration for 4-chlorophenyl(oximino)acetonitrile, H(4Cl-PhCO); and planar cis-syn geometry for 3-fluorophenyl(oximino)acetonitrile, H(3F-PhCO). All arylcyanoximes undergo deprotonation in solutions with the formation of colored anions exhibiting pronounced neg. solvatochromism in polar protic and aprotic solvents. Nine Tl(I) cyanoximates were obtained using the reaction between hot (∼95°) aqueous solutions of Tl2CO3 and solid powdery monohalogenated arylcyanoximes HL. Crystal structures of two Tl(I) cyanoximates [Tl(2Cl-PhCO) and Tl(4Br-PhCO)] contained centrosym. dimeric units (TlL)2 that are connected to a coordination polymer by an O atom of the oxime group of the neighboring mol. Cyanoxime anions act as bridging ligands in both structures where the polymeric motif consists of double-stranded Tl-O chains interconnected with the formation of zigzagging Tl2O2 planar rhombes. Tl atoms form infinite linear arrays with close intermetallic separations The nearest Tl(I)···Tl(I) distances are 3.838 and 4.058 Å in the Tl(2Cl-PhCO) and Tl(4Br-PhCO) structures, resp., close to that in metallic Tl (3.456 Å). Monosubstituted Ph groups are well aligned in π-stacking columns that are perpendicular to the array of Tl(I) atoms and stabilize formed structures. Coordination polyhedrons of Tl(I) in these complexes represent distorted trigonal pyramids with stereoactive lone pair. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5)

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He, Wu’s team published research in Journal of Medicinal Chemistry in 2015 | CAS: 31938-07-5

In 2015,He, Wu; Zhou, Bin; Liu, Weijia; Zhang, Meizi; Shen, Zhenhua; Han, Zhifu; Jiang, Qingwei; Yang, Qinghua; Song, Chuanjun; Wang, Ruiyong; Niu, Tianhui; Han, Shengna; Zhang, Lirong; Wu, Jie; Guo, Feima; Zhao, Renbin; Yu, Wenquan; Chai, Jijie; Chang, Junbiao published 《Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)》.Journal of Medicinal Chemistry published the findings.Product Details of 31938-07-5 The information in the text is summarized as follows:

N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide I is found to be an inhibitor of the fat mass and obesity associated protein (FTO). The crystal structure of human FTO with I reveals a novel binding site for the FTO inhibitor and defines the mol. basis for recognition by FTO of the inhibitor. The identification of the new binding site offers new opportunities for further development of selective and potent inhibitors of FTO, which is expected to provide information concerning novel therapeutic targets for treatment of obesity or obesity-associated diseases. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Product Details of 31938-07-5)

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Gayathri, Parthasarathy’s team published research in CrystEngComm in 2019 | CAS: 31938-07-5

In 2019,CrystEngComm included an article by Gayathri, Parthasarathy; Karthikeyan, Subramanian; Pannipara, Mehboobali; Al-Sehemi, Abdullah G.; Moon, Dohyun; Anthony, Savarimuthu Philip. Related Products of 31938-07-5. The article was titled 《Aggregation-enhanced emissive mechanofluorochromic carbazole-halogen positional isomers: tunable fluorescence via conformational polymorphism and crystallization-induced fluorescence switching》. The information in the text is summarized as follows:

Carbazole-based donor-acceptor derivatives of halogen-substituted positional isomers were synthesized and the effect of the halogen and position on the solid-state fluorescence and mechanofluorochromism was explored. All compounds showed good solid-state fluorescence (Φf = 15.67 to 31.32%). Interestingly, the crystallization of the positional isomers produced concomitant blue and green fluorescent polymorphs and tunable solid-state fluorescence. Solid-state structural anal. revealed a subtle conformational change in the acceptor unit, which led to polymorphism and tunable fluorescence. Halogen substitution induced a higher conformational twist and a large fluorescence shift between the polymorphs. The supramol. interactions (H-bonding, C-H···π and π···π) observed in the crystal lattice rigidified the fluorophores and enhanced the solid-state fluorescence. Computational studies were performed to gain insights into the electronic energy level of the fluorophore and fluorescence modulation. All fluorophores showed mechanofluorochromism (MFC), reversible fluorescence switching, upon crushing and heating. The crushed solids also showed self-reversible fluorescence switching with a longer time. Interestingly, OFF-ON reversible fluorescence switching was also demonstrated by melting and warming/scratching. The powder X-ray diffraction studies supported self-reversible and crystallization-induced fluorescence switching. In the experimental materials used by the author, we found 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Related Products of 31938-07-5)

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Nitrile – Wikipedia,
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Boda, Sakram’s team published research in Synthetic Communications in 2019 | CAS: 31938-07-5

2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) has been used in the synthesis of a series of aminoethylbiphenyls, novel 5-HT7 receptor ligands or 2-(1-cyano-1-(3-bromophenyl))methylidene-3-phenylthiazolidine-4,5-dione.Safety of 2-(3-Bromophenyl)acetonitrile

Safety of 2-(3-Bromophenyl)acetonitrileIn 2019 ,《A conventional and solid-state synthesis, biological activity, and molecular docking studies of 6-arylbenzo[4,5]imidazo[1,2-a] [1,8]naphthyridin-10-ols》 was published in Synthetic Communications. The article was written by Boda, Sakram; Dharavath, Ravi; Madhavaram, Madhavi; Adem, Kurumanna; Palithapu, Madhu; Maloth, Govan; T, Parthasarathy. The article contains the following contents:

An effective, practical, and simple approach toward the preparation of highly-substituted 6-arylbenzo[4, 5]imidazo[1,2-a][1,8]naphthyridin-10-ols I (R = H, 3-NO2, 2-CF3, etc.) by the reaction of 3-aryl-1,8-naphthyridin-2-amines with benzoquinone in acid catalyzed cyclization under solid-state method, as well as conventional conditions, has been described. The products are obtained in good yields and in a solid of high purity. The major advantages of solid states are easy workup, low costs, short reaction time, good efficacy, and environment-friendly procedure. The newly synthesized compounds were thoroughly characterized using spectral data and elemental analyses. All compounds were screened for their biol. evaluation. Predominantly and compounds showed the highest antibacterial activity. Moreover, all the synthesized compounds were docked against topoisomerase II DNA gyrase enzyme. In the experiment, the researchers used many compounds, for example, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)

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Nitrile – Wikipedia,
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Liu, Yang’s team published research in Journal of Organic Chemistry in 2010 | CAS: 31938-07-5

In 2010,Liu, Yang; Huang, Liping; Xie, Fuchun; Hu, Youhong published 《Base-Promoted One-Pot Tandem Reaction of 3-(1-Alkynyl)chromones under Microwave Irradiation to Functionalized Amino-Substituted Xanthones》.Journal of Organic Chemistry published the findings.Synthetic Route of C8H6BrN The information in the text is summarized as follows:

A base-promoted one-pot tandem reaction has been developed from 3-(1-alkynyl)chromones, e.g., I, with various acetonitriles to afford functionalized amino-substituted xanthones, e.g., II, under microwave irradiation This tandem process involves multiple reactions, such as Michael addition/cyclization/1,2-addition, without a transition metal catalyst. This method provides an efficient approach to build up natural product-like diversified amino-substituted xanthone scaffolds rapidly.2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN) was used in this study.

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Nitrile – Wikipedia,
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Sonyanaik, Banoth’s team published research in Heterocyclic Letters in 2017 | CAS: 31938-07-5

In 2017,Sonyanaik, Banoth; Sakram, Boda published 《Design and synthesis of novel substituted 1,8-naphthyridin-2-yl-amide derivatives at ambient temperature and evaluation of their antimicrobial activity》.Heterocyclic Letters published the findings.Application In Synthesis of 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

A new series of substituted 1,8-naphthyridin-2-yl-amide derivatives I (R1 = H, 3-NO2, 4-Br, etc.; R2 = H, 4-Cl) have been successfully synthesized in good yields at ambient temperature by reaction of various substituted 3-phenyl-1,8-naphthyridin-2-amines with aryl benzoic acids. All the newly synthesized compounds were evaluated for their in vitro antimicrobial activity. All these compounds exhibit good antibacterial and excellent antifungal activity. Among them, compound I (R1 = H, 4-Br, 4-NO2; R2 = 4-Cl) showed remarkable inhibition of antimicrobial activity. The results came from multiple reactions, including the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Application In Synthesis of 2-(3-Bromophenyl)acetonitrile)

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Nitrile – Wikipedia,
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Xu, Xuezhao’s team published research in Organic Chemistry Frontiers in 2017 | CAS: 31938-07-5

In 2017,Xu, Xuezhao; Li, Bingnan; Zhao, Yingwei; Song, Qiuling published 《Aerobic oxidative decyanation-amidation of arylacetonitriles with urea as a nitrogen source》.Organic Chemistry Frontiers published the findings.Recommanded Product: 2-(3-Bromophenyl)acetonitrile The information in the text is summarized as follows:

An iron-catalyzed aerobic oxidative amidation reaction of the inert C-CN bond of aryl acetonitriles to afford aryl amides ArCONH2 (Ar = C6H5, 3-CH3OC6H4, 4-FC6H4, etc.) has been developed. Urea is used as an efficient and convenient nitrogen source. This reaction provides practical access toward amide synthesis. The experimental process involved the reaction of 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Recommanded Product: 2-(3-Bromophenyl)acetonitrile)

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Nitrile – Wikipedia,
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Gayathri, Parthasarathy’s team published research in ChemistrySelect in 2019 | CAS: 31938-07-5

The author of 《Halogen Atom and Position Dependent Strong Enhancement of Solid-State Fluorescence and Stimuli Responsive Reversible Fluorescence Switching》 were Gayathri, Parthasarathy; Karthikeyan, Subramanian; Moon, Dohyun; Anthony, Savarimuthu Philip. And the article was published in ChemistrySelect in 2019. Synthetic Route of C8H6BrN The author mentioned the following in the article:

Halogen (F, Cl and Br) substituted triphenylamine (TPA)-phenylacetonitrile donor-acceptor aggregation enhanced emissive (AEE) compounds have been synthesized and investigated halogen atom and substitution position dependent solid-state fluorescence. Interestingly, para position substituted compounds exhibited stronger fluorescence compared to meta position substituted compounds Further, strong enhancement of fluorescence efficiency was observed with increase of at. size from H to Br (Φf=11.81 to 33.05%). Solid state structural studies revealed formation of halogen-H and halogen-π interactions in the crystal lattice that rigidified the fluorophores and enhanced the fluorescence. Computational studies have been performed to get insight on the fluorescence efficiency modulation by halogen. Integration of propeller shaped TPA lead to external stimuli induced reversible/self-reversible fluorescence switching. PXRD studies confirmed self-recovering of crystalline state after crushing. Fluorescent PMMA polymer thin films of halogen derivatives showed off-on fluorescence switching upon exposure of acid and base/heating. Thus, the present studies indicate that halogen could be employed for strongly enhancing fluorescence efficiency of organic compounds that might be of potential interest for optoelectronic device application. In the part of experimental materials, we found many familiar compounds, such as 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Synthetic Route of C8H6BrN)

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts