Category: 4592-94-3

Adding a certain compound to certain chemical reactions, such as: 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4592-94-3, Quality Control of 3-(4-Bromophenyl)-3-oxopropanenitrile

General procedure: A mixture of 1,2-bis(bromomethyl)benzene (1.0 mmol), alpha-cyanoacetophenone (1.0 mmol) and Cs2CO3 (3.0 mmol) in DMSO (5 mL) was stirred at 80 C for 4 h till almost full conversion of the substrates by TLC analysis. The resulting mixture was dropped into 100 mL 1 M HCl (aq) and extracted with EtOAc three times (3×50 mL). The organic extract was dried with Na2SO4, filtered and concentrated. The crude product was purified by column chromatography on silica gel (eluent: petroleum ether/EtOAc=50/1) to afford the product 3aa as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Wang, Jungang; Xiang, Jiachen; Wang, Miao; Guan, Jie; Wu, Anxin; Tetrahedron; vol. 70; 7; (2014); p. 1412 – 1417;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4592-94-3, COA of Formula: C9H6BrNO

Example 36 Preparation of 3-(4-bromophenyl)-3-hydroxypropanenitrile A suspension of 4-bromobenzoylacetonitrile (500 mg) in ethanol (5 mL) and acetic acid (300 muL) was heated with sodium cyanoborohydride (280 mg) using an 80 C. hot plate for 2 hours. After cooling to ambient temperature, the mixture was diluted with water and concentrated to a syrup, which was diluted with ethyl acetate and washed with water, sat. NaHCO3, and brine. The extract was dried with mgSO4, filtered, and evaporated to provide 510 mg of a cloudy oil, which was filtered through silica gel using 1:1 ethyl acetate/hexane to provide the product (496 mg) as a thick oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ProLynx LLC; Santi, Daniel V.; Ashley, Gary W.; (80 pag.)US9387254; (2016); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 4592-94-3, The chemical industry reduces the impact on the environment during synthesis 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, I believe this compound will play a more active role in future production and life.

To a mixture of 3-(4-bromophenyl)-3-oxo-propanenitrile (7.00 g, 31.2 mmol) and nickel chloride hexahydrate (18.6 g, 78.1 mmol) in anhydrous tetrahydrofuran (150 mL)was added sodium borohydride (5.91 g, 156 mmol) portion-wise at 0 C under a nitrogen. The mixture was warmed to rt and stirred for 2 hours. On completion, ammonium chloride (10 mL) was added to the reaction and the mixture was extracted with EtOAc (3 X 100 mL). The organic layer was dried over anhydrous sodium sulfate, and filtered. The residue was concentrated in vacuo to give the title compound. LCMS: (ESj m/z (M+H) = 230.0, tR= 1.069.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Bromophenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; (163 pag.)WO2017/156179; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, A new synthetic method of this compound is introduced below., Quality Control of 3-(4-Bromophenyl)-3-oxopropanenitrile

To a cooled (0C) and stirred solution of 3-(4-bromophenyl)-3-oxopropanenitrile (Example 230, 4.00 g, 17.85 mmol) in THF (20 mL) was added sodium hydride (60% in oil dispersion, 857 mg, 21.4 mmol). After gas evolution ceased, the mixture was warmed to rt, and isatoic anhydride (3.49 g, 17.85 mmol) was added. The reaction was heated to reflux for 16 h and then cooled to rt. The reaction was quenched and adjusted to pH 5 by slow addition of hydrochloric acid (1 N aqueous solution). The resulting white solid was collected by filtration and triturated with diethyl ether/acetone (3:1) to afford 3.5 g (60%) of desired product. 1H NMR (400 MHz, DMSOd6) delta 12.73 (br s, 1 H), 8.13 (dd, 1 H), 7.70-7.87 (m, 6 H), 7.49 (dddd, 1 H); ES-MS m/z 326.8 [M+H]+, HPLC RT (min) 2.95

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/34491; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 4592-94-3, These common heterocyclic compound, 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the 1 mol eq. of 3-aryl-3-oxopropanonitrile (2) was added1 mol eq. of hydrazine hydrate (1) in Toluene/EtOH (9:1) and thereaction mixture was refluxed for 30 min then another 1 mol eq. ofdifferent 3-aryl-3-oxopropanonitrile (2) and catalytic amount ofPTSA (0.01 mol eq.) was added. Again reaction mixture wasrefluxed up to 4 h. On completion of the reaction, excess solvent was distilled off. The solid so obtained was filtered and washedwith cold ethanol. Solid was neutralised with aq. sodium bicarbonatesolution and again filtered. Compound thus obtained wasair dried and recrystallized from ethanol.

The synthetic route of 4592-94-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Aggarwal, Ranjana; Singh, Gulshan; Kaushik, Pawan; Kaushik, Dhirender; Paliwal, Deepika; Kumar, Ajay; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 326 – 333;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

These common heterocyclic compound, 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 4592-94-3

General procedure: To a stirred solution of 3-oxo-3-aryl-propionitriles 2 and Et3N (0.101 g, 1 mmol) inCH3OH:H2O (2:1, 6 mL) was added adducts of ninhydrin and malononitrile 9 (0.208 g, 1 mmol)at room temperature. After completion of the reaction [about 30-120 min, TLC (n-hexan/EtOAc,2:1) monitoring], the solvent was evaporated under vacuum and the crude product wascrystallized from CH2Cl2/n-hexan.

The synthetic route of 3-(4-Bromophenyl)-3-oxopropanenitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yavari, Issa; Khajeh-Khezri, Aliyeh; Bahemmat, Samira; Halvagar, Mohammad Reza; Synlett; vol. 28; 14; (2017); p. 1785 – 1788;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 4592-94-3, These common heterocyclic compound, 4592-94-3, name is 3-(4-Bromophenyl)-3-oxopropanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a stirred solution of 3-oxo-3-aryl-propionitriles 2 and Et3N (0.101 g, 1 mmol) inCH3OH:H2O (2:1, 6 mL) was added adducts of acenaphthoquinone and malononitrile or ethylcycnoacetate 1 (1 mmol) at room temperature. After completion of the reaction [about 30-120min, TLC (n-hexan/EtOAc, 2:1) monitoring], the solvent was evaporated under vacuum and thecrude product was purified by flash column chromatography on silica gel using EtOAc/n-hexane(1:2) as eluent (for compound 3a-d) and or was washed by methanol (for compounds 3e-h) toafford the pure product 3.

Statistics shows that 3-(4-Bromophenyl)-3-oxopropanenitrile is playing an increasingly important role. we look forward to future research findings about 4592-94-3.

Reference:
Article; Yavari, Issa; Khajeh-Khezri, Aliyeh; Bahemmat, Samira; Halvagar, Mohammad Reza; Synlett; vol. 28; 14; (2017); p. 1785 – 1788;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts