Category: 5098-14-6

On June 14, 2012, Shi, Ce; Xiong, Zhengming; Chittepu, Padmaja; Aldrich, Courtney C.; Ohlfest, John R.; Ferguson, David M. published an article.Computed Properties of 5098-14-6 The title of the article was Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction. And the article contained the following:

Toll-like receptors (TLRs) are key targets in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments. The imidazoquinolines, imiquimod and resiquimod, have been shown to activate TLR-7 and -8, which in turn induce cytokine production as part of the innate immune response. Herein, we report the synthesis and discovery of a C7-methoxycarbonyl derivative of imiquimod (5, I) that stimulates cytokine production but is devoid of TLR-7/8 activity. Data are presented that shows that this analog not only induces IL-12p40 and TNF production, similar to that of imiquimod and resiquimod, but greatly enhances the production of IL-1β, a key cytokine involved in the activation of CD4 T cells. It is further demonstrated that TLR-7/8 activation can be recovered by the addition of a C2-alkyl substituent to this newly discovered analog. The results support the existence of an alternative mechanism of action by which imidazoquinolines can stimulate cytokine production The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6

The Article related to imidazoquinoline preparation toll like receptor cytokine sar, Pharmacology: Structure-Activity and other aspects.Computed Properties of 5098-14-6

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On February 24, 2021, Cheng, Qiuli; Asha, Anika Benozir; Liu, Yang; Peng, Yi-Yang; Diaz-Dussan, Diana; Shi, Zuosen; Cui, Zhanchen; Narain, Ravin published an article.Product Details of 5098-14-6 The title of the article was Antifouling and Antibacterial Polymer-Coated Surfaces Based on the Combined Effect of Zwitterions and the Natural Borneol. And the article contained the following:

The development and application of natural antibacterial materials have always been the focus of biomedical research. Borneol as a natural antibacterial compound has received extensive attention. However, the hydrophobicity caused by its unique structure limits its application range to a certain extent. In this study, we combine zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) with a complex bicyclic monoterpene structure borneol compound and prepare an excellent antifouling and antibacterial surface via the Schiff-base bond. The prepared coating has excellent hydrophilicity verified by the contact angle (CA), and its polymer layer is confirmed by XPS. The zwitterion MPC and borneol moieties in the copolymer play a coordinating role, relying on super hydration and the special stereochem. structure to prevent protein adsorption and inhibit bacterial adhesion, resp., which are demonstrated by bovine serum albumin (BSA) adsorption and antibacterial activity test. Moreover, the water-soluble borneol derivative as the antibacterial surfaces we designed here was biocompatible toward MRC-5 (lung fibroblasts), as showed by in vitro cytotoxicity assays. Such results indicate the potential application of the as-prepared hydrophilic surfaces in the biomedical materials. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Product Details of 5098-14-6

The Article related to antifouling antibacterial polymer surface coating zwitterion borneol biocompatibility, antibacterial, antifouling, biocompatibility, hydrophilic, zwitterion, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Product Details of 5098-14-6

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Bizzarri, Bruno Mattia; Fanelli, Angelica; Botta, Lorenzo; De Angelis, Marta; Palamara, Anna Teresa; Nencioni, Lucia; Saladino, Raffaele published an article in 2021, the title of the article was Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chem. of aminomalononitrile as a tool for generating high chem. diversity. These compounds were used as annulation synthons for the preparation of 8,9-disubstituted-6,9-dihydro-1H-purin-6-ones by reaction with formic acid as a simple C-1 donor reagent. The novel heterocycles were characterized by significant activity against influenza A virus, amino imidazole carbonitrile derivatives showing the highest activity. Thus, the chem. complexity generated by prebiotic chem. furnished a general tool for the identification of novel antiviral agents. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to imidazole purine derivative aminomalononitrile prebiotic chem antiinfluenza virus activity, Placeholder for records without volume info and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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Cox, Oakley B.; Krojer, Tobias; Collins, Patrick; Monteiro, Octovia; Talon, Romain; Bradley, Anthony; Fedorov, Oleg; Amin, Jahangir; Marsden, Brian D.; Spencer, John; von Delft, Frank; Brennan, Paul E. published an article in 2016, the title of the article was A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Research into the chem. biol. of bromodomains has been driven by the development of acetyl-lysine mimetics. The ligands are typically anchored by binding to a highly conserved asparagine residue. Atypical bromodomains, for which the asparagine is mutated, have thus far proven elusive targets, including PHIP(2) whose parent protein, PHIP, has been linked to disease progression in diabetes and cancers. The PHIP(2) binding site contains a threonine in place of asparagine, and solution screening have yielded no convincing hits. We have overcome this hurdle by combining the sensitivity of X-ray crystallog., used as the primary fragment screen, with a strategy for rapid follow-up synthesis using a chem.-poised fragment library, which allows hits to be readily modified by parallel chem. both peripherally and in the core. Our approach yielded the first reported hit compounds of PHIP(2) with measurable IC50 values by an AlphaScreen competition assay. The follow-up libraries of four poised fragment hits improved potency into the sub-mM range while showing good ligand efficiency and detailed structural data. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to poised fragment library phip inhibitor bromodomain crystal structure, Placeholder for records without volume info and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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On June 30, 2001, Steiner, Thomas published an article.Related Products of 5098-14-6 The title of the article was The C-H…O hydrogen bond in (dicyanomethyl)ammonium p-toluenesulfonate. And the article contained the following:

