Category: 3336-34-3

Moreland, D. E. published the artcileComparative effects of dichlobenil and its phenolic alteration products on photo- and oxidative phosphorylation, Name: 2,6-Dichloro-3-hydroxybenzonitrile, the publication is Pesticide Biochemistry and Physiology (1974), 4(3), 356-64, database is CAplus.

The effects of dichlobenil (2,6-dichlorobenzonitrile)(I) [1194-65-6] and its phenolic degradation products, 2,6-dichloro-3-hydroxybenzonitrile (II) [3336-34-3] and 2,6-dichloro-4-hydroxybenzonitrile (III) [3336-19-4] on electron transport and phosphorylation were studied in isolated spinach (Spinacia oleracea) chloroplasts and mung bean (Phaseolus aureus) mitochondria. II and III inhibited photoreduction, coupled phosphorylation, and cyclic phosphorylation in chloroplasts and acted as uncouplers of oxidative phosphorylation in mitochondria. II and III also decreased ATP in mung bean hypocotyls. In all assays only limited inhibition was caused by I, even at relatively high concentrations (1.0 mM).

Pesticide Biochemistry and Physiology published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Name: 2,6-Dichloro-3-hydroxybenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Carpenter, K. published the artcileHerbicidal activity of halogenohydroxybenzonitriles, SDS of cas: 3336-34-3, the publication is Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent (1964), 29(3), 644-54, database is CAplus.

The activities of analogs of ioxynil (4-hydroxy-3,5-diiodobenzonitrile) (I) were compared in greenhouse experiments I applied in amounts of 0.25 kg./ha. to the leaves of seedlings, kills weed spp. belonging to the Compositae, Cruciferae, Chenopodiaceae, Polygonaceae, and Caryophyllaceae families. Replacement of one or both of the iodine atoms in I by Cl or Br influences the herbicidal spectrum, but not the general level of herbicidal activity as determined in the greenhouse. However, the number of halogens introduced and their positions in the nucleus are both critical, since the peak of activity occurs with dihalogenation in the 3- and 5-positions. Conversion of the CN group into either a CONH₂ or COOH group and changes in the position of the OH group are all detrimental to activity. Acetylation of the OH group results in no loss of activity, but methylation causes some reduction in the herbicidal activity.

Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, SDS of cas: 3336-34-3.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Carpenter, K. published the artcileHerbicidal activity of halo hydroxybenzonitriles, Name: 2,6-Dichloro-3-hydroxybenzonitrile, the publication is Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent (1964), 29(3), 644-54, database is CAplus.

The activity of 37 specified analogs of the new herbicide ioxynil (4-hydroxy-3,5-diiodobenzonitrile) are compared in greenhouse screening experiments Ioxynil, applied to the leaves of seedlings, kills weed species belonging to the Compositae, Cruciferae, Chenopodiaceae, Polygonaceae, and Caryophyllaceae families. Replacement of one or both of the I atoms in ioxynil by Cl or Br influences the herbicidal spectrum but not the general level of herbicidal activity. However, the number of halogens introduced and their positions in the nucleus are both critical, since the peak of activity occurs with dihalogenation in the 3 and 5 positions. Conversion of the nitrile group into either the amide or carboxyl group and changes in the position of the hydroxyl group are all detrimental to activity. Acetylation of the hydroxyl group results in no loss of activity, but methylation causes some reduction of the herbicidal activity.

Mededelingen van de Landbouwhogeschool en de Opzoekingsstations van de Staat te Gent published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Name: 2,6-Dichloro-3-hydroxybenzonitrile.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts

Davison, K. L. published the artcileIntermediary metabolism of 2,6-dichlorobenzonitrile (dichlobenil) in chickens and growth of chickens fed dichlobenil, Product Details of C7H3Cl2NO, the publication is Xenobiotica (1988), 18(8), 941-8, database is CAplus and MEDLINE.

Ten ¹⁴C-labeled metabolites were isolated from either bile (6 metabolites) or urine (7 metabolites) from chickens given single oral doses of 2,6-dichlorobenzo[¹⁴C]nitrile ([¹⁴C]dichlobenil). 2-(S-Glutathionyl)-3-hydroxy-6-chlorobenzo[¹⁴C]nitrile perfused through chicken kidneys in situ was excreted in urine from the perfused kidney (44% dose) as 2-mercapto-3-hydroxy-6-chlorobenzonitrile. Dichlobenil was fed at 0, 75, 150, or 225 ppm in the diet to broiler and laying strains of cockerels to determine biol. activity. Feed consumption and growth were not affected, but liver and kidney weights were higher in chicks fed the dichlobenil. The percentage of lipid or nitrogen in the livers and kidneys from chicks fed dichlobenil did not differ from controls and histol. or ultrastructural changes were not observed in these tissues.

Xenobiotica published new progress about 3336-34-3. 3336-34-3 belongs to nitriles-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene,Phenol, name is 2,6-Dichloro-3-hydroxybenzonitrile, and the molecular formula is C7H3Cl2NO, Product Details of C7H3Cl2NO.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts