Category: 4556-23-4

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4556-23-4, is researched, SMILESS is SC1=CC=NC=C1, Molecular C5H5NSJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Desulfonative Suzuki-Miyaura Coupling of Sulfonyl Fluorides, Author is Chatelain, Paul; Muller, Cyprien; Sau, Abhijit; Brykczynska, Daria; Bahadori, Maryam; Rowley, Christopher N.; Moran, Joseph, the main research direction is sulfonyl fluoride desulfonative Suzuki Miyaura coupling palladium; SuFEx; cross-coupling; heterocycles; palladium; reaction mechanisms.Safety of Pyridine-4-thiol.

Sulfonyl fluorides have emerged as powerful “”click”” electrophiles to access sulfonylated derivatives Yet, they are relatively inert towards C-C bond forming transformations, notably under transition-metal catalysis. Here, authors describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki-Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogs of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S-Nu and C-C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C-S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Chemical Modifications of Gold Surfaces with Basic Groups and a Fluorescent Nanoparticle Adhesion Assay To Determine Their Surface pKa, published in 2019-06-04, which mentions a compound: 4556-23-4, Name is Pyridine-4-thiol, Molecular C5H5NS, Category: nitriles-buliding-blocks.

Purpose For pharmaceutical, biol. and biomedical applications the functionalization of gold surfaces with pH-sensitive groups has great potential. The aim of this work was to modify gold surfaces with pH-sensitive groups and to determine the pKa of the modified gold surfaces using a fluorescent nanoparticle adhesion assay. Methods To introduce pH-sensitive groups onto gold surfaces, we modified gold-coated silicon slides with four different bases: 4-mercaptopyridine (4-MP), 4-pyridylethylmercaptan (4-PEM), 4-aminothiophenol (4-ATP), and 2-mercaptoethylamine (2-MEA). To screen whether the modifications were successful, the binding of neg. charged fluorescently-labeled nanoparticles to the pos. charged surfaces was visualized by fluorescence microscopy and at. force microscopy. Next, the pKa of the modified surfaces was determined by quantifying the pH-dependent adhesion of the fluorescently-labeled nanoparticles with fluorescence spectroscopy. Results Fluorescence microscopy showed that the gold surfaces were successfully modified with the four different basic mols. Moreover, fluorescence spectroscopy revealed that fluorescently-labeled neg. charged nanoparticles bound onto gold surfaces that were modified with one of the four bases in a pH-dependent manner. By quantifying the adsorption of neg. charged fluorescently-labeled nanoparticles onto the functionalized gold surfaces and using the Henderson-Hasselbalch equation, the pKa of these surfaces was determined to be 3.7 ± 0.1 (4-MP), 5.0 ± 0.1 (4-PEM), 5.4 ± 0.1 (4-ATP), and 7.4 ± 0.3 (2-MEA). Conclusion We successfully functionalized gold surfaces with four different basic mols., yielding modified surfaces with different pKa values as determined with a fluorescent nanoparticle adhesion assay.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Revealing Mitochondrial Microenvironmental Evolution Triggered by Photodynamic Therapy, the main research direction is mitochondrial microenvironment cancer photodynamic therapy nanosensor sequence.Formula: C5H5NS.

Mitochondrion is one of the most important organelles and becomes a target in many cancer therapeutic strategies. Mitochondrial microenvironments in response to therapeutic methods are the key to understand therapeutic mechanisms. However, they are almost rarely studied. Herein, the mitochondrial microenvironments, including mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) after different photodynamic therapy (PDT) dosages, were monitored by fluorescent imaging and compared among three cell lines (HepG2, MCF-7, and LO2). Furthermore, the fluctuations of intramitochondrial pHs were revealed via a plasmonic mitochondrion-targeting surface-enhanced Raman scattering (SERS) pH nanosensor. Results indicate that the MMP decreases gradually with the ROS generation and the cancerous cells exhibit less response to excess ROS relative to normal cells. On the other hand, the pH value in the mitochondria decreases initially and then increases when the amount of ROS increases. The LO2 cell is preliminarily evidenced to have a higher self-adjustment ability due to its better tolerance to differential intra/extracellular pHs. This study may provide a basis for an in-depth understanding of the mechanisms of the mitochondrial targeting-based PDT therapeutic processes. It is also helpful for more accurate and useful diagnosis according to intramitochondrial microenvironments and improvement on therapy efficiency of cancers.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.Category: catalysis-chemistry. The article 《Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes》 in relation to this compound, is published in Analytical Chemistry (Washington, DC, United States). Let’s take a look at the latest research on this compound (cas:4556-23-4).

Intracellular pH is an important parameter that is highly associated with diverse physiol. processes. The reliable measurement of pH values inside cells remains a formidable challenge because of the complexity of cytoplasm. Herein, we report a robust Prussian blue (PB)-caged pH-responsive surface-enhanced Raman scattering (SERS) probe for precisely mapping the dynamic pH values in live cells. The PB shell has a subnanoscale porous structure that allows only very small biospecies such as H+ or OH- to pass freely through the shell and react with the encased pH-responsive SERS probe, while phys. resisting the entry of large biomols. This probe achieved unmatched detection linearity (R2 > 0.999) for pH measurements in diverse complex biol. samples. Moreover, the nitrile (CN) in PB shows a sharp band in the cellular Raman-silent region, which serves as a background-free internal standard for accurate profiling of the probe distribution inside the cells. We applied the proposed probe to monitor the dynamic pH changes during cellular autophagy induced by different stimuli and thereby demonstrated that the PB-caged probe can reliably quantify subtle intracellular pH variations, providing an effective tool for revealing the relationship between abnormal intracellular pH and cellular functions.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-4-thiol(SMILESS: SC1=CC=NC=C1,cas:4556-23-4) is researched.Related Products of 178396-31-1. The article 《Hybrid octahedral Au nanocrystals and Ag nanohole arrays as substrates for highly sensitive and reproducible surface-enhanced Raman scattering》 in relation to this compound, is published in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices. Let’s take a look at the latest research on this compound (cas:4556-23-4).

Surface enhanced Raman scattering (SERS) substrates with excellent enhancement and reproducibility have seen continuous research in recent years. Herein, we report a high performance hybrid SERS substrate which is composed of octahedral Au nanocrystals (AuNCs) and Ag nanohole (AgNH) arrays to achieve both high enhancement and reproducibility. The octahedral AuNCs were prepared by controllable chem. synthesis and the AgNHs over 5 × 5 mm2 in area were fabricated by a surface plasmon lithog. (SPL) technique. The hybrid structure was prepared by self-assembly of the colloidal AuNCs onto the AgNHs. The SERS substrate shows an enhancement factor (EF) of 3.6 × 106, which is much higher than that of either the AuNCs or AgNHs. The high SERS enhancement is ascribed to the high-d. hotspots with a 3-dimensional (3D) distribution and the effect of plasmonic coupling from these hybrid structures. In addition, the substrate shows excellent reproducibility and stability. The relative standard deviation (RSD) is less than 7% and the SERS intensity only decreases by 32% after 100 days of exposure to air. It is expected that the designed hybrid structure of AuNCs and AgNHs with excellent SERS performance is a potential candidate for applications, such as in food safety, disease diagnosis, environmental monitoring and other practical trace detection.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Base-Activated Latent Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Catalyzed Cross-Coupling Reactions.Electric Literature of C5H5NS.

Heteroaromatic sulfinates, e.g., I, are effective nucleophilic reagents in Pd(0)-catalyzed cross-coupling reactions with aryl halides e.g., 4-methoxy-bromobenzene. However, metal sulfinate salts can be challenging to purify and solubilize in reaction media, and are not tolerant to multi-step transformations. Here base-activated, latent sulfinate reagents: β-nitrile and β-ester sulfones were introduced. It was shown that, under the cross-coupling conditions, these species generate the sulfinate salt in situ, which then undergo efficient palladium-catalyzed desulfinative cross-coupling with (hetero)aryl bromides to deliver a broad range of biaryls, e.g., II. These latent sulfinate reagents have proven to be stable through multi-step substrate elaboration, and amenable to scale-up.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Pyridine-4-thiol( cas:4556-23-4 ) is researched.Category: nitriles-buliding-blocks.Guo, Huiyuan; Huang, Qishen; Leng, Weinan; Zhan, Ying; Behkam, Bahareh; Willner, Marjorie R.; Wei, Haoran; Marr, Linsey C.; Vikesland, Peter J. published the article 《Bromide ion-functionalized nanoprobes for sensitive and reliable pH measurement by surface-enhanced Raman spectroscopy》 about this compound( cas:4556-23-4 ) in Analyst (Cambridge, United Kingdom). Keywords: bromide ion functionalized nanoprobe pH surface enhanced Raman spectroscopy. Let’s learn more about this compound (cas:4556-23-4).