In the title compound, C3H4N3+·C7H7O3S-, the activated C-H group of the cation forms a short but bent C-H…O H bond with a sulfonate O atom of the anion; C…O = 3.075(5) Å and C-H…O = 130°. Crystallog. data are given. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to mol structure cyanomethylammonium toluenesulfonate, hydrogen bonding cyanomethylammonium toluenesulfonate, Crystallography and Liquid Crystals: Crystal Structure and other aspects.Related Products of 5098-14-6

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On July 30, 2019, Toh, Rou Jun; Evans, Richard; Thissen, Helmut; Voelcker, Nicolas H.; d’Ischia, Marco; Ball, Vincent published an article.Category: nitriles-buliding-blocks The title of the article was Deposition of Aminomalononitrile-Based Films: Kinetics, Chemistry, and Morphology. And the article contained the following:

In the last few years, the development of versatile coating chemistries has become a hot topic in surface science after the discovery that catecholamines can lead to conformal coatings upon oxidation from aqueous solutions Recently, it was found that aminomalononitrile (AMN), a mol. implicated in the appearance of life on earth, is an excellent prototype of novel material-independent surface functionalizing agents leading to conformal and biocompatible coatings in a simple and direct chem. process from aqueous solutions So far, very little insight has been gained regarding the mechanisms underlying coating deposition. In this paper, we show that the chem. evolution of AMN film deposition under slightly basic conditions is different in solution and on silica. Thereon, the coating proceeds via a nucleation process followed by further deposition of islands which evolve to produce nitrogen-rich superhydrophilic fibrillar structures. Addnl., we show that AMN-based material can form films at the air-solution interface from unshaken solutions These results open new vistas into the chem. of HCN-derived species of potential relevance in materials science. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to aminomalononitrile film surface structure, Surface Chemistry and Colloids: Solid-Liquid Systems and other aspects.Category: nitriles-buliding-blocks

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On January 31, 1993, Yu, Euy Kyung; Ryu, Seoung Ryuall published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Studies on the synthesis of the 2-desamino and 2-desamino-2-methyl analogs of aminopterin intermediate at pteridine-C7 side chain. And the article contained the following:

Title aminopterin intermediates I (R = H, Me, NH2) were prepared from pyrazine II. Thus, dithiobisbenzoate III was reduced by NaBH4 and then treated with II to give pyrazine IV. The cyclization of IV with RC(:NH)NH2.HCl (R = H, Me, NH2) in the presence of NaOEt followed by basic hydrolysis gave I (R = H, Me, NH2). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminopterin intermediate pteridine c side chain, desamino analog aminopterin intermediate, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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Thanassi, John W. published an article in 1975, the title of the article was Reactions of aminomalononitrile with electrophiles.Related Products of 5098-14-6 And the article contains the following content:

Aminomalononitrile reacted with electrophiles, aldehydes and CH2:CHCN, under very mild conditions of temperature and pH to produce intermediates which, after acid hydrolysis, yielded amino acids, glycine, DL-erythro- and DL-threo-β-hydroxyaspartic acids, DL-glutamic acid, DL-threonine and allothreonine. The mechanism of their formation and the possible significance of these reactions in prebiotic syntheses are discussed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Related Products of 5098-14-6

The Article related to aminomalononitrile electrophile reaction, aldehyde aminomalononitrile reaction, acrylonitrile aminomalononitrile reaction, amino acid biogenetic model, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Related Products of 5098-14-6

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On October 31, 1980, Taylor, Edward C.; Sun, Jung Hui published an article.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A new synthesis of aminomalononitrile tosylate. And the article contained the following:

The title salt (I) was prepared from NaCH(CN)2. Thus, 2,4,6-Me3C6H2SO2ONH2 was added to NaCH(CN)2 in THF, the mixture stirred under N2 2.5 h at 0°, the 2,4,6-Me3C6H2SO3Na formed was separated, 4-MeC6H4SO3H added, and the mixture refrigerated overnight to give I. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminomalononitrile tosylate, malononitrile amino tosylate, Aliphatic Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

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Boche, Gernot; Mendiola, Javier; Rincon, Juan A.; Mateos, Carlos; Soriano, Jose Francisco; de Frutos, Oscar published an article in 2011, the title of the article was O-(mesitylsulfonyl)hydroxylamine.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Synthesis, properties and applications of O-(mesitylsulfonyl)hydroxylamine as a reagent for electrophilic aminations, and for transfer of NH2 to electrophiles were reviewed. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to review mesitylsulfonyl hydroxylamine preparation amination amino group transfer, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Reviews and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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