4-Mercaptopyridine (4-Mpy) is a pH reporter mol. commonly used to functionalize nanoprobes for surface-enhanced Raman spectroscopy (SERS) based pH measurements. However, nanoprobes functionalized by 4-Mpy alone have low pH sensitivity and are subject to interference by halide ions in sample media. To improve nanoprobe pH sensitivity and reliability, we functionalized gold nanoparticles (AuNPs) with both 4-Mpy and bromide ion (Br-). Br- electrostatically stabilizes protonated 4-Mpy, thus enabling sensitive SERS detection of the protonation state of 4-Mpy as a function of pH while also reducing variability caused by external halide ions. Through optimization of the functionalization parameters, including suspension pH, [4-Mpy], and [Br-], the developed nanoprobes enable monitoring of pH from 2.1 to 10 with high SERS activity and minimal interference from halide ions within the sample matrix. As a proof of concept, we were able to track nanoprobe location and image the pH distribution inside individual cancer cells. This study provides a novel way to engineer reliable 4-Mpy-functionalized SERS nanoprobes for the sensitive anal. of spatially localized pH features in halide ion-containing microenvironments.

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Computed Properties of C5H5NS. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Tuning single-molecule conductance in metalloporphyrin-based wires via supramolecular interactions. Author is Aragones, Albert C.; Martin-Rodriguez, Alejandro; Aravena, Daniel; Puigmarti-Luis, Josep; Amabilino, David B.; Aliaga-Alcalde, Nuria; Gonzalez-Campo, Arantzazu; Ruiz, Eliseo; Diez-Perez, Ismael.

Nature has developed supramol. constructs to deliver outstanding charge-transport capabilities using metalloporphyrin-based supramol. arrays. Herein we incorporate simple, naturally inspired supramol. interactions via the axial complexation of metalloporphyrins into the formation of a single-mol. wire in a nanoscale gap. Small structural changes in the axial coordinating linkers result in dramatic changes in the transport properties of the metalloporphyrin-based wire. The increased flexibility of a pyridine-4-yl-methanethiol ligand due to an extra Me group, as compared to a more rigid 4-pyridinethiol linker, allows the pyridine-4-yl-methanethiol ligand to adopt an unexpected highly conductive stacked structure between the two junction electrodes and the metalloporphyrin ring. DFT calculations reveal a mol. junction structure composed of a shifted stack of the two pyridinic linkers and the metalloporphyrin ring. In contrast, the more rigid 4-mercaptopyridine ligand presents a more classical lifted octahedral coordination of the metalloporphyrin metal center, leading to a longer electron pathway of lower conductance. This works opens to supramol. electronics, a concept already exploited in natural organisms.

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Application of 4556-23-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Pyridine-4-thiol, is researched, Molecular C5H5NS, CAS is 4556-23-4, about Aerobic Cross-Dehydrogenative Coupling Reactions for Selective Mono- and Dithiolation of Phenols. Author is Han, Dong-Yang; Liu, Xiao-Peng; Li, Ruo-Pu; Xu, Da-Zhen.

A highly efficient strategy for the direct thiolation of phenols, e.g., 1-pyrenol under transition metal-free and solvent-free conditions has been developed. These reactions are operationally simple with employing air (mol. oxygen) as an ideal oxidant and can selectively provide mono- and dithiolation products, e.g., I in good to excellent yields under basic conditions. The reaction tolerates a broad range of aryl thiols RSH (R = Ph, 2-naphthyl, pyridin-4-yl, etc.) and arenes and is especially applicable for large-scale synthesis.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4556-23-4, is researched, Molecular C5H5NS, about Distinguishing Enantiomers by Tip-Enhanced Raman Scattering: Chemically Modified Silver Tip with an Asymmetric Atomic Arrangement, the main research direction is distinguishing enantiomer tip enhanced raman scattering modified silver tip; Raman spectroscopy; charge transfer; chirality; hydrogen bonding; silver.Product Details of 4556-23-4.

Discrimination between enantiomers is achieved by tip-enhanced Raman scattering (TERS) using a silver tip that is chem. modified by an achiral para-mercaptopyridine (pMPY) probe mol. Differences in the relative intensities of the pMPY spectra were monitored for three pairs of enantiomers containing hydroxy (-OH) and/or amino (-NH2) groups. The N: or N+-H functionality of the pMPY-modified tip participates in hydrogen-bond interactions with a particular mol. orientation of each chiral isomer. The asym. arrangement of silver atoms at the apex of the tip induces an asym. elec. field, which causes the tip to become a chiral center. Differences in the charge-transfer (CT) states of the metal-achiral probe system in conjunction with the asym. elec. field produce different enhancements in the Raman signals of the two enantiomers. The near-field effect of the asym. elec. field, which depends on the number of analyte functional groups capable of hydrogen-bond formation, improves the degree of discrimination.

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